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Protein

MAPK/MAK/MRK overlapping kinase

Gene

MOK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Activity regulationi

Phosphorylation appears to increase the enzymatic activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei128Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9UQ07

Names & Taxonomyi

Protein namesi
Recommended name:
MAPK/MAK/MRK overlapping kinase (EC:2.7.11.22By similarity)
Alternative name(s):
MOK protein kinase
Renal tumor antigen 1
Short name:
RAGE-1
Gene namesi
Name:MOK
Synonyms:RAGE, RAGE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000080823.21
HGNCiHGNC:9833 MOK
MIMi605762 gene
neXtProtiNX_Q9UQ07

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5891
OpenTargetsiENSG00000080823
PharmGKBiPA34187

Polymorphism and mutation databases

BioMutaiMOK

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863411 – 419MAPK/MAK/MRK overlapping kinaseAdd BLAST419

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UQ07
PaxDbiQ9UQ07
PeptideAtlasiQ9UQ07
PRIDEiQ9UQ07
ProteomicsDBi85485
85486 [Q9UQ07-2]
85487 [Q9UQ07-3]
85488 [Q9UQ07-4]
TopDownProteomicsiQ9UQ07-4 [Q9UQ07-4]

PTM databases

iPTMnetiQ9UQ07
PhosphoSitePlusiQ9UQ07

Expressioni

Tissue specificityi

Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.

Gene expression databases

BgeeiENSG00000080823 Expressed in 163 organ(s), highest expression level in right uterine tube
CleanExiHS_RAGE
ExpressionAtlasiQ9UQ07 baseline and differential
GenevisibleiQ9UQ07 HS

Organism-specific databases

HPAiHPA027292

Interactioni

Protein-protein interaction databases

BioGridi111828, 12 interactors
IntActiQ9UQ07, 4 interactors
MINTiQ9UQ07
STRINGi9606.ENSP00000355304

Structurei

3D structure databases

ProteinModelPortaliQ9UQ07
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 285Protein kinasePROSITE-ProRule annotationAdd BLAST282

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0661 Eukaryota
ENOG410XPBB LUCA
GeneTreeiENSGT00650000093283
HOGENOMiHOG000233024
HOVERGENiHBG106271
InParanoidiQ9UQ07
KOiK08830
OMAiAMNFDFP
OrthoDBiEOG091G0DU3
PhylomeDBiQ9UQ07
TreeFamiTF328769

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UQ07-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKNYKAIGKI GEGTFSEVMK MQSLRDGNYY ACKQMKQRFE SIEQVNNLRE
60 70 80 90 100
IQALRRLNPH PNILMLHEVV FDRKSGSLAL ICELMDMNIY ELIRGRRYPL
110 120 130 140 150
SEKKIMHYMY QLCKSLDHIH RNGIFHRDVK PENILIKQDV LKLGDFGSCR
160 170 180 190 200
SVYSKQPYTE YISTRWYRAP ECLLTDGFYT YKMDLWSAGC VFYEIASLQP
210 220 230 240 250
LFPGVNELDQ ISKIHDVIGT PAQKILTKFK QSRAMNFDFP FKKGSGIPLL
260 270 280 290 300
TTNLSPQCLS LLHAMVAYDP DERIAAHQAL QHPYFQEQRK TEKRALGSHR
310 320 330 340 350
KAGFPEHPVA PEPLSNSCQI SKEGRKQKQS LKQEEDRPKR RGPAYVMELP
360 370 380 390 400
KLKLSGVVRL SSYSSPTLQS VLGSGTNGRV PVLRPLKCIP ASKKTDPQKD
410
LKPAPQQCRL PTIVRKGGR
Length:419
Mass (Da):48,014
Last modified:May 1, 2000 - v1
Checksum:iCDA7D9C1E80AAE8F
GO
Isoform 2 (identifier: Q9UQ07-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-419: Missing.

Note: No experimental confirmation available.
Show »
Length:231
Mass (Da):27,120
Checksum:iD0665FAE077D3B76
GO
Isoform 3 (identifier: Q9UQ07-3) [UniParc]FASTAAdd to basket
Also known as: RAGE-1 ORF5, RAGE-2 ORF5, RAGE-3 ORF5

The sequence of this isoform differs from the canonical sequence as follows:
     1-346: Missing.

