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Protein

Putative uracil phosphoribosyltransferase urg2

Gene

urg2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.Curated

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.By similarity

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.By similarity

Activity regulationi

Allosterically activated by GTP.Curated

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uracil.
Proteins known to be involved in this subpathway in this organism are:
  1. Uracil phosphoribosyltransferase 1 (SPAC1B3.01c), Uracil phosphoribosyltransferase 2 (SPAC1399.04c), Putative uracil phosphoribosyltransferase urg2 (urg2)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uracil, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei755-phospho-alpha-D-ribose 1-diphosphateBy similarity1
Binding sitei1005-phospho-alpha-D-ribose 1-diphosphateBy similarity1
Binding sitei187Ribose-5-phosphateBy similarity1
Binding sitei188Uracil; via amide nitrogenBy similarity1
Binding sitei1945-phospho-alpha-D-ribose 1-diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Glycosyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00574;UER00636

Names & Taxonomyi

Protein namesi
Recommended name:
Putative uracil phosphoribosyltransferase urg2 (EC:2.4.2.9)
Short name:
UPRTase urg2
Alternative name(s):
UMP pyrophosphorylase urg2
Gene namesi
Name:urg2Imported
ORF Names:SPAC1002.17c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1002.17c
PomBaseiSPAC1002.17c urg2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003095581 – 204Putative uracil phosphoribosyltransferase urg2Add BLAST204

Proteomic databases

MaxQBiQ9US43
PaxDbiQ9US43
PRIDEiQ9US43

PTM databases

iPTMnetiQ9US43

Interactioni

Protein-protein interaction databases

BioGridi279688, 17 interactors
STRINGi4896.SPAC1002.17c.1

Structurei

3D structure databases

ProteinModelPortaliQ9US43
SMRiQ9US43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 1345-phospho-alpha-D-ribose 1-diphosphate bindingBy similarity9
Regioni193 – 195Uracil bindingBy similarity3

Sequence similaritiesi

Belongs to the UPRTase family.Sequence analysis

Phylogenomic databases

HOGENOMiHOG000262754
InParanoidiQ9US43
KOiK00761
OMAiRICGYEI
OrthoDBiEOG092C538X

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
SUPFAMiSSF53271 SSF53271, 1 hit

Sequencei

Sequence statusi: Complete.

Q9US43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTTTTVSAI RTVEEMSNIT ISSHPVVNEQ IAILRDRSLK PSQVRSVVDE
60 70 80 90 100
ISRFLAYEST KTLKSPSVSI VPVLRSGMSM MSAFSKVLPD VPIYHIGIFR
110 120 130 140 150
EKSTLQPIEY YNKLPKKSTD TAVILDPVMA TGGTANAVIT TLQEWGCKNI
160 170 180 190 200
IFVSVLASEQ ALTRFSNIPG VEFVIGAVDK SLDAKGYLVP GVGDIGDRLY

GATA
Length:204
Mass (Da):22,084
Last modified:June 13, 2012 - v2
Checksum:i4F52E9EFB6BDAF8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB65617.2
RefSeqiNP_593505.2, NM_001018939.2

Genome annotation databases

EnsemblFungiiSPAC1002.17c.1; SPAC1002.17c.1:pep; SPAC1002.17c
GeneIDi2543260
KEGGispo:SPAC1002.17c

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB65617.2
RefSeqiNP_593505.2, NM_001018939.2

3D structure databases

ProteinModelPortaliQ9US43
SMRiQ9US43
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279688, 17 interactors
STRINGi4896.SPAC1002.17c.1

PTM databases

iPTMnetiQ9US43

Proteomic databases

MaxQBiQ9US43
PaxDbiQ9US43
PRIDEiQ9US43

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1002.17c.1; SPAC1002.17c.1:pep; SPAC1002.17c
GeneIDi2543260
KEGGispo:SPAC1002.17c

Organism-specific databases

EuPathDBiFungiDB:SPAC1002.17c
PomBaseiSPAC1002.17c urg2

Phylogenomic databases

HOGENOMiHOG000262754
InParanoidiQ9US43
KOiK00761
OMAiRICGYEI
OrthoDBiEOG092C538X

Enzyme and pathway databases

UniPathwayi
UPA00574;UER00636

Miscellaneous databases

PROiPR:Q9US43

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
SUPFAMiSSF53271 SSF53271, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUPP3_SCHPO
AccessioniPrimary (citable) accession number: Q9US43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 13, 2012
Last modified: September 12, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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