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UniProtKB - Q9UQ49 (NEUR3_HUMAN)

Entry version 162 (10 Feb 2021)
Sequence version 1 (01 May 2000)
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Protein

Sialidase-3

Gene

NEU3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:11298736, PubMed:15847605, PubMed:10861246, PubMed:20511247, PubMed:28646141, PubMed:10405317, PubMed:12011038). Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR (PubMed:17334392, PubMed:25922362). Desialylates EGFR and activates downstream signaling in proliferating cells (PubMed:25922362). Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (PubMed:26251452).10 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=47 µM for ganglioside GD1a1 Publication

    pH dependencei

    Optimum pH is 4.5-6.5.2 Publications

    Temperature dependencei

    Optimum temperature is 20 degrees Celsius.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei25SubstrateBy similarity1
    Binding sitei45SubstrateCurated1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei50Proton acceptor1 Publication1
    Binding sitei179SubstrateCurated1
    Binding sitei181SubstrateCurated1
    Binding sitei225SubstrateCurated1
    Binding sitei245SubstrateCurated1
    Binding sitei340SubstrateCurated1
    Active sitei370Nucleophile1 Publication1
    Active sitei387Sequence analysis1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosidase, Hydrolase
    Biological processCarbohydrate metabolism, Lipid degradation, Lipid metabolism

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		3.2.1.18, 2681

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		Q9UQ49

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-1660662, Glycosphingolipid metabolism
    R-HSA-4085001, Sialic acid metabolism

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		Q9UQ49

    Protein family/group databases

    Carbohydrate-Active enZymes

    More...    CAZyi    		GH33, Glycoside Hydrolase Family 33

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...    SwissLipidsi    		SLP:000001372 [Q9UQ49-1]

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Sialidase-3 (EC:3.2.1.186 Publications)
    Alternative name(s):
    Ganglioside sialidasedis
    Membrane sialidase
    N-acetyl-alpha-neuraminidase 3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:NEU3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:7760, NEU3

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		604617, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q9UQ49

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...    VEuPathDBi    		HostDB:ENSG00000162139.9

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cell membrane, Endosome, Lysosome, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi25R → H: Loss of enzyme activity. 1 Publication1
    Mutagenesisi45R → V: Loss of enzyme activity. 1 Publication1
    Mutagenesisi50D → S or A: Nearly abolishes enzyme activity. 2 Publications1
    Mutagenesisi51E → D: Decreases enzyme activity. 1 Publication1
    Mutagenesisi88N → D: Markedly decreases enzyme activity. 1 Publication1
    Mutagenesisi107V → M: Markedly decreases enzyme activity. 1 Publication1
    Mutagenesisi114R → Q: Decreases enzyme activity. 1 Publication1
    Mutagenesisi162G → A: Markedly decreases enzyme activity. 1 Publication1
    Mutagenesisi179Y → F: Loss of enzyme activity. 1 Publication1
    Mutagenesisi181Y → A: Markedly decreases the recruitment within caveola. 1 Publication1
    Mutagenesisi181Y → F: Nearly abolishes enzyme activity. 1 Publication1
    Mutagenesisi187F → R: Decreases the recruitment within caveola. 1 Publication1
    Mutagenesisi225E → S: Loss of enzyme activity. 1 Publication1
    Mutagenesisi245R → A: Loss of enzyme activity. 1 Publication1
    Mutagenesisi340R → A: Loss of enzyme activity. 1 Publication1
    Mutagenesisi370Y → F or C: Loss of enzyme activity. 3 Publications1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		10825

    Open Targets

    More...    OpenTargetsi    		ENSG00000162139

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA31562

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q9UQ49, Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL3046

    DrugCentral

    More...    DrugCentrali    		Q9UQ49

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		NEU3

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		17369720

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002089031 – 428Sialidase-3Add BLAST428

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei313PhosphoserineBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Palmitoylated; may regulate intracellular trafficking and anchorage to plasma membrane and endomembranes.1 Publication

    Keywords - PTMi

    Lipoprotein, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q9UQ49

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q9UQ49

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q9UQ49

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q9UQ49

    PeptideAtlas

    More...    PeptideAtlasi    		Q9UQ49

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q9UQ49

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		1854
    85507 [Q9UQ49-1]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q9UQ49

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q9UQ49

    SwissPalm database of S-palmitoylation events

    More...    SwissPalmi    		Q9UQ49

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Highly expressed in skeletal muscle, testis, adrenal gland and thymus, followed by pancreas, liver, heart and thymus. Weakly expressed in kidney, placenta, brain and lung.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000162139, Expressed in quadriceps femoris and 174 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q9UQ49, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q9UQ49, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000162139, Tissue enhanced (testis)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with CAV1; this interaction enhances NEU3 sialidase activity within caveola (PubMed:12011038).