Note: No experimental confirmation available.
Show »
Length:73
Mass (Da):7,879
Checksum:i38B1376ECFEDF351
GO
Isoform 4 (identifier: Q9UQ07-4) [UniParc]FASTAAdd to basket
Also known as: RAGE-4 ORF3

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.
     290-329: KTEKRALGSH...ISKEGRKQKQ → TQNGSEDEAS...LPGRSVTLLV
     330-419: Missing.

Note: No experimental confirmation available.
Show »
Length:95
Mass (Da):10,482
Checksum:i8B155074ED025D9A
GO
Isoform 5 (identifier: Q9UQ07-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-71: Missing.

Note: No experimental confirmation available.
Show »
Length:389
Mass (Da):44,425
Checksum:i72B60D201632301B
GO
Isoform 6 (identifier: Q9UQ07-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-138: Missing.

Note: Gene prediction based on EST data.
Show »
Length:418
Mass (Da):47,886
Checksum:i75769950EB76F3F7
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RI85E5RI85_HUMAN
MAPK/MAK/MRK overlapping kinase
MOK
151Annotation score:
H0YM36H0YM36_HUMAN
MAPK/MAK/MRK overlapping kinase
MOK
173Annotation score:
H3BNF8H3BNF8_HUMAN
MAPK/MAK/MRK overlapping kinase
MOK
89Annotation score:
E5RHY4E5RHY4_HUMAN
MAPK/MAK/MRK overlapping kinase
MOK
59Annotation score:
E5RFX9E5RFX9_HUMAN
MAPK/MAK/MRK overlapping kinase
MOK
44Annotation score:
H0YMY9H0YMY9_HUMAN
MAPK/MAK/MRK overlapping kinase
MOK
96Annotation score:
H0YBV8H0YBV8_HUMAN
MAPK/MAK/MRK overlapping kinase
MOK
113Annotation score:
E5RHT7E5RHT7_HUMAN
MAPK/MAK/MRK overlapping kinase
MOK
125Annotation score:
H0YKX6H0YKX6_HUMAN
MAPK/MAK/MRK overlapping kinase
MOK
95Annotation score:
H0YLZ5H0YLZ5_HUMAN
MAPK/MAK/MRK overlapping kinase
MOK
47Annotation score:

Sequence cautioni

The sequence AAB38087 differs from that shown. Reason: Frameshift at position 299.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti269D → G in BAG35641 (PubMed:14702039).Curated1
Sequence conflicti313P → L in BAG35641 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04201138R → H1 PublicationCorresponds to variant dbSNP:rs34114580Ensembl.1
Natural variantiVAR_04201286D → N1 PublicationCorresponds to variant dbSNP:rs34084056Ensembl.1
Natural variantiVAR_070930217V → I1 PublicationCorresponds to variant dbSNP:rs148360666Ensembl.1
Natural variantiVAR_042013230K → R1 PublicationCorresponds to variant dbSNP:rs34965156Ensembl.1
Natural variantiVAR_042014248P → S1 PublicationCorresponds to variant dbSNP:rs34299975Ensembl.1
Natural variantiVAR_042015272E → D in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_024576398Q → R1 PublicationCorresponds to variant dbSNP:rs2236493Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0091431 – 346Missing in isoform 3. 1 PublicationAdd BLAST346
Alternative sequenceiVSP_0091421 – 234Missing in isoform 4. 1 PublicationAdd BLAST234
Alternative sequenceiVSP_05473442 – 71Missing in isoform 5. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_054735138Missing in isoform 6. Curated1
Alternative sequenceiVSP_009144232 – 419Missing in isoform 2. 1 PublicationAdd BLAST188
Alternative sequenceiVSP_009145290 – 329KTEKR…RKQKQ → TQNGSEDEASAVLLPIQTRS SLNPLLSTCMLPGRSVTLLV in isoform 4. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_009146330 – 419Missing in isoform 4. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022694 mRNA Translation: BAA81688.1
U46191 mRNA Translation: AAB38079.1
U46192 mRNA Translation: AAB38082.1
U46193 mRNA Translation: AAB38085.1
U46194 mRNA Translation: AAB38087.1 Frameshift.
AK302349 mRNA Translation: BAH13682.1
AK312778 mRNA Translation: BAG35641.1
AL352978 Genomic DNA No translation available.
AL359402 Genomic DNA No translation available.
BC053536 mRNA Translation: AAH53536.1
CCDSiCCDS61552.1 [Q9UQ07-5]
CCDS81854.1 [Q9UQ07-6]
CCDS9971.1 [Q9UQ07-1]
RefSeqiNP_001258940.1, NM_001272011.1 [Q9UQ07-5]
NP_001317163.1, NM_001330234.1 [Q9UQ07-6]
NP_055041.1, NM_014226.2 [Q9UQ07-1]
UniGeneiHs.104119
Hs.36859

