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UniProtKB - Q9USV1 (SFR1_SCHPO)
Protein
Swi5-dependent recombination DNA repair protein 1
Gene
sfr1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Involved in DNA recombination repair and meiotic chromosome segregation.
2 PublicationsGO - Molecular functioni
- ATPase activator activity Source: PomBase
- double-stranded DNA binding Source: PomBase
- single-stranded DNA binding Source: PomBase
GO - Biological processi
- chromosome segregation Source: UniProtKB-KW
- DNA recombinase assembly Source: PomBase
- DNA recombination Source: GO_Central
- double-strand break repair involved in meiotic recombination Source: PomBase
- double-strand break repair via homologous recombination Source: PomBase
- meiotic DNA recombinase assembly involved in reciprocal meiotic recombination Source: PomBase
- meiotic joint molecule formation Source: PomBase
- meiotic strand invasion Source: PomBase
- mitotic intra-S DNA damage checkpoint signaling Source: PomBase
- negative regulation of DNA recombinase disassembly Source: PomBase
- reciprocal meiotic recombination Source: PomBase
- strand invasion Source: PomBase
Keywordsi
Biological process | Chromosome partition, DNA damage, DNA repair, Meiosis |
Names & Taxonomyi
Protein namesi | Recommended name: Swi5-dependent recombination DNA repair protein 1Alternative name(s): DNA repair protein dds20 Meiotically up-regulated gene 13 protein |
Gene namesi | Name:sfr1 Synonyms:dds20, mug13 ORF Names:SPBC28F2.07 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBC28F2.07, sfr1 |
VEuPathDBi | FungiDB:SPBC28F2.07 |
Subcellular locationi
Cytosol
- cytosol Source: PomBase
Nucleus
- nucleus Source: PomBase
- Swi5-Sfr1 complex Source: PomBase
Other locations
- site of double-strand break Source: PomBase
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097710 | 1 – 299 | Swi5-dependent recombination DNA repair protein 1Add BLAST | 299 |
Proteomic databases
MaxQBi | Q9USV1 |
PaxDbi | Q9USV1 |
PTM databases
iPTMneti | Q9USV1 |
Interactioni
Subunit structurei
Interacts with swi5 and rhp51.
1 PublicationBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 277110, 29 interactors |
DIPi | DIP-29234N |
IntActi | Q9USV1, 74 interactors |
STRINGi | 4896.SPBC28F2.07.1 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q9USV1 |
SMRi | Q9USV1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 52 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 132 – 152 | DisorderedSequence analysisAdd BLAST | 21 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 177 – 236 | Sequence analysisAdd BLAST | 60 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 21 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 28 – 52 | Polar residuesSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the SFR1/MEI5 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502SAMI, Eukaryota |
HOGENOMi | CLU_082817_0_0_1 |
InParanoidi | Q9USV1 |
OMAi | YAEYSID |
PhylomeDBi | Q9USV1 |
Family and domain databases
IDEALi | IID50104 |
InterProi | View protein in InterPro IPR018468, SFR1/Mei5 |
Pfami | View protein in Pfam PF10376, Mei5, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9USV1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQTINSELN ENATSQCKED LKVSLSESDL RDSQGQLGIE NPPKCNNSGN
60 70 80 90 100
HSDNLGFIEQ SETVHPENEK ALTPDLRDTK IHTSLPITTP FSKKRAREAK
110 120 130 140 150
NILLKPFKSP LRQTASPQVA DTNLKPSLAV TNLNSDETNT SSEPVTSPLR
160 170 180 190 200
TTPNSIKRQK RLFKSPISNC LNPKSDPEIT QLLSRRLKLE KEVRNLQEQL
210 220 230 240 250
ITAETARKVE AKNEDKDLQT LIQKWKNAAQ QAAEVLFKPM AERIRLAGGV
260 270 280 290
TQSFRIEEGE NKGQIQEVRT EFTMSMFLNQ FGVPVHLMSF DEENGDWKS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | Q → H in BAA12180 (Ref. 3) Curated | 1 | |
Sequence conflicti | 80 | K → Q in BAA12180 (Ref. 3) Curated | 1 | |
Sequence conflicti | 172 | N → T in BAA12180 (Ref. 3) Curated | 1 | |
Sequence conflicti | 209 – 214 | VEAKNE → GGTKNG (Ref. 3) Curated | 6 | |
Sequence conflicti | 216 – 299 | Missing (Ref. 3) CuratedAdd BLAST | 84 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB089500 Genomic DNA Translation: BAC77073.1 AY275538 mRNA Translation: AAQ19997.1 D83992 Genomic DNA Translation: BAA12180.1 CU329671 Genomic DNA Translation: CAB57936.1 |
PIRi | T40050 |
RefSeqi | NP_595668.1, NM_001021563.2 |
Genome annotation databases
EnsemblFungii | SPBC28F2.07.1; SPBC28F2.07.1:pep; SPBC28F2.07 |
GeneIDi | 2540584 |
KEGGi | spo:SPBC28F2.07 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB089500 Genomic DNA Translation: BAC77073.1 AY275538 mRNA Translation: AAQ19997.1 D83992 Genomic DNA Translation: BAA12180.1 CU329671 Genomic DNA Translation: CAB57936.1 |
PIRi | T40050 |
RefSeqi | NP_595668.1, NM_001021563.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3VIQ | X-ray | 2.20 | A/C | 181-299 | [»] | |
AlphaFoldDBi | Q9USV1 | |||||
SMRi | Q9USV1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 277110, 29 interactors |
DIPi | DIP-29234N |
IntActi | Q9USV1, 74 interactors |
STRINGi | 4896.SPBC28F2.07.1 |
PTM databases
iPTMneti | Q9USV1 |
Proteomic databases
MaxQBi | Q9USV1 |
PaxDbi | Q9USV1 |
Genome annotation databases
EnsemblFungii | SPBC28F2.07.1; SPBC28F2.07.1:pep; SPBC28F2.07 |
GeneIDi | 2540584 |
KEGGi | spo:SPBC28F2.07 |
Organism-specific databases
PomBasei | SPBC28F2.07, sfr1 |
VEuPathDBi | FungiDB:SPBC28F2.07 |
Phylogenomic databases
eggNOGi | ENOG502SAMI, Eukaryota |
HOGENOMi | CLU_082817_0_0_1 |
InParanoidi | Q9USV1 |
OMAi | YAEYSID |
PhylomeDBi | Q9USV1 |
Miscellaneous databases
PROi | PR:Q9USV1 |
Family and domain databases
IDEALi | IID50104 |
InterProi | View protein in InterPro IPR018468, SFR1/Mei5 |
Pfami | View protein in Pfam PF10376, Mei5, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SFR1_SCHPO | |
Accessioni | Q9USV1Primary (citable) accession number: Q9USV1 Secondary accession number(s): P78932 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 27, 2002 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families