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Protein

Transposon Tf2-11 polyprotein

Gene

Tf2-11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Tf2 retrotransposons belong to the gypsy-like elements (metaviridae).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei271For protease activityPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi502Magnesium; catalytic; for reverse transcriptase activityBy similarity1
Metal bindingi566Magnesium; catalytic; for reverse transcriptase activityBy similarity1
Metal bindingi567Magnesium; catalytic; for reverse transcriptase activityBy similarity1
Metal bindingi990Magnesium; catalytic; for integrase activityBy similarity1
Metal bindingi1050Magnesium; catalytic; for integrase activityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAspartyl protease, DNA-binding, DNA-directed DNA polymerase, Endonuclease, Hydrolase, Multifunctional enzyme, Nuclease, Nucleotidyltransferase, Protease, RNA-binding, RNA-directed DNA polymerase, Transferase
Biological processDNA integration, DNA recombination
LigandMagnesium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transposon Tf2-11 polyprotein
Alternative name(s):
Retrotransposable element Tf2 155 kDa protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tf2-11
ORF Names:SPBC1289.17, SPBC8E4.11c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:SPBC1289.17

Schizosaccharomyces pombe database

More...
PomBasei
SPBC1289.17 Tf2-11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000975061 – 1333Transposon Tf2-11 polyproteinAdd BLAST1333

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Processing of the polyproteins proceeds by an ordered pathway, called maturation. It involves the initial cleavage of a 27 kDa capsid protein (CA) from the N-terminus of the polyprotein, followed by the cleavage of a 56 kDa integrase (IN) from the C-terminus. This leaves a 72 kDa protease-reverse transcriptase fusion protein (PR-RT), which does not seem to be processed further (By similarity).By similarity

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UR07

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UR07

PRoteomics IDEntifications database

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PRIDEi
Q9UR07

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
276578, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4896.SPBC1289.17.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UR07

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UR07

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini266 – 342Peptidase A2Add BLAST77
Domaini436 – 615Reverse transcriptasePROSITE-ProRule annotationAdd BLAST180
Domaini979 – 1138Integrase catalyticPROSITE-ProRule annotationAdd BLAST160

