UniProtKB - Q9UQ90 (SPG7_HUMAN)
Paraplegin
SPG7
Functioni
Caution
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 312 | ATP; via amide nitrogen and carbonyl oxygen | 1 | |
Binding sitei | 492 | ATPCombined sources1 Publication | 1 | |
Metal bindingi | 574 | Zinc; catalyticBy similarity | 1 | |
Active sitei | 575 | By similarity | 1 | |
Metal bindingi | 578 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 650 | Zinc; catalyticBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 349 – 357 | ATPCombined sources1 Publication | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP-dependent peptidase activity Source: InterPro
- metalloendopeptidase activity Source: MGI
- peptidase activity Source: ProtInc
- unfolded protein binding Source: ProtInc
- zinc ion binding Source: InterPro
GO - Biological processi
- cristae formation Source: GO_Central
- mitochondrial calcium ion transmembrane transport Source: Reactome
- mitochondrial fusion Source: GO_Central
- mitochondrial outer membrane permeabilization involved in programmed cell death Source: UniProtKB
- mitochondrial protein processing Source: GO_Central
- nervous system development Source: ProtInc
- protein-containing complex assembly Source: GO_Central
- proteolysis Source: ProtInc
- regulation of mitochondrial membrane permeability Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 3.4.24.B18, 2681 |
PathwayCommonsi | Q9UQ90 |
Reactomei | R-HSA-8949664, Processing of SMDT1 |
Protein family/group databases
MEROPSi | M41.006 |
Names & Taxonomyi
Protein namesi | Recommended name: ParapleginBy similarity (EC:3.4.24.-)Alternative name(s): Cell matrix adhesion regulatorImported Spastic paraplegia 7 proteinImported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11237, SPG7 |
MIMi | 602783, gene |
neXtProti | NX_Q9UQ90 |
VEuPathDBi | HostDB:ENSG00000197912.13 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB
- mitochondrial permeability transition pore complex Source: UniProtKB
- mitochondrion Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 106 – 144 | Mitochondrial matrixSequence analysisAdd BLAST | 39 | |
Transmembranei | 145 – 165 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 166 – 248 | Mitochondrial intermembraneSequence analysisAdd BLAST | 83 | |
Transmembranei | 249 – 269 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 270 – 795 | Mitochondrial matrixSequence analysisAdd BLAST | 526 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Involvement in diseasei
Spastic paraplegia 7, autosomal recessive (SPG7)5 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063607 | 349 | G → S in SPG7; function impaired. 1 PublicationCorresponds to variant dbSNP:rs141659620EnsemblClinVar. | 1 | |
Natural variantiVAR_063609 | 510 | A → V in SPG7; function impaired. 3 PublicationsCorresponds to variant dbSNP:rs61755320EnsemblClinVar. | 1 | |
Natural variantiVAR_063611 | 581 | Missing in SPG7. 1 Publication | 1 | |
Natural variantiVAR_063612 | 583 | W → C in SPG7; function impaired. 1 PublicationCorresponds to variant dbSNP:rs267607085EnsemblClinVar. | 1 | |
Natural variantiVAR_045898 | 692 | S → T in SPG7. 1 PublicationCorresponds to variant dbSNP:rs121918357EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 574 | H → G: Loss of proteolytic activity but no loss of interaction with PPIF; when associated with G-575 and S-577. 1 Publication | 1 | |
