UniProtKB - Q9UQ88 (CD11A_HUMAN)
Cyclin-dependent kinase 11A
CDK11A
Functioni
Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
2 PublicationsMiscellaneous
Caution
Catalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 455 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 550 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 432 – 440 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
- protein kinase activity Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
GO - Biological processi
- apoptotic process Source: UniProtKB
- mitotic cell cycle Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of apoptotic process Source: ComplexPortal
- regulation of cell cycle Source: ComplexPortal
- regulation of cell growth Source: UniProtKB
- regulation of centrosome cycle Source: ComplexPortal
- regulation of mitotic cell cycle Source: GO_Central
- regulation of mRNA processing Source: UniProtKB
- regulation of RNA splicing Source: ComplexPortal
- regulation of transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis, Cell cycle |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9UQ88 |
Reactomei | R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes |
SignaLinki | Q9UQ88 |
SIGNORi | Q9UQ88 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinase 11A (EC:2.7.11.22)Alternative name(s): Cell division cycle 2-like protein kinase 2 Cell division protein kinase 11A Galactosyltransferase-associated protein kinase p58/GTA PITSLRE serine/threonine-protein kinase CDC2L2 |
Gene namesi | Name:CDK11A Synonyms:CDC2L2, CDC2L3, PITSLREB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1730, CDK11A |
MIMi | 116951, gene |
neXtProti | NX_Q9UQ88 |
VEuPathDBi | HostDB:ENSG00000008128 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB
Other locations
- cyclin-dependent protein kinase holoenzyme complex Source: ComplexPortal
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 728642 |
OpenTargetsi | ENSG00000008128 |
PharmGKBi | PA26263 |
Miscellaneous databases
Pharosi | Q9UQ88, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5416 |
DrugCentrali | Q9UQ88 |
Genetic variation databases
BioMutai | CDK11A |
DMDMi | 317373559 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000024315 | 1 – 783 | Cyclin-dependent kinase 11AAdd BLAST | 783 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 47 | PhosphoserineBy similarity | 1 | |
Modified residuei | 72 | PhosphoserineBy similarity | 1 | |
Modified residuei | 271 | PhosphoserineBy similarity | 1 | |
Modified residuei | 470 | Phosphoserine; by CDK7By similarity | 1 | |
Modified residuei | 476 | Phosphothreonine; by CDK7By similarity | 1 | |
Modified residuei | 577 | PhosphoserineBy similarity | 1 | |
Modified residuei | 582 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 583 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 739 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 740 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UQ88 |
jPOSTi | Q9UQ88 |
MassIVEi | Q9UQ88 |
MaxQBi | Q9UQ88 |
PeptideAtlasi | Q9UQ88 |
PRIDEi | Q9UQ88 |
ProteomicsDBi | 85520 [Q9UQ88-1] 85521 [Q9UQ88-10] 85522 [Q9UQ88-2] 85523 [Q9UQ88-3] 85524 [Q9UQ88-4] 85525 [Q9UQ88-5] 85526 [Q9UQ88-8] 85527 [Q9UQ88-9] |
PTM databases
GlyGeni | Q9UQ88, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UQ88 |
PhosphoSitePlusi | Q9UQ88 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000008128, Expressed in small intestine Peyer's patch and 114 other tissues |
ExpressionAtlasi | Q9UQ88, baseline and differential |
Genevisiblei | Q9UQ88, HS |
Organism-specific databases
HPAi | ENSG00000008128, Low tissue specificity |
Interactioni
Subunit structurei
The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1. The p58 isoform but not the p110 isoform or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing CCNL1 and SFRS7.
