UniProtKB - Q9UQ49 (NEUR3_HUMAN)

BLAST

>sp|Q9UQ49|NEUR3_HUMAN Sialidase-3 OS=Homo sapiens OX=9606 GN=NEU3 PE=1 SV=1
MEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAFAEKRSTRRDEDALHLVLRR
GLRIGQLVQWGPLKPLMEATLPGHRTMNPCPVWEQKSGCVFLFFICVRGHVTERQQIVSG
RNAARLCFIYSQDAGCSWSEVRDLTEEVIGSELKHWATFAVGPGHGIQLQSGRLVIPAYT
YYIPSWFFCFQLPCKTRPHSLMIYSDDLGVTWHHGRLIRPMVTVECEVAEVTGRAGHPVL
YCSARTPNRCRAEALSTDHGEGFQRLALSRQLCEPPHGCQGSVVSFRPLEIPHRCQDSSS
KDAPTIQQSSPGSSLRLEEEAGTPSESWLLYSHPTSRKQRVDLGIYLNQTPLEAACWSRP
WILHCGPCGYSDLAALEEEGLFGCLFECGTKQECEQIAFRLFTHREILSHLQGDCTSPGR
NPSQFKSN

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History
Entry version 146 (07 Nov 2018)
Sequence version 1 (01 May 2000)
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Protein

Sialidase-3

Gene

NEU3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates.2 Publications

Catalytic activityⁱ

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.2 Publications

pH dependenceⁱ

Optimum pH is 3.8.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	25	SubstrateBy similarity	1
Binding siteⁱ	45	SubstrateCurated	1
Active siteⁱ	50	Proton acceptor1 Publication	1
Binding siteⁱ	179	SubstrateCurated	1
Binding siteⁱ	181	SubstrateCurated	1
Binding siteⁱ	225	SubstrateCurated	1
Binding siteⁱ	245	SubstrateCurated	1
Binding siteⁱ	340	SubstrateCurated	1
Active siteⁱ	370	Nucleophile1 Publication	1
Active siteⁱ	387	Sequence analysis	1

GO - Molecular functionⁱ

alpha-sialidase activity
Source: MGI
Inferred from direct assayⁱ
- 12730204
exo-alpha-(2->3)-sialidase activity Source: UniProtKB
exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
exo-alpha-(2->8)-sialidase activity Source: UniProtKB
exo-alpha-sialidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10861246

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate metabolic process
Source: MGI
Inferred from direct assayⁱ
- 12730204
ganglioside catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 10861246
glycosphingolipid metabolic process Source: Reactome
oligosaccharide catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 10861246

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosidase, Hydrolase
Biological process	Carbohydrate metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAⁱ	3.2.1.18 2681
Reactomeⁱ	R-HSA-1660662 Glycosphingolipid metabolism R-HSA-4085001 Sialic acid metabolism
SABIO-RKⁱ	Q9UQ49

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GH33 Glycoside Hydrolase Family 33

CAZyⁱ

GH33 Glycoside Hydrolase Family 33

Chemistry databases

SwissLipidsⁱ	SLP:000001372 [Q9UQ49-1]

SwissLipidsⁱ

SLP:000001372 [Q9UQ49-1]

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sialidase-3 (EC:3.2.1.18) Alternative name(s): Ganglioside sialidase Membrane sialidase N-acetyl-alpha-neuraminidase 3
Gene namesⁱ	Name:NEU3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162139.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7760 NEU3
MIMⁱ	604617 gene
neXtProtⁱ	NX_Q9UQ49

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	45	R → V: Loss of enzyme activity. 1 Publication	1
Mutagenesisⁱ	50	D → S: Nearly abolishes enzyme activity. 1 Publication	1
Mutagenesisⁱ	179	Y → F: Loss of enzyme activity. 1 Publication	1
Mutagenesisⁱ	181	Y → F: Nearly abolishes enzyme activity. 1 Publication	1
Mutagenesisⁱ	225	E → S: Loss of enzyme activity. 1 Publication	1
Mutagenesisⁱ	245	R → A: Loss of enzyme activity. 1 Publication	1
Mutagenesisⁱ	340	R → A: Loss of enzyme activity. 1 Publication	1
Mutagenesisⁱ	370	Y → F: Loss of enzyme activity. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10825
Open Targets More...OpenTargetsⁱ	ENSG00000162139
PharmGKBⁱ	PA31562

