UniProtKB - Q9UQ03 (COR2B_HUMAN)
Protein
Coronin-2B
Gene
CORO2B
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in the reorganization of neuronal actin structure.
GO - Molecular functioni
- actin binding Source: UniProtKB
- actin filament binding Source: GO_Central
- talin binding Source: MGI
- vinculin binding Source: MGI
GO - Biological processi
- actin cytoskeleton organization Source: UniProtKB
- focal adhesion assembly Source: Ensembl
- negative regulation of cell-substrate adhesion Source: MGI
- negative regulation of establishment of protein localization Source: MGI
- negative regulation of stress fiber assembly Source: Ensembl
- positive regulation of establishment of protein localization Source: MGI
- regulation of actin cytoskeleton organization Source: MGI
- regulation of cellular response to stress Source: MGI
- regulation of glomerular filtration Source: Ensembl
Keywordsi
Molecular function | Actin-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9UQ03 |
SignaLinki | Q9UQ03 |
Names & Taxonomyi
Protein namesi | Recommended name: Coronin-2BAlternative name(s): Coronin-like protein C Short name: Clipin-C Protein FC96 |
Gene namesi | Name:CORO2B Synonyms:KIAA0925 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000103647.12 |
HGNCi | HGNC:2256, CORO2B |
MIMi | 605002, gene |
neXtProti | NX_Q9UQ03 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Curated
Cytoskeleton
- actin cytoskeleton Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB-KW
- focal adhesion Source: MGI
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 10391 |
OpenTargetsi | ENSG00000103647 |
PharmGKBi | PA26772 |
Miscellaneous databases
Pharosi | Q9UQ03, Tdark |
Polymorphism and mutation databases
BioMutai | CORO2B |
DMDMi | 254763439 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050930 | 1 – 480 | Coronin-2BAdd BLAST | 480 |
Proteomic databases
EPDi | Q9UQ03 |
jPOSTi | Q9UQ03 |
MassIVEi | Q9UQ03 |
PaxDbi | Q9UQ03 |
PeptideAtlasi | Q9UQ03 |
PRIDEi | Q9UQ03 |
ProteomicsDBi | 85482 [Q9UQ03-1] 85483 [Q9UQ03-2] |
PTM databases
iPTMneti | Q9UQ03 |
PhosphoSitePlusi | Q9UQ03 |
Expressioni
Tissue specificityi
Expressed predominantly in brain.
Gene expression databases
Bgeei | ENSG00000103647, Expressed in C1 segment of cervical spinal cord and 176 other tissues |
Genevisiblei | Q9UQ03, HS |
Organism-specific databases
HPAi | ENSG00000103647, Tissue enhanced (brain, fallopian tube) |
Interactioni
Subunit structurei
Binds to F-actin and to vinculin.
Binary interactionsi
Q9UQ03
With | #Exp. | IntAct |
---|---|---|
APPBP2 [Q92624] | 6 | EBI-723376,EBI-743771 |
GO - Molecular functioni
- actin binding Source: UniProtKB
- actin filament binding Source: GO_Central
- talin binding Source: MGI
- vinculin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 115663, 7 interactors |
IntActi | Q9UQ03, 8 interactors |
STRINGi | 9606.ENSP00000454783 |
Miscellaneous databases
RNActi | Q9UQ03, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 29 – 77 | WD 1Add BLAST | 49 | |
Repeati | 78 – 127 | WD 2Add BLAST | 50 | |
Repeati | 128 – 170 | WD 3Add BLAST | 43 | |
Repeati | 171 – 212 | WD 4Add BLAST | 42 | |
Repeati | 213 – 259 | WD 5Add BLAST | 47 | |
