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Protein

Pregnancy-specific beta-1-glycoprotein 11

Gene

PSG11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • female pregnancy Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 11
Short name:
PS-beta-G-11
Short name:
PSBG-11
Short name:
Pregnancy-specific glycoprotein 11
Alternative name(s):
Pregnancy-specific beta-1-glycoprotein 13
Short name:
PS-beta-G-13
Short name:
PSBG-13
Short name:
Pregnancy-specific glycoprotein 13
Gene namesi
Name:PSG11
Synonyms:PSG13, PSG14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000243130.7
HGNCiHGNC:9516 PSG11
MIMi176401 gene
neXtProtiNX_Q9UQ72

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000243130
PharmGKBiPA164742300

Polymorphism and mutation databases

BioMutaiPSG11
DMDMi296452992

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001491835 – 335Pregnancy-specific beta-1-glycoprotein 11Add BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi169 ↔ 217PROSITE-ProRule annotation
Disulfide bondi261 ↔ 301PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9UQ72
PeptideAtlasiQ9UQ72
PRIDEiQ9UQ72
ProteomicsDBi85512
85513 [Q9UQ72-2]

PTM databases

iPTMnetiQ9UQ72
PhosphoSitePlusiQ9UQ72

Expressioni

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiENSG00000243130 Expressed in 59 organ(s), highest expression level in placenta
CleanExiHS_PSG11
ExpressionAtlasiQ9UQ72 baseline and differential
GenevisibleiQ9UQ72 HS

Organism-specific databases

HPAiHPA042240

Interactioni

Protein-protein interaction databases

BioGridi111653, 4 interactors
IntActiQ9UQ72, 1 interactor
STRINGi9606.ENSP00000319140

Structurei

3D structure databases

ProteinModelPortaliQ9UQ72
SMRiQ9UQ72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-typeAdd BLAST110
Domaini147 – 234Ig-like C2-type 1Add BLAST88
Domaini242 – 317Ig-like C2-type 2Add BLAST76

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 129Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JG1N Eukaryota
ENOG410YTW2 LUCA
GeneTreeiENSGT00760000119187
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiQ9UQ72
KOiK06500
OrthoDBiEOG091G0AMM
PhylomeDBiQ9UQ72
TreeFamiTF336859

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UQ72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPLSAPPCT EHIKWKGLLL TALLLNFWNL PTTAQVMIEA QPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLTGYIWYKG QIRDLYHYIT SYVVDGQIII YGPAYSGRET
110 120 130 140 150
VYSNASLLIQ NVTREDAGSY TLHIIKRGDG TRGVTGYFTF TLYLETPKPS
160 170 180 190 200
ISSSNLNPRE AMETVILTCN PETPDASYLW WMNGQSLPMT HRMQLSETNR
210 220 230 240 250
TLFLFGVTKY TAGPYECEIW NSGSASRSDP VTLNLLHGPD LPRIFPSVTS
260 270 280 290 300
YYSGENLDLS CFANSNPPAQ YSWTINGKFQ LSGQKLFIPQ ITPKHNGLYA
310 320 330
CSARNSATGE ESSTSLTIRV IAPPGLGTFA FNNPT
Length:335
Mass (Da):37,146
Last modified:May 18, 2010 - v3
Checksum:i4C58685C2CA0FF29
GO
Isoform 2 (identifier: Q9UQ72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-144: ALLLNFWNLP...TGYFTFTLYL → V

Show »
Length:213
Mass (Da):23,359
Checksum:iF4D06A2D193656FA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R276M0R276_HUMAN
Pregnancy-specific beta-1-glycoprot...
PSG11
320Annotation score:
M0R2P9M0R2P9_HUMAN
Pregnancy-specific beta-1-glycoprot...
PSG11
126Annotation score:

Sequence cautioni

The sequence AAA36516 differs from that shown. Reason: Frameshift at position 330.Curated
The sequence AAA75299 differs from that shown. Reason: Frameshift at position 330.Curated
The sequence AAH20711 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06132583V → I1 PublicationCorresponds to variant dbSNP:rs2471952Ensembl.1
Natural variantiVAR_056076176A → T. Corresponds to variant dbSNP:rs1058085Ensembl.1
Natural variantiVAR_060365264N → D2 PublicationsCorresponds to variant dbSNP:rs10414166Ensembl.1
Natural variantiVAR_061326310E → K. Corresponds to variant dbSNP:rs10412348Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00787622 – 144ALLLN…FTLYL → V in isoform 2. 1 PublicationAdd BLAST123

