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Protein

Exonuclease 1

Gene

EXO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.12 Publications

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi30Magnesium 1By similarity1
Metal bindingi78Magnesium 1By similarity1
Metal bindingi150Magnesium 1By similarity1
Metal bindingi152Magnesium 1By similarity1
Metal bindingi171Magnesium 2By similarity1
Metal bindingi173Magnesium 2By similarity1
Metal bindingi225Magnesium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Endonuclease, Excision nuclease, Exonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA excision, DNA repair, Immunity, Meiosis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.11.1 2681
ReactomeiR-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint
SIGNORiQ9UQ84

Names & Taxonomyi

Protein namesi
Recommended name:
Exonuclease 1 (EC:3.1.-.-)
Short name:
hExo1
Alternative name(s):
Exonuclease I
Short name:
hExoI
Gene namesi
Name:EXO1
Synonyms:EXOI, HEX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000174371.16
HGNCiHGNC:3511 EXO1
MIMi606063 gene
neXtProtiNX_Q9UQ84

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi78D → A: Abrogates double-stranded DNA exonuclease activity and endonuclease activity against 5'-overhanging flap structures. Also reduces DNA-binding to 5'-overhanging flap structures. 1 Publication1
Mutagenesisi173D → A: Abrogates double-stranded DNA exonuclease activity and endonuclease activity against 5'-overhanging flap structures. No effect on DNA-binding to 5'-overhanging flap structures. 2 Publications1
Mutagenesisi225D → A: Abrogates double-stranded DNA exonuclease activity and endonuclease activity against 5'-overhanging flap structures. Also enhances DNA-binding to 5'-overhanging flap structures. 1 Publication1
Mutagenesisi418K → A or T: Complete loss of nuclear localization. 1 Publication1
Mutagenesisi419R → A: Complete loss of nuclear localization. 1 Publication1
Mutagenesisi454S → A: No rescue of HU-induced degradation. No rescue of HU-induced degradation; when associated with A-714. Loss of HU-sensitivity and resistance to HU-induced degradation; when associated with A-621 and A-714. 1 Publication1
Mutagenesisi621T → A: No rescue of HU-induced degradation. No rescue of HU-induced degradation; when associated with A-714. Loss of HU-sensitivity and resistance to HU-induced degradation; when associated with A-454 and A-714. 1 Publication1
Mutagenesisi714S → A: No rescue of HU-induced degradation and loss of HU-induced increase of phosphorylation. No rescue of HU-induced degradation; when associated with A-621. No rescue of HU-induced degradation; when associated with A-454. Loss of HU-sensitivity and resistance to HU-induced degradation; when associated with A-454 and A-621. 1 Publication1

Organism-specific databases

DisGeNETi9156
OpenTargetsiENSG00000174371
PharmGKBiPA27923

Polymorphism and mutation databases

BioMutaiEXO1
DMDMi85700954

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001540391 – 846Exonuclease 1Add BLAST846

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei376Phosphoserine1 Publication1
Modified residuei422PhosphoserineCombined sources1 Publication1
Modified residuei454Phosphoserine1 Publication1
Modified residuei482N6-acetyllysine1 Publication1
Modified residuei581Phosphothreonine1 Publication1
Modified residuei598PhosphoserineCombined sources1 Publication1
Modified residuei610PhosphoserineCombined sources1
Modified residuei621Phosphothreonine1 Publication1
Modified residuei623PhosphoserineCombined sources1 Publication1
Modified residuei639Phosphoserine1 Publication1
Modified residuei660Phosphoserine1 Publication1
Modified residuei674Phosphoserine1 Publication1
Modified residuei714Phosphoserine; by ATR1 Publication1
Modified residuei746Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated upon DNA damage and in response to agents stalling DNA replication, probably by ATM or ATR. Phosphorylation at Ser-454, Thr-621 and Ser-714 is induced upon DNA-damage caused by treatment with hydroxyurea (HU) but not upon IR treatment. The HU-induced EXO1 triple phosphorylation facilitates destabilisation/degradation of the protein.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9UQ84
PaxDbiQ9UQ84
PeptideAtlasiQ9UQ84
PRIDEiQ9UQ84
ProteomicsDBi85518
85519 [Q9UQ84-4]

