Cyclin-dependent kinase 11A

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Caution

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 12501247
• cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
• protein kinase activity Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 9750192
• protein serine/threonine kinase activity Source: UniProtKBInferred from direct assayⁱ
  • 12501247

GO - Biological processⁱ

• apoptotic process Source: UniProtKBNon-traceable author statementⁱ
  • 9750192
• mitotic cell cycle Source: UniProtKBNon-traceable author statementⁱ
  • 1639388
• protein phosphorylation Source: UniProtKBInferred from direct assayⁱ
  • 12501247
• regulation of cell growth Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 10882096
• regulation of mitotic cell cycle Source: GO_Central
• regulation of mRNA processing Source: UniProtKBInferred from direct assayⁱ
  • 12501247
• regulation of transcription, DNA-templated Source: UniProtKBNon-traceable author statementⁱ
  • 9750192

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 8 described isoforms and 6 potential isoforms that are <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>computationally mapped.ⁱShow all

        10         20         30         40         50
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE 
        60         70         80         90        100
GELRDHCMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKVHHR 
       110        120        130        140        150
KDEKRKEKWK HARVKEREHE RRKRHREEQD KARREWERQK RREMAREHSR 
       160        170        180        190        200
RERDRLEQLE RKRERERKMR EQQKEQREQK ERERRAEERR KEREARREVS 
       210        220        230        240        250
AHHRTMREDY SDKVKASHWS RSPPRPPRER FELGDGRKPG EARPAPAQKP 
       260        270        280        290        300
AQLKEEKMEE RDLLSDLQDI SDSERKTSSA ESSSAESGSG SEEEEEEEEE 
       310        320        330        340        350
EEEEGSTSEE SEEEEEEEEE EEEETGSNSE EASEQSAEEV SEEEMSEDEE 
       360        370        380        390        400
RENENHLLVV PESRFDRDSG ESEEAEEEVG EGTPQSSALT EGDYVPDSPA 
       410        420        430        440        450
LLPIELKQEL PKYLPALQGC RSVEEFQCLN RIEEGTYGVV YRAKDKKTDE 
       460        470        480        490        500
IVALKRLKME KEKEGFPITS LREINTILKA QHPNIVTVRE IVVGSNMDKI 
       510        520        530        540        550
YIVMNYVEHD LKSLMETMKQ PFLPGEVKTL MIQLLRGVKH LHDNWILHRD 
       560        570        580        590        600
LKTSNLLLSH AGILKVGDFG LAREYGSPLK AYTPVVVTQW YRAPELLLGA 
       610        620        630        640        650
KEYSTAVDMW SVGCIFGELL TQKPLFPGNS EIDQINKVFK ELGTPSEKIW 
       660        670        680        690        700
PGYSELPVVK KMTFSEHPYN NLRKRFGALL SDQGFDLMNK FLTYFPGRRI 
       710        720        730        740        750
SAEDGLKHEY FRETPLPIDP SMFPTWPAKS EQQRVKRGTS PRPPEGGLGY 
       760        770        780 
SQLGDDDLKE TGFHLTTTNQ GASAAGPGFS LKF                   

        10         20         30         40         50
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE 
        60         70         80         90        100
GELRDHCMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKVHHR 
       110        120        130        140        150
KDEKRKEKCR HHSHSAEGGK HARVKEREHE RRKRHREEQD KARREWERQK 
       160        170        180        190        200
RREMAREHSR RERDRLEQLE RKRERERKMR EQQKEQREQK ERERRAEERR 
       210        220        230        240        250
KEREARREVS AHHRTMREDY SDKVKASHWS RSPPRPPRER FELGDGRKPV 
       260        270        280        290        300
KEEKMEERDL LSDLQDISDS ERKTSSAESS SAESGSGSEE EEEEEEEEEE 
       310        320        330        340        350
EGSTSEESEE EEEEEEEEEE ETGSNSEEAS EQSAEEVSEE EMSEDEEREN 
       360        370        380        390        400
ENHLLVVPES RFDRDSGESE EAEEEVGEGT PQSSALTEGD YVPDSPALLP 
       410        420        430        440        450
IELKQELPKY LPALQGCRSV EEFQCLNRIE EGTYGVVYRA KDKKTDEIVA 
       460        470        480        490        500
LKRLKMEKEK EGFPITSLRE INTILKAQHP NIVTVREIVV GSNMDKIYIV 
       510        520        530        540        550
MNYVEHDLKS LMETMKQPFL PGEVKTLMIQ LLRGVKHLHD NWILHRDLKT 
       560        570        580        590        600
SNLLLSHAGI LKVGDFGLAR EYGSPLKAYT PVVVTQWYRA PELLLGAKEY 
       610        620        630        640        650
STAVDMWSVG CIFGELLTQK PLFPGNSEID QINKVFKELG TPSEKIWPGY 
       660        670        680        690        700
SELPVVKKMT FSEHPYNNLR KRFGALLSDQ GFDLMNKFLT YFPGRRISAE 
       710        720        730        740        750
DGLKHEYFRE TPLPIDPSMF PTWPAKSEQQ RVKRGTSPRP PEGGLGYSQL 
       760        770        780
GDDDLKETGF HLTTTNQGAS AAGPGFSLKF                       

