UniProtKB - Q9UPZ9 (CILK1_HUMAN)
Serine/threonine-protein kinase ICK
CILK1
Functioni
Required for ciliogenesis (PubMed:24797473).
Phosphorylates KIF3A (By similarity).
Involved in the control of ciliary length (PubMed:24853502).
Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity).
May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity).
Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity).
By similarity2 PublicationsCatalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 33 | ATPPROSITE-ProRule annotation1 Publication | 1 | |
Active sitei | 125 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 18 | ATPPROSITE-ProRule annotationBy similarity | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- magnesium ion binding Source: UniProtKB
- protein kinase activity Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
GO - Biological processi
- cilium assembly Source: UniProtKB
- intracellular signal transduction Source: UniProtKB
- intraciliary anterograde transport Source: UniProtKB
- intraciliary retrograde transport Source: UniProtKB
- intraciliary transport Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- signal transduction Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cilium biogenesis/degradation |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9UPZ9 |
SignaLinki | Q9UPZ9 |
SIGNORi | Q9UPZ9 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase ICK (EC:2.7.11.11 Publication)Alternative name(s): Ciliogenesis associated kinase 1Curated Intestinal cell kinase Short name: hICK Laryngeal cancer kinase 2 Short name: LCK2 MAK-related kinase Short name: MRK |
Gene namesi | Name:CILK1 Synonyms:ICK, KIAA0936 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21219, CILK1 |
MIMi | 612325, gene |
neXtProti | NX_Q9UPZ9 |
VEuPathDBi | HostDB:ENSG00000112144 |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol By similarity
Cytoskeleton
- cilium basal body By similarity
Nucleus
- Nucleus 2 Publications
Other locations
- cilium 1 Publication
Note: Also found at the ciliary tip (PubMed:24797473). Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360, PubMed:19185282).3 Publications
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Predominant cytoplasmic localization has been observed with a N-terminally GFP-tagged construct.1 Publication
Cytoskeleton
- ciliary basal body Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB-SubCell
Nucleus
- fibrillar center Source: HPA
- nucleus Source: UniProtKB
Other locations
- ciliary base Source: UniProtKB
- ciliary tip Source: UniProtKB
- cilium Source: UniProtKB
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cell projection, Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Involvement in diseasei
Endocrine-cerebroosteodysplasia (ECO)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057994 | 272 | R → Q in ECO; significantly impairs kinase activity; decreased localization at the ciliary tips; impaired ciliogenesis; results in abnormally elongated cilia; impairs mitosis, cell-cycle exit and radial neuroblast migration, while promoting apoptosis, when tested in a heterologous system; loss of nuclear localization. 4 PublicationsCorresponds to variant dbSNP:rs118203918EnsemblClinVar. | 1 |
Juvenile myoclonic epilepsy 10 (EJM10)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080554 | 102 | I → L in EJM10; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs748539319EnsemblClinVar. | 1 | |
Natural variantiVAR_080555 | 220 | K → E in EJM10; impairs mitosis, cell-cycle exit and radial neuroblast migration, while promoting apoptosis, when tested in a heterologous system. 1 Publication | 1 | |
Natural variantiVAR_080556 | 305 | K → T in EJM10; impairs mitosis, cell-cycle exit and radial neuroblast migration, while promoting apoptosis, when tested in a heterologous system. 1 PublicationCorresponds to variant dbSNP:rs765078446EnsemblClinVar. | 1 | |
Natural variantiVAR_080557 | 369 – 373 | Missing in EJM10; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201964851Ensembl. | 5 | |
