Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat protein SHOC-2

Gene

SHOC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.3 Publications

GO - Molecular functioni

  • protein phosphatase 1 binding Source: UniProtKB
  • protein phosphatase binding Source: UniProtKB
  • protein phosphatase regulator activity Source: UniProtKB
  • protein serine/threonine phosphatase activity Source: GO_Central

GO - Biological processi

  • fibroblast growth factor receptor signaling pathway Source: UniProtKB
  • positive regulation of Ras protein signal transduction Source: UniProtKB
  • protein dephosphorylation Source: GO_Central
  • Ras protein signal transduction Source: UniProtKB

Enzyme and pathway databases

SignaLinkiQ9UQ13
SIGNORiQ9UQ13

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat protein SHOC-2
Alternative name(s):
Protein soc-2 homolog
Protein sur-8 homolog
Gene namesi
Name:SHOC2
Synonyms:KIAA0862
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000108061.11
HGNCiHGNC:15454 SHOC2
MIMi602775 gene
neXtProtiNX_Q9UQ13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Noonan syndrome-like disorder with loose anagen hair 1 (NSLH1)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair.
See also OMIM:607721
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0601992S → G in NSLH1; creates a N-myristoylation site, resulting in myristoylation of the protein and aberrant targeting to the plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs267607048EnsemblClinVar.1
Natural variantiVAR_074030173M → I in NSLH1; significantly decreases ERK1/2 activity; does not affect cytoplasm and nucleus localization; does not affect SHOC2-MRAS-RAF1 complex assembly; impairs interaction with phosphatase 1c. 1 PublicationCorresponds to variant dbSNP:rs730881020EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi8036
MalaCardsiSHOC2
MIMi607721 phenotype
OpenTargetsiENSG00000108061
Orphaneti2701 Noonan syndrome-like disorder with loose anagen hair
PharmGKBiPA37960

Polymorphism and mutation databases

BioMutaiSHOC2
DMDMi14423936

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977371 – 582Leucine-rich repeat protein SHOC-2Add BLAST582

Proteomic databases

EPDiQ9UQ13
PaxDbiQ9UQ13
PeptideAtlasiQ9UQ13
PRIDEiQ9UQ13
ProteomicsDBi85490
85491 [Q9UQ13-2]

PTM databases

iPTMnetiQ9UQ13
PhosphoSitePlusiQ9UQ13

Expressioni

Gene expression databases

BgeeiENSG00000108061 Expressed in 235 organ(s), highest expression level in female gonad
CleanExiHS_SHOC2
ExpressionAtlasiQ9UQ13 baseline and differential
GenevisibleiQ9UQ13 HS

Organism-specific databases

HPAiHPA009164

Interactioni

Subunit structurei

Interacts with M-Ras/MRAS, and RAF1. Forms a multiprotein complex with Ras (M-Ras/MRAS), Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC). Interacts with ERBIN; disrupts the interaction with RAF1 and Ras, leading to prevent activation of the Ras signaling pathway. Specifically binds K-Ras/KRAS, M-Ras/MRAS and N-Ras/NRAS but not H-Ras/HRAS.4 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113729, 21 interactors
IntActiQ9UQ13, 8 interactors
MINTiQ9UQ13
STRINGi9606.ENSP00000358464

Structurei

3D structure databases

ProteinModelPortaliQ9UQ13
SMRiQ9UQ13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati101 – 122LRR 1Add BLAST22
Repeati124 – 145LRR 2Add BLAST22
Repeati147 – 169LRR 3Add BLAST23
Repeati170 – 191LRR 4Add BLAST22
Repeati193 – 214LRR 5Add BLAST22
Repeati216 – 237LRR 6Add BLAST22
Repeati239 – 260LRR 7Add BLAST22
Repeati262 – 283LRR 8Add BLAST22
Repeati285 – 307LRR 9Add BLAST23
Repeati308 – 329LRR 10Add BLAST22
Repeati332 – 353LRR 11Add BLAST22
Repeati356 – 377LRR 12Add BLAST22
Repeati380 – 400LRR 13Add BLAST21
Repeati403 – 424LRR 14Add BLAST22
Repeati426 – 448LRR 15Add BLAST23
Repeati449 – 470LRR 16Add BLAST22
Repeati472 – 494LRR 17Add BLAST23
Repeati495 – 516LRR 18Add BLAST22
Repeati518 – 540LRR 19Add BLAST23
Repeati542 – 563LRR 20Add BLAST22

