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Protein

Thrombospondin type-1 domain-containing protein 7A

Gene

THSD7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thrombospondin type-1 domain-containing protein 7A: Plays a role in actin cytoskeleton rearrangement.1 Publication
Thrombospondin type-1 domain-containing protein 7A, soluble form: The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thrombospondin type-1 domain-containing protein 7A
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THSD7A
Synonyms:KIAA0960
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000005108.15

Human Gene Nomenclature Database

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HGNCi
HGNC:22207 THSD7A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612249 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UPZ6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini48 – 1607ExtracellularSequence analysisAdd BLAST1560
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1608 – 1628HelicalSequence analysisAdd BLAST21
Topological domaini1629 – 1657CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Autoantibodies against THSD7A have been detected in serum and glomeruli from patients with idiopathic membranous nephropathy (PubMed:25394321). The majority of the autoantibodies react with the two most N-terminal TSP type-1 domains (PubMed:29555830).2 Publications

Organism-specific databases

DisGeNET

More...
DisGeNETi
221981

Open Targets

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OpenTargetsi
ENSG00000005108

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162405715

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
THSD7A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453024

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 47Sequence analysisAdd BLAST47
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025612648 – 1657Thrombospondin type-1 domain-containing protein 7AAdd BLAST1610
ChainiPRO_000044443048 – ?Thrombospondin type-1 domain-containing protein 7A, soluble form

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi435 ↔ 505PROSITE-ProRule annotation
Glycosylationi450N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi455 ↔ 509PROSITE-ProRule annotation
Disulfide bondi466 ↔ 494PROSITE-ProRule annotation
Glycosylationi500N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi635 ↔ 677PROSITE-ProRule annotation
Disulfide bondi646 ↔ 650PROSITE-ProRule annotation
Glycosylationi679N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi689 ↔ 694PROSITE-ProRule annotation
Disulfide bondi707 ↔ 764PROSITE-ProRule annotation
Glycosylationi717N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi728 ↔ 768PROSITE-ProRule annotation
Disulfide bondi739 ↔ 752PROSITE-ProRule annotation
Disulfide bondi772 ↔ 814PROSITE-ProRule annotation
Disulfide bondi783 ↔ 787PROSITE-ProRule annotation
Disulfide bondi824 ↔ 830PROSITE-ProRule annotation
Glycosylationi968N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi972 ↔ 1028PROSITE-ProRule annotation
Disulfide bondi994 ↔ 1032PROSITE-ProRule annotation
Disulfide bondi1005 ↔ 1018PROSITE-ProRule annotation
Disulfide bondi1036 ↔ 1073PROSITE-ProRule annotation
Glycosylationi1043N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1047 ↔ 1051PROSITE-ProRule annotation
Disulfide bondi1090 ↔ 1094PROSITE-ProRule annotation
Glycosylationi1182N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1213 ↔ 1219PROSITE-ProRule annotation
Glycosylationi1225N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1232 ↔ 1279PROSITE-ProRule annotation
Disulfide bondi1240 ↔ 1283PROSITE-ProRule annotation
Disulfide bondi1251 ↔ 1264PROSITE-ProRule annotation
Glycosylationi1276N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1287 ↔ 1325PROSITE-ProRule annotation
Disulfide bondi1298 ↔ 1302PROSITE-ProRule annotation
Disulfide bondi1335 ↔ 1340PROSITE-ProRule annotation
Disulfide bondi1351 ↔ 1407PROSITE-ProRule annotation
Disulfide bondi1358 ↔ 1411PROSITE-ProRule annotation
Glycosylationi1366N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1369 ↔ 1388PROSITE-ProRule annotation
Disulfide bondi1415 ↔ 1459PROSITE-ProRule annotation
Disulfide bondi1426 ↔ 1430PROSITE-ProRule annotation
Disulfide bondi1469 ↔ 1474PROSITE-ProRule annotation
Glycosylationi1500N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1547N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form.1 Publication
Extensively N-glycosylated.3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9UPZ6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UPZ6

PeptideAtlas

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PeptideAtlasi
Q9UPZ6

PRoteomics IDEntifications database

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PRIDEi
Q9UPZ6

ProteomicsDB human proteome resource

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ProteomicsDBi
85479

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
Q9UPZ6

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UPZ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9UPZ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected on kidney podocytes along the glomerular capillary wall (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000005108 Expressed in 198 organ(s), highest expression level in chorionic villus

CleanEx database of gene expression profiles

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CleanExi
HS_THSD7A

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UPZ6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UPZ6 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA000923

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
128774, 3 interactors

Protein interaction database and analysis system

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IntActi
Q9UPZ6, 11 interactors

Molecular INTeraction database

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MINTi
Q9UPZ6

STRING: functional protein association networks

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STRINGi
9606.ENSP00000406482