Chemistry databases

ChEMBLⁱ	CHEMBL3046

ChEMBLⁱ

CHEMBL3046

Polymorphism and mutation databases

DMDMⁱ	17369720

DMDMⁱ

17369720

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000208903	1 – 428	Sialidase-3Add BLAST		428

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	313	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9UQ49
PaxDbⁱ	Q9UQ49
PeptideAtlas More...PeptideAtlasⁱ	Q9UQ49
PRIDEⁱ	Q9UQ49
ProteomicsDBⁱ	85507

PTM databases

iPTMnetⁱ	Q9UQ49
PhosphoSitePlusⁱ	Q9UQ49
SwissPalmⁱ	Q9UQ49

Expressionⁱ

Tissue specificityⁱ

Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000162139 Expressed in 162 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_NEU3
ExpressionAtlasⁱ	Q9UQ49 baseline and differential
Genevisibleⁱ	Q9UQ49 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038729 HPA038730 HPA070381

HPAⁱ

HPA038729
HPA038730
HPA070381

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	116038, 7 interactors
STRINGⁱ	9606.ENSP00000294064

Chemistry databases

BindingDBⁱ

Q9UQ49

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UQ49
SMRⁱ	Q9UQ49
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	129 – 140	BNR 1Add BLAST	12
Repeatⁱ	203 – 214	BNR 2Add BLAST	12
Repeatⁱ	254 – 265	BNR 3Add BLAST	12

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	24 – 27	FRIP motif		4

Sequence similaritiesⁱ

Belongs to the glycosyl hydrolase 33 family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IFVF Eukaryota ENOG410Y74Z LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011171
HOGENOMⁱ	HOG000233778
HOVERGENⁱ	HBG052608
InParanoidⁱ	Q9UQ49
KEGG Orthology (KO) More...KOⁱ	K12357
OMAⁱ	VYLFFIC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08BI
PhylomeDBⁱ	Q9UQ49
TreeFamⁱ	TF331063

Family and domain databases

InterProⁱ	View protein in InterPro IPR011040 Sialidase IPR026944 Sialidase-3 IPR026856 Sialidase_fam IPR036278 Sialidase_sf
PANTHERⁱ	PTHR10628 PTHR10628, 1 hit PTHR10628:SF23 PTHR10628:SF23, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13088 BNR_2, 1 hit
SUPFAMⁱ	SSF50939 SSF50939, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UQ49-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEVTTCSFN SPLFRQEDDR GITYRIPALL YIPPTHTFLA FAEKRSTRRD 
        60         70         80         90        100
EDALHLVLRR GLRIGQLVQW GPLKPLMEAT LPGHRTMNPC PVWEQKSGCV 
       110        120        130        140        150
FLFFICVRGH VTERQQIVSG RNAARLCFIY SQDAGCSWSE VRDLTEEVIG 
       160        170        180        190        200
SELKHWATFA VGPGHGIQLQ SGRLVIPAYT YYIPSWFFCF QLPCKTRPHS 
       210        220        230        240        250
LMIYSDDLGV TWHHGRLIRP MVTVECEVAE VTGRAGHPVL YCSARTPNRC 
       260        270        280        290        300
RAEALSTDHG EGFQRLALSR QLCEPPHGCQ GSVVSFRPLE IPHRCQDSSS 
       310        320        330        340        350
KDAPTIQQSS PGSSLRLEEE AGTPSESWLL YSHPTSRKQR VDLGIYLNQT 
       360        370        380        390        400
PLEAACWSRP WILHCGPCGY SDLAALEEEG LFGCLFECGT KQECEQIAFR 
       410        420 
LFTHREILSH LQGDCTSPGR NPSQFKSN

Length:428

Mass (Da):48,252

Last modified:May 1, 2000 - v1

Checksum:ⁱ35D1DD9359A78C98

Isoform 2 (identifier: Q9UQ49-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MRPADLPPRPMEESPASSSAPTETEEPGSSAEVM