PTM databases

iPTMnetiQ9UQ84
PhosphoSitePlusiQ9UQ84

Expressioni

Tissue specificityi

Highly expressed in bone marrow, testis and thymus. Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach.4 Publications

Developmental stagei

Highly expressed in fetal liver and at lower levels in fetal brain, heart, kidney, spleen and thymus.1 Publication

Gene expression databases

BgeeiENSG00000174371 Expressed in 105 organ(s), highest expression level in lung
CleanExiHS_EXO1
ExpressionAtlasiQ9UQ84 baseline and differential
GenevisibleiQ9UQ84 HS

Organism-specific databases

HPAiHPA053079
HPA069738

Interactioni

Subunit structurei

Interacts with the MLH1-PMS2 heterodimer via MLH1. Interacts with MSH3. Interacts with the MSH2-MSH6 heterodimer via MSH2, and this interaction may increase the processivity of the 5'->3' exonuclease activity. Interacts with PCNA, and this interaction may both stimulate the cryptic 3'->5' exonuclease activity and suppress the 5'->3' exonuclease activity. Interacts with WRN, and this interaction stimulates both the 5'->3' exonuclease activity and cleavage of 5'-overhanging flap structures. Interacts with RECQL/RECQ1, and this interaction stimulates cleavage of 5'-overhanging flap structures.9 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi114602, 30 interactors
CORUMiQ9UQ84
DIPiDIP-36701N
IntActiQ9UQ84, 15 interactors
MINTiQ9UQ84
STRINGi9606.ENSP00000311873

Structurei

Secondary structure

1846
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UQ84
SMRiQ9UQ84
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UQ84

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 99N-domainAdd BLAST99
Regioni129 – 387Interaction with MSH31 PublicationAdd BLAST259
Regioni138 – 229I-domainAdd BLAST92
Regioni388 – 490Interaction with MLH1Add BLAST103
Regioni600 – 846Interaction with MSH2Add BLAST247
Regioni787 – 846Interaction with MLH1Add BLAST60

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi418 – 421Nuclear localization signal4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2518 Eukaryota
COG0258 LUCA
GeneTreeiENSGT00510000047676
HOVERGENiHBG081488
InParanoidiQ9UQ84
KOiK10746
OMAiEPIHVRK
OrthoDBiEOG091G06DK
PhylomeDBiQ9UQ84
TreeFamiTF314997