    Interacts with EGFR; this interaction mediates desialylation of EGFR and enhances downstream signaling (PubMed:17334392).

    2 Publications

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		116038, 8 interactors

    Protein interaction database and analysis system

    More...    IntActi    		Q9UQ49, 2 interactors

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000294064

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		Q9UQ49

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q9UQ49, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q9UQ49

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati129 – 140BNR 1Add BLAST12
    Repeati203 – 214BNR 2Add BLAST12
    Repeati254 – 265BNR 3Add BLAST12

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi24 – 27FRIP motif4

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycosyl hydrolase 33 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		ENOG502QSFT, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00950000182944

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_024620_2_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q9UQ49

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		HSVQWGP

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q9UQ49

    TreeFam database of animal gene trees

    More...    TreeFami    		TF331063

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR011040, Sialidase
    IPR026944, Sialidase-3
    IPR026856, Sialidase_fam
    IPR036278, Sialidase_sf

    The PANTHER Classification System

    More...    PANTHERi    		PTHR10628, PTHR10628, 1 hit
    PTHR10628:SF23, PTHR10628:SF23, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF13088, BNR_2, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF50939, SSF50939, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9UQ49-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MEEVTTCSFN SPLFRQEDDR GITYRIPALL YIPPTHTFLA FAEKRSTRRD 
            60         70         80         90        100
    EDALHLVLRR GLRIGQLVQW GPLKPLMEAT LPGHRTMNPC PVWEQKSGCV 
           110        120        130        140        150
    FLFFICVRGH VTERQQIVSG RNAARLCFIY SQDAGCSWSE VRDLTEEVIG 
           160        170        180        190        200
    SELKHWATFA VGPGHGIQLQ SGRLVIPAYT YYIPSWFFCF QLPCKTRPHS 
           210        220        230        240        250
    LMIYSDDLGV TWHHGRLIRP MVTVECEVAE VTGRAGHPVL YCSARTPNRC 
           260        270        280        290        300
    RAEALSTDHG EGFQRLALSR QLCEPPHGCQ GSVVSFRPLE IPHRCQDSSS 
           310        320        330        340        350
    KDAPTIQQSS PGSSLRLEEE AGTPSESWLL YSHPTSRKQR VDLGIYLNQT 
           360        370        380        390        400
    PLEAACWSRP WILHCGPCGY SDLAALEEEG LFGCLFECGT KQECEQIAFR 
           410        420 
    LFTHREILSH LQGDCTSPGR NPSQFKSN
    Length:428
    Mass (Da):48,252
    Last modified:May 1, 2000 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35D1DD9359A78C98
    GO
    Isoform 2 (identifier: Q9UQ49-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MRPADLPPRPMEESPASSSAPTETEEPGSSAEVM

    Show »
    Length:461
    Mass (Da):51,675
    Checksum:i37D6EBA8FD7458AD
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    E9PNK1E9PNK1_HUMAN
    Sialidase-3
    NEU3
    		170Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PR25E9PR25_HUMAN
    Sialidase-3
    NEU3
    		139Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PI40E9PI40_HUMAN
    Sialidase-3
    NEU3
    		58Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PMZ3E9PMZ3_HUMAN
    Sialidase-3
    NEU3
    		101Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence CAB96131 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05583915R → Q. Corresponds to variant dbSNP:rs7115499Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0541451M → MRPADLPPRPMEESPASSSA PTETEEPGSSAEVM in isoform 2. 2 Publications1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AB008185 mRNA Translation: BAA82611.1
    Y18563 mRNA Translation: CAB96131.1 Different initiation.
    AK022450 mRNA Translation: BAG51074.1
    AK290442 mRNA Translation: BAF83131.1
    AP001992 Genomic DNA No translation available.
    CH471076 Genomic DNA Translation: EAW74953.1
    BC136397 mRNA Translation: AAI36398.1
    BC144059 mRNA Translation: AAI44060.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS44682.1 [Q9UQ49-2]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_006647.3, NM_006656.5 [Q9UQ49-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000294064; ENSP00000294064; ENSG00000162139 [Q9UQ49-2]
    ENST00000531509; ENSP00000432097; ENSG00000162139 [Q9UQ49-2]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		10825

