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UniProtKB - Q9USR3 (STT4_SCHPO)
Protein
Phosphatidylinositol 4-kinase stt4
Gene
stt4
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate.
By similarityCatalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H+EC:2.7.1.67
GO - Molecular functioni
- 1-phosphatidylinositol 4-kinase activity Source: PomBase
- ATP binding Source: UniProtKB-KW
- phosphatidylinositol kinase activity Source: GO_Central
GO - Biological processi
- phosphatidylethanolamine biosynthetic process Source: PomBase
- phosphatidylinositol-mediated signaling Source: PomBase
- phosphatidylinositol phosphate biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SPO-1483248, Synthesis of PIPs at the ER membrane R-SPO-1660514, Synthesis of PIPs at the Golgi membrane |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol 4-kinase stt4 (EC:2.7.1.67)Short name: PI4-kinase Short name: PtdIns-4-kinase |
Gene namesi | Name:stt4 ORF Names:SPBC577.06c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBC577.06c, stt4 |
VEuPathDBi | FungiDB:SPBC577.06c |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: PomBase
Mitochondrion
- mitochondrion Source: PomBase
Plasma Membrane
- plasma membrane Source: PomBase
Other locations
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000314092 | 1 – 1877 | Phosphatidylinositol 4-kinase stt4Add BLAST | 1877 |
Proteomic databases
MaxQBi | Q9USR3 |
PaxDbi | Q9USR3 |
PRIDEi | Q9USR3 |
PTM databases
iPTMneti | Q9USR3 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 277400, 11 interactors |
STRINGi | 4896.SPBC577.06c.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1305 – 1491 | PIK helicalPROSITE-ProRule annotationAdd BLAST | 187 | |
Domaini | 1593 – 1861 | PI3K/PI4K catalyticPROSITE-ProRule annotationAdd BLAST | 269 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1492 – 1625 | Pleckstrin homology (PH) domain conferring phosphoinositide binding specificityBy similarityAdd BLAST | 134 | |
Regioni | 1599 – 1605 | G-loopPROSITE-ProRule annotation | 7 | |
Regioni | 1728 – 1736 | Catalytic loopPROSITE-ProRule annotation | 9 | |
Regioni | 1747 – 1771 | Activation loopPROSITE-ProRule annotationAdd BLAST | 25 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0902, Eukaryota |
HOGENOMi | CLU_000893_3_0_1 |
InParanoidi | Q9USR3 |
OMAi | HENPRME |
PhylomeDBi | Q9USR3 |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit 1.25.40.70, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR001263, PI3K_accessory_dom IPR042236, PI3K_accessory_sf IPR045495, PI4K_N IPR015433, PI_Kinase |
PANTHERi | PTHR10048, PTHR10048, 1 hit |
Pfami | View protein in Pfam PF00454, PI3_PI4_kinase, 1 hit PF00613, PI3Ka, 1 hit PF19274, PI4K_N, 1 hit |
SMARTi | View protein in SMART SM00145, PI3Ka, 1 hit SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit PS51545, PIK_HELICAL, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9USR3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDCIDKSIRR ESLRKLGCLP DHGWNLFVQS SNRYSKLLEA DSKLFKAQRI
60 70 80 90 100
EDTVLSICEV TLENKASENA LTLFQQLRFY LLNYLFLEDT SEYKSVLCSL
110 120 130 140 150
DESVYPNLLP LTANICPCIL KALLALVRQH RELSSDIVKF LNSIFLALTR
160 170 180 190 200
ILNTPHSSNN NPTHTKTTIF EKVFYASHLG FFFEEIADAC ISALPQDACL
210 220 230 240 250
WAMEVCNTIL VSDLPCKLID LHNDSFLHHS NYYAGFGLSY YLYLSSMKAY
260 270 280 290 300
INSSGCLWYE DATSFWDIVK HRPSSPEEKP FLTQFQSILN LSDKFLSKTG
310 320 330 340 350
TLRLQEKLGT SCNLFFVLVL KLALLSSSYI GFVPYTYSDW INVLLGSISE
360 370 380 390 400
DPELLPHLIE LMASLACVFP THFQFAMKRL RLIAIYAPRF DDGNVTYAQL
410 420 430 440 450
ASRKLAQLFN YSSRDTAITS IYQFANLLSP ADTPDSYLAA PKERLSISDN
460 470 480 490 500
MSSSSSQTAT VNTISNYLNV IDSVREIALT VNDEKIYGLA ISLLIQKFSR
510 520 530 540 550
KFDSRVSTEL VRTLADISTK ANDRDFSILV QFYSIQNKML VKNGDEALTI
560 570 580 590 600
AICDSRCLIA RGTESNSFKR SDLLKSLLEE IIHIGIVRDT PAPELKGYYF
610 620 630 640 650
GMSKAVQALV ECVAGTDWSS LPKEEMYPAL FRDMWFTLVI NRFRYSVDLG
660 670 680 690 700