« Hide

        10         20         30         40         50
MRPADLPPRP MEESPASSSA PTETEEPGSS AEVMEEVTTC SFNSPLFRQE 
        60         70         80         90        100
DDRGITYRIP ALLYIPPTHT FLAFAEKRST RRDEDALHLV LRRGLRIGQL 
       110        120        130        140        150
VQWGPLKPLM EATLPGHRTM NPCPVWEQKS GCVFLFFICV RGHVTERQQI 
       160        170        180        190        200
VSGRNAARLC FIYSQDAGCS WSEVRDLTEE VIGSELKHWA TFAVGPGHGI 
       210        220        230        240        250
QLQSGRLVIP AYTYYIPSWF FCFQLPCKTR PHSLMIYSDD LGVTWHHGRL 
       260        270        280        290        300
IRPMVTVECE VAEVTGRAGH PVLYCSARTP NRCRAEALST DHGEGFQRLA 
       310        320        330        340        350
LSRQLCEPPH GCQGSVVSFR PLEIPHRCQD SSSKDAPTIQ QSSPGSSLRL 
       360        370        380        390        400
EEEAGTPSES WLLYSHPTSR KQRVDLGIYL NQTPLEAACW SRPWILHCGP 
       410        420        430        440        450
CGYSDLAALE EEGLFGCLFE CGTKQECEQI AFRLFTHREI LSHLQGDCTS 
       460 
PGRNPSQFKS N

Show »

Length:461

Mass (Da):51,675

Checksum:ⁱ37D6EBA8FD7458AD

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PR25	E9PR25_HUMAN	Sialidase-3 Sialidase-3	NEU3	139	Annotation score:
E9PNK1	E9PNK1_HUMAN	Sialidase-3 Sialidase-3	NEU3	170	Annotation score:
E9PI40	E9PI40_HUMAN	Sialidase-3 Sialidase-3	NEU3	58	Annotation score:
E9PMZ3	E9PMZ3_HUMAN	Sialidase-3 Sialidase-3	NEU3	101	Annotation score:

Sequence cautionⁱ

The sequence CAB96131 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_055839	15	R → Q. Corresponds to variant dbSNP:rs7115499Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054145	1	M → MRPADLPPRPMEESPASSSA PTETEEPGSSAEVM in isoform 2. 2 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB008185 mRNA Translation: BAA82611.1 Y18563 mRNA Translation: CAB96131.1 Different initiation. AK022450 mRNA Translation: BAG51074.1 AK290442 mRNA Translation: BAF83131.1 AP001992 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74953.1 BC136397 mRNA Translation: AAI36398.1 BC144059 mRNA Translation: AAI44060.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44682.1 [Q9UQ49-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_006647.3, NM_006656.5 [Q9UQ49-2]
UniGeneⁱ	Hs.191074

Genome annotation databases

Ensemblⁱ	ENST00000294064; ENSP00000294064; ENSG00000162139 [Q9UQ49-2] ENST00000531509; ENSP00000432097; ENSG00000162139 [Q9UQ49-2]
GeneIDⁱ	10825
KEGGⁱ	hsa:10825
UCSC genome browser More...UCSCⁱ	uc001ovw.4 human [Q9UQ49-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UQ49	Sialidase 3 (Membrane sialidase), isoform CRA_a		HUMAN		461	UniRef100_Q9UQ49
Isoform 2 of Sialidase-3		HUMAN		461
cDNA FLJ53523, highly similar to Sialidase-3		HUMAN		352

Protein	Similar proteins		Species	Score	Length	Source
Q9UQ49	Sialidase 3 (Membrane sialidase), isoform CRA_a		HUMAN		461	UniRef90_Q9UQ49
NEU3 isoform 2		PONAB		461
Uncharacterized protein (Fragment)		MACMU		461
Sialidase 3 (Membrane sialidase)		PANTR		461
Uncharacterized protein		RHIRO		461
+16

Protein	Similar proteins		Species	Score	Length	Source
Q9UQ49	Sialidase-3		RAT		418	UniRef50_Q9UQ49
Sialidase-3		MOUSE		418
Sialidase 3 (Membrane sialidase), isoform CRA_a		HUMAN		461
Uncharacterized protein		AOTNA		461
Uncharacterized protein		RHIBE		461
+160