Genome annotation databases

EnsembliENST00000361847; ENSP00000355304; ENSG00000080823 [Q9UQ07-1]
ENST00000522874; ENSP00000429469; ENSG00000080823 [Q9UQ07-6]
ENST00000524214; ENSP00000428942; ENSG00000080823 [Q9UQ07-5]
GeneIDi5891
KEGGihsa:5891
UCSCiuc001ylm.5 human [Q9UQ07-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022694 mRNA Translation: BAA81688.1
U46191 mRNA Translation: AAB38079.1
U46192 mRNA Translation: AAB38082.1
U46193 mRNA Translation: AAB38085.1
U46194 mRNA Translation: AAB38087.1 Frameshift.
AK302349 mRNA Translation: BAH13682.1
AK312778 mRNA Translation: BAG35641.1
AL352978 Genomic DNA No translation available.
AL359402 Genomic DNA No translation available.
BC053536 mRNA Translation: AAH53536.1
CCDSiCCDS61552.1 [Q9UQ07-5]
CCDS81854.1 [Q9UQ07-6]
CCDS9971.1 [Q9UQ07-1]
RefSeqiNP_001258940.1, NM_001272011.1 [Q9UQ07-5]
NP_001317163.1, NM_001330234.1 [Q9UQ07-6]
NP_055041.1, NM_014226.2 [Q9UQ07-1]
UniGeneiHs.104119
Hs.36859

3D structure databases

ProteinModelPortaliQ9UQ07
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111828, 12 interactors
IntActiQ9UQ07, 4 interactors
MINTiQ9UQ07
STRINGi9606.ENSP00000355304

PTM databases

iPTMnetiQ9UQ07
PhosphoSitePlusiQ9UQ07

Polymorphism and mutation databases

BioMutaiMOK

Proteomic databases

EPDiQ9UQ07
PaxDbiQ9UQ07
PeptideAtlasiQ9UQ07
PRIDEiQ9UQ07
ProteomicsDBi85485
85486 [Q9UQ07-2]
85487 [Q9UQ07-3]
85488 [Q9UQ07-4]
TopDownProteomicsiQ9UQ07-4 [Q9UQ07-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361847; ENSP00000355304; ENSG00000080823 [Q9UQ07-1]
ENST00000522874; ENSP00000429469; ENSG00000080823 [Q9UQ07-6]
ENST00000524214; ENSP00000428942; ENSG00000080823 [Q9UQ07-5]
GeneIDi5891
KEGGihsa:5891
UCSCiuc001ylm.5 human [Q9UQ07-1]

Organism-specific databases

CTDi5891
DisGeNETi5891
EuPathDBiHostDB:ENSG00000080823.21
GeneCardsiMOK
H-InvDBiHIX0011985
HGNCiHGNC:9833 MOK
HPAiHPA027292
MIMi605762 gene
neXtProtiNX_Q9UQ07
OpenTargetsiENSG00000080823
PharmGKBiPA34187
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0661 Eukaryota
ENOG410XPBB LUCA
GeneTreeiENSGT00650000093283
HOGENOMiHOG000233024
HOVERGENiHBG106271
InParanoidiQ9UQ07
KOiK08830
OMAiAMNFDFP
OrthoDBiEOG091G0DU3
PhylomeDBiQ9UQ07
TreeFamiTF328769

Enzyme and pathway databases

SignaLinkiQ9UQ07

Miscellaneous databases

ChiTaRSiMOK human
GeneWikiiRAGE_(gene)
GenomeRNAii5891
PROiPR:Q9UQ07
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000080823 Expressed in 163 organ(s), highest expression level in right uterine tube
CleanExiHS_RAGE
ExpressionAtlasiQ9UQ07 baseline and differential
GenevisibleiQ9UQ07 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOK_HUMAN
AccessioniPrimary (citable) accession number: Q9UQ07
Secondary accession number(s): B2R6Z4
, B7Z7P6, E7ER76, E7ERR8, Q92790, Q93067
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 1, 2000
Last modified: September 12, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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