UniProtKB - Q9UQF2 (JIP1_HUMAN)
C-Jun-amino-terminal kinase-interacting protein 1
MAPK8IP1
Functioni
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8+ T-cells.
By similarityMiscellaneous
GO - Molecular functioni
- kinesin binding Source: UniProtKB
- MAP-kinase scaffold activity Source: UniProtKB
- protein kinase binding Source: Ensembl
- protein kinase inhibitor activity Source: ProtInc
GO - Biological processi
- JUN phosphorylation Source: Ensembl
- negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
- negative regulation of JUN kinase activity Source: UniProtKB
- positive regulation of JNK cascade Source: UniProtKB
- regulation of CD8-positive, alpha-beta T cell proliferation Source: UniProtKB
- regulation of JNK cascade Source: UniProtKB
- regulation of transcription, DNA-templated Source: Ensembl
- vesicle-mediated transport Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q9UQF2 |
SignaLinki | Q9UQF2 |
SIGNORi | Q9UQF2 |
Names & Taxonomyi
Protein namesi | Recommended name: C-Jun-amino-terminal kinase-interacting protein 1Short name: JIP-1 Short name: JNK-interacting protein 1 Alternative name(s): Islet-brain 1 Short name: IB-1 JNK MAP kinase scaffold protein 1 Mitogen-activated protein kinase 8-interacting protein 1 |
Gene namesi | Name:MAPK8IP1 Synonyms:IB1, JIP1, PRKM8IP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6882, MAPK8IP1 |
MIMi | 604641, gene |
neXtProti | NX_Q9UQF2 |
VEuPathDBi | HostDB:ENSG00000121653 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Mitochondrion
Cytoplasm and Cytosol
- Cytoplasm By similarity
Endoplasmic reticulum
Other locations
- perinuclear region By similarity
Note: Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity).By similarity
Cytosol
- cytosol Source: Ensembl
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cell body Source: Ensembl
- cytoplasm Source: UniProtKB
- dendrite Source: Ensembl
- dentate gyrus mossy fiber Source: Ensembl
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
- synapse Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, NucleusPathology & Biotechi
Involvement in diseasei
Diabetes mellitus, non-insulin-dependent (NIDDM)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012243 | 59 | S → N in NIDDM. 1 PublicationCorresponds to variant dbSNP:rs119489103EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 160 | R → G: Abolishes MAPK9 interaction. 1 Publication | 1 | |
Mutagenesisi | 161 | P → G: Abolishes MAPK9 interaction. 1 Publication | 1 | |
Mutagenesisi | 704 | P → A: No effect on KNS2 binding. 1 Publication | 1 | |
Mutagenesisi | 709 | Y → A: Abolishes KNS2 binding. 1 Publication | 1 |
Keywords - Diseasei
Diabetes mellitus, Disease variantOrganism-specific databases
DisGeNETi | 9479 |
MalaCardsi | MAPK8IP1 |
MIMi | 125853, phenotype |
OpenTargetsi | ENSG00000121653 |
PharmGKBi | PA30626 |
Miscellaneous databases
Pharosi | Q9UQF2, Tbio |
Chemistry databases
DrugBanki | DB07276, 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE DB07218, 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE DB11157, Anthralin DB07272, N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE DB01782, Pyrazolanthrone |
Genetic variation databases
BioMutai | MAPK8IP1 |
DMDMi | 17433093 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220628 | 1 – 711 | C-Jun-amino-terminal kinase-interacting protein 1Add BLAST | 711 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 15 | PhosphoserineBy similarity | 1 | |
Modified residuei | 29 | PhosphoserineBy similarity | 1 | |
Modified residuei | 40 | Phosphoserine1 Publication | 1 | |
Modified residuei | 103 | Phosphothreonine; by MAPK8, MAPK9 and MAPK101 Publication | 1 | |
Modified residuei | 152 | Phosphoserine1 Publication | 1 | |