Sequence similaritiesi

Belongs to the SHOC2 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00840000129686
HOGENOMiHOG000116557
HOVERGENiHBG055661
InParanoidiQ9UQ13
KOiK19613
OMAiNQFTSYP
OrthoDBiEOG091G05NZ
PhylomeDBiQ9UQ13
TreeFamiTF315742

Family and domain databases

Gene3Di3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 4 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 16 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 17 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UQ13-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSSLGKEKD SKEKDPKVPS AKEREKEAKA SGGFGKESKE KEPKTKGKDA
60 70 80 90 100
KDGKKDSSAA QPGVAFSVDN TIKRPNPAPG TRKKSSNAEV IKELNKCREE
110 120 130 140 150
NSMRLDLSKR SIHILPSSIK ELTQLTELYL YSNKLQSLPA EVGCLVNLMT
160 170 180 190 200
LALSENSLTS LPDSLDNLKK LRMLDLRHNK LREIPSVVYR LDSLTTLYLR
210 220 230 240 250
FNRITTVEKD IKNLSKLSML SIRENKIKQL PAEIGELCNL ITLDVAHNQL
260 270 280 290 300
EHLPKEIGNC TQITNLDLQH NELLDLPDTI GNLSSLSRLG LRYNRLSAIP
310 320 330 340 350
RSLAKCSALE ELNLENNNIS TLPESLLSSL VKLNSLTLAR NCFQLYPVGG
360 370 380 390 400
PSQFSTIYSL NMEHNRINKI PFGIFSRAKV LSKLNMKDNQ LTSLPLDFGT
410 420 430 440 450
WTSMVELNLA TNQLTKIPED VSGLVSLEVL ILSNNLLKKL PHGLGNLRKL
460 470 480 490 500
RELDLEENKL ESLPNEIAYL KDLQKLVLTN NQLTTLPRGI GHLTNLTHLG
510 520 530 540 550
LGENLLTHLP EEIGTLENLE ELYLNDNPNL HSLPFELALC SKLSIMSIEN
560 570 580
CPLSHLPPQI VAGGPSFIIQ FLKMQGPYRA MV
Length:582
Mass (Da):64,888
Last modified:June 20, 2001 - v2
Checksum:iF3F828646642A855
GO
Isoform 2 (identifier: Q9UQ13-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-279: Missing.

Note: No experimental confirmation available.
Show »
Length:536
Mass (Da):59,743
Checksum:i7F662A1A4580F3B7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RI37X6RI37_HUMAN
Leucine-rich repeat protein SHOC-2
SHOC2
372Annotation score:

Sequence cautioni

The sequence BAA74885 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAG52235 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti475K → E in BAF85522 (PubMed:14702039).Curated1
Sequence conflicti535F → L in BAA74885 (PubMed:10048485).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0601992S → G in NSLH1; creates a N-myristoylation site, resulting in myristoylation of the protein and aberrant targeting to the plasma membrane. 2 PublicationsCorresponds to variant dbSNP:rs267607048EnsemblClinVar.1
Natural variantiVAR_074030173M → I in NSLH1; significantly decreases ERK1/2 activity; does not affect cytoplasm and nucleus localization; does not affect SHOC2-MRAS-RAF1 complex assembly; impairs interaction with phosphatase 1c. 1 PublicationCorresponds to variant dbSNP:rs730881020EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038188234 – 279Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068920 mRNA Translation: AAC39856.1
AF054828 mRNA Translation: AAC25698.1
AB020669 mRNA Translation: BAA74885.2 Different initiation.
AK090820 mRNA Translation: BAG52235.1 Different initiation.
AK292833 mRNA Translation: BAF85522.1
AL158163 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49548.1
BC050445 mRNA Translation: AAH50445.1
CCDSiCCDS58095.1 [Q9UQ13-2]
CCDS7568.1 [Q9UQ13-1]
RefSeqiNP_001255968.1, NM_001269039.2 [Q9UQ13-2]
NP_001311265.1, NM_001324336.1 [Q9UQ13-1]
NP_001311266.1, NM_001324337.1 [Q9UQ13-1]
NP_031399.2, NM_007373.3 [Q9UQ13-1]
XP_016872191.1, XM_017016702.1
XP_016872192.1, XM_017016703.1
XP_016872193.1, XM_017016704.1
UniGeneiHs.104315

