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Entry version 116 (10 Feb 2021)
Sequence version 1 (01 May 2000)
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Protein

Pseudouridine-metabolizing bifunctional protein C1861.05

Gene

SPBC1861.05

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional enzyme that catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP), and the reversible cleavage of pseudouridine 5'-phosphate to ribose 5-phosphate and uracil. Is involved in a pseudouridine degradation pathway.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei61Proton donor; for PsiMP glycosidase activityBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei123SubstrateBy similarity1
Binding sitei143Substrate; via amide nitrogenBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi175ManganeseBy similarity1
Active sitei196Nucleophile; for PsiMP glycosidase activityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase, Kinase, Lyase, Transferase
LigandATP-binding, Manganese, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pseudouridine-metabolizing bifunctional protein C1861.05
Including the following 2 domains:
Pseudouridine-5'-phosphate glycosidaseBy similarity (EC:4.2.1.70By similarity)
Short name:
PsiMP glycosidaseBy similarity
Pseudouridine kinaseBy similarity (EC:2.7.1.83By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:SPBC1861.05
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPBC1861.05

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPBC1861.05

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003621591 – 747Pseudouridine-metabolizing bifunctional protein C1861.05Add BLAST747

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9USY1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9USY1

PRoteomics IDEntifications database

More...
PRIDEi
Q9USY1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
276314, 46 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC1861.05.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9USY1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 379Pseudouridine-5'-phosphate glycosidaseAdd BLAST379
Regioni177 – 179Substrate bindingBy similarity3
Regioni380 – 747Pseudouridine kinaseAdd BLAST368

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the pseudouridine-5'-phosphate glycosidase family.Curated
In the C-terminal section; belongs to the carbohydrate kinase PfkB family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3009, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012201_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9USY1

Identification of Orthologs from Complete Genome Data

More...
OMAi
YTHGFPY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9USY1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1790.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01876, PsiMP_glycosidase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002173, Carboh/pur_kinase_PfkB_CS
IPR022830, Indigdn_synthA-like
IPR011611, PfkB_dom
IPR007342, PsuG
IPR029056, Ribokinase-like

The PANTHER Classification System

More...
PANTHERi
PTHR42909, PTHR42909, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04227, Indigoidine_A, 1 hit
PF00294, PfkB, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF110581, SSF110581, 1 hit
SSF53613, SSF53613, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00583, PFKB_KINASES_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9USY1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLIVMNRGCR LVSRIPLGFR RLKRNPNPGL RNILCRRYSP LALSKEVTEA
60 70 80 90 100
LKNNVPVVAL ESTIITHGMP YPQNEELAIQ VESKVRSMGA VPATIALLNG
110 120 130 140 150
QCTIGLEQFQ LSELAKSGET AYKVSRRDLS YVASQRLNGG TTVAATMILA
160 170 180 190 200
RAAGIDVFAT GGIGGVHRGA ENSMDISADL IELGRTRVAV VSAGVKSILD
210 220 230 240 250
IGRTLEVLET QGVPVVTLGP PKSAFPAFFS RESKFQSPLS LETPQLIANM
260 270 280 290 300
LFSNIQLGQE CGTLVAIPTP HHCSIDYEKM EALIETCLQR SVQLGITGKN
310 320 330 340 350
VTPWLLGELL RESKGKSLNT NIDLVLNNAE KASLIAKELA VLKEKSSFFP
360 370 380 390 400
TNTGNTFETK PVKQDFFYGK VSDKGVSSSK KKITETTSKP AEVVCVGSVS
410 420 430 440 450
IDSVLKLDNP LTSKFLGTSH PCHSEQAFGG VAHNMALASS LMGASTKLVS
460 470 480 490 500
CVGTKSVPTS SIKEYLTKSS LQHTIVEKSN FTSCSYTAIN DCNGNLLLAG
510 520 530 540 550
ADMAIMENLS YSEIKDDLND AKYICFDGNI SPSLMLDITT SKSSKQRVVF
560 570 580 590 600
EPTSGPKTLK ILKVLSVASI DFITPNKFEL DVLFQAMKDG NFFENESWWQ
610 620 630 640 650
KLNSFGITSS FYNEIERFTK STGIEEITEN GILQKCFHLL PFIKNIIVKL
660 670 680 690 700
GPNGALLISS EKLQGVNSNS ASLFTPGNVT VKYYPVPKVI ATPVNASGTG
710 720 730 740
DTFIGTFTAL LSKGWGMDDA IDTAQKAAGL TLQCNFSVNP EIKTLLK
Length:747
Mass (Da):80,759
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6AD61E36FE7D9420
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB52741.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T39744

NCBI Reference Sequences

More...
RefSeqi
NP_596722.1, NM_001022647.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC1861.05.1; SPBC1861.05.1:pep; SPBC1861.05

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2539763

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC1861.05

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB52741.1
PIRiT39744
RefSeqiNP_596722.1, NM_001022647.2

3D structure databases

SMRiQ9USY1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi276314, 46 interactors
STRINGi4896.SPBC1861.05.1

Proteomic databases

MaxQBiQ9USY1
PaxDbiQ9USY1
PRIDEiQ9USY1

Genome annotation databases

EnsemblFungiiSPBC1861.05.1; SPBC1861.05.1:pep; SPBC1861.05
GeneIDi2539763
KEGGispo:SPBC1861.05

Organism-specific databases

PomBaseiSPBC1861.05
VEuPathDBiFungiDB:SPBC1861.05

Phylogenomic databases

eggNOGiKOG3009, Eukaryota
HOGENOMiCLU_012201_3_0_1
InParanoidiQ9USY1
OMAiYTHGFPY
PhylomeDBiQ9USY1

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9USY1

Family and domain databases

Gene3Di3.40.1790.10, 1 hit
HAMAPiMF_01876, PsiMP_glycosidase, 1 hit
InterProiView protein in InterPro
IPR002173, Carboh/pur_kinase_PfkB_CS
IPR022830, Indigdn_synthA-like
IPR011611, PfkB_dom
IPR007342, PsuG
IPR029056, Ribokinase-like
PANTHERiPTHR42909, PTHR42909, 1 hit
PfamiView protein in Pfam
PF04227, Indigoidine_A, 1 hit
PF00294, PfkB, 2 hits
SUPFAMiSSF110581, SSF110581, 1 hit
SSF53613, SSF53613, 1 hit
PROSITEiView protein in PROSITE
PS00583, PFKB_KINASES_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYOW5_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9USY1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 1, 2000
Last modified: February 10, 2021
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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