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Entry version 148 (16 Oct 2019)
Sequence version 1 (01 May 2000)
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Protein

Syncytin-1

Gene

ERVW-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).3 Publications
Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.

Miscellaneous

Probably involved in the development of multiple sclerosis (MS). MS is a neurodegenerative disease characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. It leads to physical and cognitive disabilities. Viral particles or intracellular RNA of HERV-W family members have been detected in tissue from patients with multiple sclerosis or schizophrenia.
Orthologs in P.troglodytes, G.gorilla, P.pygmaeus and H.moloch.
It can make pseudotypes with HIV-1 virions and confer infectivity. Can also induce cellular resistance to spleen necrosis virus in vitro.
HERV-W family subgenomic RNAs have been observed.
This provirus is intergenic, the closest flanking genes being ODAG and PEX1.
The human genome contains a high percentage of proviral-like elements, also called endogenous retroviruses (ERVs) that are the genomic traces of ancient infections of the germline by exogenous retroviruses. Although most of these elements are defective, some have conserved a functional envelope (env) gene, most probably diverted by the host for its benefit.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.G.9.1.1 the syncytin (syncytin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Syncytin-1
Alternative name(s):
Endogenous retrovirus group W member 1
Env-W
Envelope polyprotein gPr73
Enverin
HERV-7q Envelope protein
HERV-W envelope protein
HERV-W_7q21.2 provirus ancestral Env polyprotein
Syncytin
Cleaved into the following 2 chains:
Surface protein
Short name:
SU
Alternative name(s):
gp50
Transmembrane protein
Short name:
TM
Alternative name(s):
gp24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERVW-1
Synonyms:ERVWE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13525 ERVW-1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604659 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UQF0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 443ExtracellularSequence analysisAdd BLAST423
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Topological domaini465 – 538CytoplasmicSequence analysisAdd BLAST74

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane, Viral envelope protein, Virion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi314 – 316RNK → AAA: Complete loss of cleavage between SU and TM. Loss of fusiogenic function. 1 Publication3
Mutagenesisi317R → T: Complete loss of cleavage between SU and TM. Loss of fusiogenic function. 1 Publication1
Mutagenesisi405C → A: Loss of fusiogenic function. No effect on cleavage between SU and TM. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
30816

Open Targets

More...
OpenTargetsi
ENSG00000242950

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27878

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UQF0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ERVW-1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47605755

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000848521 – 538Syncytin-1Add BLAST518
ChainiPRO_000000848621 – 317Surface proteinAdd BLAST297
ChainiPRO_0000008487318 – 538Transmembrane proteinAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi186 ↔ 405Interchain (between SU and TM chains, or C-189 with C-405); in linked form1 Publication
Disulfide bondi186 ↔ 189By similarity
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi281N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi397 ↔ 404By similarity
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins. Envelope glycoproteins are synthesized as an inactive precursor that is heavily N-glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence [KR]-X-[KR]-R. The intracytoplasmic tail cleavage by the viral protease that is required for the fusiogenic activity of some retroviruses envelope proteins seems to have been lost during evolution.1 Publication
The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei317 – 318Cleavage1 Publication2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UQF0

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9UQF0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UQF0

PeptideAtlas

More...
PeptideAtlasi
Q9UQF0

PRoteomics IDEntifications database

More...
PRIDEi
Q9UQF0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85550

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UQF0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UQF0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.4 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In placenta, detected at higher level during early pregnancy and at lower level during late pregnancy.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000242950 Expressed in 92 organ(s), highest expression level in chorionic villus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UQF0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UQF0 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The mature envelope protein (Env) consists of a trimer of SU-TM heterodimers attached probably by a labile interchain disulfide bond.

