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Protein

Coronin-2B

Gene

CORO2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the reorganization of neuronal actin structure.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9UQ03

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coronin-2B
Alternative name(s):
Coronin-like protein C
Short name:
Clipin-C
Protein FC96
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CORO2B
Synonyms:KIAA0925
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000103647.12

Human Gene Nomenclature Database

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HGNCi
HGNC:2256 CORO2B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605002 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UQ03

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10391

Open Targets

More...
OpenTargetsi
ENSG00000103647

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26772

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CORO2B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
254763439

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000509301 – 480Coronin-2BAdd BLAST480

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UQ03

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UQ03

PeptideAtlas

More...
PeptideAtlasi
Q9UQ03

PRoteomics IDEntifications database

More...
PRIDEi
Q9UQ03

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85482
85483 [Q9UQ03-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UQ03

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UQ03

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103647 Expressed in 161 organ(s), highest expression level in C1 segment of cervical spinal cord

CleanEx database of gene expression profiles

More...
CleanExi
HS_CORO2B

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UQ03 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017960

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to F-actin and to vinculin.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926245EBI-723376,EBI-743771

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115663, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UQ03, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000454783

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UQ03

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UQ03

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati29 – 77WD 1Add BLAST49
Repeati78 – 127WD 2Add BLAST50
Repeati128 – 170WD 3Add BLAST43
Repeati171 – 212WD 4Add BLAST42
Repeati213 – 259WD 5Add BLAST47
Repeati260 – 305WD 6Add BLAST46
Repeati306 – 345WD 7Add BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili436 – 479Sequence analysisAdd BLAST44

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0303 Eukaryota
ENOG410XQAD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158689

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000166356

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG059978

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UQ03

KEGG Orthology (KO)

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KOi
K13887

Identification of Orthologs from Complete Genome Data

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OMAi
IEWHPTS

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03H5

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UQ03

TreeFam database of animal gene trees

More...
TreeFami
TF314280

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027339 CORO2B
IPR015505 Coronin
IPR015048 DUF1899
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10856 PTHR10856, 1 hit
PTHR10856:SF17 PTHR10856:SF17, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08953 DUF1899, 1 hit
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01166 DUF1899, 1 hit
SM00320 WD40, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9UQ03-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTVTKMSWRP QYRSSKFRNV YGKVANREHC FDGIPITKNV HDNHFCAVNT
60 70 80 90 100
RFLAIVTESA GGGSFLVIPL EQTGRIEPNY PKVCGHQGNV LDIKWNPFID
110 120 130 140 150
NIIASCSEDT SVRIWEIPEG GLKRNMTEAL LELHGHSRRV GLVEWHPTTN
160 170 180 190 200
NILFSAGYDY KVLIWNLDVG EPVKMIDCHT DVILCMSFNT DGSLLTTTCK
210 220 230 240 250
DKKLRVIEPR SGRVLQEANC KNHRVNRVVF LGNMKRLLTT GVSRWNTRQI
260 270 280 290 300
ALWDQEDLSM PLIEEEIDGL SGLLFPFYDA DTHMLYLAGK GDGNIRYYEI
310 320 330 340 350
STEKPYLSYL MEFRSPAPQK GLGVMPKHGL DVSACEVFRF YKLVTLKGLI
360 370 380 390 400
EPISMIVPRR SDSYQEDIYP MTPGTEPALT PDEWLGGINR DPVLMSLKEG
410 420 430 440 450
YKKSSKMVFK APIKEKKSVV VNGIDLLENV PPRTENELLR MFFRQQDEIR
460 470 480
RLKEELAQKD IRIRQLQLEL KNLRNSPKNC
Length:480
Mass (Da):54,953
Last modified:July 28, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE91834164A23D79
GO
Isoform 2 (identifier: Q9UQ03-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MTVTKM → M

Show »
Length:475
Mass (Da):54,393
Checksum:i5C85A21F2202A197
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH26335 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA36341 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti128E → A in BAA36341 (PubMed:10224093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_058323238L → V1 PublicationCorresponds to variant dbSNP:rs17852400Ensembl.1
Natural variantiVAR_035878318P → L in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0377061 – 6MTVTKM → M in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB010098 mRNA Translation: BAA36341.1 Different initiation.
AK289678 mRNA Translation: BAF82367.1
AC090734 Genomic DNA No translation available.
AC105014 Genomic DNA No translation available.
BC026335 mRNA Translation: AAH26335.1 Different initiation.
AB023142 mRNA Translation: BAA76769.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10229.2 [Q9UQ03-1]
CCDS53952.1 [Q9UQ03-2]