Family and domain databases

CDDicd09908 H3TH_EXO1, 1 hit
InterProiView protein in InterPro
IPR036279 5-3_exonuclease_C_sf
IPR032641 Exo1
IPR037315 EXO1_H3TH
IPR008918 HhH2
IPR029060 PIN-like_dom_sf
IPR006086 XPG-I_dom
IPR006084 XPG/Rad2
IPR019974 XPG_CS
IPR006085 XPG_DNA_repair_N
PANTHERiPTHR11081 PTHR11081, 1 hit
PTHR11081:SF8 PTHR11081:SF8, 1 hit
PfamiView protein in Pfam
PF00867 XPG_I, 1 hit
PF00752 XPG_N, 1 hit
PRINTSiPR00853 XPGRADSUPER
SMARTiView protein in SMART
SM00279 HhH2, 1 hit
SM00484 XPGI, 1 hit
SM00485 XPGN, 1 hit
SUPFAMiSSF47807 SSF47807, 1 hit
SSF88723 SSF88723, 1 hit
PROSITEiView protein in PROSITE
PS00841 XPG_1, 1 hit
PS00842 XPG_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UQ84-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGIQGLLQFI KEASEPIHVR KYKGQVVAVD TYCWLHKGAI ACAEKLAKGE
60 70 80 90 100
PTDRYVGFCM KFVNMLLSHG IKPILVFDGC TLPSKKEVER SRRERRQANL
110 120 130 140 150
LKGKQLLREG KVSEARECFT RSINITHAMA HKVIKAARSQ GVDCLVAPYE
160 170 180 190 200
ADAQLAYLNK AGIVQAIITE DSDLLAFGCK KVILKMDQFG NGLEIDQARL
210 220 230 240 250
GMCRQLGDVF TEEKFRYMCI LSGCDYLSSL RGIGLAKACK VLRLANNPDI
260 270 280 290 300
VKVIKKIGHY LKMNITVPED YINGFIRANN TFLYQLVFDP IKRKLIPLNA
310 320 330 340 350
YEDDVDPETL SYAGQYVDDS IALQIALGNK DINTFEQIDD YNPDTAMPAH
360 370 380 390 400
SRSHSWDDKT CQKSANVSSI WHRNYSPRPE SGTVSDAPQL KENPSTVGVE
410 420 430 440 450
RVISTKGLNL PRKSSIVKRP RSAELSEDDL LSQYSLSFTK KTKKNSSEGN
460 470 480 490 500
KSLSFSEVFV PDLVNGPTNK KSVSTPPRTR NKFATFLQRK NEESGAVVVP
510 520 530 540 550
GTRSRFFCSS DSTDCVSNKV SIQPLDETAV TDKENNLHES EYGDQEGKRL
560 570 580 590 600
VDTDVARNSS DDIPNNHIPG DHIPDKATVF TDEESYSFES SKFTRTISPP
610 620 630 640 650
TLGTLRSCFS WSGGLGDFSR TPSPSPSTAL QQFRRKSDSP TSLPENNMSD
660 670 680 690 700
VSQLKSEESS DDESHPLREE ACSSQSQESG EFSLQSSNAS KLSQCSSKDS
710 720 730 740 750
DSEESDCNIK LLDSQSDQTS KLRLSHFSKK DTPLRNKVPG LYKSSSADSL
760 770 780 790 800
STTKIKPLGP ARASGLSKKP ASIQKRKHHN AENKPGLQIK LNELWKNFGF
810 820 830 840
KKDSEKLPPC KKPLSPVRDN IQLTPEAEED IFNKPECGRV QRAIFQ
Length:846
Mass (Da):94,103
Last modified:January 24, 2006 - v2
Checksum:i850BC21CA9790D08
GO
Isoform 2 (identifier: Q9UQ84-4) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     803-803: D → F
     804-846: Missing.

Show »
Length:803
Mass (Da):89,231
Checksum:i1EDC61DB5D70A0B6
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T397Q5T397_HUMAN
Exonuclease 1
EXO1
169Annotation score:
Q5T398Q5T398_HUMAN
Exonuclease 1
EXO1
166Annotation score:
Q5T399Q5T399_HUMAN
Exonuclease 1
EXO1
135Annotation score:
E5RGY3E5RGY3_HUMAN
Exonuclease 1
EXO1
95Annotation score:
H0YAZ2H0YAZ2_HUMAN
Exonuclease 1
EXO1
208Annotation score:
E5RHK1E5RHK1_HUMAN
Exonuclease 1
EXO1
11Annotation score:

Sequence cautioni

The sequence AAC33874 differs from that shown. Reason: Frameshift at position 793.Curated

