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Protein

Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Gene

DHDH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH.
D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei71May play an important role in coenzyme bindingBy similarity1
Sitei79May play an important role in coenzyme bindingBy similarity1
Sitei97May play an important role in coenzyme bindingBy similarity1
Sitei176May play an important role for the adaptation of the alcohol substrate into the binding siteBy similarity1
Sitei180May play an important role in catalytic activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC:1.3.1.20)
Alternative name(s):
D-xylose 1-dehydrogenase
D-xylose-NADP dehydrogenase (EC:1.1.1.179)
Dimeric dihydrodiol dehydrogenase
Hum2DD
Gene namesi
Name:DHDH
Synonyms:2DD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104808.7
HGNCiHGNC:17887 DHDH
MIMi606377 gene
neXtProtiNX_Q9UQ10

Pathology & Biotechi

Organism-specific databases

DisGeNETi27294
OpenTargetsiENSG00000104808
PharmGKBiPA27322

Polymorphism and mutation databases

BioMutaiDHDH
DMDMi74735193

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003153611 – 334Trans-1,2-dihydrobenzene-1,2-diol dehydrogenaseAdd BLAST334

Proteomic databases

PaxDbiQ9UQ10
PRIDEiQ9UQ10
ProteomicsDBi85489

PTM databases

PhosphoSitePlusiQ9UQ10

Expressioni

Tissue specificityi

Small intestine.1 Publication

Gene expression databases

BgeeiENSG00000104808 Expressed in 98 organ(s), highest expression level in duodenum
CleanExiHS_DHDH
ExpressionAtlasiQ9UQ10 baseline and differential
GenevisibleiQ9UQ10 HS

Organism-specific databases

HPAiHPA044131

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi118118, 2 interactors
STRINGi9606.ENSP00000221403

Structurei

3D structure databases

ProteinModelPortaliQ9UQ10
SMRiQ9UQ10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.Curated

Phylogenomic databases

eggNOGiKOG2741 Eukaryota
COG0673 LUCA
GeneTreeiENSGT00390000007946
HOGENOMiHOG000227440
HOVERGENiHBG105348
InParanoidiQ9UQ10
KOiK00078
OMAiINYCQYS
OrthoDBiEOG091G0DNU
PhylomeDBiQ9UQ10
TreeFamiTF324504

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR000683 Oxidoreductase_N
PfamiView protein in Pfam
PF01408 GFO_IDH_MocA, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q9UQ10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRWGIVSV GLISSDFTAV LQTLPRSEHQ VVAVAARDLS RAKEFAQKHD
60 70 80 90 100
IPKAYGSYEE LAKDPSVEVA YIGTQHPQHK AAVMLCLAAG KAVLCEKPTG
110 120 130 140 150
VNAAEVREMV AEARSRALFL MEAIWTRFFP ASEALRSVLA QGTLGDLRVA
160 170 180 190 200
RAEFGKNLIH VPRAVDRAQA GGALLDIGIY CVQFTSMVFG GQKPEKISVV
210 220 230 240 250
GRRHETGVDD TVTVLLQYPG EVHGSFTCSI TVQLSNTASV SGTKGMVQLL
260 270 280 290 300
NPCWCPTELV VKGEHKEFPL PPVPKDCNFD NGAGMSYEAK HVWECLRKGM
310 320 330
KESPVIPLSE SELLADILEE VRKAIGVTFP QDKR
Length:334
Mass (Da):36,382
Last modified:May 1, 2000 - v1
Checksum:i1E2E11DF0B55214B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RGT8E5RGT8_HUMAN
Trans-1,2-dihydrobenzene-1,2-diol d...
DHDH
242Annotation score:
E5RFE0E5RFE0_HUMAN
Trans-1,2-dihydrobenzene-1,2-diol d...
DHDH
195Annotation score:
H0YBU7H0YBU7_HUMAN
Trans-1,2-dihydrobenzene-1,2-diol d...
DHDH
137Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0381742A → P. Corresponds to variant dbSNP:rs10401800Ensembl.1
Natural variantiVAR_03817566S → N. Corresponds to variant dbSNP:rs2270941Ensembl.1
Natural variantiVAR_038176200V → M. Corresponds to variant dbSNP:rs35453148Ensembl.1
Natural variantiVAR_038177247V → A. Corresponds to variant dbSNP:rs11666105Ensembl.1
Natural variantiVAR_038178282G → R. Corresponds to variant dbSNP:rs3765148Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC032730 mRNA Translation: AAH32730.1
AB021933 mRNA Translation: BAA83490.1
CH471177 Genomic DNA Translation: EAW52414.1
CCDSiCCDS12741.1
RefSeqiNP_055290.1, NM_014475.3
UniGeneiHs.631555

Genome annotation databases

EnsembliENST00000221403; ENSP00000221403; ENSG00000104808
GeneIDi27294
KEGGihsa:27294
UCSCiuc002ple.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDHDH_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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