2 PublicationsBinary interactionsi
Isoform SV6 [Q9UQ88-1]
With | #Exp. | IntAct |
---|---|---|
CHEK2 [O96017] | 2 | EBI-11579223,EBI-1180783 |
Protein-protein interaction databases
BioGRIDi | 609064, 112 interactors |
ComplexPortali | CPX-341, Cyclin L1-CDK11A(p110) complex [Q9UQ88-1] CPX-343, Cyclin L2-CDK11A(p110) complex [Q9UQ88-1] CPX-344, Cyclin L1-CDK11A(p58) complex [Q9UQ88-10] CPX-347, Cyclin L2-CDK11A(p58) complex [Q9UQ88-10] |
IntActi | Q9UQ88, 57 interactors |
MINTi | Q9UQ88 |
Chemistry databases
BindingDBi | Q9UQ88 |
Miscellaneous databases
RNActi | Q9UQ88, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 427 – 647 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 221 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 18 – 396 | DisorderedSequence analysisAdd BLAST | 379 | |
Regioni | 721 – 783 | DisorderedSequence analysisAdd BLAST | 63 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 18 – 83 | Basic and acidic residuesSequence analysisAdd BLAST | 66 | |
Compositional biasi | 98 – 120 | Basic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 121 – 239 | Basic and acidic residuesSequence analysisAdd BLAST | 119 | |
Compositional biasi | 250 – 276 | Basic and acidic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 288 – 350 | Acidic residuesSequence analysisAdd BLAST | 63 | |
Compositional biasi | 351 – 370 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000158459 |
HOGENOMi | CLU_000288_91_3_1 |
InParanoidi | Q9UQ88 |
OMAi | DSWHVKS |
OrthoDBi | 925637at2759 |
PhylomeDBi | Q9UQ88 |
TreeFami | TF101035 |
Family and domain databases
CDDi | cd07843, STKc_CDC2L1, 1 hit |
InterProi | View protein in InterPro IPR045267, CDK11/PITSLRE_STKc IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (8+)i Sequence
Sequence statusi: Complete.
This entry describes 8 produced by isoformsialternative splicing and alternative initiation. AlignAdd to basketThis entry has 8 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE
60 70 80 90 100
GELRDHCMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKVHHR
110 120 130 140 150
KDEKRKEKWK HARVKEREHE RRKRHREEQD KARREWERQK RREMAREHSR
160 170 180 190 200
RERDRLEQLE RKRERERKMR EQQKEQREQK ERERRAEERR KEREARREVS
210 220 230 240 250
AHHRTMREDY SDKVKASHWS RSPPRPPRER FELGDGRKPG EARPAPAQKP
260 270 280 290 300
AQLKEEKMEE RDLLSDLQDI SDSERKTSSA ESSSAESGSG SEEEEEEEEE
310 320 330 340 350
EEEEGSTSEE SEEEEEEEEE EEEETGSNSE EASEQSAEEV SEEEMSEDEE
360 370 380 390 400
RENENHLLVV PESRFDRDSG ESEEAEEEVG EGTPQSSALT EGDYVPDSPA
410 420 430 440 450
LLPIELKQEL PKYLPALQGC RSVEEFQCLN RIEEGTYGVV YRAKDKKTDE
460 470 480 490 500
IVALKRLKME KEKEGFPITS LREINTILKA QHPNIVTVRE IVVGSNMDKI
510 520 530 540 550
YIVMNYVEHD LKSLMETMKQ PFLPGEVKTL MIQLLRGVKH LHDNWILHRD
560 570 580 590 600
LKTSNLLLSH AGILKVGDFG LAREYGSPLK AYTPVVVTQW YRAPELLLGA
610 620 630 640 650
KEYSTAVDMW SVGCIFGELL TQKPLFPGNS EIDQINKVFK ELGTPSEKIW
660 670 680 690 700
PGYSELPVVK KMTFSEHPYN NLRKRFGALL SDQGFDLMNK FLTYFPGRRI
710 720 730 740 750
SAEDGLKHEY FRETPLPIDP SMFPTWPAKS EQQRVKRGTS PRPPEGGLGY
760 770 780
SQLGDDDLKE TGFHLTTTNQ GASAAGPGFS LKF
The sequence of this isoform differs from the canonical sequence as follows:
109-109: W → CRHHSHSAEGG
240-253: GEARPAPAQKPAQL → V
The sequence of this isoform differs from the canonical sequence as follows:
153-153: R → RGNDGFCLFR
240-253: GEARPAPAQKPAQL → V
The sequence of this isoform differs from the canonical sequence as follows:
240-253: GEARPAPAQKPAQL → V
The sequence of this isoform differs from the canonical sequence as follows:
1-386: Missing.
