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UniProtKB - Q9UQ49 (NEUR3_HUMAN)

Entry version 166 (23 Feb 2022)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

Sialidase-3

Gene

NEU3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:11298736, PubMed:15847605, PubMed:10861246, PubMed:20511247, PubMed:28646141, PubMed:10405317, PubMed:12011038).

Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR (PubMed:17334392, PubMed:25922362).

Desialylates EGFR and activates downstream signaling in proliferating cells (PubMed:25922362).

Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (PubMed:26251452).

10 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=47 µM for ganglioside GD1a1 Publication

pH dependencei

Optimum pH is 4.5-6.5.2 Publications

Temperature dependencei

Optimum temperature is 20 degrees Celsius.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei25SubstrateBy similarity1
Binding sitei45SubstrateCurated1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei50Proton acceptor1 Publication1
Binding sitei179SubstrateCurated1
Binding sitei181SubstrateCurated1
Binding sitei225SubstrateCurated1
Binding sitei245SubstrateCurated1
Binding sitei340SubstrateCurated1
Active sitei370Nucleophile1 Publication1
Active sitei387Sequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.2.1.18, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UQ49

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1660662, Glycosphingolipid metabolism
R-HSA-4085001, Sialic acid metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q9UQ49

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UQ49

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GH33, Glycoside Hydrolase Family 33

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001372 [Q9UQ49-1]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sialidase-3 (EC:3.2.1.186 Publications)
Alternative name(s):
Ganglioside sialidasedis
Membrane sialidase
N-acetyl-alpha-neuraminidase 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NEU3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7760, NEU3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604617, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UQ49

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000162139

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi25R → H: Loss of enzyme activity. 1 Publication1
Mutagenesisi45R → V: Loss of enzyme activity. 1 Publication1
Mutagenesisi50D → S or A: Nearly abolishes enzyme activity. 2 Publications1
Mutagenesisi51E → D: Decreases enzyme activity. 1 Publication1
Mutagenesisi88N → D: Markedly decreases enzyme activity. 1 Publication1
Mutagenesisi107V → M: Markedly decreases enzyme activity. 1 Publication1
Mutagenesisi114R → Q: Decreases enzyme activity. 1 Publication1
Mutagenesisi162G → A: Markedly decreases enzyme activity. 1 Publication1
Mutagenesisi179Y → F: Loss of enzyme activity. 1 Publication1
Mutagenesisi181Y → A: Markedly decreases the recruitment within caveola. 1 Publication1
Mutagenesisi181Y → F: Nearly abolishes enzyme activity. 1 Publication1
Mutagenesisi187F → R: Decreases the recruitment within caveola. 1 Publication1
Mutagenesisi225E → S: Loss of enzyme activity. 1 Publication1
Mutagenesisi245R → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi340R → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi370Y → F or C: Loss of enzyme activity. 3 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		10825

Open Targets

More...OpenTargetsi		ENSG00000162139

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31562

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UQ49, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3046

DrugCentral

More...DrugCentrali		Q9UQ49

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NEU3

Domain mapping of disease mutations (DMDM)

More...DMDMi		17369720

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002089031 – 428Sialidase-3Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei313PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated; may regulate intracellular trafficking and anchorage to plasma membrane and endomembranes.1 Publication

Keywords - PTMi

Lipoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UQ49

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UQ49

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UQ49

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UQ49

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UQ49

PeptideAtlas

More...PeptideAtlasi		Q9UQ49

PRoteomics IDEntifications database

More...PRIDEi		Q9UQ49

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1854
85507 [Q9UQ49-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UQ49

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UQ49

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9UQ49

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000162139, Expressed in quadriceps femoris and 174 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UQ49, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UQ49, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000162139, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CAV1; this interaction enhances NEU3 sialidase activity within caveola (PubMed:12011038).