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154219

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UR07

Identification of Orthologs from Complete Genome Data

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OMAi
NISRIEY

Database of Orthologous Groups

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OrthoDBi
EOG092C0KYC

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UR07

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.70.10, 1 hit
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001969 Aspartic_peptidase_AS
IPR001584 Integrase_cat-core
IPR024648 Pept_A2E_retrotransp
IPR021109 Peptidase_aspartic_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR000477 RT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12382 Peptidase_A2E, 1 hit
PF00665 rve, 1 hit
PF00078 RVT_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00141 ASP_PROTEASE, 1 hit
PS50994 INTEGRASE, 1 hit
PS50878 RT_POL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9UR07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYANYRYMK ARAKRWRPEN LDGIQTSDEH LINLFAKILS KHVPEIGKFD
60 70 80 90 100
PNKDVESYIS KLDQHFTEYP SLFPNEHTKR QYTLNHLEEL EQQFAERMFS
110 120 130 140 150
ENGSLTWQEL LRQPGKVQGS NKGDRLTKTF EGFRNQLDKV QFIRKLMSKA
160 170 180 190 200
NVDDFHTRLF ILWMLPYSLR KLKERNYWKS EISEIYDFLE DKRTASYGKT
210 220 230 240 250
HKRFQPQNKN LGKEFLPKKN NTTNSRNLRK TNISRIEYSS NKFLNHTRKR
260 270 280 290 300
YEMVLQAELP DFKCSIPCLI DTGTQANIIT EETVRAHKLP TRPWSKSVIY
310 320 330 340 350
GGVYPNKINR KTIKLNISLN GISIKTEFLV VKKFSHPAAI SFTTLYDNNI
360 370 380 390 400
EISSSKHTLS QMNKVSNIVK EPELPDIYKE FKDITAETNT EKLPKPIKGL
410 420 430 440 450
EFEVELTQEN YRLPIRNYPL PPGKMQAMND EINQGLKSGI IRESKAINAC
460 470 480 490 500
PVMFVPKKEG TLRMVVDYKP LNKYVKPNIY PLPLIEQLLA KIQGSTIFTK
510 520 530 540 550
LDLKSAYHLI RVRKGDEHKL AFRCPRGVFE YLVMPYGISI APAHFQYFIN
560 570 580 590 600
TILGEVKESH VVCYMDNILI HSKSESEHVK HVKDVLQKLK NANLIINQAK
610 620 630 640 650
CEFHQSQVKF IGYHISEKGF TPCQENIDKV LQWKQPKNRK ELRQFLGSVN
660 670 680 690 700
YLRKFIPKTS QLTHPLNNLL KKDVRWKWTP TQTQAIENIK QCLVSPPVLR
710 720 730 740 750
HFDFSKKILL ETDASDVAVG AVLSQKHDDD KYYPVGYYSA KMSKAQLNYS
760 770 780 790 800
VSDKEMLAII KSLKHWRHYL ESTIEPFKIL TDHRNLIGRI TNESEPENKR
810 820 830 840 850
LARWQLFLQD FNFEINYRPG SANHIADALS RIVDETEPIP KDSEDNSINF
860 870 880 890 900
VNQISITDDF KNQVVTEYTN DTKLLNLLNN EDKRVEENIQ LKDGLLINSK
910 920 930 940 950
DQILLPNDTQ LTRTIIKKYH EEGKLIHPGI ELLTNIILRR FTWKGIRKQI
960 970 980 990 1000
QEYVQNCHTC QINKSRNHKP YGPLQPIPPS ERPWESLSMD FITALPESSG
1010 1020 1030 1040 1050
YNALFVVVDR FSKMAILVPC TKSITAEQTA RMFDQRVIAY FGNPKEIIAD
1060 1070 1080 1090 1100
NDHIFTSQTW KDFAHKYNFV MKFSLPYRPQ TDGQTERTNQ TVEKLLRCVC
1110 1120 1130 1140 1150
STHPNTWVDH ISLVQQSYNN AIHSATQMTP FEIVHRYSPA LSPLELPSFS
1160 1170 1180 1190 1200
DKTDENSQET IQVFQTVKEH LNTNNIKMKK YFDMKIQEIE EFQPGDLVMV
1210 1220 1230 1240 1250
KRTKTGFLHK SNKLAPSFAG PFYVLQKSGP NNYELDLPDS IKHMFSSTFH
1260 1270 1280 1290 1300
VSHLEKYRHN SELNYATIDE SDIGTILHIL EHKNREQVLY LNVKYISNLN
1310 1320 1330
PSTIMSGWTT LATALQADKA IVNDYIKNNN LNI
Length:1,333
Mass (Da):155,066
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73D8F262C7D9389C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB64236.1

NCBI Reference Sequences

More...
RefSeqi
NP_596839.1, NM_001023860.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC1289.17.1; SPBC1289.17.1:pep; SPBC1289.17

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540036

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC1289.17

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB64236.1
RefSeqiNP_596839.1, NM_001023860.1

3D structure databases

ProteinModelPortaliQ9UR07
SMRiQ9UR07
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276578, 1 interactor
STRINGi4896.SPBC1289.17.1

Proteomic databases

MaxQBiQ9UR07
PaxDbiQ9UR07
PRIDEiQ9UR07

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1289.17.1; SPBC1289.17.1:pep; SPBC1289.17
GeneIDi2540036
KEGGispo:SPBC1289.17

Organism-specific databases

EuPathDBiFungiDB:SPBC1289.17
PomBaseiSPBC1289.17 Tf2-11

Phylogenomic databases

HOGENOMiHOG000154219
InParanoidiQ9UR07
OMAiNISRIEY
OrthoDBiEOG092C0KYC
PhylomeDBiQ9UR07

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9UR07

Family and domain databases

Gene3Di2.40.70.10, 1 hit
3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR001969 Aspartic_peptidase_AS
IPR001584 Integrase_cat-core
IPR024648 Pept_A2E_retrotransp
IPR021109 Peptidase_aspartic_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR000477 RT_dom
PfamiView protein in Pfam
PF12382 Peptidase_A2E, 1 hit
PF00665 rve, 1 hit
PF00078 RVT_1, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 1 hit
PS50994 INTEGRASE, 1 hit
PS50878 RT_POL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTF211_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UR07
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome, Transposable element

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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