Mutagenesisi | 575 | E → G: Loss of proteolytic activity but no loss of interaction with PPIF; when associated with G-574 and S-577. 1 Publication | 1 | |
Mutagenesisi | 577 | G → S: No loss of interaction with PPIF. Loss of proteolytic activity but no loss of interaction with PPIF; when associated with G-574 and G-575. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Hereditary spastic paraplegia, Neurodegeneration, Osteogenesis imperfectaOrganism-specific databases
DisGeNETi | 6687 |
GeneReviewsi | SPG7 |
MalaCardsi | SPG7 |
MIMi | 607259, phenotype |
OpenTargetsi | ENSG00000197912 |
Orphaneti | 35689, Primary lateral sclerosis 99013, Spastic paraplegia type 7 |
PharmGKBi | PA36067 |
Miscellaneous databases
Pharosi | Q9UQ90, Tbio |
Genetic variation databases
BioMutai | SPG7 |
DMDMi | 116242796 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 43 | MitochondrionBy similarityAdd BLAST | 43 | |
PropeptideiPRO_0000442305 | 44 – 105 | Removed in mature formBy similarityAdd BLAST | 62 | |
ChainiPRO_0000084675 | 106 – 795 | ParapleginAdd BLAST | 690 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 505 | 3'-nitrotyrosineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
NitrationProteomic databases
EPDi | Q9UQ90 |
jPOSTi | Q9UQ90 |
MassIVEi | Q9UQ90 |
PaxDbi | Q9UQ90 |
PeptideAtlasi | Q9UQ90 |
PRIDEi | Q9UQ90 |
ProteomicsDBi | 85528 [Q9UQ90-1] 85529 [Q9UQ90-2] |
PTM databases
iPTMneti | Q9UQ90 |
PhosphoSitePlusi | Q9UQ90 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000197912, Expressed in left lobe of thyroid gland and 239 other tissues |
ExpressionAtlasi | Q9UQ90, baseline and differential |
Genevisiblei | Q9UQ90, HS |
Organism-specific databases
HPAi | ENSG00000197912, Low tissue specificity |
Interactioni
Subunit structurei
Forms heterooligomers with AFG3L1 and AFG3L2 (By similarity).
Component of the mitochondrial permeability transition pore complex (mPTPC), at least composed of SPG7, VDAC1 and PPIF (PubMed:26387735).
Interacts with AFG3L2; the interaction is required for the efficient assembly of mitochondrial complex I (PubMed:14623864, PubMed:26387735).
Interacts with AFG3L1 (By similarity).
Interacts with MAIP1 (PubMed:27499296).
Interacts with VDAC1 and PPIF (PubMed:26387735).
By similarity3 PublicationsBinary interactionsi
Hide detailsQ9UQ90
GO - Molecular functioni
- unfolded protein binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 112565, 68 interactors |
CORUMi | Q9UQ90 |
IntActi | Q9UQ90, 54 interactors |
MINTi | Q9UQ90 |
STRINGi | 9606.ENSP00000268704 |
Miscellaneous databases
RNActi | Q9UQ90, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9UQ90 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9UQ90 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 701 – 795 | Interaction with PPIF1 PublicationAdd BLAST | 95 |
Sequence similaritiesi
Keywords - Domaini
Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0731, Eukaryota |
GeneTreei | ENSGT00940000156329 |
HOGENOMi | CLU_000688_23_2_1 |
InParanoidi | Q9UQ90 |
OMAi | TRMKSMK |
OrthoDBi | 217929at2759 |
PhylomeDBi | Q9UQ90 |
TreeFami | TF105003 |
Family and domain databases
Gene3Di | 1.20.58.760, 1 hit |
