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UniProtKB - Q9URZ4 (CAT1_SCHPO)

Entry version 127 (23 Feb 2022)
Sequence version 3 (16 May 2012)
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Protein

Cationic amino acid transporter 1

Gene

cat1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major permease specifically involved in arginine and lysine uptake.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.3.10.21, the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cationic amino acid transporter 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cat1
ORF Names:SPAC869.11, SPAC922.08c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...PomBasei		SPAC869.11, cat1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:SPAC869.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 90CytoplasmicBy similarityAdd BLAST90
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 115ExtracellularBy similarity4
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 158CytoplasmicBy similarityAdd BLAST22
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 193ExtracellularBy similarityAdd BLAST14
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215 – 222CytoplasmicBy similarity8
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Topological domaini244 – 272ExtracellularBy similarityAdd BLAST29
Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
Topological domaini294 – 310CytoplasmicBy similarityAdd BLAST17
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 354ExtracellularBy similarityAdd BLAST23
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 405CytoplasmicBy similarityAdd BLAST30
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 444ExtracellularBy similarityAdd BLAST18
Transmembranei445 – 465HelicalSequence analysisAdd BLAST21
Topological domaini466 – 491CytoplasmicBy similarityAdd BLAST26
Transmembranei492 – 512HelicalSequence analysisAdd BLAST21
Topological domaini513 – 520ExtracellularBy similarity8
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Topological domaini542 – 580CytoplasmicBy similarityAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Leads to a dramatic decrease in the uptake of arginine or lysine and resistance to canavanine and thialysine.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000541791 – 587Cationic amino acid transporter 1Add BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei29Phosphoserine1 Publication1
Modified residuei30Phosphoserine1 Publication1
Modified residuei37Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9URZ4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9URZ4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9URZ4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		279988, 36 interactors

STRING: functional protein association networks

More...STRINGi		4896.SPAC869.11.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9URZ4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the amino acid-polyamine-organocation (APC) superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1286, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007946_12_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9URZ4

Identification of Orthologs from Complete Genome Data

More...OMAi		TIGYWND

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR004840, Amoino_acid_permease_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00324, AA_permease, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00218, AMINO_ACID_PERMEASE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9URZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHSDFNMEP EYVSFSDKDT KSILNESKSS LKDVKPSLEE KSYITPGLVD 
        60         70         80         90        100
DVEPKGKNFV VRFFDDFKPA KATGEDGTAL KRSLKSRHMQ MISIGGAIGT 
       110        120        130        140        150
GLYVGSGSSL ADGGPASVII NYSLIGIMMF FIVYALGEMA VAYPVAGGFN 
       160        170        180        190        200
TYATRFIDPA WGFAVSWNYF INYFVTFPLE LTTCAITFRY WTDINSAAWI 
       210        220        230        240        250
SIFLVVIIIV NLFGVRAYGE VEFILSTVKV VATFGFIILA IIINCGGVPT 
       260        270        280        290        300
DHRGYIGGSI IKHKPFRHGF KGFCSVFTTA AFSFSGTEVI GLAAAEVDNP 
       310        320        330        340        350
QKALPHAVKQ VFWRIAIFYV VSLILIGLLI SPDDPNLMGN GSTSVSPFVL 
       360        370        380        390        400
AIKEANIKGL PSVFNAVIII SVVSVTNSST YTAGRTLHGM ANLKQAPSFF 
       410        420        430        440        450
KYTDRLGRPL LAMIVVLLFG FFAYINEADK NGNDVSDTVF NWLLALSGLS 
       460        470        480        490        500
NFFTWGSICL CHIIFRLAFK KQGHSLKELG FVSPMGIWGS CIGLFFNILC 
       510        520        530        540        550
LMAQFYVSLF PIGGKPNAND FFQGYLAAPV TLAFFIGYKI YDRSHIPSLD 
       560        570        580 
KLDITTGLKT YENLDEEEDE PTTASKRIFK KISSVFC
Length:587
Mass (Da):64,479
Last modified:May 16, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFBB74D5ADAE52B27
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB63555.3

Protein sequence database of the Protein Information Resource

More...PIRi		T39122

NCBI Reference Sequences

More...RefSeqi		NP_595008.3, NM_001020439.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		SPAC869.11.1; SPAC869.11.1:pep; SPAC869.11

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2543573

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		spo:SPAC869.11

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB63555.3
PIRiT39122
RefSeqiNP_595008.3, NM_001020439.2

3D structure databases

SMRiQ9URZ4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi279988, 36 interactors
STRINGi4896.SPAC869.11.1

Protein family/group databases

TCDBi2.A.3.10.21, the amino acid-polyamine-organocation (apc) family

PTM databases

iPTMnetiQ9URZ4

Proteomic databases

MaxQBiQ9URZ4
PaxDbiQ9URZ4

Genome annotation databases

EnsemblFungiiSPAC869.11.1; SPAC869.11.1:pep; SPAC869.11
GeneIDi2543573
KEGGispo:SPAC869.11

Organism-specific databases

PomBaseiSPAC869.11, cat1
VEuPathDBiFungiDB:SPAC869.11

Phylogenomic databases

eggNOGiKOG1286, Eukaryota
HOGENOMiCLU_007946_12_0_1
InParanoidiQ9URZ4
OMAiTIGYWND

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9URZ4

Family and domain databases

InterProiView protein in InterPro
IPR004841, AA-permease/SLC12A_dom
IPR004840, Amoino_acid_permease_CS
PfamiView protein in Pfam
PF00324, AA_permease, 1 hit
PROSITEiView protein in PROSITE
PS00218, AMINO_ACID_PERMEASE_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAT1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9URZ4
Secondary accession number(s): Q9URW8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: May 16, 2012
Last modified: February 23, 2022
This is version 127 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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