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Entry version 163 (05 Jun 2019)
Sequence version 2 (06 Mar 2007)
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Protein

Serine/arginine repetitive matrix protein 2

Gene

SRRM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for pre-mRNA splicing as component of the spliceosome.8 Publications

Miscellaneous

Can functionally substitute for CWC12 in yeast.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-72163 mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/arginine repetitive matrix protein 2
Alternative name(s):
300 kDa nuclear matrix antigen
Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa
Short name:
SR-related nuclear matrix protein of 300 kDa
Short name:
Ser/Arg-related nuclear matrix protein of 300 kDa
Splicing coactivator subunit SRm300
Tax-responsive enhancer element-binding protein 803
Short name:
TaxREB803
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SRRM2
Synonyms:KIAA0324, SRL300, SRM300
ORF Names:HSPC075
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16639 SRRM2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606032 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UQ35

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
23524

Open Targets

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OpenTargetsi
ENSG00000167978

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38178

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SRRM2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143928063

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002481541 – 2752Serine/arginine repetitive matrix protein 2Add BLAST2752

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei101N6-acetyllysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki108Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei145PhosphotyrosineCombined sources1
Modified residuei169N6-acetyllysineCombined sources1
Modified residuei220PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei286PhosphothreonineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei300PhosphoserineCombined sources1
Modified residuei322PhosphoserineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei359PhosphothreonineCombined sources1
Modified residuei367PhosphothreonineCombined sources1
Modified residuei377PhosphoserineCombined sources1
Modified residuei383PhosphothreonineCombined sources1
Modified residuei384PhosphothreonineCombined sources1
Modified residuei387PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1
Modified residuei398PhosphoserineCombined sources1
Modified residuei404PhosphoserineCombined sources1
Modified residuei408PhosphoserineCombined sources1
Modified residuei424PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei436PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei440PhosphoserineCombined sources1
Modified residuei454PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Modified residuei486PhosphoserineCombined sources1
Modified residuei506PhosphoserineCombined sources1
Modified residuei508PhosphoserineCombined sources1
Modified residuei510PhosphoserineCombined sources1
Modified residuei534PhosphoserineCombined sources1
Modified residuei536PhosphoserineCombined sources1
Modified residuei543PhosphoserineCombined sources1
Modified residuei702PhosphoserineCombined sources1
Modified residuei704PhosphoserineCombined sources1
Modified residuei706PhosphoserineCombined sources1
Modified residuei778PhosphoserineCombined sources1
Modified residuei780PhosphoserineCombined sources1
Modified residuei783PhosphoserineCombined sources1
Modified residuei846PhosphoserineCombined sources1
Modified residuei854PhosphoserineBy similarity1
Modified residuei856PhosphothreonineBy similarity1
Modified residuei857PhosphoserineCombined sources1
Modified residuei864PhosphoserineCombined sources1
Modified residuei866PhosphothreonineCombined sources1
Modified residuei871PhosphoserineCombined sources1
Modified residuei875PhosphoserineCombined sources1
Modified residuei876PhosphoserineCombined sources1
Modified residuei908PhosphoserineCombined sources1
Modified residuei935PhosphoserineCombined sources1
Modified residuei950PhosphoserineCombined sources1
Modified residuei952PhosphoserineCombined sources1
Modified residuei954PhosphoserineCombined sources1
Modified residuei957PhosphoserineCombined sources1
Modified residuei968PhosphoserineCombined sources1
Modified residuei970PhosphoserineCombined sources1
Modified residuei972PhosphoserineCombined sources1
Modified residuei973PhosphoserineCombined sources1
Modified residuei974PhosphoserineCombined sources1
Modified residuei977PhosphothreonineCombined sources1
Modified residuei983PhosphothreonineCombined sources1
Modified residuei992PhosphoserineCombined sources1
Modified residuei994PhosphoserineCombined sources1
Modified residuei996PhosphotyrosineCombined sources1
Modified residuei1003PhosphothreonineCombined sources1
Modified residuei1010PhosphoserineCombined sources1
Modified residuei1014PhosphoserineCombined sources1
Modified residuei1024PhosphoserineBy similarity1
Modified residuei1028PhosphoserineCombined sources1
Modified residuei1032PhosphoserineCombined sources1
Modified residuei1042PhosphoserineBy similarity1
Modified residuei1043PhosphothreonineCombined sources1
Modified residuei1049PhosphotyrosineCombined sources1
Modified residuei1064PhosphoserineCombined sources1
Modified residuei1069PhosphoserineCombined sources1
Modified residuei1072PhosphoserineCombined sources1
Modified residuei1073PhosphoserineCombined sources1
Modified residuei1083PhosphoserineCombined sources1
Modified residuei1099PhosphoserineCombined sources1
Modified residuei1101PhosphoserineCombined sources1
Modified residuei1102PhosphoserineCombined sources1
Modified residuei1103PhosphoserineCombined sources1
Modified residuei1106PhosphothreonineCombined sources1
Modified residuei1112PhosphoserineCombined sources1
Modified residuei1122PhosphoserineCombined sources1
Modified residuei1124PhosphoserineCombined sources1
Modified residuei1129PhosphoserineCombined sources1
Modified residuei1132PhosphoserineCombined sources1
Modified residuei1152PhosphoserineCombined sources1
Modified residuei1179PhosphoserineCombined sources1
Modified residuei1188PhosphoserineCombined sources1
Modified residuei1198PhosphoserineCombined sources1
Modified residuei1208PhosphothreonineCombined sources1
Modified residuei1214PhosphoserineCombined sources1
Modified residuei1219PhosphoserineCombined sources1
Modified residuei1227PhosphoserineCombined sources1
Modified residuei1254PhosphoserineCombined sources1
Modified residuei1257PhosphoserineCombined sources1
Modified residuei1258PhosphoserineCombined sources1
Modified residuei1266PhosphoserineBy similarity1
Modified residuei1270PhosphoserineBy similarity1
Modified residuei1271PhosphoserineBy similarity1
Modified residuei1311PhosphoserineCombined sources1
Modified residuei1318PhosphoserineCombined sources1
Modified residuei1320PhosphoserineCombined sources1
Modified residuei1326PhosphoserineCombined sources1
Modified residuei1329PhosphoserineCombined sources1
Modified residuei1336PhosphoserineCombined sources1
Modified residuei1348PhosphoserineBy similarity1
Modified residuei1368PhosphoserineCombined sources1
Modified residuei1382PhosphoserineCombined sources1
Modified residuei1383PhosphoserineBy similarity1
Modified residuei1384PhosphoserineBy similarity1
Modified residuei1387PhosphoserineCombined sources1
Modified residuei1401PhosphoserineCombined sources1
Modified residuei1403PhosphoserineCombined sources1
Modified residuei1404PhosphoserineCombined sources1
Modified residuei1413PhosphothreonineCombined sources1
Modified residuei1415PhosphoserineCombined sources1
Modified residuei1421PhosphoserineCombined sources1
Modified residuei1423PhosphoserineBy similarity1
Modified residuei1424PhosphoserineCombined sources1
Modified residuei1434PhosphothreonineCombined sources1
Modified residuei1444PhosphoserineCombined sources