HAMAPi | MF_01458, FtsH, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR005936, FtsH IPR027417, P-loop_NTPase IPR011546, Pept_M41_FtsH_extracell IPR000642, Peptidase_M41 IPR037219, Peptidase_M41-like |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF06480, FtsH_ext, 1 hit PF01434, Peptidase_M41, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF140990, SSF140990, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01241, FtsH_fam, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 42 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAVLLLLLRA LRRGPGPGPR PLWGPGPAWS PGFPARPGRG RPYMASRPPG
60 70 80 90 100
DLAEAGGRAL QSLQLRLLTP TFEGINGLLL KQHLVQNPVR LWQLLGGTFY
110 120 130 140 150
FNTSRLKQKN KEKDKSKGKA PEEDEEERRR RERDDQMYRE RLRTLLVIAV
160 170 180 190 200
VMSLLNALST SGGSISWNDF VHEMLAKGEV QRVQVVPESD VVEVYLHPGA
210 220 230 240 250
VVFGRPRLAL MYRMQVANID KFEEKLRAAE DELNIEAKDR IPVSYKRTGF
260 270 280 290 300
FGNALYSVGM TAVGLAILWY VFRLAGMTGR EGGFSAFNQL KMARFTIVDG
310 320 330 340 350
KMGKGVSFKD VAGMHEAKLE VREFVDYLKS PERFLQLGAK VPKGALLLGP
360 370 380 390 400
PGCGKTLLAK AVATEAQVPF LAMAGPEFVE VIGGLGAARV RSLFKEARAR
410 420 430 440 450
APCIVYIDEI DAVGKKRSTT MSGFSNTEEE QTLNQLLVEM DGMGTTDHVI
460 470 480 490 500
VLASTNRADI LDGALMRPGR LDRHVFIDLP TLQERREIFE QHLKSLKLTQ
510 520 530 540 550
SSTFYSQRLA ELTPGFSGAD IANICNEAAL HAAREGHTSV HTLNFEYAVE
560 570 580 590 600
RVLAGTAKKS KILSKEEQKV VAFHESGHAL VGWMLEHTEA VMKVSITPRT
610 620 630 640 650
NAALGFAQML PRDQHLFTKE QLFERMCMAL GGRASEALSF NEVTSGAQDD
660 670 680 690 700
LRKVTRIAYS MVKQFGMAPG IGPISFPEAQ EGLMGIGRRP FSQGLQQMMD
710 720 730 740 750
HEARLLVAKA YRHTEKVLQD NLDKLQALAN ALLEKEVINY EDIEALIGPP
760 770 780 790
PHGPKKMIAP QRWIDAQREK QDLGEEETEE TQQPPLGGEE PTWPK
Computationally mapped potential isoform sequencesi
There are 42 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y726 | A0A2R8Y726_HUMAN | Paraplegin | SPG7 | 659 | Annotation score: | ||
A0A2R8Y3M4 | A0A2R8Y3M4_HUMAN | Paraplegin | SPG7 | 809 | Annotation score: | ||
A0A2R8Y4Y7 | A0A2R8Y4Y7_HUMAN | Paraplegin | SPG7 | 751 | Annotation score: | ||
A0A2R8Y7B8 | A0A2R8Y7B8_HUMAN | Paraplegin | SPG7 | 681 | Annotation score: | ||
A0A2R8YFW4 | A0A2R8YFW4_HUMAN | Paraplegin | SPG7 | 780 | Annotation score: | ||
A0A2U3TZH1 | A0A2U3TZH1_HUMAN | Paraplegin | SPG7 | 788 | Annotation score: | ||
A0A2R8Y7E2 | A0A2R8Y7E2_HUMAN | Paraplegin | SPG7 | 617 | Annotation score: | ||
A0A2R8Y6K2 | A0A2R8Y6K2_HUMAN | Paraplegin | SPG7 | 641 | Annotation score: | ||
A0A2R8YDQ1 | A0A2R8YDQ1_HUMAN | Paraplegin | SPG7 | 758 | Annotation score: | ||
A0A2R8YGZ0 | A0A2R8YGZ0_HUMAN | Paraplegin | SPG7 | 415 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | R → G in AAD28099 (PubMed:10480368).Curated | 1 | |
Sequence conflicti | 376 | P → A in AAH36104 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063603 | 2 | A → T1 PublicationCorresponds to variant dbSNP:rs535030441EnsemblClinVar. | 1 | |
Natural variantiVAR_063604 | 82 | Missing Might be implicated in the hereditary spastic paraplegia phenotype. 1 Publication | 1 | |
Natural variantiVAR_063605 | 284 | F → P Requires 2 nucleotide substitutions; might be implicated in the hereditary spastic paraplegia phenotype. 1 Publication | 1 | |
Natural variantiVAR_063606 | 294 | R → H1 PublicationCorresponds to variant dbSNP:rs115661328EnsemblClinVar. | 1 | |
Natural variantiVAR_063607 | 349 | G → S in SPG7; function impaired. 1 PublicationCorresponds to variant dbSNP:rs141659620EnsemblClinVar. | 1 | |
Natural variantiVAR_063608 | 486 | R → Q. Corresponds to variant dbSNP:rs111475461EnsemblClinVar. | 1 | |