Natural variantiVAR_042005 | 615 | A → T in EJM10; unknown pathological significance; impairs mitosis, cell-cycle exit and radial neuroblast migration, while promoting apoptosis, when tested in a heterologous system. 2 PublicationsCorresponds to variant dbSNP:rs55932059EnsemblClinVar. | 1 | |
Natural variantiVAR_080558 | 632 | Missing in EJM10; impairs mitosis, cell-cycle exit and radial neuroblast migration, while promoting apoptosis, when tested in a heterologous system. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 33 | K → R: Loss of activity and autophosphorylation; when associated with R-34; R-36 and R-38. 1 Publication | 1 | |
Mutagenesisi | 34 | K → R: Loss of activity and autophosphorylation; when associated with R-33; R-36 and R-38. 1 Publication | 1 | |
Mutagenesisi | 36 | K → R: Loss of activity and autophosphorylation; when associated with R-33; R-34 and R-38. 1 Publication | 1 | |
Mutagenesisi | 38 | K → R: Loss of activity and autophosphorylation; when associated with R-33; R-34 and R-36. 1 Publication | 1 | |
Mutagenesisi | 157 | T → A: Reduction of activity and loss of autophosphorylation. Loss of activity and autophosphorylation; when associated with F-159. 1 Publication | 1 | |
Mutagenesisi | 159 | Y → F: Reduction of activity and loss of autophosphorylation. Loss of activity and autophosphorylation; when associated with A-157. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, EpilepsyOrganism-specific databases
DisGeNETi | 22858 |
MalaCardsi | CILK1 |
MIMi | 612651, phenotype 617924, phenotype |
OpenTargetsi | ENSG00000112144 |
Orphaneti | 199332, Endocrine-cerebro-osteodysplasia syndrome 307, Juvenile myoclonic epilepsy |
PharmGKBi | PA134894544 |
Miscellaneous databases
Pharosi | Q9UPZ9, Tchem |
Chemistry databases
ChEMBLi | CHEMBL1163126 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9UPZ9 |
Genetic variation databases
BioMutai | ICK |
DMDMi | 48428273 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086007 | 1 – 632 | Serine/threonine-protein kinase ICKAdd BLAST | 632 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 157 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 159 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 161 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UPZ9 |
jPOSTi | Q9UPZ9 |
MassIVEi | Q9UPZ9 |
PaxDbi | Q9UPZ9 |
PeptideAtlasi | Q9UPZ9 |
PRIDEi | Q9UPZ9 |
ProteomicsDBi | 85480 [Q9UPZ9-1] 85481 [Q9UPZ9-2] |
PTM databases
iPTMneti | Q9UPZ9 |
PhosphoSitePlusi | Q9UPZ9 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000112144, Expressed in nasal cavity mucosa and 233 other tissues |
ExpressionAtlasi | Q9UPZ9, baseline and differential |
Genevisiblei | Q9UPZ9, HS |
Organism-specific databases
HPAi | ENSG00000112144, Low tissue specificity |
Interactioni
Binary interactionsi
Q9UPZ9
With | #Exp. | IntAct |
---|---|---|
HSP90AB1 [P08238] | 2 | EBI-6381479,EBI-352572 |
Protein-protein interaction databases
BioGRIDi | 116527, 51 interactors |
IntActi | Q9UPZ9, 26 interactors |
MINTi | Q9UPZ9 |
STRINGi | 9606.ENSP00000349458 |
Chemistry databases
BindingDBi | Q9UPZ9 |
Miscellaneous databases
RNActi | Q9UPZ9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 284 | Protein kinasePROSITE-ProRule annotationCuratedAdd BLAST | 281 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 290 – 344 | DisorderedSequence analysisAdd BLAST | 55 | |
Regioni | 457 – 481 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 582 – 632 | DisorderedSequence analysisAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 314 – 328 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 330 – 344 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 462 – 480 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0661, Eukaryota |
GeneTreei | ENSGT00940000158807 |
HOGENOMi | CLU_000288_181_25_1 |
InParanoidi | Q9UPZ9 |
OrthoDBi | 76933at2759 |
PhylomeDBi | Q9UPZ9 |
TreeFami | TF328769 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNRYTTIRQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE
60 70 80 90 100
VKSLKKLNHA NVVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES
110 120 130 140 150
AIRNIMYQIL QGLAFIHKHG FFHRDLKPEN LLCMGPELVK IADFGLAREI
160 170 180 190 200
RSKPPYTDYV STRWYRAPEV LLRSTNYSSP IDVWAVGCIM AEVYTLRPLF
210 220 230 240 250
PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFRWPQ CVPNNLKTLI
260 270 280 290 300
PNASSEAVQL LRDMLQWDPK KRPTASQALR YPYFQVGHPL GSTTQNLQDS
310 320 330 340 350
EKPQKGILEK AGPPPYIKPV PPAQPPAKPH TRISSRQHQA SQPPLHLTYP
360 370 380 390 400
YKAEVSRTDH PSHLQEDKPS PLLFPSLHNK HPQSKITAGL EHKNGEIKPK
410 420 430 440 450
SRRRWGLISR STKDSDDWAD LDDLDFSPSL SRIDLKNKKR QSDDTLCRFE
460 470 480 490 500
SVLDLKPSEP VGTGNSAPTQ TSYQRRDTPT LRSAAKQHYL KHSRYLPGIS
510 520 530 540 550
IRNGILSNPG KEFIPPNPWS SSGLSGKSSG TMSVISKVNS VGSSSTSSSG
560 570 580 590 600
LTGNYVPSFL KKEIGSAMQR VHLAPIPDPS PGYSSLKAMR PHPGRPFFHT
610 620 630
QPRSTPGLIP RPPAAQPVHG RTDWASKYAS RR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A7I2PIU1 | A0A7I2PIU1_HUMAN | Serine/threonine-protein kinase ICK | CILK1 | 639 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 48 | L → Q in AAF37278 (PubMed:10699974).Curated | 1 | |
Sequence conflicti | 119 | H → L in AAF37278 (PubMed:10699974).Curated | 1 | |
Sequence conflicti | 310 | K → R in AAF37278 (PubMed:10699974).Curated | 1 | |
Sequence conflicti | 598 – 599 | FH → LD in AAF37278 (PubMed:10699974).Curated | 2 | |
Sequence conflicti | 629 | A → P in AAF37278 (PubMed:10699974).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053931 | 98 | P → L. Corresponds to variant dbSNP:rs1493105Ensembl. | 1 | |
Natural variantiVAR_080554 | 102 | I → L in EJM10; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs748539319EnsemblClinVar. | 1 | |
Natural variantiVAR_042001 | 115 | F → Y in a renal clear cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_080555 | 220 | K → E in EJM10; impairs mitosis, cell-cycle exit and radial neuroblast migration, while promoting apoptosis, when tested in a heterologous system. 1 Publication | 1 | |
Natural variantiVAR_057994 | 272 | R → Q in ECO; significantly impairs kinase activity; decreased localization at the ciliary tips; impaired ciliogenesis; results in abnormally elongated cilia; impairs mitosis, cell-cycle exit and radial neuroblast migration, while promoting apoptosis, when tested in a heterologous system; loss of nuclear localization. 4 PublicationsCorresponds to variant dbSNP:rs118203918EnsemblClinVar. | 1 | |
Natural variantiVAR_080556 | 305 | K → T in EJM10; impairs mitosis, cell-cycle exit and radial neuroblast migration, while promoting apoptosis, when tested in a heterologous system. 1 PublicationCorresponds to variant dbSNP:rs765078446EnsemblClinVar. | 1 | |
Natural variantiVAR_042002 | 320 | V → I2 PublicationsCorresponds to variant dbSNP:rs33936662Ensembl. | 1 | |
Natural variantiVAR_080557 | 369 – 373 | Missing in EJM10; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201964851Ensembl. | 5 | |
Natural variantiVAR_042003 | 471 | T → K1 PublicationCorresponds to variant dbSNP:rs56164633Ensembl. | 1 | |
Natural variantiVAR_042004 | 476 | R → Q1 PublicationCorresponds to variant dbSNP:rs55895113Ensembl. | 1 | |
Natural variantiVAR_042005 | 615 | A → T in EJM10; unknown pathological significance; impairs mitosis, cell-cycle exit and radial neuroblast migration, while promoting apoptosis, when tested in a heterologous system. 2 PublicationsCorresponds to variant dbSNP:rs55932059EnsemblClinVar. | 1 | |
Natural variantiVAR_080558 | 632 | Missing in EJM10; impairs mitosis, cell-cycle exit and radial neuroblast migration, while promoting apoptosis, when tested in a heterologous system. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_050752 | 278 – 292 | ALRYP…HPLGS → VFFHFLVITFISNSE in isoform 2. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_050753 | 293 – 632 | Missing in isoform 2. 1 PublicationAdd BLAST | 340 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF225919 mRNA Translation: AAF37278.1 AF152469 mRNA Translation: AAG43364.1 AB023153 mRNA Translation: BAA76780.2 Different initiation. AL031178 Genomic DNA No translation available. AL162581 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04400.1 BC035807 mRNA Translation: AAH35807.1 BC136420 mRNA Translation: AAI36421.1 BC136421 mRNA Translation: AAI36422.1 BC152464 mRNA Translation: AAI52465.1 |
CCDSi | CCDS4949.1 [Q9UPZ9-1] |
RefSeqi | NP_055735.1, NM_014920.3 [Q9UPZ9-1] NP_057597.2, NM_016513.4 [Q9UPZ9-1] XP_016865977.1, XM_017010488.1 XP_016865978.1, XM_017010489.1 XP_016865979.1, XM_017010490.1 XP_016865980.1, XM_017010491.1 XP_016865981.1, XM_017010492.1 |
Genome annotation databases
Ensembli | ENST00000356971; ENSP00000349458; ENSG00000112144 ENST00000676107; ENSP00000501692; ENSG00000112144 |
GeneIDi | 22858 |
KEGGi | hsa:22858 |
MANE-Selecti | ENST00000676107.1; ENSP00000501692.1; NM_014920.5; NP_055735.1 |
UCSCi | uc003pbh.3, human [Q9UPZ9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF225919 mRNA Translation: AAF37278.1 AF152469 mRNA Translation: AAG43364.1 AB023153 mRNA Translation: BAA76780.2 Different initiation. AL031178 Genomic DNA No translation available. AL162581 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04400.1 BC035807 mRNA Translation: AAH35807.1 BC136420 mRNA Translation: AAI36421.1 BC136421 mRNA Translation: AAI36422.1 BC152464 mRNA Translation: AAI52465.1 |
CCDSi | CCDS4949.1 [Q9UPZ9-1] |
RefSeqi | NP_055735.1, NM_014920.3 [Q9UPZ9-1] NP_057597.2, NM_016513.4 [Q9UPZ9-1] XP_016865977.1, XM_017010488.1 XP_016865978.1, XM_017010489.1 XP_016865979.1, XM_017010490.1 XP_016865980.1, XM_017010491.1 XP_016865981.1, XM_017010492.1 |
3D structure databases
SMRi | Q9UPZ9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116527, 51 interactors |
IntActi | Q9UPZ9, 26 interactors |
MINTi | Q9UPZ9 |
STRINGi | 9606.ENSP00000349458 |
Chemistry databases
BindingDBi | Q9UPZ9 |
ChEMBLi | CHEMBL1163126 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9UPZ9 |
PTM databases
iPTMneti | Q9UPZ9 |
PhosphoSitePlusi | Q9UPZ9 |
Genetic variation databases
BioMutai | ICK |
DMDMi | 48428273 |
Proteomic databases
EPDi | Q9UPZ9 |
jPOSTi | Q9UPZ9 |
MassIVEi | Q9UPZ9 |
PaxDbi | Q9UPZ9 |
PeptideAtlasi | Q9UPZ9 |
PRIDEi | Q9UPZ9 |
ProteomicsDBi | 85480 [Q9UPZ9-1] 85481 [Q9UPZ9-2] |
Protocols and materials databases
Antibodypediai | 605, 298 antibodies from 24 providers |
DNASUi | 22858 |
Genome annotation databases
Ensembli | ENST00000356971; ENSP00000349458; ENSG00000112144 ENST00000676107; ENSP00000501692; ENSG00000112144 |
GeneIDi | 22858 |
KEGGi | hsa:22858 |
MANE-Selecti | ENST00000676107.1; ENSP00000501692.1; NM_014920.5; NP_055735.1 |
UCSCi | uc003pbh.3, human [Q9UPZ9-1] |
Organism-specific databases
CTDi | 22858 |
DisGeNETi | 22858 |
GeneCardsi | CILK1 |
HGNCi | HGNC:21219, CILK1 |
HPAi | ENSG00000112144, Low tissue specificity |
MalaCardsi | CILK1 |
MIMi | 612325, gene 612651, phenotype 617924, phenotype |
neXtProti | NX_Q9UPZ9 |
OpenTargetsi | ENSG00000112144 |
Orphaneti | 199332, Endocrine-cerebro-osteodysplasia syndrome 307, Juvenile myoclonic epilepsy |
PharmGKBi | PA134894544 |
VEuPathDBi | HostDB:ENSG00000112144 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0661, Eukaryota |
GeneTreei | ENSGT00940000158807 |
HOGENOMi | CLU_000288_181_25_1 |
InParanoidi | Q9UPZ9 |
OrthoDBi | 76933at2759 |
PhylomeDBi | Q9UPZ9 |
TreeFami | TF328769 |
Enzyme and pathway databases
PathwayCommonsi | Q9UPZ9 |
SignaLinki | Q9UPZ9 |
SIGNORi | Q9UPZ9 |
Miscellaneous databases
BioGRID-ORCSi | 22858, 6 hits in 1074 CRISPR screens |
ChiTaRSi | ICK, human |
GeneWikii | ICK_(gene) |
GenomeRNAii | 22858 |
Pharosi | Q9UPZ9, Tchem |
PROi | PR:Q9UPZ9 |
RNActi | Q9UPZ9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112144, Expressed in nasal cavity mucosa and 233 other tissues |
ExpressionAtlasi | Q9UPZ9, baseline and differential |
Genevisiblei | Q9UPZ9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CILK1_HUMAN | |
Accessioni | Q9UPZ9Primary (citable) accession number: Q9UPZ9 Secondary accession number(s): A7MD41 Q9NYX3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2004 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families