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Protein

Microtubule protein alp7

Gene

alp7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for bipolar spindle formation and proper chromosome segregation. Has an indirect role in connecting the kinetochores and the plus end of pole to chromosome microtubules by targeting alp14 to the spindle pole body. Involved in the emergence of large microtubule organizing centers (MTOC) in interphase cells. Attaches to the minus ends of microtubules and associates with the sites of microtubule attachment on the nuclear envelope. This leads to the stabilzation of the microtubule bundles.2 Publications

GO - Molecular functioni

  • microtubule binding Source: PomBase

GO - Biological processi

  • astral microtubule organization Source: PomBase
  • attachment of mitotic spindle microtubules to kinetochore Source: PomBase
  • cytoplasmic microtubule organization Source: PomBase
  • establishment or maintenance of cell polarity regulating cell shape Source: PomBase
  • microtubule nucleation by interphase microtubule organizing center Source: PomBase
  • mitotic chromosome movement towards spindle pole Source: PomBase
  • mitotic spindle assembly Source: PomBase
  • mitotic spindle elongation during mitotic anaphase Source: PomBase
  • mitotic spindle elongation during mitotic prophase Source: PomBase
  • protein transport along microtubule to kinetochore Source: PomBase

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule protein alp7
Alternative name(s):
Altered polarity protein 7
Transforming acidic coiled-coil protein mia1
Short name:
TACC protein mia1
Gene namesi
Name:alp7
Synonyms:mia1
ORF Names:SPAC890.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC890.02c
PomBaseiSPAC890.02c alp7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000645701 – 474Microtubule protein alp7Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9URY2
PaxDbiQ9URY2
PRIDEiQ9URY2

PTM databases

iPTMnetiQ9URY2

Interactioni

Subunit structurei

Interacts with alp14.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • microtubule binding Source: PomBase

Protein-protein interaction databases

BioGridi279804, 25 interactors
DIPiDIP-39987N
IntActiQ9URY2, 7 interactors
MINTiQ9URY2
STRINGi4896.SPAC890.02c.1

Structurei

3D structure databases

ProteinModelPortaliQ9URY2
SMRiQ9URY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili219 – 273Sequence analysisAdd BLAST55
Coiled coili367 – 471Sequence analysisAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 20Poly-Ser6

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ9URY2
OrthoDBiEOG092C360D

Family and domain databases

InterProiView protein in InterPro
IPR024312 TACC_fungi
PfamiView protein in Pfam
PF12709 Kinetocho_Slk19, 1 hit

Sequencei

Sequence statusi: Complete.

Q9URY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDIVSSSTD YSRRSPSSSS IGTNETDHTG FHEKRQGASS ESLIPPAQRS
60 70 80 90 100
SEESMPAPKL FPKLTSKPNP QLNLKDTLNK RVSDRLQALE LNKSFDFSGT
110 120 130 140 150
PRPMHPISHP LSQHKTPEFK HRKRNVESIL TPKNPSLFSS SNAASQRGSL
160 170 180 190 200
NTAPSNFAYS HSSSLQTSAS SRPPVLSNGS FPRQTNTAPL NPPVHLKDNI
210 220 230 240 250
RNSATPSTSQ ADIPTQYPIN STQKQQAKYE AEIEGYKAKL AGTYHEISVL
260 270 280 290 300
QNTIVNVSGQ LIAVNDQLQQ LRSGKASTSP STKDTNMRLV EGHNEETLAL
310 320 330 340 350
QRGKYTQEEV DKLIQERMEK VAEDLHAQYS AKHTQKINAF KANYARKYEA
360 370 380 390 400
TIQELQNQIG TAPNAPKISN SNWEEERRAL KADNQTLQKQ LEKAIQERQD
410 420 430 440 450
MSDFLNNFKA DMAKSDKLLM QQQSQQTGDL ETLRLQLQAL QEELRVEREE
460 470
RQQLIQMSED LVIAMDQLNL EQKS
Length:474
Mass (Da):53,175
Last modified:May 1, 2000 - v1
Checksum:i22B4216C196E310C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB63493.1
AB027802 Genomic DNA Translation: BAA87106.1
PIRiT50258
RefSeqiNP_594820.1, NM_001020249.2

Genome annotation databases

EnsemblFungiiSPAC890.02c.1; SPAC890.02c.1:pep; SPAC890.02c
GeneIDi2543382
KEGGispo:SPAC890.02c

Entry informationi

Entry nameiALP7_SCHPO
AccessioniPrimary (citable) accession number: Q9URY2
Secondary accession number(s): Q9UU56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: May 1, 2000
Last modified: July 18, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

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