Interacts with EGFR; this interaction mediates desialylation of EGFR and enhances downstream signaling (PubMed:17334392).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116038, 16 interactors

Protein interaction database and analysis system

More...IntActi		Q9UQ49, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000294064

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9UQ49

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UQ49, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UQ49

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati129 – 140BNR 1Add BLAST12
Repeati203 – 214BNR 2Add BLAST12
Repeati254 – 265BNR 3Add BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni294 – 318DisorderedSequence analysisAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi24 – 27FRIP motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi298 – 316Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSFT, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182944

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_024620_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UQ49

Identification of Orthologs from Complete Genome Data

More...OMAi		YTYYIPY

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UQ49

TreeFam database of animal gene trees

More...TreeFami		TF331063

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011040, Sialidase
IPR026944, Sialidase-3
IPR026856, Sialidase_fam
IPR036278, Sialidase_sf

The PANTHER Classification System

More...PANTHERi		PTHR10628, PTHR10628, 1 hit
PTHR10628:SF23, PTHR10628:SF23, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13088, BNR_2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50939, SSF50939, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UQ49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEVTTCSFN SPLFRQEDDR GITYRIPALL YIPPTHTFLA FAEKRSTRRD 
        60         70         80         90        100
EDALHLVLRR GLRIGQLVQW GPLKPLMEAT LPGHRTMNPC PVWEQKSGCV 
       110        120        130        140        150
FLFFICVRGH VTERQQIVSG RNAARLCFIY SQDAGCSWSE VRDLTEEVIG 
       160        170        180        190        200
SELKHWATFA VGPGHGIQLQ SGRLVIPAYT YYIPSWFFCF QLPCKTRPHS 
       210        220        230        240        250
LMIYSDDLGV TWHHGRLIRP MVTVECEVAE VTGRAGHPVL YCSARTPNRC 
       260        270        280        290        300
RAEALSTDHG EGFQRLALSR QLCEPPHGCQ GSVVSFRPLE IPHRCQDSSS 
       310        320        330        340        350
KDAPTIQQSS PGSSLRLEEE AGTPSESWLL YSHPTSRKQR VDLGIYLNQT 
       360        370        380        390        400
PLEAACWSRP WILHCGPCGY SDLAALEEEG LFGCLFECGT KQECEQIAFR 
       410        420 
LFTHREILSH LQGDCTSPGR NPSQFKSN
Length:428
Mass (Da):48,252
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35D1DD9359A78C98
GO
Isoform 2 (identifier: Q9UQ49-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRPADLPPRPMEESPASSSAPTETEEPGSSAEVM

Show »
Length:461
Mass (Da):51,675
Checksum:i37D6EBA8FD7458AD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PNK1E9PNK1_HUMAN
Sialidase-3
NEU3
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR25E9PR25_HUMAN
Sialidase-3
NEU3
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI40E9PI40_HUMAN
Sialidase-3
NEU3
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMZ3E9PMZ3_HUMAN
Sialidase-3
NEU3
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB96131 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05583915R → Q. Corresponds to variant dbSNP:rs7115499Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0541451M → MRPADLPPRPMEESPASSSA PTETEEPGSSAEVM in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB008185 mRNA Translation: BAA82611.1
Y18563 mRNA Translation: CAB96131.1 Different initiation.
AK022450 mRNA Translation: BAG51074.1
AK290442 mRNA Translation: BAF83131.1
AP001992 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74953.1
BC136397 mRNA Translation: AAI36398.1
BC144059 mRNA Translation: AAI44060.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44682.1 [Q9UQ49-2]

NCBI Reference Sequences

More...RefSeqi		NP_006647.3, NM_006656.5 [Q9UQ49-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000294064; ENSP00000294064; ENSG00000162139 [Q9UQ49-2]
ENST00000531509; ENSP00000432097; ENSG00000162139 [Q9UQ49-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10825

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10825

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000294064.9; ENSP00000294064.4; NM_006656.6; NP_006647.3 [Q9UQ49-2]

