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Protein

Shk1 kinase-binding protein 5

Gene

skb5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates catalytic function of the p21-activated kinase homolog shk1.1 Publication

GO - Molecular functioni

  • protein kinase activator activity Source: PomBase
  • protein kinase binding Source: UniProtKB

GO - Biological processi

  • intracellular signal transduction Source: PomBase

Names & Taxonomyi

Protein namesi
Recommended name:
Shk1 kinase-binding protein 5
Gene namesi
Name:skb5
ORF Names:SPCC24B10.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC24B10.13
PomBaseiSPCC24B10.13 skb5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977771 – 140Shk1 kinase-binding protein 5Add BLAST140

Post-translational modificationi

Phosphorylated in vivo. In vitro, phosphorylated by shk1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9US59
PRIDEiQ9US59

Interactioni

Subunit structurei

Interacts with N-terminal regulatory domain of shk1 via SH3 domain.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi275807, 35 interactors
STRINGi4896.SPCC24B10.13.1

Structurei

3D structure databases

ProteinModelPortaliQ9US59
SMRiQ9US59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 140SH3PROSITE-ProRule annotationCuratedAdd BLAST61

Keywords - Domaini

SH3 domain

Phylogenomic databases

InParanoidiQ9US59
OMAiYDFEPLH
OrthoDBiEOG092C550C
PhylomeDBiQ9US59

Family and domain databases

InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9US59-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEETEEDYL VVGRDYLYPP DHELHYGFHA RVIEEEEERF VDDTFDETIE
60 70 80 90 100
GSDDSESIDD TEVFYDAEES ESTHPSASFN VLADAVALYD FEPLHDNELG
110 120 130 140
FTTGQRLCIL SESSDGWLIA YDDASGRSGL VPETFVKLEV
Length:140
Mass (Da):15,857
Last modified:May 1, 2000 - v1
Checksum:i152B7D68DED80A20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192549 Genomic DNA Translation: AAF19175.1
CU329672 Genomic DNA Translation: CAB76222.1
PIRiT50420
RefSeqiNP_588016.1, NM_001023007.1

Genome annotation databases

EnsemblFungiiSPCC24B10.13.1; SPCC24B10.13.1:pep; SPCC24B10.13
GeneIDi2539237
KEGGispo:SPCC24B10.13

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192549 Genomic DNA Translation: AAF19175.1
CU329672 Genomic DNA Translation: CAB76222.1
PIRiT50420
RefSeqiNP_588016.1, NM_001023007.1

3D structure databases

ProteinModelPortaliQ9US59
SMRiQ9US59
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275807, 35 interactors
STRINGi4896.SPCC24B10.13.1

Proteomic databases

PaxDbiQ9US59
PRIDEiQ9US59

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC24B10.13.1; SPCC24B10.13.1:pep; SPCC24B10.13
GeneIDi2539237
KEGGispo:SPCC24B10.13

Organism-specific databases

EuPathDBiFungiDB:SPCC24B10.13
PomBaseiSPCC24B10.13 skb5

Phylogenomic databases

InParanoidiQ9US59
OMAiYDFEPLH
OrthoDBiEOG092C550C
PhylomeDBiQ9US59

Miscellaneous databases

PROiPR:Q9US59

Family and domain databases

InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSKB5_SCHPO
AccessioniPrimary (citable) accession number: Q9US59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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