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:10825

    UCSC genome browser

    More...    UCSCi    		uc001ovw.4, human [Q9UQ49-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AB008185 mRNA Translation: BAA82611.1
    Y18563 mRNA Translation: CAB96131.1 Different initiation.
    AK022450 mRNA Translation: BAG51074.1
    AK290442 mRNA Translation: BAF83131.1
    AP001992 Genomic DNA No translation available.
    CH471076 Genomic DNA Translation: EAW74953.1
    BC136397 mRNA Translation: AAI36398.1
    BC144059 mRNA Translation: AAI44060.1
    CCDSiCCDS44682.1 [Q9UQ49-2]
    RefSeqiNP_006647.3, NM_006656.5 [Q9UQ49-2]

    3D structure databases

    SMRiQ9UQ49
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi116038, 8 interactors
    IntActiQ9UQ49, 2 interactors
    STRINGi9606.ENSP00000294064

    Chemistry databases

    BindingDBiQ9UQ49
    ChEMBLiCHEMBL3046
    DrugCentraliQ9UQ49
    SwissLipidsiSLP:000001372 [Q9UQ49-1]

    Protein family/group databases

    CAZyiGH33, Glycoside Hydrolase Family 33

    PTM databases

    iPTMnetiQ9UQ49
    PhosphoSitePlusiQ9UQ49
    SwissPalmiQ9UQ49

    Genetic variation databases

    BioMutaiNEU3
    DMDMi17369720

    Proteomic databases

    EPDiQ9UQ49
    jPOSTiQ9UQ49
    MassIVEiQ9UQ49
    PaxDbiQ9UQ49
    PeptideAtlasiQ9UQ49
    PRIDEiQ9UQ49
    ProteomicsDBi1854
    85507 [Q9UQ49-1]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		56317, 69 antibodies

    Genome annotation databases

    EnsembliENST00000294064; ENSP00000294064; ENSG00000162139 [Q9UQ49-2]
    ENST00000531509; ENSP00000432097; ENSG00000162139 [Q9UQ49-2]
    GeneIDi10825
    KEGGihsa:10825
    UCSCiuc001ovw.4, human [Q9UQ49-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		10825
    DisGeNETi10825

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		NEU3
    HGNCiHGNC:7760, NEU3
    HPAiENSG00000162139, Tissue enhanced (testis)
    MIMi604617, gene
    neXtProtiNX_Q9UQ49
    OpenTargetsiENSG00000162139
    PharmGKBiPA31562
    VEuPathDBiHostDB:ENSG00000162139.9

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiENOG502QSFT, Eukaryota
    GeneTreeiENSGT00950000182944
    HOGENOMiCLU_024620_2_0_1
    InParanoidiQ9UQ49
    OMAiHSVQWGP
    PhylomeDBiQ9UQ49
    TreeFamiTF331063

    Enzyme and pathway databases

    BRENDAi3.2.1.18, 2681
    PathwayCommonsiQ9UQ49
    ReactomeiR-HSA-1660662, Glycosphingolipid metabolism
    R-HSA-4085001, Sialic acid metabolism
    SABIO-RKiQ9UQ49

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		10825, 10 hits in 876 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		NEU3, human

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		NEU3

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		10825
    PharosiQ9UQ49, Tbio

    Protein Ontology

    More...    PROi    		PR:Q9UQ49
    RNActiQ9UQ49, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000162139, Expressed in quadriceps femoris and 174 other tissues
    ExpressionAtlasiQ9UQ49, baseline and differential
    GenevisibleiQ9UQ49, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR011040, Sialidase
    IPR026944, Sialidase-3
    IPR026856, Sialidase_fam
    IPR036278, Sialidase_sf
    PANTHERiPTHR10628, PTHR10628, 1 hit
    PTHR10628:SF23, PTHR10628:SF23, 1 hit
    PfamiView protein in Pfam
    PF13088, BNR_2, 1 hit
    SUPFAMiSSF50939, SSF50939, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEUR3_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UQ49
    Secondary accession number(s): A8K327, Q9NQE1
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: May 1, 2000
    Last modified: February 10, 2021
    This is version 162 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with genetic variants
      List of human entries with genetic variants
    3. Human variants curated from literature reports
      Index of human variants curated from literature reports
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families
    6. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
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