Modified residuei | 181 | Phosphoserine1 Publication | 1 | |
Modified residuei | 187 | Phosphoserine1 Publication | 1 | |
Modified residuei | 193 | Phosphoserine1 Publication | 1 | |
Modified residuei | 195 | Phosphoserine1 Publication | 1 | |
Modified residuei | 196 | Phosphoserine1 Publication | 1 | |
Modified residuei | 205 | Phosphothreonine; by MAPK8, MAPK9 and MAPK101 Publication | 1 | |
Modified residuei | 214 | Phosphoserine1 Publication | 1 | |
Modified residuei | 311 | Phosphoserine1 Publication | 1 | |
Modified residuei | 328 | Phosphoserine1 Publication | 1 | |
Modified residuei | 330 | Phosphoserine1 Publication | 1 | |
Modified residuei | 340 | Phosphoserine1 Publication | 1 | |
Modified residuei | 355 | Phosphoserine1 Publication | 1 | |
Modified residuei | 366 | Phosphoserine1 Publication | 1 | |
Modified residuei | 369 | Phosphoserine1 Publication | 1 | |
Modified residuei | 407 | Phosphoserine1 Publication | 1 | |
Modified residuei | 409 | Phosphoserine1 Publication | 1 | |
Modified residuei | 411 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 444 | Phosphoserine1 Publication | 1 | |
Modified residuei | 447 | Phosphoserine1 Publication | 1 | |
Modified residuei | 448 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 469 | Phosphoserine1 Publication | 1 | |
Modified residuei | 471 | Phosphoserine1 Publication | 1 | |
Modified residuei | 472 | Phosphoserine1 Publication | 1 | |
Modified residuei | 473 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
MassIVEi | Q9UQF2 |
PaxDbi | Q9UQF2 |
PeptideAtlasi | Q9UQF2 |
PRIDEi | Q9UQF2 |
ProteomicsDBi | 85551 |
PTM databases
GlyGeni | Q9UQF2, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UQF2 |
PhosphoSitePlusi | Q9UQF2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000121653, Expressed in C1 segment of cervical spinal cord and 139 other tissues |
ExpressionAtlasi | Q9UQF2, baseline and differential |
Genevisiblei | Q9UQF2, HS |
Organism-specific databases
HPAi | ENSG00000121653, Tissue enhanced (brain, pituitary gland) |
Interactioni
Subunit structurei
Forms homo- or heterooligomeric complexes. Binds specific components of the JNK signaling pathway namely, MAPK8/JNK1, MAPK9/JNK2, MAPK10/JNK3, MAP2K7/MKK7, MAP3K11/MLK3 and DLK1. Also binds the proline-rich domain-containing splice variant of apolipoprotein E receptor 2 (ApoER2).
Interacts, via the PID domain, with ARHGEF28. Binds the cytoplasmic tails of LRP1 and LRP2 (Megalin). Binds the TPR motif-containing C-terminal of KNS2, then the pre-assembled MAPK8IP1 scaffolding complexes are transported as a cargo of kinesin, to the required subcellular location.
Interacts with the cytoplasmic domain of APP.
Interacts with DCLK2 (By similarity).
Interacts with MAP3K7/TAK1.
Interacts with isoform 1 and isoform 2 of VRK2.
Found in a complex with SH3RF1, RAC1, MAP3K11/MLK3, MAP2K7/MKK7 and MAPK8/JNK1.
Found in a complex with SH3RF1, RAC2, MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and MAPK9/JNK2.
Interacts with SH3RF2 (By similarity).
By similarity6 PublicationsBinary interactionsi
Q9UQF2
GO - Molecular functioni
- kinesin binding Source: UniProtKB
- protein kinase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 114864, 46 interactors |
CORUMi | Q9UQF2 |
ELMi | Q9UQF2 |
IntActi | Q9UQF2, 26 interactors |
MINTi | Q9UQF2 |
STRINGi | 9606.ENSP00000241014 |
Miscellaneous databases
RNActi | Q9UQF2, protein |
Structurei
3D structure databases
SMRi | Q9UQF2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UQF2 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 488 – 549 | SH3PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 561 – 700 | PIDPROSITE-ProRule annotationAdd BLAST | 140 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 27 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 78 – 371 | DisorderedSequence analysisAdd BLAST | 294 | |