387-418: SALTEGDYVPDSPALLPIELKQELPKYLPALQ → MKNEKMKTTSWLFQSHGSTEIPGRVKKQRKKW
The sequence of this isoform differs from the canonical sequence as follows:
1-616: Missing.
617-658: GELLTQKPLF...IWPGYSELPV → MGKTEEKGNG...QDAGAAEGAA
The sequence of this isoform differs from the canonical sequence as follows:
1-57: Missing.
153-153: R → RGNDGFCLFR
240-253: GEARPAPAQKPAQL → V
567-600: GDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGA → SPPPSGPSQGDPPGPTHSRPSVVAGG
601-783: Missing.
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5QPR3 | Q5QPR3_HUMAN | Cyclin-dependent kinase 11A | CDK11A | 779 | Annotation score: | ||
Q5QPR4 | Q5QPR4_HUMAN | Cyclin-dependent kinase 11A | CDK11A | 746 | Annotation score: | ||
E9PFJ2 | E9PFJ2_HUMAN | Cyclin-dependent kinase 11A | CDK11A | 151 | Annotation score: | ||
E7ESP2 | E7ESP2_HUMAN | Cyclin-dependent kinase 11A | CDK11A | 420 | Annotation score: | ||
J3KS35 | J3KS35_HUMAN | Cyclin-dependent kinase 11A | CDK11A | 407 | Annotation score: | ||
Q5QPQ9 | Q5QPQ9_HUMAN | Cyclin-dependent kinase 11A | CDK11A | 37 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 109 | Missing in AAA19594 (PubMed:8195233).Curated | 1 | ||
Sequence conflicti | 109 | Missing in AAA19595 (PubMed:8195233).Curated | 1 | ||
Sequence conflicti | 246 | P → R in AAC72087 (PubMed:9750192).Curated | 1 | ||
Sequence conflicti | 312 – 314 | Missing in AAA19594 (PubMed:8195233).Curated | 3 | ||
Sequence conflicti | 312 – 314 | Missing in AAA19595 (PubMed:8195233).Curated | 3 | ||
Sequence conflicti | 312 – 314 | Missing in AAC72084 (PubMed:9750192).Curated | 3 | ||
Sequence conflicti | 312 – 314 | Missing in AAC72085 (PubMed:9750192).Curated | 3 | ||
Sequence conflicti | 312 – 314 | Missing in AAC72086 (PubMed:9750192).Curated | 3 | ||
Sequence conflicti | 312 – 314 | Missing in AAC72087 (PubMed:9750192).Curated | 3 | ||
Sequence conflicti | 312 – 314 | Missing in AAC72090 (PubMed:9750192).Curated | 3 | ||
Sequence conflicti | 424 | E → D in AAA19585 (PubMed:8195233).Curated | 1 | ||
Sequence conflicti | 424 | E → D in AAA19594 (PubMed:8195233).Curated | 1 | ||
Sequence conflicti | 424 | E → D in AAA19595 (PubMed:8195233).Curated | 1 | ||
Sequence conflicti | 463 | K → N in AAA19585 (PubMed:8195233).Curated | 1 | ||
Sequence conflicti | 463 | K → N in AAA19594 (PubMed:8195233).Curated | 1 | ||
Sequence conflicti | 463 | K → N in AAA19595 (PubMed:8195233).Curated | 1 | ||
Sequence conflicti | 666 | E → R in AAA19585 (PubMed:8195233).Curated | 1 | ||
Sequence conflicti | 666 | E → R in AAA19594 (PubMed:8195233).Curated | 1 | ||
Sequence conflicti | 666 | E → R in AAA19595 (PubMed:8195233).Curated | 1 | ||
Sequence conflicti | 682 | D → E in AAA19585 (PubMed:8195233).Curated | 1 | ||
Sequence conflicti | 682 | D → E in AAA19594 (PubMed:8195233).Curated | 1 | ||
Sequence conflicti | 682 | D → E in AAA19595 (PubMed:8195233).Curated | 1 | ||