Polymorphismi

Most naturally occurring variants in this protein are not associated with familial disposition to hereditary non-polyposis colorectal cancer (HNPCC) (PubMed:12517792). Furthermore, germline deletions involving this locus are not associated with clinically manifested colorectal tumors (PubMed:14623461).2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02496627V → A1 Publication1
Natural variantiVAR_02496776V → I1 PublicationCorresponds to variant dbSNP:rs4149864Ensembl.1
Natural variantiVAR_02496893R → G1 PublicationCorresponds to variant dbSNP:rs4149865Ensembl.1
Natural variantiVAR_024969109E → K Abrogates exonuclease activity. 2 PublicationsCorresponds to variant dbSNP:rs143546023Ensembl.1
Natural variantiVAR_024970137A → S1 PublicationCorresponds to variant dbSNP:rs147663824Ensembl.1
Natural variantiVAR_077352153A → V1 Publication1
Natural variantiVAR_024971279N → S1 PublicationCorresponds to variant dbSNP:rs4149909Ensembl.1
Natural variantiVAR_024972299N → S1 PublicationCorresponds to variant dbSNP:rs4149910Ensembl.1
Natural variantiVAR_024973354H → R5 PublicationsCorresponds to variant dbSNP:rs735943Ensembl.1
Natural variantiVAR_024974410L → R Abrogates exonuclease activity. 3 PublicationsCorresponds to variant dbSNP:rs571928768Ensembl.1
Natural variantiVAR_024975428D → N1 PublicationCorresponds to variant dbSNP:rs4149962Ensembl.1
Natural variantiVAR_024976438F → C1 Publication1
Natural variantiVAR_024977439T → M May be associated with an increased risk of colorectal cancer. 3 PublicationsCorresponds to variant dbSNP:rs4149963Ensembl.1
Natural variantiVAR_024978456S → Y1 PublicationCorresponds to variant dbSNP:rs4149964Ensembl.1
Natural variantiVAR_024979458V → M1 PublicationCorresponds to variant dbSNP:rs4149965Ensembl.1
Natural variantiVAR_024980460V → L1 PublicationCorresponds to variant dbSNP:rs4149966Ensembl.1
Natural variantiVAR_024981503R → T1 PublicationCorresponds to variant dbSNP:rs4149967Ensembl.1
Natural variantiVAR_024982589E → K6 PublicationsCorresponds to variant dbSNP:rs1047840Ensembl.1
Natural variantiVAR_024983610S → G2 PublicationsCorresponds to variant dbSNP:rs12122770Ensembl.1
Natural variantiVAR_024984634R → Q1 PublicationCorresponds to variant dbSNP:rs4149978Ensembl.1
Natural variantiVAR_024985640P → A2 PublicationsCorresponds to variant dbSNP:rs61736331Ensembl.1
Natural variantiVAR_024986640P → S Reduces interaction with MSH2; abrogates interaction with MSH2; when associated with L-770. 3 PublicationsCorresponds to variant dbSNP:rs61736331Ensembl.1
Natural variantiVAR_024987670E → G8 PublicationsCorresponds to variant dbSNP:rs1776148Ensembl.1
Natural variantiVAR_024988723R → C7 PublicationsCorresponds to variant dbSNP:rs1635498Ensembl.1
Natural variantiVAR_024989726H → P1 Publication1
Natural variantiVAR_024990757P → L May be associated with a reduced risk of colorectal cancer. 4 PublicationsCorresponds to variant dbSNP:rs9350Ensembl.1
Natural variantiVAR_024991759G → E Reduces interaction with MSH2; abrogates interaction with MSH2; when associated with L-770. 4 PublicationsCorresponds to variant dbSNP:rs4150001EnsemblClinVar.1
Natural variantiVAR_024992770P → L Reduces interaction with MSH2; abrogates interaction with MSH2; when associated with S-640 or E-759. 2 PublicationsCorresponds to variant dbSNP:rs200622305Ensembl.1
Natural variantiVAR_024993827A → V1 PublicationCorresponds to variant dbSNP:rs145975455Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017029803D → F in isoform 2. 1 Publication1
Alternative sequenceiVSP_017030804 – 846Missing in isoform 2. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084974 mRNA Translation: AAD13754.1
AF091740 mRNA Translation: AAC63043.1
AF091754
, AF091742, AF091743, AF091744, AF091745, AF091746, AF091747, AF091748, AF091749, AF091750, AF091751, AF091752, AF091753 Genomic DNA Translation: AAC69879.1
AF091754
, AF091742, AF091743, AF091744, AF091745, AF091746, AF091747, AF091748, AF091749, AF091750, AF091751, AF091752, AF091753 Genomic DNA Translation: AAC69880.1
AF042282 mRNA Translation: AAC32259.1
AC004783 Genomic DNA Translation: AAC32424.1
AF060479 mRNA Translation: AAC33874.1 Frameshift.
AF549168 Genomic DNA Translation: AAN39382.1
AL365366 Genomic DNA No translation available.
BC007491 mRNA Translation: AAH07491.1
AL080139 mRNA Translation: CAB45733.1
CCDSiCCDS1620.1 [Q9UQ84-1]
CCDS44336.1 [Q9UQ84-4]
PIRiT12524
RefSeqiNP_003677.4, NM_003686.4 [Q9UQ84-4]
NP_006018.4, NM_006027.4 [Q9UQ84-1]
NP_569082.2, NM_130398.3 [Q9UQ84-1]
XP_006711903.1, XM_006711840.2 [Q9UQ84-1]
XP_011542623.1, XM_011544321.1 [Q9UQ84-1]
XP_011542624.1, XM_011544322.1 [Q9UQ84-1]
UniGeneiHs.498248