UCSC genome browser

More...UCSCi		uc001ovw.4, human [Q9UQ49-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008185 mRNA Translation: BAA82611.1
Y18563 mRNA Translation: CAB96131.1 Different initiation.
AK022450 mRNA Translation: BAG51074.1
AK290442 mRNA Translation: BAF83131.1
AP001992 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74953.1
BC136397 mRNA Translation: AAI36398.1
BC144059 mRNA Translation: AAI44060.1
CCDSiCCDS44682.1 [Q9UQ49-2]
RefSeqiNP_006647.3, NM_006656.5 [Q9UQ49-2]

3D structure databases

SMRiQ9UQ49
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116038, 16 interactors
IntActiQ9UQ49, 2 interactors
STRINGi9606.ENSP00000294064

Chemistry databases

BindingDBiQ9UQ49
ChEMBLiCHEMBL3046
DrugCentraliQ9UQ49
SwissLipidsiSLP:000001372 [Q9UQ49-1]

Protein family/group databases

CAZyiGH33, Glycoside Hydrolase Family 33

PTM databases

iPTMnetiQ9UQ49
PhosphoSitePlusiQ9UQ49
SwissPalmiQ9UQ49

Genetic variation databases

BioMutaiNEU3
DMDMi17369720

Proteomic databases

EPDiQ9UQ49
jPOSTiQ9UQ49
MassIVEiQ9UQ49
MaxQBiQ9UQ49
PaxDbiQ9UQ49
PeptideAtlasiQ9UQ49
PRIDEiQ9UQ49
ProteomicsDBi1854
85507 [Q9UQ49-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		56317, 76 antibodies from 14 providers

The DNASU plasmid repository

More...DNASUi		10825

Genome annotation databases

EnsembliENST00000294064; ENSP00000294064; ENSG00000162139 [Q9UQ49-2]
ENST00000531509; ENSP00000432097; ENSG00000162139 [Q9UQ49-2]
GeneIDi10825
KEGGihsa:10825
MANE-SelectiENST00000294064.9; ENSP00000294064.4; NM_006656.6; NP_006647.3 [Q9UQ49-2]
UCSCiuc001ovw.4, human [Q9UQ49-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10825
DisGeNETi10825

GeneCards: human genes, protein and diseases

More...GeneCardsi		NEU3
HGNCiHGNC:7760, NEU3
HPAiENSG00000162139, Low tissue specificity
MIMi604617, gene
neXtProtiNX_Q9UQ49
OpenTargetsiENSG00000162139
PharmGKBiPA31562
VEuPathDBiHostDB:ENSG00000162139

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSFT, Eukaryota
GeneTreeiENSGT00950000182944
HOGENOMiCLU_024620_2_0_1
InParanoidiQ9UQ49
OMAiYTYYIPY
PhylomeDBiQ9UQ49
TreeFamiTF331063

Enzyme and pathway databases

BRENDAi3.2.1.18, 2681
PathwayCommonsiQ9UQ49
ReactomeiR-HSA-1660662, Glycosphingolipid metabolism
R-HSA-4085001, Sialic acid metabolism
SABIO-RKiQ9UQ49
SignaLinkiQ9UQ49

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10825, 10 hits in 1048 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NEU3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NEU3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10825
PharosiQ9UQ49, Tbio

Protein Ontology

More...PROi		PR:Q9UQ49
RNActiQ9UQ49, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000162139, Expressed in quadriceps femoris and 174 other tissues
ExpressionAtlasiQ9UQ49, baseline and differential
GenevisibleiQ9UQ49, HS

Family and domain databases

InterProiView protein in InterPro
IPR011040, Sialidase
IPR026944, Sialidase-3
IPR026856, Sialidase_fam
IPR036278, Sialidase_sf
PANTHERiPTHR10628, PTHR10628, 1 hit
PTHR10628:SF23, PTHR10628:SF23, 1 hit
PfamiView protein in Pfam
PF13088, BNR_2, 1 hit
SUPFAMiSSF50939, SSF50939, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEUR3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UQ49
Secondary accession number(s): A8K327, Q9NQE1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 1, 2000
Last modified: February 23, 2022
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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