Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Contactin-6

Gene

CNTN6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion, Notch signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-447041 CHL1 interactions
SignaLinkiQ9UQ52
SIGNORiQ9UQ52

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-6
Alternative name(s):
Neural recognition molecule NB-3
Short name:
hNB-3
Gene namesi
Name:CNTN6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000134115.12
HGNCiHGNC:2176 CNTN6
MIMi607220 gene
neXtProtiNX_Q9UQ52

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27255
OpenTargetsiENSG00000134115
PharmGKBiPA26690

Polymorphism and mutation databases

BioMutaiCNTN6
DMDMi55976622

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001472720 – 999Contactin-6Add BLAST980
PropeptideiPRO_00000147281000 – 1028Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 100PROSITE-ProRule annotation
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi144 ↔ 196PROSITE-ProRule annotation
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi249 ↔ 297PROSITE-ProRule annotation
Disulfide bondi339 ↔ 386PROSITE-ProRule annotation
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi431 ↔ 479PROSITE-ProRule annotation
Glycosylationi468N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi521 ↔ 577PROSITE-ProRule annotation
Glycosylationi659N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi765N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi860N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi865N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei882PhosphotyrosineCombined sources1
Glycosylationi895N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi931N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi956N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi957N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi999GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9UQ52
PaxDbiQ9UQ52
PeptideAtlasiQ9UQ52
PRIDEiQ9UQ52
ProteomicsDBi85508

PTM databases

iPTMnetiQ9UQ52
PhosphoSitePlusiQ9UQ52

Expressioni

Tissue specificityi

Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord.

Gene expression databases

BgeeiENSG00000134115 Expressed in 111 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_CNTN6
ExpressionAtlasiQ9UQ52 baseline and differential
GenevisibleiQ9UQ52 HS

Organism-specific databases

HPAiHPA016645

Interactioni

Subunit structurei

Interacts with PTPRG.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341882

Structurei

3D structure databases

ProteinModelPortaliQ9UQ52
SMRiQ9UQ52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 117Ig-like C2-type 1Add BLAST92
Domaini122 – 208Ig-like C2-type 2Add BLAST87
Domaini227 – 308Ig-like C2-type 3Add BLAST82
Domaini318 – 402Ig-like C2-type 4Add BLAST85
Domaini408 – 495Ig-like C2-type 5Add BLAST88
Domaini499 – 587Ig-like C2-type 6Add BLAST89
Domaini600 – 698Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini703 – 800Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini805 – 901Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST97
Domaini902 – 996Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST95

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
GeneTreeiENSGT00760000118840
HOGENOMiHOG000059617
HOVERGENiHBG051047
InParanoidiQ9UQ52
KOiK06764
OMAiCLNWEHV
OrthoDBiEOG091G00X7
PhylomeDBiQ9UQ52
TreeFamiTF351103

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR033009 Contactin-6
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PANTHERiPTHR43905:SF6 PTHR43905:SF6, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9UQ52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLLWKLVIL LPLINSSAGD GLLSRPIFTQ EPHDVIFPLD LSKSEVILNC
60 70 80 90 100
AANGYPSPHY RWKQNGTDID FTMSYHYRLD GGSLAINSPH TDQDIGMYQC
110 120 130 140 150
LATNLLGTIL SRKAKLQFAY IEDFETKTRS TVSVREGQGV VLLCGPPPHF
160 170 180 190 200
GDLSYAWTFN DNPLYVQEDN RRFVSQETGN LYIAKVEPSD VGNYTCFITN
210 220 230 240 250
KEAQRSVQGP PTPLVQRTDG VMGEYEPKIE VRFPETIQAA KDSSVKLECF
260 270 280 290 300
ALGNPVPDIS WRRLDGSPLP GKVKYSKSQA ILEIPNFQQE DEGFYECIAS
310 320 330 340 350
NLRGRNLAKG QLIFYAPPEW EQKIQNTHLS IYDNLLWECK ASGKPNPWYT
360 370 380 390 400
WLKNGERLNP EERIQIENGT LIITMLNVSD SGVYQCAAEN KYQIIYANAE
410 420 430 440 450
LRVLASAPDF SKSPVKKKSF VQVGGDIVIG CKPNAFPRAA ISWKRGTETL
460 470 480 490 500
RQSKRIFLLE DGSLKIYNIT RSDAGSYTCI ATNQFGTAKN TGSLIVKERT
510 520 530 540 550
VITVPPSKMD VTVGESIVLP CQVSHDPSIE VVFVWFFNGD VIDLKKGVAH
560 570 580 590 600
FERIGGESVG DLMIRNIQLH HSGKYLCTVQ TTLESLSAVA DIIVRGPPGP
610 620 630 640 650
PEDVQVEDIS STTSQLSWRA GPDNNSPIQI FTIQTRTPFS VGWQAVATVP
660 670 680 690 700
EILNGKTYNA TVVGLSPWVE YEFRVVAGNS IGIGEPSEPS ELLRTKASVP
710 720 730 740 750
VVAPVNIHGG GGSRSELVIT WESIPEELQN GEGFGYIIMF RPVGSTTWSK
760 770 780 790 800
EKVSSVESSR FVYRNESIIP LSPFEVKVGV YNNEGEGSLS TVTIVYSGED
810 820 830 840 850
EPQLAPRGTS LQSFSASEME VSWNAIAWNR NTGRVLGYEV LYWTDDSKES
860 870 880 890 900
MIGKIRVSGN VTTKNITGLK ANTIYFASVR AYNTAGTGPS SPPVNVTTKK
910 920 930 940 950
SPPSQPPANI AWKLTNSKLC LNWEHVKTME NESEVLGYKI LYRQNRQSKT
960 970 980 990 1000
HILETNNTSA ELLVPFEEDY LIEIRTVSDG GDGSSSEEIR IPKMSSLSSR
1010 1020
GIQFLEPSTH FLSIVIVIFH CFAIQPLI
Length:1,028
Mass (Da):113,956
Last modified:May 1, 2000 - v1
Checksum:i8B5A2ED2F29936A6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WDQ0F8WDQ0_HUMAN
Contactin-6
CNTN6
41Annotation score:
F8VWS7F8VWS7_HUMAN
Contactin-6
CNTN6
63Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035509108T → A in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_033611150F → S. Corresponds to variant dbSNP:rs6808056Ensembl.1
Natural variantiVAR_065744303R → Q1 PublicationCorresponds to variant dbSNP:rs41293401Ensembl.1
Natural variantiVAR_065745314F → V1 PublicationCorresponds to variant dbSNP:rs774763830Ensembl.1
Natural variantiVAR_019913440A → S. Corresponds to variant dbSNP:rs265771Ensembl.1
Natural variantiVAR_035510585S → C in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_065746954E → V in a patient with amyotrophic lateral sclerosis. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003592 mRNA Translation: BAA82612.1
BC113118 mRNA Translation: AAI13119.1
CCDSiCCDS2557.1
RefSeqiNP_001276009.1, NM_001289080.1
NP_001276010.1, NM_001289081.1
NP_055276.1, NM_014461.3
XP_005265115.1, XM_005265058.3
XP_011531892.1, XM_011533590.2
XP_016861660.1, XM_017006171.1
XP_016861661.1, XM_017006172.1
UniGeneiHs.387300
Hs.590078