Repeati | 260 – 305 | WD 6Add BLAST | 46 | |
Repeati | 306 – 345 | WD 7Add BLAST | 40 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 436 – 479 | Sequence analysisAdd BLAST | 44 |
Sequence similaritiesi
Belongs to the WD repeat coronin family.Curated
Keywords - Domaini
Coiled coil, Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0303, Eukaryota |
GeneTreei | ENSGT00940000158689 |
HOGENOMi | CLU_026859_4_0_1 |
InParanoidi | Q9UQ03 |
OMAi | CENIIAS |
OrthoDBi | 552726at2759 |
PhylomeDBi | Q9UQ03 |
TreeFami | TF314280 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR027339, CORO2B IPR015505, Coronin IPR015048, DUF1899 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10856, PTHR10856, 1 hit PTHR10856:SF17, PTHR10856:SF17, 1 hit |
Pfami | View protein in Pfam PF08953, DUF1899, 1 hit PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM01166, DUF1899, 1 hit SM00320, WD40, 4 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9UQ03-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTVTKMSWRP QYRSSKFRNV YGKVANREHC FDGIPITKNV HDNHFCAVNT
60 70 80 90 100
RFLAIVTESA GGGSFLVIPL EQTGRIEPNY PKVCGHQGNV LDIKWNPFID
110 120 130 140 150
NIIASCSEDT SVRIWEIPEG GLKRNMTEAL LELHGHSRRV GLVEWHPTTN
160 170 180 190 200
NILFSAGYDY KVLIWNLDVG EPVKMIDCHT DVILCMSFNT DGSLLTTTCK
210 220 230 240 250
DKKLRVIEPR SGRVLQEANC KNHRVNRVVF LGNMKRLLTT GVSRWNTRQI
260 270 280 290 300
ALWDQEDLSM PLIEEEIDGL SGLLFPFYDA DTHMLYLAGK GDGNIRYYEI
310 320 330 340 350
STEKPYLSYL MEFRSPAPQK GLGVMPKHGL DVSACEVFRF YKLVTLKGLI
360 370 380 390 400
EPISMIVPRR SDSYQEDIYP MTPGTEPALT PDEWLGGINR DPVLMSLKEG
410 420 430 440 450
YKKSSKMVFK APIKEKKSVV VNGIDLLENV PPRTENELLR MFFRQQDEIR
460 470 480
RLKEELAQKD IRIRQLQLEL KNLRNSPKNC
Sequence cautioni
The sequence AAH26335 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA36341 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 128 | E → A in BAA36341 (PubMed:10224093).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058323 | 238 | L → V1 PublicationCorresponds to variant dbSNP:rs17852400Ensembl. | 1 | |
Natural variantiVAR_035878 | 318 | P → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1314209013Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037706 | 1 – 6 | MTVTKM → M in isoform 2. 1 Publication | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB010098 mRNA Translation: BAA36341.1 Different initiation. AK289678 mRNA Translation: BAF82367.1 AC090734 Genomic DNA No translation available. AC105014 Genomic DNA No translation available. BC026335 mRNA Translation: AAH26335.1 Different initiation. AB023142 mRNA Translation: BAA76769.1 |
CCDSi | CCDS10229.2 [Q9UQ03-1] CCDS53952.1 [Q9UQ03-2] |
RefSeqi | NP_001177385.1, NM_001190456.1 [Q9UQ03-2] NP_001177386.1, NM_001190457.1 [Q9UQ03-2] NP_001310943.1, NM_001324014.1 [Q9UQ03-2] NP_001310944.1, NM_001324015.1 [Q9UQ03-2] NP_006082.3, NM_006091.4 [Q9UQ03-1] |
Genome annotation databases
Ensembli | ENST00000261861; ENSP00000261861; ENSG00000103647 [Q9UQ03-1] ENST00000540068; ENSP00000446250; ENSG00000103647 [Q9UQ03-2] ENST00000543950; ENSP00000443819; ENSG00000103647 [Q9UQ03-2] |
GeneIDi | 10391 |
KEGGi | hsa:10391 |