Regioni | 127 – 285 | JNK-binding domain (JBD)Add BLAST | 159 | |
Regioni | 157 – 176 | Minimal inhibitory domain (MID)Add BLAST | 20 | |
Regioni | 283 – 471 | Interaction with MAP3K71 PublicationAdd BLAST | 189 | |
Regioni | 429 – 451 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 471 – 660 | Interaction with VRK21 PublicationAdd BLAST | 190 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 353 – 360 | D-box 1 | 8 | |
Motifi | 364 – 372 | D-box 2 | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 135 – 153 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 166 – 203 | Polar residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 220 – 242 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 259 – 275 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, SH3 domainPhylogenomic databases
eggNOGi | KOG3775, Eukaryota |
GeneTreei | ENSGT00940000157089 |
HOGENOMi | CLU_006711_1_1_1 |
InParanoidi | Q9UQF2 |
OMAi | GHHRERI |
OrthoDBi | 372907at2759 |
PhylomeDBi | Q9UQF2 |
TreeFami | TF325073 |
Family and domain databases
CDDi | cd11943, SH3_JIP1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
IDEALi | IID00227 |
InterProi | View protein in InterPro IPR035638, JIP1_SH3 IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00640, PID, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAERESGGLG GGAASPPAAS PFLGLHIASP PNFRLTHDIS LEEFEDEDLS
60 70 80 90 100
EITDECGISL QCKDTLSLRP PRAGLLSAGG GGAGSRLQAE MLQMDLIDAT
110 120 130 140 150
GDTPGAEDDE EDDDEERAAR RPGAGPPKAE SGQEPASRGQ GQSQGQSQGP
160 170 180 190 200
GSGDTYRPKR PTTLNLFPQV PRSQDTLNNN SLGKKHSWQD RVSRSSSPLK
210 220 230 240 250
TGEQTPPHEH ICLSDELPPQ SGPAPTTDRG TSTDSPCRRS TATQMAPPGG
260 270 280 290 300
PPAAPPGGRG HSHRDRIHYQ ADVRLEATEE IYLTPVQRPP DAAEPTSAFL
310 320 330 340 350
PPTESRMSVS SDPDPAAYPS TAGRPHPSIS EEEEGFDCLS SPERAEPPGG
360 370 380 390 400
GWRGSLGEPP PPPRASLSSD TSALSYDSVK YTLVVDEHAQ LELVSLRPCF
410 420 430 440 450
GDYSDESDSA TVYDNCASVS SPYESAIGEE YEEAPRPQPP ACLSEDSTPD
460 470 480 490 500
EPDVHFSKKF LNVFMSGRSR SSSAESFGLF SCIINGEEQE QTHRAIFRFV
510 520 530 540 550
PRHEDELELE VDDPLLVELQ AEDYWYEAYN MRTGARGVFP AYYAIEVTKE
560 570 580 590 600
PEHMAALAKN SDWVDQFRVK FLGSVQVPYH KGNDVLCAAM QKIATTRRLT
610 620 630 640 650
VHFNPPSSCV LEISVRGVKI GVKADDSQEA KGNKCSHFFQ LKNISFCGYH
660 670 680 690 700
PKNNKYFGFI TKHPADHRFA CHVFVSEDST KALAESVGRA FQQFYKQFVE
710
YTCPTEDIYL E
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PBB9 | E9PBB9_HUMAN | C-Jun-amino-terminal kinase-interac... | MAPK8IP1 | 701 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012243 | 59 | S → N in NIDDM. 1 PublicationCorresponds to variant dbSNP:rs119489103EnsemblClinVar. | 1 | |
Natural variantiVAR_049664 | 322 | A → V. Corresponds to variant dbSNP:rs34420676Ensembl. | 1 | |
Natural variantiVAR_049665 | 353 | R → Q. Corresponds to variant dbSNP:rs12295161EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF074091 mRNA Translation: AAD20443.1 CH471064 Genomic DNA Translation: EAW68027.1 CH471064 Genomic DNA Translation: EAW68028.1 AF007134 mRNA Translation: AAC19150.1 |
CCDSi | CCDS7916.1 |
RefSeqi | NP_005447.1, NM_005456.3 |
Genome annotation databases
Ensembli | ENST00000241014; ENSP00000241014; ENSG00000121653 |
GeneIDi | 9479 |
KEGGi | hsa:9479 |
MANE-Selecti | ENST00000241014.6; ENSP00000241014.2; NM_005456.4; NP_005447.1 |
UCSCi | uc001nbr.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF074091 mRNA Translation: AAD20443.1 CH471064 Genomic DNA Translation: EAW68027.1 CH471064 Genomic DNA Translation: EAW68028.1 AF007134 mRNA Translation: AAC19150.1 |
CCDSi | CCDS7916.1 |
RefSeqi | NP_005447.1, NM_005456.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2G01 | X-ray | 3.50 | F/G | 157-167 | [»] | |