Isoform SV1 (identifier: Q9UQ88-2) | |||||
Sequence conflicti | 109 | C → R in AAA19594 (PubMed:8195233).Curated | 1 | ||
Sequence conflicti | 112 | H → R in AAA19594 (PubMed:8195233).Curated | 1 | ||
Isoform SV2 (identifier: Q9UQ88-3) | |||||
Sequence conflicti | 158 | F → V in AAA19595 (PubMed:8195233).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060152 | 57 | C → R. Corresponds to variant dbSNP:rs1059832Ensembl. | 1 | |
Natural variantiVAR_062200 | 92 | S → P. Corresponds to variant dbSNP:rs7531938Ensembl. | 1 | |
Natural variantiVAR_031716 | 93 | R → W2 PublicationsCorresponds to variant dbSNP:rs1059831Ensembl. | 1 | |
Natural variantiVAR_031717 | 402 | L → S1 PublicationCorresponds to variant dbSNP:rs1059828Ensembl. | 1 | |
Natural variantiVAR_060153 | 658 | V → A. Corresponds to variant dbSNP:rs866149312Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008284 | 1 – 616 | Missing in isoform SV12. 1 PublicationAdd BLAST | 616 | |
Alternative sequenceiVSP_008283 | 1 – 386 | Missing in isoform SV7. 2 PublicationsAdd BLAST | 386 | |
Alternative sequenceiVSP_018836 | 1 – 344 | Missing in isoform 4. 1 PublicationAdd BLAST | 344 | |
Alternative sequenceiVSP_008281 | 1 – 57 | Missing in isoform SV13. 1 PublicationAdd BLAST | 57 | |
Alternative sequenceiVSP_008286 | 109 | W → CRHHSHSAEGG in isoform SV1. 2 Publications | 1 | |
Alternative sequenceiVSP_008287 | 153 | R → RGNDGFCLFR in isoform SV2 and isoform SV13. 2 Publications | 1 | |
Alternative sequenceiVSP_008288 | 240 – 253 | GEARP…KPAQL → V in isoform SV1, isoform SV2, isoform SV3 and isoform SV13. 2 PublicationsAdd BLAST | 14 | |
Alternative sequenceiVSP_008289 | 387 – 418 | SALTE…LPALQ → MKNEKMKTTSWLFQSHGSTE IPGRVKKQRKKW in isoform SV7. 2 PublicationsAdd BLAST | 32 | |
Alternative sequenceiVSP_008290 | 567 – 600 | GDFGL…LLLGA → SPPPSGPSQGDPPGPTHSRP SVVAGG in isoform SV13. 1 PublicationAdd BLAST | 34 | |
Alternative sequenceiVSP_008291 | 601 – 783 | Missing in isoform SV13. 1 PublicationAdd BLAST | 183 | |
Alternative sequenceiVSP_008292 | 617 – 658 | GELLT…SELPV → MGKTEEKGNGKGAFQERKGP LGAVRKEAGAGAQDAGAAEG AA in isoform SV12. 1 PublicationAdd BLAST | 42 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000358779.9; ENSP00000351629.5; ENSG00000008128.23 [Q9UQ88-4] ENST00000378633.5; ENSP00000367900.1; ENSG00000008128.23 ENST00000404249.8; ENSP00000384442.3; ENSG00000008128.23 [Q9UQ88-2] |
GeneIDi | 728642 |
KEGGi | hsa:728642 |
MANE-Selecti | ENST00000404249.8; ENSP00000384442.3; NM_024011.4; NP_076916.2 [Q9UQ88-2] |
UCSCi | uc009vkr.4, human [Q9UQ88-1] |
Keywords - Coding sequence diversityi
Alternative initiation, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
AlphaFoldDBi | Q9UQ88 |
SMRi | Q9UQ88 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 609064, 112 interactors |