UCSCi | uc002arj.5, human [Q9UQ03-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB010098 mRNA Translation: BAA36341.1 Different initiation. AK289678 mRNA Translation: BAF82367.1 AC090734 Genomic DNA No translation available. AC105014 Genomic DNA No translation available. BC026335 mRNA Translation: AAH26335.1 Different initiation. AB023142 mRNA Translation: BAA76769.1 |
CCDSi | CCDS10229.2 [Q9UQ03-1] CCDS53952.1 [Q9UQ03-2] |
RefSeqi | NP_001177385.1, NM_001190456.1 [Q9UQ03-2] NP_001177386.1, NM_001190457.1 [Q9UQ03-2] NP_001310943.1, NM_001324014.1 [Q9UQ03-2] NP_001310944.1, NM_001324015.1 [Q9UQ03-2] NP_006082.3, NM_006091.4 [Q9UQ03-1] |
3D structure databases
SMRi | Q9UQ03 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115663, 7 interactors |
IntActi | Q9UQ03, 8 interactors |
STRINGi | 9606.ENSP00000454783 |
PTM databases
iPTMneti | Q9UQ03 |
PhosphoSitePlusi | Q9UQ03 |
Polymorphism and mutation databases
BioMutai | CORO2B |
DMDMi | 254763439 |
Proteomic databases
EPDi | Q9UQ03 |
jPOSTi | Q9UQ03 |
MassIVEi | Q9UQ03 |
PaxDbi | Q9UQ03 |
PeptideAtlasi | Q9UQ03 |
PRIDEi | Q9UQ03 |
ProteomicsDBi | 85482 [Q9UQ03-1] 85483 [Q9UQ03-2] |
Protocols and materials databases
Antibodypediai | 2828, 164 antibodies |
DNASUi | 10391 |
Genome annotation databases
Ensembli | ENST00000261861; ENSP00000261861; ENSG00000103647 [Q9UQ03-1] ENST00000540068; ENSP00000446250; ENSG00000103647 [Q9UQ03-2] ENST00000543950; ENSP00000443819; ENSG00000103647 [Q9UQ03-2] |
GeneIDi | 10391 |
KEGGi | hsa:10391 |
UCSCi | uc002arj.5, human [Q9UQ03-1] |
Organism-specific databases
CTDi | 10391 |
DisGeNETi | 10391 |
EuPathDBi | HostDB:ENSG00000103647.12 |
GeneCardsi | CORO2B |
HGNCi | HGNC:2256, CORO2B |
HPAi | ENSG00000103647, Tissue enhanced (brain, fallopian tube) |
MIMi | 605002, gene |
neXtProti | NX_Q9UQ03 |
OpenTargetsi | ENSG00000103647 |
PharmGKBi | PA26772 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0303, Eukaryota |
GeneTreei | ENSGT00940000158689 |
HOGENOMi | CLU_026859_4_0_1 |
InParanoidi | Q9UQ03 |
OMAi | CENIIAS |
OrthoDBi | 552726at2759 |
PhylomeDBi | Q9UQ03 |
TreeFami | TF314280 |
Enzyme and pathway databases
PathwayCommonsi | Q9UQ03 |
SignaLinki | Q9UQ03 |
Miscellaneous databases
BioGRID-ORCSi | 10391, 3 hits in 842 CRISPR screens |
ChiTaRSi | CORO2B, human |
GenomeRNAii | 10391 |
Pharosi | Q9UQ03, Tdark |
PROi | PR:Q9UQ03 |
RNActi | Q9UQ03, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103647, Expressed in C1 segment of cervical spinal cord and 176 other tissues |
Genevisiblei | Q9UQ03, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR027339, CORO2B IPR015505, Coronin IPR015048, DUF1899 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10856, PTHR10856, 1 hit PTHR10856:SF17, PTHR10856:SF17, 1 hit |
Pfami | View protein in Pfam PF08953, DUF1899, 1 hit PF00400, WD40, 2 hits |
SMARTi | View protein in SMART SM01166, DUF1899, 1 hit SM00320, WD40, 4 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COR2B_HUMAN | |
Accessioni | Q9UQ03Primary (citable) accession number: Q9UQ03 Secondary accession number(s): A8K0W3, O94767, Q8TAN1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | July 28, 2009 | |
Last modified: | December 2, 2020 | |
This is version 167 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations