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Protein

GPI transamidase component gaa1

Gene

gaa1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the GPI transamidase complex. Required for a terminal step of GPI anchor attachment onto proteins (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Biological processi

Keywordsi

Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayi
UPA00196

Names & Taxonomyi

Protein namesi
Recommended name:
GPI transamidase component gaa1
Gene namesi
Name:gaa1
ORF Names:SPAC1002.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1002.11
PomBaseiSPAC1002.11 gaa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 366LumenalSequence analysisAdd BLAST328
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Topological domaini388 – 403CytoplasmicSequence analysisAdd BLAST16
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Topological domaini425 – 427LumenalSequence analysis3
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 467CytoplasmicSequence analysisAdd BLAST19
Transmembranei468 – 488HelicalSequence analysisAdd BLAST21
Topological domaini489 – 500LumenalSequence analysisAdd BLAST12
Transmembranei501 – 521HelicalSequence analysisAdd BLAST21
Topological domaini522 – 548CytoplasmicSequence analysisAdd BLAST27
Transmembranei549 – 569HelicalSequence analysisAdd BLAST21
Topological domaini570 – 581LumenalSequence analysisAdd BLAST12

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003165981 – 581GPI transamidase component gaa1Add BLAST581

Proteomic databases

PaxDbiQ9US48
PRIDEiQ9US48

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAC1002.11.1

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi577 – 581Prevents secretion from ERSequence analysis5

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ9US48
KOiK05289
OMAiAYHTSLD
OrthoDBiEOG092C1A6N
PhylomeDBiQ9US48

Family and domain databases

InterProiView protein in InterPro
IPR007246 Gaa1
PANTHERiPTHR13304 PTHR13304, 1 hit
PfamiView protein in Pfam
PF04114 Gaa1, 1 hit
PIRSFiPIRSF036762 GAA1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9US48-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLFTFVQIR VFPFLQRHLF FLQLSLTLIG LSWIFILPRN EIIDRLHVSE
60 70 80 90 100
SALLPGQVNT YFENRYSKTV SSSLTAANTW SHLDASVGTN TMYDDLEQIF
110 120 130 140 150
TAMGLPTQKQ NYSINIPGSE FNGSNFITTL RAPRGDATES LLLCVPWKDH
160 170 180 190 200
IGQYNEAGVA LAISLLKYFQ GWSLWSKDII LVIFDDPVYG PSSFLTSYFD
210 220 230 240 250
QTTPYISYTP LKIRSGSIQA GLSLELVTTE NNSDVLEVLY QATNGQLPNL
260 270 280 290 300
DLFNTISRIF MQHFNYPLRL QGYDFHANSG SSYTSRLKSL WMGMLTQAVS
310 320 330 340 350
NVTSAHALFP QYRIDMLTLR MKVKDPFSFD MFRFGQAIES TFRSLNNLLE
360 370 380 390 400
HLHQSFFFYF ILDHLHFISI GNYMPSILIL AASFMLGAYR HWINHEKKID
410 420 430 440 450
LWRPFSFWLF SIFCTIAAYY LVSSSTKITV FIFLYLMLTF IGIIFSTFMT
460 470 480 490 500
SEDAELVLSY DLMSKSLFIS VVSTLNFSLS FVVAILLVPL QFISFRFNRR
510 520 530 540 550
LSLLFAVLTY FSTFIFLCSL SKILNGPLVP FWLWAKEYEL FNSWLMPSVF
560 570 580
MILVLPEIIF SVTSFFSLWN EPSVKTKTKT L
Length:581
Mass (Da):66,877
Last modified:May 1, 2000 - v1
Checksum:i8B2BE07F2D605047
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB65611.1
RefSeqiNP_593498.1, NM_001018932.2

Genome annotation databases

EnsemblFungiiSPAC1002.11.1; SPAC1002.11.1:pep; SPAC1002.11
GeneIDi2543268
KEGGispo:SPAC1002.11

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB65611.1
RefSeqiNP_593498.1, NM_001018932.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4896.SPAC1002.11.1

Proteomic databases

PaxDbiQ9US48
PRIDEiQ9US48

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1002.11.1; SPAC1002.11.1:pep; SPAC1002.11
GeneIDi2543268
KEGGispo:SPAC1002.11

Organism-specific databases

EuPathDBiFungiDB:SPAC1002.11
PomBaseiSPAC1002.11 gaa1

Phylogenomic databases

InParanoidiQ9US48
KOiK05289
OMAiAYHTSLD
OrthoDBiEOG092C1A6N
PhylomeDBiQ9US48

Enzyme and pathway databases

UniPathwayi
UPA00196

Miscellaneous databases

PROiPR:Q9US48

Family and domain databases

InterProiView protein in InterPro
IPR007246 Gaa1
PANTHERiPTHR13304 PTHR13304, 1 hit
PfamiView protein in Pfam
PF04114 Gaa1, 1 hit
PIRSFiPIRSF036762 GAA1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGAA1_SCHPO
AccessioniPrimary (citable) accession number: Q9US48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2000
Last modified: February 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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