Natural variantiVAR_017433 | 503 | T → A2 PublicationsCorresponds to variant dbSNP:rs2292954EnsemblClinVar. | 1 | |
Natural variantiVAR_063609 | 510 | A → V in SPG7; function impaired. 3 PublicationsCorresponds to variant dbSNP:rs61755320EnsemblClinVar. | 1 | |
Natural variantiVAR_063610 | 545 | F → L1 PublicationCorresponds to variant dbSNP:rs758338586Ensembl. | 1 | |
Natural variantiVAR_063611 | 581 | Missing in SPG7. 1 Publication | 1 | |
Natural variantiVAR_063612 | 583 | W → C in SPG7; function impaired. 1 PublicationCorresponds to variant dbSNP:rs267607085EnsemblClinVar. | 1 | |
Natural variantiVAR_063613 | 603 | A → T1 PublicationCorresponds to variant dbSNP:rs370852816EnsemblClinVar. | 1 | |
Natural variantiVAR_048117 | 623 | F → C. Corresponds to variant dbSNP:rs17783943Ensembl. | 1 | |
Natural variantiVAR_063614 | 635 | S → L Might be implicated in the hereditary spastic paraplegia phenotype. 1 PublicationCorresponds to variant dbSNP:rs864622507EnsemblClinVar. | 1 | |
Natural variantiVAR_059086 | 645 | S → T1 PublicationCorresponds to variant dbSNP:rs2099104EnsemblClinVar. | 1 | |
Natural variantiVAR_063615 | 650 | D → H Might be implicated in the hereditary spastic paraplegia phenotype. 1 Publication | 1 | |
Natural variantiVAR_017434 | 688 | R → Q2 PublicationsCorresponds to variant dbSNP:rs12960EnsemblClinVar. | 1 | |
Natural variantiVAR_045898 | 692 | S → T in SPG7. 1 PublicationCorresponds to variant dbSNP:rs121918357EnsemblClinVar. | 1 | |
Natural variantiVAR_048118 | 730 | N → D1 PublicationCorresponds to variant dbSNP:rs35749032EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009192 | 443 – 489 | MGTTD…RREIF → ASLDQLPSQGTMRKLRGKTP ACSCLTEPTGSRRAMEGHSL CWGCLLH in isoform 2. 1 PublicationAdd BLAST | 47 | |
Alternative sequenceiVSP_009193 | 490 – 795 | Missing in isoform 2. 1 PublicationAdd BLAST | 306 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y16610 mRNA Translation: CAA76314.1 AF080525 , AF080511, AF080512, AF080513, AF080514, AF080515, AF080516, AF080517, AF080518, AF080519, AF080520, AF080521, AF080522, AF080523, AF080524 Genomic DNA Translation: AAD28099.1 BC007692 mRNA No translation available. BC035929 mRNA Translation: AAH35929.1 Different initiation. BC036104 mRNA Translation: AAH36104.1 BC110530 mRNA No translation available. BC110531 mRNA No translation available. |
CCDSi | CCDS10977.1 [Q9UQ90-1] CCDS10978.1 [Q9UQ90-2] |
RefSeqi | NP_003110.1, NM_003119.3 [Q9UQ90-1] NP_955399.1, NM_199367.2 [Q9UQ90-2] XP_016879088.1, XM_017023599.1 |
Genome annotation databases
Ensembli | ENST00000341316; ENSP00000341157; ENSG00000197912 [Q9UQ90-2] ENST00000645818; ENSP00000495795; ENSG00000197912 [Q9UQ90-1] ENST00000646263; ENSP00000494119; ENSG00000197912 [Q9UQ90-2] |
GeneIDi | 6687 |
KEGGi | hsa:6687 |
UCSCi | uc002fni.4, human [Q9UQ90-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Osteogenesis imperfecta variant database Paraplegin (SPG7) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y16610 mRNA Translation: CAA76314.1 AF080525 , AF080511, AF080512, AF080513, AF080514, AF080515, AF080516, AF080517, AF080518, AF080519, AF080520, AF080521, AF080522, AF080523, AF080524 Genomic DNA Translation: AAD28099.1 BC007692 mRNA No translation available. BC035929 mRNA Translation: AAH35929.1 Different initiation. BC036104 mRNA Translation: AAH36104.1 BC110530 mRNA No translation available. BC110531 mRNA No translation available. |