Genome annotation databases

EnsembliENST00000265277; ENSP00000265277; ENSG00000108061 [Q9UQ13-2]
ENST00000369452; ENSP00000358464; ENSG00000108061 [Q9UQ13-1]
GeneIDi8036
KEGGihsa:8036
UCSCiuc001kzl.5 human [Q9UQ13-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

The matchmaker - Issue 121 of September 2010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF068920 mRNA Translation: AAC39856.1
AF054828 mRNA Translation: AAC25698.1
AB020669 mRNA Translation: BAA74885.2 Different initiation.
AK090820 mRNA Translation: BAG52235.1 Different initiation.
AK292833 mRNA Translation: BAF85522.1
AL158163 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49548.1
BC050445 mRNA Translation: AAH50445.1
CCDSiCCDS58095.1 [Q9UQ13-2]
CCDS7568.1 [Q9UQ13-1]
RefSeqiNP_001255968.1, NM_001269039.2 [Q9UQ13-2]
NP_001311265.1, NM_001324336.1 [Q9UQ13-1]
NP_001311266.1, NM_001324337.1 [Q9UQ13-1]
NP_031399.2, NM_007373.3 [Q9UQ13-1]
XP_016872191.1, XM_017016702.1
XP_016872192.1, XM_017016703.1
XP_016872193.1, XM_017016704.1
UniGeneiHs.104315

3D structure databases

ProteinModelPortaliQ9UQ13
SMRiQ9UQ13
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113729, 21 interactors
IntActiQ9UQ13, 8 interactors
MINTiQ9UQ13
STRINGi9606.ENSP00000358464

PTM databases

iPTMnetiQ9UQ13
PhosphoSitePlusiQ9UQ13

Polymorphism and mutation databases

BioMutaiSHOC2
DMDMi14423936

Proteomic databases

EPDiQ9UQ13
PaxDbiQ9UQ13
PeptideAtlasiQ9UQ13
PRIDEiQ9UQ13
ProteomicsDBi85490
85491 [Q9UQ13-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265277; ENSP00000265277; ENSG00000108061 [Q9UQ13-2]
ENST00000369452; ENSP00000358464; ENSG00000108061 [Q9UQ13-1]
GeneIDi8036
KEGGihsa:8036
UCSCiuc001kzl.5 human [Q9UQ13-1]

Organism-specific databases

CTDi8036
DisGeNETi8036
EuPathDBiHostDB:ENSG00000108061.11
GeneCardsiSHOC2
HGNCiHGNC:15454 SHOC2
HPAiHPA009164
MalaCardsiSHOC2
MIMi602775 gene
607721 phenotype
neXtProtiNX_Q9UQ13
OpenTargetsiENSG00000108061
Orphaneti2701 Noonan syndrome-like disorder with loose anagen hair
PharmGKBiPA37960
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00840000129686
HOGENOMiHOG000116557
HOVERGENiHBG055661
InParanoidiQ9UQ13
KOiK19613
OMAiNQFTSYP
OrthoDBiEOG091G05NZ
PhylomeDBiQ9UQ13
TreeFamiTF315742

Enzyme and pathway databases

SignaLinkiQ9UQ13
SIGNORiQ9UQ13

Miscellaneous databases

ChiTaRSiSHOC2 human
GeneWikiiSHOC2
GenomeRNAii8036
PROiPR:Q9UQ13
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108061 Expressed in 235 organ(s), highest expression level in female gonad
CleanExiHS_SHOC2
ExpressionAtlasiQ9UQ13 baseline and differential
GenevisibleiQ9UQ13 HS

Family and domain databases

Gene3Di3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 4 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 16 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 17 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSHOC2_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ13
Secondary accession number(s): A8K9W8
, B3KR23, O76063, Q5VZS8, Q5VZS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: November 7, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again