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB008185 mRNA Translation: BAA82611.1 Y18563 mRNA Translation: CAB96131.1 Different initiation. AK022450 mRNA Translation: BAG51074.1 AK290442 mRNA Translation: BAF83131.1 AP001992 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW74953.1 BC136397 mRNA Translation: AAI36398.1 BC144059 mRNA Translation: AAI44060.1
CCDSⁱ	CCDS44682.1 [Q9UQ49-2]
RefSeqⁱ	NP_006647.3, NM_006656.5 [Q9UQ49-2]
UniGeneⁱ	Hs.191074

3D structure databases

ProteinModelPortalⁱ	Q9UQ49
SMRⁱ	Q9UQ49
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116038, 7 interactors
STRINGⁱ	9606.ENSP00000294064

Chemistry databases

BindingDBⁱ	Q9UQ49
ChEMBLⁱ	CHEMBL3046
SwissLipidsⁱ	SLP:000001372 [Q9UQ49-1]

Protein family/group databases

CAZyⁱ	GH33 Glycoside Hydrolase Family 33

CAZyⁱ

GH33 Glycoside Hydrolase Family 33

PTM databases

iPTMnetⁱ	Q9UQ49
PhosphoSitePlusⁱ	Q9UQ49
SwissPalmⁱ	Q9UQ49

Polymorphism and mutation databases

DMDMⁱ	17369720

DMDMⁱ

17369720

Proteomic databases

EPDⁱ	Q9UQ49
PaxDbⁱ	Q9UQ49
PeptideAtlasⁱ	Q9UQ49
PRIDEⁱ	Q9UQ49
ProteomicsDBⁱ	85507

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000294064; ENSP00000294064; ENSG00000162139 [Q9UQ49-2] ENST00000531509; ENSP00000432097; ENSG00000162139 [Q9UQ49-2]
GeneIDⁱ	10825
KEGGⁱ	hsa:10825
UCSCⁱ	uc001ovw.4 human [Q9UQ49-1]

Organism-specific databases

CTDⁱ	10825
DisGeNETⁱ	10825
EuPathDBⁱ	HostDB:ENSG00000162139.9
GeneCardsⁱ	NEU3
HGNCⁱ	HGNC:7760 NEU3
HPAⁱ	HPA038729 HPA038730 HPA070381
MIMⁱ	604617 gene
neXtProtⁱ	NX_Q9UQ49
OpenTargetsⁱ	ENSG00000162139
PharmGKBⁱ	PA31562
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFVF Eukaryota ENOG410Y74Z LUCA
GeneTreeⁱ	ENSGT00390000011171
HOGENOMⁱ	HOG000233778
HOVERGENⁱ	HBG052608
InParanoidⁱ	Q9UQ49
KOⁱ	K12357
OMAⁱ	VYLFFIC
OrthoDBⁱ	EOG091G08BI
PhylomeDBⁱ	Q9UQ49
TreeFamⁱ	TF331063

Enzyme and pathway databases

BRENDAⁱ	3.2.1.18 2681
Reactomeⁱ	R-HSA-1660662 Glycosphingolipid metabolism R-HSA-4085001 Sialic acid metabolism
SABIO-RKⁱ	Q9UQ49

Miscellaneous databases

GeneWikiⁱ	NEU3
GenomeRNAiⁱ	10825
Protein Ontology More...PROⁱ	PR:Q9UQ49
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000162139 Expressed in 162 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_NEU3
ExpressionAtlasⁱ	Q9UQ49 baseline and differential
Genevisibleⁱ	Q9UQ49 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011040 Sialidase IPR026944 Sialidase-3 IPR026856 Sialidase_fam IPR036278 Sialidase_sf
PANTHERⁱ	PTHR10628 PTHR10628, 1 hit PTHR10628:SF23 PTHR10628:SF23, 1 hit
Pfamⁱ	View protein in Pfam PF13088 BNR_2, 1 hit
SUPFAMⁱ	SSF50939 SSF50939, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NEUR3_HUMAN
Accessionⁱ	Q9UQ49Primary (citable) accession number: Q9UQ49 Secondary accession number(s): A8K327, Q9NQE1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UQ49 (NEUR3_HUMAN)

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Sialidase-3

NEU3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Keywords - Technical termi

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Functionⁱ

pH dependenceⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