        10         20         30         40         50
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE 
        60         70         80         90        100
GELRDHCMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKVHHR 
       110        120        130        140        150
KDEKRKEKWK HARVKEREHE RRKRHREEQD KARREWERQK RREMAREHSR 
       160        170        180        190        200
RERGNDGFCL FRDRLEQLER KRERERKMRE QQKEQREQKE RERRAEERRK 
       210        220        230        240        250
EREARREVSA HHRTMREDYS DKVKASHWSR SPPRPPRERF ELGDGRKPVK 
       260        270        280        290        300
EEKMEERDLL SDLQDISDSE RKTSSAESSS AESGSGSEEE EEEEEEEEEE 
       310        320        330        340        350
GSTSEESEEE EEEEEEEEEE TGSNSEEASE QSAEEVSEEE MSEDEERENE 
       360        370        380        390        400
NHLLVVPESR FDRDSGESEE AEEEVGEGTP QSSALTEGDY VPDSPALLPI 
       410        420        430        440        450
ELKQELPKYL PALQGCRSVE EFQCLNRIEE GTYGVVYRAK DKKTDEIVAL 
       460        470        480        490        500
KRLKMEKEKE GFPITSLREI NTILKAQHPN IVTVREIVVG SNMDKIYIVM 
       510        520        530        540        550
NYVEHDLKSL METMKQPFLP GEVKTLMIQL LRGVKHLHDN WILHRDLKTS 
       560        570        580        590        600
NLLLSHAGIL KVGDFGLARE YGSPLKAYTP VVVTQWYRAP ELLLGAKEYS 
       610        620        630        640        650
TAVDMWSVGC IFGELLTQKP LFPGNSEIDQ INKVFKELGT PSEKIWPGYS 
       660        670        680        690        700
ELPVVKKMTF SEHPYNNLRK RFGALLSDQG FDLMNKFLTY FPGRRISAED 
       710        720        730        740        750
GLKHEYFRET PLPIDPSMFP TWPAKSEQQR VKRGTSPRPP EGGLGYSQLG 
       760        770 
DDDLKETGFH LTTTNQGASA AGPGFSLKF                        

        10         20         30         40         50
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE 
        60         70         80         90        100
GELRDHCMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKVHHR 
       110        120        130        140        150
KDEKRKEKWK HARVKEREHE RRKRHREEQD KARREWERQK RREMAREHSR 
       160        170        180        190        200
RERDRLEQLE RKRERERKMR EQQKEQREQK ERERRAEERR KEREARREVS 
       210        220        230        240        250
AHHRTMREDY SDKVKASHWS RSPPRPPRER FELGDGRKPV KEEKMEERDL 
       260        270        280        290        300
LSDLQDISDS ERKTSSAESS SAESGSGSEE EEEEEEEEEE EGSTSEESEE 
       310        320        330        340        350
EEEEEEEEEE ETGSNSEEAS EQSAEEVSEE EMSEDEEREN ENHLLVVPES 
       360        370        380        390        400
RFDRDSGESE EAEEEVGEGT PQSSALTEGD YVPDSPALLP IELKQELPKY 
       410        420        430        440        450
LPALQGCRSV EEFQCLNRIE EGTYGVVYRA KDKKTDEIVA LKRLKMEKEK 
       460        470        480        490        500
EGFPITSLRE INTILKAQHP NIVTVREIVV GSNMDKIYIV MNYVEHDLKS 
       510        520        530        540        550
LMETMKQPFL PGEVKTLMIQ LLRGVKHLHD NWILHRDLKT SNLLLSHAGI 
       560        570        580        590        600
LKVGDFGLAR EYGSPLKAYT PVVVTQWYRA PELLLGAKEY STAVDMWSVG 
       610        620        630        640        650
CIFGELLTQK PLFPGNSEID QINKVFKELG TPSEKIWPGY SELPVVKKMT 
       660        670        680        690        700
FSEHPYNNLR KRFGALLSDQ GFDLMNKFLT YFPGRRISAE DGLKHEYFRE 
       710        720        730        740        750
TPLPIDPSMF PTWPAKSEQQ RVKRGTSPRP PEGGLGYSQL GDDDLKETGF 
       760        770
HLTTTNQGAS AAGPGFSLKF                                  

