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Entry version 105 (08 May 2019)
Sequence version 1 (01 May 2000)
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Protein

Probable NAD-specific glutamate dehydrogenase

Gene

gdh2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NAD+-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei654By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glutamate dehydrogenase (NAD+) activity Source: PomBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNAD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable NAD-specific glutamate dehydrogenase (EC:1.4.1.2)
Short name:
NAD-GDH
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gdh2
ORF Names:SPCC132.04c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:SPCC132.04c

Schizosaccharomyces pombe database

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PomBasei
SPCC132.04c gdh2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003103531 – 1106Probable NAD-specific glutamate dehydrogenaseAdd BLAST1106

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9USN5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9USN5

PRoteomics IDEntifications database

More...
PRIDEi
Q9USN5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9USN5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
275720, 13 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPCC132.04c.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000162582

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9USN5

KEGG Orthology (KO)

More...
KOi
K15371

Identification of Orthologs from Complete Genome Data

More...
OMAi
SVDFFHF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9USN5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006096 Glu/Leu/Phe/Val_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR028971 NAD-GDH
IPR016210 NAD-GDH_euk

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05088 Bac_GDH, 1 hit
PF00208 ELFV_dehydrog, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000184 GDH_NAD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00839 ELFV_dehydrog, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9USN5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYLTKQIPHY SRIHTTQLLT VVNHRTIPFK IRGSFSNCRR YSNFATVPLL
60 70 80 90 100
ERPFKNKSKH NTARASRPFS TQKMLLTKSH PPNMYKDSVF FGYRPIVFSG
110 120 130 140 150
KQDQKSKVIQ CLRTERKTIP DDLVEDEVDR FYNKLGLDDY YFQMEPVSII
160 170 180 190 200
ADHIEIIYAA KIAAHASHAK EELNIHVKNE NEDLAIYLDS SPVTQPELDQ
210 220 230 240 250
SSAVEESIST RYLDPFKLTD PTAYRVESFT SVTNIDRTST ENSNIYTYFV
260 270 280 290 300
TKCDFVDNPK KDASPDVPTD IASVSDKTFL EKASDNTIEM YQDVMNSVLT
310 320 330 340 350
RFGPVVRLFD YQGRSEIRLV VGYRRGSIFQ YFPSLSKLFR YYGLHSTRTY
360 370 380 390 400
VEQFSNGVTI ISYNFKPELF KNAAVTSINE LFSQITREAS LLYCLPSTDF
410 420 430 440 450
QPLFVSEKLS IQEVTYAHCV RIFCEHVMNK LGPEYSSLSA ILDHSNNIHA
460 470 480 490 500
EILETIKRRL STLAFTRTKI HDTIMQYPGL VHTLFEQFYL EHAINHNSTP
510 520 530 540 550
HLHRAKSATS LADEASTYSI TPMSATALMD LIQKTCTNEE DVSVMEMFVK
560 570 580 590 600
FNTHLLKTNF FQTTKVALSF RFDPSFLDST QYKDPLYAMI MSIGNEFRGF
610 620 630 640 650
HLRFRDVARG GIRLIKSANP EAFGLNARGL FDENYNLAKT QMLKNKDIPE
660 670 680 690 700
GGAKGVILLG KDCQDKPELA FMKYIDSIID LLIVNKSQPL VDKLGKPEIL
710 720 730 740 750
FMGPDENTAD LVNWATIHAH RRNAPWWKSF FTGKKPTMGG IPHDKYGMTS
760 770 780 790 800
LSVRCYVEGI YKKLNITDPS KLTKVQTGGP DGDLGSNEIK LSNEKYIAVI
810 820 830 840 850
DGSGVLYDPA GLDRTELLRL ADERKTIDHF DAGKLSPEGY RVLVKDTNLK
860 870 880 890 900
LPNGEIVRNG TIFRNTAHLR YKADTFVPCG GRPNAININN VEQLIDDHGR
910 920 930 940 950
PAFKYLVEGA NLFITQDAKS VLEKAGVIVI RDASANKGGV TSSSLEVLAS
960 970 980 990 1000
LSFDDASFKE NMCVHDGKVP TFYADYVNEV KRIIQRNANL EFEAIWKGHS
1010 1020 1030 1040 1050
ENKIPYTSLS NHLSTEIVKL DHDIYNYEKL WADVGFRNAV LRASIPKTLQ
1060 1070 1080 1090 1100
AKIGLEKMLE RIPESYLRAI FSTYLASRFV YQHVVSSDPF AFFDYISTEM

KMLKDA
Length:1,106
Mass (Da):125,712
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AFFEAB84F1295CA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAB58131.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40931

NCBI Reference Sequences

More...
RefSeqi
NP_588149.1, NM_001023138.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPCC132.04c.1; SPCC132.04c.1:pep; SPCC132.04c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2539148

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPCC132.04c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAB58131.1
PIRiT40931
RefSeqiNP_588149.1, NM_001023138.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi275720, 13 interactors
STRINGi4896.SPCC132.04c.1

PTM databases

iPTMnetiQ9USN5

Proteomic databases

MaxQBiQ9USN5
PaxDbiQ9USN5
PRIDEiQ9USN5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC132.04c.1; SPCC132.04c.1:pep; SPCC132.04c
GeneIDi2539148
KEGGispo:SPCC132.04c

Organism-specific databases

EuPathDBiFungiDB:SPCC132.04c
PomBaseiSPCC132.04c gdh2

Phylogenomic databases

HOGENOMiHOG000162582
InParanoidiQ9USN5
KOiK15371
OMAiSVDFFHF
PhylomeDBiQ9USN5

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9USN5

Family and domain databases

InterProiView protein in InterPro
IPR006096 Glu/Leu/Phe/Val_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR028971 NAD-GDH
IPR016210 NAD-GDH_euk
PfamiView protein in Pfam
PF05088 Bac_GDH, 1 hit
PF00208 ELFV_dehydrog, 1 hit
PIRSFiPIRSF000184 GDH_NAD, 1 hit
SMARTiView protein in SMART
SM00839 ELFV_dehydrog, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGDH2_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9USN5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 1, 2000
Last modified: May 8, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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