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69245 mRNA Translation: AAA36516.1 Frameshift.
U25988 mRNA Translation: AAA75299.1 Frameshift.
AC004784 Genomic DNA No translation available.
AC005947 Genomic DNA No translation available.
BC020711 mRNA Translation: AAH20711.2 Different initiation.
AH007522 Genomic DNA Translation: AAD21024.1
AF129398 Genomic DNA Translation: AAD38357.1
CCDSiCCDS12614.2 [Q9UQ72-1]
CCDS12615.2 [Q9UQ72-2]
PIRiJC4122
JN0067
RefSeqiNP_001106881.1, NM_001113410.1 [Q9UQ72-2]
NP_002776.3, NM_002785.2 [Q9UQ72-1]
NP_976032.2, NM_203287.1 [Q9UQ72-2]
UniGeneiHs.741150

Genome annotation databases

EnsembliENST00000306322; ENSP00000304913; ENSG00000243130 [Q9UQ72-2]
ENST00000320078; ENSP00000319140; ENSG00000243130 [Q9UQ72-1]
ENST00000403486; ENSP00000385427; ENSG00000243130 [Q9UQ72-2]
GeneIDi5680
KEGGihsa:5680
UCSCiuc002ovm.2 human [Q9UQ72-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69245 mRNA Translation: AAA36516.1 Frameshift.
U25988 mRNA Translation: AAA75299.1 Frameshift.
AC004784 Genomic DNA No translation available.
AC005947 Genomic DNA No translation available.
BC020711 mRNA Translation: AAH20711.2 Different initiation.
AH007522 Genomic DNA Translation: AAD21024.1
AF129398 Genomic DNA Translation: AAD38357.1
CCDSiCCDS12614.2 [Q9UQ72-1]
CCDS12615.2 [Q9UQ72-2]
PIRiJC4122
JN0067
RefSeqiNP_001106881.1, NM_001113410.1 [Q9UQ72-2]
NP_002776.3, NM_002785.2 [Q9UQ72-1]
NP_976032.2, NM_203287.1 [Q9UQ72-2]
UniGeneiHs.741150

3D structure databases

ProteinModelPortaliQ9UQ72
SMRiQ9UQ72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111653, 4 interactors
IntActiQ9UQ72, 1 interactor
STRINGi9606.ENSP00000319140

PTM databases

iPTMnetiQ9UQ72
PhosphoSitePlusiQ9UQ72

Polymorphism and mutation databases

BioMutaiPSG11
DMDMi296452992

Proteomic databases

PaxDbiQ9UQ72
PeptideAtlasiQ9UQ72
PRIDEiQ9UQ72
ProteomicsDBi85512
85513 [Q9UQ72-2]

Protocols and materials databases

DNASUi5680
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306322; ENSP00000304913; ENSG00000243130 [Q9UQ72-2]
ENST00000320078; ENSP00000319140; ENSG00000243130 [Q9UQ72-1]
ENST00000403486; ENSP00000385427; ENSG00000243130 [Q9UQ72-2]
GeneIDi5680
KEGGihsa:5680
UCSCiuc002ovm.2 human [Q9UQ72-1]

Organism-specific databases

CTDi5680
EuPathDBiHostDB:ENSG00000243130.7
GeneCardsiPSG11
H-InvDBiHIX0212777
HGNCiHGNC:9516 PSG11
HPAiHPA042240
MIMi176401 gene
neXtProtiNX_Q9UQ72
OpenTargetsiENSG00000243130
PharmGKBiPA164742300
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JG1N Eukaryota
ENOG410YTW2 LUCA
GeneTreeiENSGT00760000119187
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiQ9UQ72
KOiK06500
OrthoDBiEOG091G0AMM
PhylomeDBiQ9UQ72
TreeFamiTF336859

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

GenomeRNAii5680
PROiPR:Q9UQ72
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000243130 Expressed in 59 organ(s), highest expression level in placenta
CleanExiHS_PSG11
ExpressionAtlasiQ9UQ72 baseline and differential
GenevisibleiQ9UQ72 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPSG11_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ72
Secondary accession number(s): Q13179
, Q15242, Q8WW91, Q9UNE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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