ETLEVDLENI AKNSPLLVFE DFGSNFESNL ELNTVLRTHI EHSVISQIKS
710 720 730 740 750
ELLVRVPNID LKPLSTSEIC FLSAVLLLES LRCKSNKLSA LVEYLLDPSL
760 770 780 790 800
RDSQLPQSIR AIALYNLTSF VESLSKERRV ASSTIDEFQK LLCLCCNRVD
810 820 830 840 850
CVRQLALECM NYIMETLPHL LGIKEILFSV LELSSLLWKA RTEECTDQYV
860 870 880 890 900
PQLLYKSNKL NLSVILSDIY SCREEVLFQF NRHARSWIQN SSKAIPYQVK
910 920 930 940 950
NLLESYLADF VDFDDLEVVE LGRSLAVELG TRIVSSDRDN FVLPAFGNWT
960 970 980 990 1000
PDTSSEFMAE YTIRQRYSHV DNSILNIEGD MSTDRIDLIL NEKSKLFETH
1010 1020 1030 1040 1050
LAALKSLEDD ILQGNTVSPQ RLRNEVRKAA AHAVQEPIFQ FSVLARKIVR
1060 1070 1080 1090 1100
IPFLDFSPSS FKLGITLWNW MMNQVPSFSS FLISNIIRNW KNEIVTEKRG
1110 1120 1130 1140 1150
YFSTAKSKSP LALPMTYSPT ERASFLSYKN KVMSQMIPHL LLLQLIAGNF
1160 1170 1180 1190 1200
EGFWYGDRQT AKLIVHFMKF VLKKITSMEV NLNVLTRELH FKFVSFGLRI
1210 1220 1230 1240 1250
AENLLNSPLG SRFYNLCVDA GLCWFSGMPN WTYGADKLHV AAEISVMRSL
1260 1270 1280 1290 1300
RDKLDSFLLR YPLKVSTTLK QKLLIILLNN EMYMLYTWLT PVLHGRNVRM
1310 1320 1330 1340 1350
VEPIPDSDAA SSPITLEMLQ VAWNVSPNIV LYAPKRFQNA PLKQMALNFV
1360 1370 1380 1390 1400
IANPFTSVKH EVALEYLFEH YPSGEFPIDR KFILYWEPMY PVSGPVMFMP
1410 1420 1430 1440 1450
NVKWNPQLLQ YTMRSMESYP VSVTFFYVPQ IVQSLRYDSM GYAESFILET
1460 1470 1480 1490 1500
SGTSQLFAHQ ILWNMKANLY KDEAATVPDS IKPILDRVMD KMINSLSGED
1510 1520 1530 1540 1550
KQFYEREFTF FNEVTSISGK LKPFIRKSKP EKKAKIDEEM KKIKLDVGVY
1560 1570 1580 1590 1600
LPSNPDGVIV GIDRKSGKPL QSHAKAPFMA TFKIRKEKLV DADPEELAVN
1610 1620 1630 1640 1650
GTEEEAGDSA KKQTYEVWQS AIFKVGDDCR QDVLTLQLIA MFKNIFNSVG
1660 1670 1680 1690 1700
LDVYLFPYRV TATNPGCGVI DVLPNCISRD MLGREAVNGL YDYFRTKFGD
1710 1720 1730 1740 1750
EDSIAFQKAR SNFVQSMAAY SVITYLLQFK DRHNGNIMID DQGHILHIDF
1760 1770 1780 1790 1800
GFIFDIAPGG ITFESAPFKL TTEMIAVMGG SNKSQPFQWF QELCVKAFLA
1810 1820 1830 1840 1850
CRPYAHYICQ AVEVMLDSGL PCFKGQLTIT HCLERFALNL NERQASTFML
1860 1870
HLIEQSYANK RTLMYDQFQK ATNGIPY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAB54814.1 |
PIRi | T40550 |
RefSeqi | NP_595304.1, NM_001021211.2 |
Genome annotation databases
EnsemblFungii | SPBC577.06c.1; SPBC577.06c.1:pep; SPBC577.06c |
GeneIDi | 2540883 |
KEGGi | spo:SPBC577.06c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAB54814.1 |
PIRi | T40550 |
RefSeqi | NP_595304.1, NM_001021211.2 |
3D structure databases
SMRi | Q9USR3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 277400, 11 interactors |
STRINGi | 4896.SPBC577.06c.1 |
PTM databases
iPTMneti | Q9USR3 |
Proteomic databases
MaxQBi | Q9USR3 |
PaxDbi | Q9USR3 |
PRIDEi | Q9USR3 |
Genome annotation databases
EnsemblFungii | SPBC577.06c.1; SPBC577.06c.1:pep; SPBC577.06c |
GeneIDi | 2540883 |
KEGGi | spo:SPBC577.06c |
Organism-specific databases
PomBasei | SPBC577.06c, stt4 |
VEuPathDBi | FungiDB:SPBC577.06c |
Phylogenomic databases
eggNOGi | KOG0902, Eukaryota |
HOGENOMi | CLU_000893_3_0_1 |
InParanoidi | Q9USR3 |
OMAi | HENPRME |
PhylomeDBi | Q9USR3 |
Enzyme and pathway databases
Reactomei | R-SPO-1483248, Synthesis of PIPs at the ER membrane R-SPO-1660514, Synthesis of PIPs at the Golgi membrane |
Miscellaneous databases
PROi | PR:Q9USR3 |
Family and domain databases
Gene3Di | 1.10.1070.11, 1 hit 1.25.40.70, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR036940, PI3/4_kinase_cat_sf IPR018936, PI3/4_kinase_CS IPR001263, PI3K_accessory_dom IPR042236, PI3K_accessory_sf IPR045495, PI4K_N IPR015433, PI_Kinase |
PANTHERi | PTHR10048, PTHR10048, 1 hit |
Pfami | View protein in Pfam PF00454, PI3_PI4_kinase, 1 hit PF00613, PI3Ka, 1 hit PF19274, PI4K_N, 1 hit |
SMARTi | View protein in SMART SM00145, PI3Ka, 1 hit SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00915, PI3_4_KINASE_1, 1 hit PS00916, PI3_4_KINASE_2, 1 hit PS50290, PI3_4_KINASE_3, 1 hit PS51545, PIK_HELICAL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STT4_SCHPO | |
Accessioni | Q9USR3Primary (citable) accession number: Q9USR3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families