Interacts with the C-type lectin CD209/DC-SIGN.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000419945

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1538
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UQF0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni320 – 340Fusion peptideSequence analysisAdd BLAST21
Regioni380 – 396ImmunosuppressionBy similarityAdd BLAST17
Regioni465 – 484Essential for the fusiogenic functionAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi186 – 189CXXCCurated4
Motifi397 – 406CX6CCCurated10

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytoplasmic region is essential for the fusiogenic function.
The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JCYM Eukaryota
ENOG4111CG7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00690000102286

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UQF0

Identification of Orthologs from Complete Genome Data

More...
OMAi
FVNQSGI

Database of Orthologous Groups

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OrthoDBi
925621at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UQF0

TreeFam database of animal gene trees

More...
TreeFami
TF332233

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018154 TLV/ENV_coat_polyprotein

The PANTHER Classification System

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PANTHERi
PTHR10424 PTHR10424, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00429 TLV_coat, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9UQF0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPYHIFLF TVLLPSFTLT APPPCRCMTS SSPYQEFLWR MQRPGNIDAP
60 70 80 90 100
SYRSLSKGTP TFTAHTHMPR NCYHSATLCM HANTHYWTGK MINPSCPGGL
110 120 130 140 150
GVTVCWTYFT QTGMSDGGGV QDQAREKHVK EVISQLTRVH GTSSPYKGLD
160 170 180 190 200
LSKLHETLRT HTRLVSLFNT TLTGLHEVSA QNPTNCWICL PLNFRPYVSI
210 220 230 240 250
PVPEQWNNFS TEINTTSVLV GPLVSNLEIT HTSNLTCVKF SNTTYTTNSQ
260 270 280 290 300
CIRWVTPPTQ IVCLPSGIFF VCGTSAYRCL NGSSESMCFL SFLVPPMTIY
310 320 330 340 350
TEQDLYSYVI SKPRNKRVPI LPFVIGAGVL GALGTGIGGI TTSTQFYYKL
360 370 380 390 400
SQELNGDMER VADSLVTLQD QLNSLAAVVL QNRRALDLLT AERGGTCLFL
410 420 430 440 450
GEECCYYVNQ SGIVTEKVKE IRDRIQRRAE ELRNTGPWGL LSQWMPWILP
460 470 480 490 500
FLGPLAAIIL LLLFGPCIFN LLVNFVSSRI EAVKLQMEPK MQSKTKIYRR
510 520 530
PLDRPASPRS DVNDIKGTPP EEISAAQPLL RPNSAGSS
Length:538
Mass (Da):59,866
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC54648A3C7043870
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13 – 14LL → VS in AAD14545 (PubMed:9882319).Curated2
Sequence conflicti56S → C in AAD14545 (PubMed:9882319).Curated1
Sequence conflicti298T → A in AAD14545 (PubMed:9882319).Curated1
Sequence conflicti298T → A in AAD14548 (PubMed:9882319).Curated1
Sequence conflicti381Q → R in AAF74215 (PubMed:10826480).Curated1
Sequence conflicti388L → S in AAD14548 (PubMed:9882319).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