Genome annotation databases

EnsembliENST00000348581; ENSP00000311873; ENSG00000174371 [Q9UQ84-1]
ENST00000366548; ENSP00000355506; ENSG00000174371 [Q9UQ84-1]
ENST00000518483; ENSP00000430251; ENSG00000174371 [Q9UQ84-4]
GeneIDi9156
KEGGihsa:9156
UCSCiuc001hzh.4 human [Q9UQ84-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084974 mRNA Translation: AAD13754.1
AF091740 mRNA Translation: AAC63043.1
AF091754
, AF091742, AF091743, AF091744, AF091745, AF091746, AF091747, AF091748, AF091749, AF091750, AF091751, AF091752, AF091753 Genomic DNA Translation: AAC69879.1
AF091754
, AF091742, AF091743, AF091744, AF091745, AF091746, AF091747, AF091748, AF091749, AF091750, AF091751, AF091752, AF091753 Genomic DNA Translation: AAC69880.1
AF042282 mRNA Translation: AAC32259.1
AC004783 Genomic DNA Translation: AAC32424.1
AF060479 mRNA Translation: AAC33874.1 Frameshift.
AF549168 Genomic DNA Translation: AAN39382.1
AL365366 Genomic DNA No translation available.
BC007491 mRNA Translation: AAH07491.1
AL080139 mRNA Translation: CAB45733.1
CCDSiCCDS1620.1 [Q9UQ84-1]
CCDS44336.1 [Q9UQ84-4]
PIRiT12524
RefSeqiNP_003677.4, NM_003686.4 [Q9UQ84-4]
NP_006018.4, NM_006027.4 [Q9UQ84-1]
NP_569082.2, NM_130398.3 [Q9UQ84-1]
XP_006711903.1, XM_006711840.2 [Q9UQ84-1]
XP_011542623.1, XM_011544321.1 [Q9UQ84-1]
XP_011542624.1, XM_011544322.1 [Q9UQ84-1]
UniGeneiHs.498248

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QE9X-ray2.51Y/Z1-352[»]
3QEAX-ray3.10Z1-352[»]
3QEBX-ray3.00Z1-352[»]
5UZVX-ray2.45Z1-352[»]
5V04X-ray2.65Z1-352[»]
5V05X-ray2.90Z1-352[»]
5V06X-ray2.75Z1-352[»]
5V07X-ray2.15Z1-352[»]
5V08X-ray2.81Z1-352[»]
5V09X-ray2.75Z1-352[»]
5V0AX-ray2.38Z1-352[»]
5V0BX-ray2.63Z1-352[»]
5V0CX-ray2.58Z1-352[»]
5V0DX-ray2.63Z1-352[»]
5V0EX-ray2.74Z1-352[»]
ProteinModelPortaliQ9UQ84
SMRiQ9UQ84
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114602, 30 interactors
CORUMiQ9UQ84
DIPiDIP-36701N
IntActiQ9UQ84, 15 interactors
MINTiQ9UQ84
STRINGi9606.ENSP00000311873