ComplexPortali | CPX-341, Cyclin L1-CDK11A(p110) complex [Q9UQ88-1] CPX-343, Cyclin L2-CDK11A(p110) complex [Q9UQ88-1] CPX-344, Cyclin L1-CDK11A(p58) complex [Q9UQ88-10] CPX-347, Cyclin L2-CDK11A(p58) complex [Q9UQ88-10] |
IntActi | Q9UQ88, 57 interactors |
MINTi | Q9UQ88 |
Chemistry databases
BindingDBi | Q9UQ88 |
ChEMBLi | CHEMBL5416 |
DrugCentrali | Q9UQ88 |
PTM databases
GlyGeni | Q9UQ88, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UQ88 |
PhosphoSitePlusi | Q9UQ88 |
Genetic variation databases
BioMutai | CDK11A |
DMDMi | 317373559 |
Proteomic databases
EPDi | Q9UQ88 |
jPOSTi | Q9UQ88 |
MassIVEi | Q9UQ88 |
MaxQBi | Q9UQ88 |
PeptideAtlasi | Q9UQ88 |
PRIDEi | Q9UQ88 |
ProteomicsDBi | 85520 [Q9UQ88-1] 85521 [Q9UQ88-10] 85522 [Q9UQ88-2] 85523 [Q9UQ88-3] 85524 [Q9UQ88-4] 85525 [Q9UQ88-5] 85526 [Q9UQ88-8] 85527 [Q9UQ88-9] |
Protocols and materials databases
Antibodypediai | 4184, 139 antibodies from 21 providers |
DNASUi | 728642 |
Genome annotation databases
Ensembli | ENST00000358779.9; ENSP00000351629.5; ENSG00000008128.23 [Q9UQ88-4] ENST00000378633.5; ENSP00000367900.1; ENSG00000008128.23 ENST00000404249.8; ENSP00000384442.3; ENSG00000008128.23 [Q9UQ88-2] |
GeneIDi | 728642 |
KEGGi | hsa:728642 |
MANE-Selecti | ENST00000404249.8; ENSP00000384442.3; NM_024011.4; NP_076916.2 [Q9UQ88-2] |
UCSCi | uc009vkr.4, human [Q9UQ88-1] |
Organism-specific databases
CTDi | 728642 |
DisGeNETi | 728642 |
GeneCardsi | CDK11A |
HGNCi | HGNC:1730, CDK11A |
HPAi | ENSG00000008128, Low tissue specificity |
MIMi | 116951, gene |
neXtProti | NX_Q9UQ88 |
OpenTargetsi | ENSG00000008128 |
PharmGKBi | PA26263 |
VEuPathDBi | HostDB:ENSG00000008128 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158459 |
HOGENOMi | CLU_000288_91_3_1 |
InParanoidi | Q9UQ88 |
OMAi | DSWHVKS |
OrthoDBi | 925637at2759 |
PhylomeDBi | Q9UQ88 |
TreeFami | TF101035 |
Enzyme and pathway databases
PathwayCommonsi | Q9UQ88 |
Reactomei | R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes |
SignaLinki | Q9UQ88 |
SIGNORi | Q9UQ88 |
Miscellaneous databases
BioGRID-ORCSi | 728642, 726 hits in 1110 CRISPR screens |
ChiTaRSi | CDK11A, human |
GeneWikii | CDC2L2 |
GenomeRNAii | 728642 |
Pharosi | Q9UQ88, Tchem |
PROi | PR:Q9UQ88 |
RNActi | Q9UQ88, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000008128, Expressed in small intestine Peyer's patch and 114 other tissues |
ExpressionAtlasi | Q9UQ88, baseline and differential |
Genevisiblei | Q9UQ88, HS |
Family and domain databases
CDDi | cd07843, STKc_CDC2L1, 1 hit |
InterProi | View protein in InterPro IPR045267, CDK11/PITSLRE_STKc IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CD11A_HUMAN | |
Accessioni | Q9UQ88Primary (citable) accession number: Q9UQ88 Secondary accession number(s): O95227 Q9UQ89 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2003 |
Last sequence update: | January 11, 2011 | |
Last modified: | May 25, 2022 | |
This is version 201 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families