        10         20         30         40         50
MKNEKMKTTS WLFQSHGSTE IPGRVKKQRK KWGCRSVEEF QCLNRIEEGT 
        60         70         80         90        100
YGVVYRAKDK KTDEIVALKR LKMEKEKEGF PITSLREINT ILKAQHPNIV 
       110        120        130        140        150
TVREIVVGSN MDKIYIVMNY VEHDLKSLME TMKQPFLPGE VKTLMIQLLR 
       160        170        180        190        200
GVKHLHDNWI LHRDLKTSNL LLSHAGILKV GDFGLAREYG SPLKAYTPVV 
       210        220        230        240        250
VTQWYRAPEL LLGAKEYSTA VDMWSVGCIF GELLTQKPLF PGNSEIDQIN 
       260        270        280        290        300
KVFKELGTPS EKIWPGYSEL PVVKKMTFSE HPYNNLRKRF GALLSDQGFD 
       310        320        330        340        350
LMNKFLTYFP GRRISAEDGL KHEYFRETPL PIDPSMFPTW PAKSEQQRVK 
       360        370        380        390 
RGTSPRPPEG GLGYSQLGDD DLKETGFHLT TTNQGASAAG PGFSLKF    

        10         20         30         40         50
MGKTEEKGNG KGAFQERKGP LGAVRKEAGA GAQDAGAAEG AAVKKMTFSE 
        60         70         80         90        100
HPYNNLRKRF GALLSDQGFD LMNKFLTYFP GRRISAEDGL KHEYFRETPL 
       110        120        130        140        150
PIDPSMFPTW PAKSEQQRVK RGTSPRPPEG GLGYSQLGDD DLKETGFHLT 
       160 
TTNQGASAAG PGFSLKF                                     

        10         20         30         40         50
MEITIRNSPY RREDSMEDRG EEDDSLAIKP PQQMSRKEKV HHRKDEKRKE 
        60         70         80         90        100
KWKHARVKER EHERRKRHRE EQDKARREWE RQKRREMARE HSRRERGNDG 
       110        120        130        140        150
FCLFRDRLEQ LERKRERERK MREQQKEQRE QKERERRAEE RRKEREARRE 
       160        170        180        190        200
VSAHHRTMRE DYSDKVKASH WSRSPPRPPR ERFELGDGRK PVKEEKMEER 
       210        220        230        240        250
DLLSDLQDIS DSERKTSSAE SSSAESGSGS EEEEEEEEEE EEEGSTSEES 
       260        270        280        290        300
EEEEEEEEEE EEETGSNSEE ASEQSAEEVS EEEMSEDEER ENENHLLVVP 
       310        320        330        340        350
ESRFDRDSGE SEEAEEEVGE GTPQSSALTE GDYVPDSPAL LPIELKQELP 
       360        370        380        390        400
KYLPALQGCR SVEEFQCLNR IEEGTYGVVY RAKDKKTDEI VALKRLKMEK 
       410        420        430        440        450
EKEGFPITSL REINTILKAQ HPNIVTVREI VVGSNMDKIY IVMNYVEHDL 
       460        470        480        490        500
KSLMETMKQP FLPGEVKTLM IQLLRGVKHL HDNWILHRDL KTSNLLLSHA 
       510        520        530 
GILKVSPPPS GPSQGDPPGP THSRPSVVAG G                     

        10         20         30         40         50
MSEDEERENE NHLLVVPESR FDRDSGESEE AEEEVGEGTP QSSALTEGDY 
        60         70         80         90        100
VPDSPALLPI ELKQELPKYL PALQGCRSVE EFQCLNRIEE GTYGVVYRAK 
       110        120        130        140        150
DKKTDEIVAL KRLKMEKEKE GFPITSLREI NTILKAQHPN IVTVREIVVG 
       160        170        180        190        200
SNMDKIYIVM NYVEHDLKSL METMKQPFLP GEVKTLMIQL LRGVKHLHDN 
       210        220        230        240        250
WILHRDLKTS NLLLSHAGIL KVGDFGLARE YGSPLKAYTP VVVTQWYRAP 
       260        270        280        290        300
ELLLGAKEYS TAVDMWSVGC IFGELLTQKP LFPGNSEIDQ INKVFKELGT 
       310        320        330        340        350
PSEKIWPGYS ELPVVKKMTF SEHPYNNLRK RFGALLSDQG FDLMNKFLTY 
       360        370        380        390        400
FPGRRISAED GLKHEYFRET PLPIDPSMFP TWPAKSEQQR VKRGTSPRPP 
       410        420        430 
EGGLGYSQLG DDDLKETGFH LTTTNQGASA AGPGFSLKF             

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