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Protein

Lysosome-associated membrane glycoprotein 3

Gene

LAMP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in dendritic cell function and in adaptive immunity.1 Publication

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 3
Short name:
LAMP-3
Short name:
Lysosomal-associated membrane protein 3
Alternative name(s):
DC-lysosome-associated membrane glycoprotein
Short name:
DC LAMP
Protein TSC403
CD_antigen: CD208
Gene namesi
Name:LAMP3
Synonyms:DCLAMP, TSC403
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000078081.7
HGNCiHGNC:14582 LAMP3
MIMi605883 gene
neXtProtiNX_Q9UQV4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 381LumenalSequence analysisAdd BLAST354
Transmembranei382 – 402HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini403 – 416CytoplasmicPROSITE-ProRule annotationAdd BLAST14

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27074
OpenTargetsiENSG00000078081
PharmGKBiPA30286

Polymorphism and mutation databases

BioMutaiLAMP3
DMDMi126302564

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000022369528 – 416Lysosome-associated membrane glycoprotein 3Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi237 ↔ 274PROSITE-ProRule annotation1 Publication
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi291N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi339 ↔ 376PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9UQV4
PaxDbiQ9UQV4
PeptideAtlasiQ9UQV4
PRIDEiQ9UQV4
ProteomicsDBi85575

PTM databases

iPTMnetiQ9UQV4
PhosphoSitePlusiQ9UQV4

Expressioni

Tissue specificityi

Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues.3 Publications

Developmental stagei

Up-regulated during dendritic cell maturation.

Gene expression databases

BgeeiENSG00000078081 Expressed in 132 organ(s), highest expression level in visceral pleura
CleanExiHS_LAMP3
ExpressionAtlasiQ9UQV4 baseline and differential
GenevisibleiQ9UQV4 HS

Organism-specific databases

HPAiCAB025133
HPA051467

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi117983, 69 interactors
IntActiQ9UQV4, 6 interactors
MINTiQ9UQV4
STRINGi9606.ENSP00000265598

Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UQV4
SMRiQ9UQV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 215Thr-richAdd BLAST142

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4818 Eukaryota
ENOG410XQ96 LUCA
GeneTreeiENSGT00530000063068
HOGENOMiHOG000004835
HOVERGENiHBG081889
InParanoidiQ9UQV4
KOiK06562
OMAiCQSSGYQ
OrthoDBiEOG091G09EV
PhylomeDBiQ9UQV4
TreeFamiTF316339

Family and domain databases

InterProiView protein in InterPro
IPR002000 Lysosome-assoc_membr_glycop
PANTHERiPTHR11506 PTHR11506, 1 hit
PfamiView protein in Pfam
PF01299 Lamp, 1 hit
PRINTSiPR00336 LYSASSOCTDMP
PROSITEiView protein in PROSITE
PS51407 LAMP_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q9UQV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRQLSAAAA LFASLAVILH DGSQMRAKAF PETRDYSQPT AAATVQDIKK
60 70 80 90 100
PVQQPAKQAP HQTLAARFMD GHITFQTAAT VKIPTTTPAT TKNTATTSPI
110 120 130 140 150
TYTLVTTQAT PNNSHTAPPV TEVTVGPSLA PYSLPPTITP PAHTTGTSSS
160 170 180 190 200
TVSHTTGNTT QPSNQTTLPA TLSIALHKST TGQKPVQPTH APGTTAAAHN
210 220 230 240 250
TTRTAAPAST VPGPTLAPQP SSVKTGIYQV LNGSRLCIKA EMGIQLIVQD
260 270 280 290 300
KESVFSPRRY FNIDPNATQA SGNCGTRKSN LLLNFQGGFV NLTFTKDEES
310 320 330 340 350
YYISEVGAYL TVSDPETIYQ GIKHAVVMFQ TAVGHSFKCV SEQSLQLSAH
360 370 380 390 400
LQVKTTDVQL QAFDFEDDHF GNVDECSSDY TIVLPVIGAI VVGLCLMGMG
410
VYKIRLRCQS SGYQRI
Length:416
Mass (Da):44,346
Last modified:February 20, 2007 - v3
Checksum:iD615895D382B8F88
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ETP9E7ETP9_HUMAN
Lysosome-associated membrane glycop...
LAMP3
392Annotation score:
C9JYP5C9JYP5_HUMAN
Lysosome-associated membrane glycop...
LAMP3
180Annotation score:
C9JDI8C9JDI8_HUMAN
Lysosome-associated membrane glycop...
LAMP3
143Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145T → A in BAA34533 (PubMed:9721848).Curated1
Sequence conflicti186V → D in BAA34533 (PubMed:9721848).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03082732E → G1 PublicationCorresponds to variant dbSNP:rs17853113Ensembl.1
Natural variantiVAR_025343318I → V2 PublicationsCorresponds to variant dbSNP:rs482912Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013924 mRNA Translation: BAA34533.1
AJ005766 mRNA Translation: CAA06691.1
CH471052 Genomic DNA Translation: EAW78337.1
CH471052 Genomic DNA Translation: EAW78338.1
BC032940 mRNA Translation: AAH32940.1
CCDSiCCDS3242.1
RefSeqiNP_055213.2, NM_014398.3
UniGeneiHs.518448

Genome annotation databases

EnsembliENST00000265598; ENSP00000265598; ENSG00000078081
GeneIDi27074
KEGGihsa:27074
UCSCiuc003flh.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLAMP3_HUMAN
AccessioniPrimary (citable) accession number: Q9UQV4
Secondary accession number(s): D3DNS4, O94781, Q8NEC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 20, 2007
Last modified: September 12, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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