All variants have fusogenic properties.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018638129V → A1 PublicationCorresponds to variant dbSNP:rs142852059Ensembl.1
Natural variantiVAR_018639138R → Q1 PublicationCorresponds to variant dbSNP:rs55903518Ensembl.1
Natural variantiVAR_018640307S → N3 PublicationsCorresponds to variant dbSNP:rs10266695Ensembl.1
Natural variantiVAR_018641477S → F1 PublicationCorresponds to variant dbSNP:rs141340741Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF072503 mRNA No translation available.
AF072505 mRNA Translation: AAD14545.1
AF072506 mRNA Translation: AAD14546.2
AF072508 mRNA Translation: AAD14548.1
AF208161 mRNA Translation: AAF28334.1
AF513360 mRNA Translation: AAM47599.1
AF156963 Genomic DNA Translation: AAF74215.1
AC007566 Genomic DNA No translation available.
AY101582 Genomic DNA Translation: AAM68161.1
AY101583 Genomic DNA Translation: AAM68162.1
AY101584 Genomic DNA Translation: AAM68163.1
AY101585 Genomic DNA Translation: AAM68164.1
AF520478 Genomic DNA Translation: AAQ17561.1
AF520480 Genomic DNA Translation: AAQ17562.1
AF520482 Genomic DNA Translation: AAQ17563.1
AF520484 Genomic DNA Translation: AAQ17564.1
AF520486 Genomic DNA Translation: AAQ17565.1
AF520488 Genomic DNA Translation: AAQ17566.1
AF520490 Genomic DNA Translation: AAQ17567.1
AF520492 Genomic DNA Translation: AAQ17568.1
AF520494 Genomic DNA Translation: AAQ17569.1
AF520496 Genomic DNA Translation: AAQ17570.1
AF520498 Genomic DNA Translation: AAQ17571.1
AF520500 Genomic DNA Translation: AAQ17572.1
AF520502 Genomic DNA Translation: AAQ17573.1
AF520504 Genomic DNA Translation: AAQ17574.1
AF520506 Genomic DNA Translation: AAQ17575.1
AF520508 Genomic DNA Translation: AAQ17576.1
AF520510 Genomic DNA Translation: AAQ17577.1
AF520512 Genomic DNA Translation: AAQ17578.1
AF520514 Genomic DNA Translation: AAQ17579.1
AF520516 Genomic DNA Translation: AAQ17580.1
AF520518 Genomic DNA Translation: AAQ17581.1
AF520520 Genomic DNA Translation: AAQ17582.1
AF520522 Genomic DNA Translation: AAQ17583.1
AF520524 Genomic DNA Translation: AAQ17584.1
AF520526 Genomic DNA Translation: AAQ17585.1
AF520528 Genomic DNA Translation: AAQ17586.1
AF520530 Genomic DNA Translation: AAQ17587.1
AF520532 Genomic DNA Translation: AAQ17588.1
AF520534 Genomic DNA Translation: AAQ17589.1
AF520536 Genomic DNA Translation: AAQ17590.1
AF520538 Genomic DNA Translation: AAQ17591.1
AF520540 Genomic DNA Translation: AAQ17592.1
AF520542 Genomic DNA Translation: AAQ17593.1
AF520544 Genomic DNA Translation: AAQ17594.1
AF520546 Genomic DNA Translation: AAQ17595.1
AF520548 Genomic DNA Translation: AAQ17596.1
AF520550 Genomic DNA Translation: AAQ17597.1
AF520552 Genomic DNA Translation: AAQ17598.1
AF520554 Genomic DNA Translation: AAQ17599.1
AF520556 Genomic DNA Translation: AAQ17600.1
AF520558 Genomic DNA Translation: AAQ17601.1
AF520560 Genomic DNA Translation: AAQ17602.1
AF520562 Genomic DNA Translation: AAQ17603.1
AF520564 Genomic DNA Translation: AAQ17604.1
BC137381 mRNA Translation: AAI37382.1
AF506835 mRNA Translation: AAM33413.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5626.1

NCBI Reference Sequences

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RefSeqi
NP_001124397.1, NM_001130925.1
NP_055405.3, NM_014590.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000493463; ENSP00000419945; ENSG00000242950
ENST00000603053; ENSP00000474984; ENSG00000242950

Database of genes from NCBI RefSeq genomes

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GeneIDi
30816

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:30816

UCSC genome browser

More...
UCSCi
uc022ahe.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Protein Spotlight