2GMX | X-ray | 3.50 | F/G | 157-167 | [»] | |
2H96 | X-ray | 3.00 | F/G | 157-167 | [»] | |
3OXI | X-ray | 2.20 | J | 158-167 | [»] | |
3PTG | X-ray | 2.43 | J | 157-167 | [»] | |
3VUD | X-ray | 3.50 | F | 157-167 | [»] | |
3VUG | X-ray | 3.24 | F | 157-167 | [»] | |
3VUH | X-ray | 2.70 | F | 157-167 | [»] | |
3VUI | X-ray | 2.80 | F | 157-167 | [»] | |
3VUK | X-ray | 2.95 | F | 157-167 | [»] | |
3VUL | X-ray | 2.81 | F | 157-167 | [»] | |
3VUM | X-ray | 2.69 | F | 157-167 | [»] | |
4E73 | X-ray | 2.27 | B | 158-167 | [»] | |
4G1W | X-ray | 2.45 | B | 157-167 | [»] | |
4H39 | X-ray | 1.99 | B | 158-167 | [»] | |
4HYS | X-ray | 2.42 | B | 157-167 | [»] | |
4HYU | X-ray | 2.15 | B | 157-167 | [»] | |
4IZY | X-ray | 2.30 | B | 157-167 | [»] | |
5LW1 | X-ray | 3.20 | C/F/I | 157-167 | [»] | |
6FUZ | X-ray | 2.70 | A | 701-711 | [»] | |
SMRi | Q9UQF2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114864, 46 interactors |
CORUMi | Q9UQF2 |
ELMi | Q9UQF2 |
IntActi | Q9UQF2, 26 interactors |
MINTi | Q9UQF2 |
STRINGi | 9606.ENSP00000241014 |
Chemistry databases
DrugBanki | DB07276, 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE DB07218, 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE DB11157, Anthralin DB07272, N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE DB01782, Pyrazolanthrone |
PTM databases
GlyGeni | Q9UQF2, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UQF2 |
PhosphoSitePlusi | Q9UQF2 |
Genetic variation databases
BioMutai | MAPK8IP1 |
DMDMi | 17433093 |
Proteomic databases
MassIVEi | Q9UQF2 |
PaxDbi | Q9UQF2 |
PeptideAtlasi | Q9UQF2 |
PRIDEi | Q9UQF2 |
ProteomicsDBi | 85551 |
Protocols and materials databases
Antibodypediai | 26197, 280 antibodies from 33 providers |
DNASUi | 9479 |
Genome annotation databases
Ensembli | ENST00000241014; ENSP00000241014; ENSG00000121653 |
GeneIDi | 9479 |
KEGGi | hsa:9479 |
MANE-Selecti | ENST00000241014.6; ENSP00000241014.2; NM_005456.4; NP_005447.1 |
UCSCi | uc001nbr.4, human |
Organism-specific databases
CTDi | 9479 |
DisGeNETi | 9479 |
GeneCardsi | MAPK8IP1 |
HGNCi | HGNC:6882, MAPK8IP1 |
HPAi | ENSG00000121653, Tissue enhanced (brain, pituitary gland) |
MalaCardsi | MAPK8IP1 |
MIMi | 125853, phenotype 604641, gene |
neXtProti | NX_Q9UQF2 |
OpenTargetsi | ENSG00000121653 |
PharmGKBi | PA30626 |
VEuPathDBi | HostDB:ENSG00000121653 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3775, Eukaryota |
GeneTreei | ENSGT00940000157089 |
HOGENOMi | CLU_006711_1_1_1 |
InParanoidi | Q9UQF2 |
OMAi | GHHRERI |
OrthoDBi | 372907at2759 |
PhylomeDBi | Q9UQF2 |
TreeFami | TF325073 |
Enzyme and pathway databases
PathwayCommonsi | Q9UQF2 |
SignaLinki | Q9UQF2 |
SIGNORi | Q9UQF2 |
Miscellaneous databases
BioGRID-ORCSi | 9479, 9 hits in 1050 CRISPR screens |
ChiTaRSi | MAPK8IP1, human |
EvolutionaryTracei | Q9UQF2 |
GeneWikii | MAPK8IP1 |
GenomeRNAii | 9479 |
Pharosi | Q9UQF2, Tbio |
PROi | PR:Q9UQF2 |
RNActi | Q9UQF2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000121653, Expressed in C1 segment of cervical spinal cord and 139 other tissues |
ExpressionAtlasi | Q9UQF2, baseline and differential |
Genevisiblei | Q9UQF2, HS |
Family and domain databases
CDDi | cd11943, SH3_JIP1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
IDEALi | IID00227 |
InterProi | View protein in InterPro IPR035638, JIP1_SH3 IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00640, PID, 1 hit PF14604, SH3_9, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | JIP1_HUMAN | |
Accessioni | Q9UQF2Primary (citable) accession number: Q9UQF2 Secondary accession number(s): D3DQP4, O43407 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 5, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 200 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families