PTM databases

iPTMnetiQ9UQ84
PhosphoSitePlusiQ9UQ84

Polymorphism and mutation databases

BioMutaiEXO1
DMDMi85700954

Proteomic databases

EPDiQ9UQ84
PaxDbiQ9UQ84
PeptideAtlasiQ9UQ84
PRIDEiQ9UQ84
ProteomicsDBi85518
85519 [Q9UQ84-4]

Protocols and materials databases

DNASUi9156
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348581; ENSP00000311873; ENSG00000174371 [Q9UQ84-1]
ENST00000366548; ENSP00000355506; ENSG00000174371 [Q9UQ84-1]
ENST00000518483; ENSP00000430251; ENSG00000174371 [Q9UQ84-4]
GeneIDi9156
KEGGihsa:9156
UCSCiuc001hzh.4 human [Q9UQ84-1]

Organism-specific databases

CTDi9156
DisGeNETi9156
EuPathDBiHostDB:ENSG00000174371.16
GeneCardsiEXO1
H-InvDBiHIX0022634
HGNCiHGNC:3511 EXO1
HPAiHPA053079
HPA069738
MIMi606063 gene
neXtProtiNX_Q9UQ84
OpenTargetsiENSG00000174371
PharmGKBiPA27923
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2518 Eukaryota
COG0258 LUCA
GeneTreeiENSGT00510000047676
HOVERGENiHBG081488
InParanoidiQ9UQ84
KOiK10746
OMAiEPIHVRK
OrthoDBiEOG091G06DK
PhylomeDBiQ9UQ84
TreeFamiTF314997

Enzyme and pathway databases

BRENDAi3.1.11.1 2681
ReactomeiR-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-HSA-5685938 HDR through Single Strand Annealing (SSA)
R-HSA-5685942 HDR through Homologous Recombination (HRR)
R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
R-HSA-5693607 Processing of DNA double-strand break ends
R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-69473 G2/M DNA damage checkpoint
SIGNORiQ9UQ84

Miscellaneous databases

EvolutionaryTraceiQ9UQ84
GeneWikiiExonuclease_1
GenomeRNAii9156
PROiPR:Q9UQ84
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174371 Expressed in 105 organ(s), highest expression level in lung
CleanExiHS_EXO1
ExpressionAtlasiQ9UQ84 baseline and differential
GenevisibleiQ9UQ84 HS

Family and domain databases

CDDicd09908 H3TH_EXO1, 1 hit
InterProiView protein in InterPro
IPR036279 5-3_exonuclease_C_sf
IPR032641 Exo1
IPR037315 EXO1_H3TH
IPR008918 HhH2
IPR029060 PIN-like_dom_sf
IPR006086 XPG-I_dom
IPR006084 XPG/Rad2
IPR019974 XPG_CS
IPR006085 XPG_DNA_repair_N
PANTHERiPTHR11081 PTHR11081, 1 hit
PTHR11081:SF8 PTHR11081:SF8, 1 hit
PfamiView protein in Pfam
PF00867 XPG_I, 1 hit
PF00752 XPG_N, 1 hit
PRINTSiPR00853 XPGRADSUPER
SMARTiView protein in SMART
SM00279 HhH2, 1 hit
SM00484 XPGI, 1 hit
SM00485 XPGN, 1 hit
SUPFAMiSSF47807 SSF47807, 1 hit
SSF88723 SSF88723, 1 hit
PROSITEiView protein in PROSITE
PS00841 XPG_1, 1 hit
PS00842 XPG_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEXO1_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ84
Secondary accession number(s): O60545
, O75214, O75466, Q5T396, Q96IJ1, Q9UG38, Q9UNW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: September 12, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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