A virus for life - Issue 50 of September 2004

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072503 mRNA No translation available.
AF072505 mRNA Translation: AAD14545.1
AF072506 mRNA Translation: AAD14546.2
AF072508 mRNA Translation: AAD14548.1
AF208161 mRNA Translation: AAF28334.1
AF513360 mRNA Translation: AAM47599.1
AF156963 Genomic DNA Translation: AAF74215.1
AC007566 Genomic DNA No translation available.
AY101582 Genomic DNA Translation: AAM68161.1
AY101583 Genomic DNA Translation: AAM68162.1
AY101584 Genomic DNA Translation: AAM68163.1
AY101585 Genomic DNA Translation: AAM68164.1
AF520478 Genomic DNA Translation: AAQ17561.1
AF520480 Genomic DNA Translation: AAQ17562.1
AF520482 Genomic DNA Translation: AAQ17563.1
AF520484 Genomic DNA Translation: AAQ17564.1
AF520486 Genomic DNA Translation: AAQ17565.1
AF520488 Genomic DNA Translation: AAQ17566.1
AF520490 Genomic DNA Translation: AAQ17567.1
AF520492 Genomic DNA Translation: AAQ17568.1
AF520494 Genomic DNA Translation: AAQ17569.1
AF520496 Genomic DNA Translation: AAQ17570.1
AF520498 Genomic DNA Translation: AAQ17571.1
AF520500 Genomic DNA Translation: AAQ17572.1
AF520502 Genomic DNA Translation: AAQ17573.1
AF520504 Genomic DNA Translation: AAQ17574.1
AF520506 Genomic DNA Translation: AAQ17575.1
AF520508 Genomic DNA Translation: AAQ17576.1
AF520510 Genomic DNA Translation: AAQ17577.1
AF520512 Genomic DNA Translation: AAQ17578.1
AF520514 Genomic DNA Translation: AAQ17579.1
AF520516 Genomic DNA Translation: AAQ17580.1
AF520518 Genomic DNA Translation: AAQ17581.1
AF520520 Genomic DNA Translation: AAQ17582.1
AF520522 Genomic DNA Translation: AAQ17583.1
AF520524 Genomic DNA Translation: AAQ17584.1
AF520526 Genomic DNA Translation: AAQ17585.1
AF520528 Genomic DNA Translation: AAQ17586.1
AF520530 Genomic DNA Translation: AAQ17587.1
AF520532 Genomic DNA Translation: AAQ17588.1
AF520534 Genomic DNA Translation: AAQ17589.1
AF520536 Genomic DNA Translation: AAQ17590.1
AF520538 Genomic DNA Translation: AAQ17591.1
AF520540 Genomic DNA Translation: AAQ17592.1
AF520542 Genomic DNA Translation: AAQ17593.1
AF520544 Genomic DNA Translation: AAQ17594.1
AF520546 Genomic DNA Translation: AAQ17595.1
AF520548 Genomic DNA Translation: AAQ17596.1
AF520550 Genomic DNA Translation: AAQ17597.1
AF520552 Genomic DNA Translation: AAQ17598.1
AF520554 Genomic DNA Translation: AAQ17599.1
AF520556 Genomic DNA Translation: AAQ17600.1
AF520558 Genomic DNA Translation: AAQ17601.1
AF520560 Genomic DNA Translation: AAQ17602.1
AF520562 Genomic DNA Translation: AAQ17603.1
AF520564 Genomic DNA Translation: AAQ17604.1
BC137381 mRNA Translation: AAI37382.1
AF506835 mRNA Translation: AAM33413.1
CCDSiCCDS5626.1
RefSeqiNP_001124397.1, NM_001130925.1
NP_055405.3, NM_014590.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HA6X-ray2.00A/B343-435[»]
SMRiQ9UQF0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000419945

Protein family/group databases

TCDBi1.G.9.1.1 the syncytin (syncytin) family

PTM databases

iPTMnetiQ9UQF0
PhosphoSitePlusiQ9UQF0

Polymorphism and mutation databases

BioMutaiERVW-1
DMDMi47605755

Proteomic databases

jPOSTiQ9UQF0
MassIVEiQ9UQF0
PaxDbiQ9UQF0
PeptideAtlasiQ9UQF0
PRIDEiQ9UQF0
ProteomicsDBi85550

Genome annotation databases

EnsembliENST00000493463; ENSP00000419945; ENSG00000242950
ENST00000603053; ENSP00000474984; ENSG00000242950
GeneIDi30816
KEGGihsa:30816
UCSCiuc022ahe.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
30816
DisGeNETi30816

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ERVW-1
HGNCiHGNC:13525 ERVW-1
MIMi604659 gene
neXtProtiNX_Q9UQF0
OpenTargetsiENSG00000242950
PharmGKBiPA27878

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JCYM Eukaryota
ENOG4111CG7 LUCA
GeneTreeiENSGT00690000102286
InParanoidiQ9UQF0
OMAiFVNQSGI
OrthoDBi925621at2759
PhylomeDBiQ9UQF0
TreeFamiTF332233

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ERVW-1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ERVWE1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
30816
PharosiQ9UQF0

Protein Ontology

More...
PROi
PR:Q9UQF0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000242950 Expressed in 92 organ(s), highest expression level in chorionic villus
ExpressionAtlasiQ9UQF0 baseline and differential
GenevisibleiQ9UQF0 HS

Family and domain databases

InterProiView protein in InterPro
IPR018154 TLV/ENV_coat_polyprotein
PANTHERiPTHR10424 PTHR10424, 1 hit
PfamiView protein in Pfam
PF00429 TLV_coat, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYCY1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UQF0
Secondary accession number(s): B2RPD4
, O95244, O95245, Q8NHY7, Q9NRZ2, Q9NZG3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 1, 2000
Last modified: October 16, 2019
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, ERV, Reference proteome, Transposable element

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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