NCBI Reference Sequences

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RefSeqi
NP_001177385.1, NM_001190456.1 [Q9UQ03-2]
NP_001177386.1, NM_001190457.1 [Q9UQ03-2]
NP_001310943.1, NM_001324014.1 [Q9UQ03-2]
NP_001310944.1, NM_001324015.1 [Q9UQ03-2]
NP_006082.3, NM_006091.4 [Q9UQ03-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.551213

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261861; ENSP00000261861; ENSG00000103647 [Q9UQ03-2]
ENST00000540068; ENSP00000446250; ENSG00000103647 [Q9UQ03-2]
ENST00000543950; ENSP00000443819; ENSG00000103647 [Q9UQ03-2]
ENST00000566799; ENSP00000454783; ENSG00000103647 [Q9UQ03-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10391

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10391

UCSC genome browser

More...
UCSCi
uc002arj.5 human [Q9UQ03-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010098 mRNA Translation: BAA36341.1 Different initiation.
AK289678 mRNA Translation: BAF82367.1
AC090734 Genomic DNA No translation available.
AC105014 Genomic DNA No translation available.
BC026335 mRNA Translation: AAH26335.1 Different initiation.
AB023142 mRNA Translation: BAA76769.1
CCDSiCCDS10229.2 [Q9UQ03-1]
CCDS53952.1 [Q9UQ03-2]
RefSeqiNP_001177385.1, NM_001190456.1 [Q9UQ03-2]
NP_001177386.1, NM_001190457.1 [Q9UQ03-2]
NP_001310943.1, NM_001324014.1 [Q9UQ03-2]
NP_001310944.1, NM_001324015.1 [Q9UQ03-2]
NP_006082.3, NM_006091.4 [Q9UQ03-1]
UniGeneiHs.551213

3D structure databases

ProteinModelPortaliQ9UQ03
SMRiQ9UQ03
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115663, 7 interactors
IntActiQ9UQ03, 4 interactors
STRINGi9606.ENSP00000454783

PTM databases

iPTMnetiQ9UQ03
PhosphoSitePlusiQ9UQ03

Polymorphism and mutation databases

BioMutaiCORO2B
DMDMi254763439

Proteomic databases

EPDiQ9UQ03
PaxDbiQ9UQ03
PeptideAtlasiQ9UQ03
PRIDEiQ9UQ03
ProteomicsDBi85482
85483 [Q9UQ03-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10391
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261861; ENSP00000261861; ENSG00000103647 [Q9UQ03-2]
ENST00000540068; ENSP00000446250; ENSG00000103647 [Q9UQ03-2]
ENST00000543950; ENSP00000443819; ENSG00000103647 [Q9UQ03-2]
ENST00000566799; ENSP00000454783; ENSG00000103647 [Q9UQ03-1]
GeneIDi10391
KEGGihsa:10391
UCSCiuc002arj.5 human [Q9UQ03-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10391
DisGeNETi10391
EuPathDBiHostDB:ENSG00000103647.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CORO2B
HGNCiHGNC:2256 CORO2B
HPAiHPA017960
MIMi605002 gene
neXtProtiNX_Q9UQ03
OpenTargetsiENSG00000103647
PharmGKBiPA26772

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0303 Eukaryota
ENOG410XQAD LUCA
GeneTreeiENSGT00940000158689
HOGENOMiHOG000166356
HOVERGENiHBG059978
InParanoidiQ9UQ03
KOiK13887
OMAiIEWHPTS
OrthoDBiEOG091G03H5
PhylomeDBiQ9UQ03
TreeFamiTF314280

Enzyme and pathway databases

SignaLinkiQ9UQ03

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CORO2B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10391

Protein Ontology

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PROi
PR:Q9UQ03

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000103647 Expressed in 161 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_CORO2B
GenevisibleiQ9UQ03 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR027339 CORO2B
IPR015505 Coronin
IPR015048 DUF1899
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10856 PTHR10856, 1 hit
PTHR10856:SF17 PTHR10856:SF17, 1 hit
PfamiView protein in Pfam
PF08953 DUF1899, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM01166 DUF1899, 1 hit
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOR2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UQ03
Secondary accession number(s): A8K0W3, O94767, Q8TAN1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 28, 2009
Last modified: December 5, 2018
This is version 154 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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