Genome annotation databases

EnsembliENST00000350110; ENSP00000341882; ENSG00000134115
ENST00000446702; ENSP00000407822; ENSG00000134115
GeneIDi27255
KEGGihsa:27255
UCSCiuc003boz.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003592 mRNA Translation: BAA82612.1
BC113118 mRNA Translation: AAI13119.1
CCDSiCCDS2557.1
RefSeqiNP_001276009.1, NM_001289080.1
NP_001276010.1, NM_001289081.1
NP_055276.1, NM_014461.3
XP_005265115.1, XM_005265058.3
XP_011531892.1, XM_011533590.2
XP_016861660.1, XM_017006171.1
XP_016861661.1, XM_017006172.1
UniGeneiHs.387300
Hs.590078

3D structure databases

ProteinModelPortaliQ9UQ52
SMRiQ9UQ52
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341882

PTM databases

iPTMnetiQ9UQ52
PhosphoSitePlusiQ9UQ52

Polymorphism and mutation databases

BioMutaiCNTN6
DMDMi55976622

Proteomic databases

MaxQBiQ9UQ52
PaxDbiQ9UQ52
PeptideAtlasiQ9UQ52
PRIDEiQ9UQ52
ProteomicsDBi85508

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000350110; ENSP00000341882; ENSG00000134115
ENST00000446702; ENSP00000407822; ENSG00000134115
GeneIDi27255
KEGGihsa:27255
UCSCiuc003boz.5 human

Organism-specific databases

CTDi27255
DisGeNETi27255
EuPathDBiHostDB:ENSG00000134115.12
GeneCardsiCNTN6
HGNCiHGNC:2176 CNTN6
HPAiHPA016645
MIMi607220 gene
neXtProtiNX_Q9UQ52
OpenTargetsiENSG00000134115
PharmGKBiPA26690
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
GeneTreeiENSGT00760000118840
HOGENOMiHOG000059617
HOVERGENiHBG051047
InParanoidiQ9UQ52
KOiK06764
OMAiCLNWEHV
OrthoDBiEOG091G00X7
PhylomeDBiQ9UQ52
TreeFamiTF351103

Enzyme and pathway databases

ReactomeiR-HSA-447041 CHL1 interactions
SignaLinkiQ9UQ52
SIGNORiQ9UQ52

Miscellaneous databases

ChiTaRSiCNTN6 human
GeneWikiiCNTN6
GenomeRNAii27255
PROiPR:Q9UQ52
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134115 Expressed in 111 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_CNTN6
ExpressionAtlasiQ9UQ52 baseline and differential
GenevisibleiQ9UQ52 HS

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR033009 Contactin-6
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PANTHERiPTHR43905:SF6 PTHR43905:SF6, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 6 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCNTN6_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ52
Secondary accession number(s): Q2KHM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 1, 2000
Last modified: October 10, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again