CCDSi | CCDS10977.1 [Q9UQ90-1] CCDS10978.1 [Q9UQ90-2] |
RefSeqi | NP_003110.1, NM_003119.3 [Q9UQ90-1] NP_955399.1, NM_199367.2 [Q9UQ90-2] XP_016879088.1, XM_017023599.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2QZ4 | X-ray | 2.22 | A | 305-565 | [»] | |
SMRi | Q9UQ90 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112565, 68 interactors |
CORUMi | Q9UQ90 |
IntActi | Q9UQ90, 54 interactors |
MINTi | Q9UQ90 |
STRINGi | 9606.ENSP00000268704 |
Protein family/group databases
MEROPSi | M41.006 |
PTM databases
iPTMneti | Q9UQ90 |
PhosphoSitePlusi | Q9UQ90 |
Genetic variation databases
BioMutai | SPG7 |
DMDMi | 116242796 |
Proteomic databases
EPDi | Q9UQ90 |
jPOSTi | Q9UQ90 |
MassIVEi | Q9UQ90 |
PaxDbi | Q9UQ90 |
PeptideAtlasi | Q9UQ90 |
PRIDEi | Q9UQ90 |
ProteomicsDBi | 85528 [Q9UQ90-1] 85529 [Q9UQ90-2] |
Protocols and materials databases
Antibodypediai | 30863, 374 antibodies |
DNASUi | 6687 |
Genome annotation databases
Ensembli | ENST00000341316; ENSP00000341157; ENSG00000197912 [Q9UQ90-2] ENST00000645818; ENSP00000495795; ENSG00000197912 [Q9UQ90-1] ENST00000646263; ENSP00000494119; ENSG00000197912 [Q9UQ90-2] |
GeneIDi | 6687 |
KEGGi | hsa:6687 |
UCSCi | uc002fni.4, human [Q9UQ90-1] |
Organism-specific databases
CTDi | 6687 |
DisGeNETi | 6687 |
GeneCardsi | SPG7 |
GeneReviewsi | SPG7 |
HGNCi | HGNC:11237, SPG7 |
HPAi | ENSG00000197912, Low tissue specificity |
MalaCardsi | SPG7 |
MIMi | 602783, gene 607259, phenotype |
neXtProti | NX_Q9UQ90 |
OpenTargetsi | ENSG00000197912 |
Orphaneti | 35689, Primary lateral sclerosis 99013, Spastic paraplegia type 7 |
PharmGKBi | PA36067 |
VEuPathDBi | HostDB:ENSG00000197912.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0731, Eukaryota |
GeneTreei | ENSGT00940000156329 |
HOGENOMi | CLU_000688_23_2_1 |
InParanoidi | Q9UQ90 |
OMAi | TRMKSMK |
OrthoDBi | 217929at2759 |
PhylomeDBi | Q9UQ90 |
TreeFami | TF105003 |
Enzyme and pathway databases
BRENDAi | 3.4.24.B18, 2681 |
PathwayCommonsi | Q9UQ90 |
Reactomei | R-HSA-8949664, Processing of SMDT1 |
Miscellaneous databases
BioGRID-ORCSi | 6687, 7 hits in 995 CRISPR screens |
ChiTaRSi | SPG7, human |
EvolutionaryTracei | Q9UQ90 |
GeneWikii | Paraplegin SPG7 |
GenomeRNAii | 6687 |
Pharosi | Q9UQ90, Tbio |
PROi | PR:Q9UQ90 |
RNActi | Q9UQ90, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197912, Expressed in left lobe of thyroid gland and 239 other tissues |
ExpressionAtlasi | Q9UQ90, baseline and differential |
Genevisiblei | Q9UQ90, HS |
Family and domain databases
Gene3Di | 1.20.58.760, 1 hit |
HAMAPi | MF_01458, FtsH, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR005936, FtsH IPR027417, P-loop_NTPase IPR011546, Pept_M41_FtsH_extracell IPR000642, Peptidase_M41 IPR037219, Peptidase_M41-like |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF06480, FtsH_ext, 1 hit PF01434, Peptidase_M41, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF140990, SSF140990, 1 hit SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01241, FtsH_fam, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPG7_HUMAN | |
Accessioni | Q9UQ90Primary (citable) accession number: Q9UQ90 Secondary accession number(s): O75756 Q96IB0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | October 17, 2006 | |
Last modified: | April 7, 2021 | |
This is version 207 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families