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UPZ6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UPZ6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 116TSP type-1 1PROSITE-ProRule annotationAdd BLAST60
Domaini120 – 192TSP type-1 2Sequence analysisAdd BLAST73
Domaini194 – 247TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini360 – 416TSP type-1 4PROSITE-ProRule annotationAdd BLAST57
Domaini423 – 510TSP type-1 5PROSITE-ProRule annotationAdd BLAST88
Domaini512 – 574TSP type-1 6PROSITE-ProRule annotationAdd BLAST63
Domaini634 – 695TSP type-1 7PROSITE-ProRule annotationAdd BLAST62
Domaini696 – 769TSP type-1 8PROSITE-ProRule annotationAdd BLAST74
Domaini771 – 831TSP type-1 9PROSITE-ProRule annotationAdd BLAST61
Domaini832 – 904TSP type-1 10Sequence analysisAdd BLAST73
Domaini906 – 959TSP type-1 11PROSITE-ProRule annotationAdd BLAST54
Domaini960 – 1033TSP type-1 12PROSITE-ProRule annotationAdd BLAST74
Domaini1035 – 1095TSP type-1 13PROSITE-ProRule annotationAdd BLAST61
Domaini1096 – 1163TSP type-1 14Sequence analysisAdd BLAST68
Domaini1166 – 1220TSP type-1 15Sequence analysisAdd BLAST55
Domaini1221 – 1284TSP type-1 16PROSITE-ProRule annotationAdd BLAST64
Domaini1286 – 1341TSP type-1 17PROSITE-ProRule annotationAdd BLAST56
Domaini1342 – 1412TSP type-1 18PROSITE-ProRule annotationAdd BLAST71
Domaini1414 – 1475TSP type-1 19PROSITE-ProRule annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili267 – 315Sequence analysisAdd BLAST49

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Sequence analysis combined with the expression of constructs corresponding each to two or three adjacent TSP type-1 domains suggests the presence of 21 TSP type-1 domains; not all of these are detected by standard bioinformatic tools.1 Publication

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INDB Eukaryota
ENOG410XR0P LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155427

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000154569

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG094038

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UPZ6

Identification of Orthologs from Complete Genome Data

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OMAi
CVLSMWS

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UPZ6

TreeFam database of animal gene trees

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TreeFami
TF329791

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.20.100.10, 11 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00090 TSP_1, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00209 TSP1, 16 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF82895 SSF82895, 13 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50092 TSP1, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UPZ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLQARRWAS GSRGAAGPRR GVLQLLPLPL PLPLLLLLLL RPGAGRAAAQ
60 70 80 90 100
GEAEAPTLYL WKTGPWGRCM GDECGPGGIQ TRAVWCAHVE GWTTLHTNCK
110 120 130 140 150
QAERPNNQQN CFKVCDWHKE LYDWRLGPWN QCQPVISKSL EKPLECIKGE
160 170 180 190 200
EGIQVREIAC IQKDKDIPAE DIICEYFEPK PLLEQACLIP CQQDCIVSEF
210 220 230 240 250
SAWSECSKTC GSGLQHRTRH VVAPPQFGGS GCPNLTEFQV CQSSPCEAEE
260 270 280 290 300
LRYSLHVGPW STCSMPHSRQ VRQARRRGKN KEREKDRSKG VKDPEARELI
310 320 330 340 350
KKKRNRNRQN RQENKYWDIQ IGYQTREVMC INKTGKAADL SFCQQEKLPM
360 370 380 390 400
TFQSCVITKE CQVSEWSEWS PCSKTCHDMV SPAGTRVRTR TIRQFPIGSE
410 420 430 440 450
KECPEFEEKE PCLSQGDGVV PCATYGWRTT EWTECRVDPL LSQQDKRRGN
460 470 480 490 500
QTALCGGGIQ TREVYCVQAN ENLLSQLSTH KNKEASKPMD LKLCTGPIPN
510 520 530 540 550
TTQLCHIPCP TECEVSPWSA WGPCTYENCN DQQGKKGFKL RKRRITNEPT
560 570 580 590 600
GGSGVTGNCP HLLEAIPCEE PACYDWKAVR LGNCEPDNGK ECGPGTQVQE
610 620 630 640 650
VVCINSDGEE VDRQLCRDAI FPIPVACDAP CPKDCVLSTW STWSSCSHTC
660 670 680 690 700
SGKTTEGKQI RARSILAYAG EEGGIRCPNS SALQEVRSCN EHPCTVYHWQ
710 720 730 740 750
TGPWGQCIED TSVSSFNTTT TWNGEASCSV GMQTRKVICV RVNVGQVGPK
760 770 780 790 800
KCPESLRPET VRPCLLPCKK DCIVTPYSDW TSCPSSCKEG DSSIRKQSRH
810 820 830 840 850
RVIIQLPANG GRDCTDPLYE EKACEAPQAC QSYRWKTHKW RRCQLVPWSV
860 870 880 890 900
QQDSPGAQEG CGPGRQARAI TCRKQDGGQA GIHECLQYAG PVPALTQACQ
910 920 930 940 950
IPCQDDCQLT SWSKFSSCNG DCGAVRTRKR TLVGKSKKKE KCKNSHLYPL
960 970 980 990 1000
IETQYCPCDK YNAQPVGNWS DCILPEGKVE VLLGMKVQGD IKECGQGYRY
1010 1020 1030 1040 1050
QAMACYDQNG RLVETSRCNS HGYIEEACII PCPSDCKLSE WSNWSRCSKS
1060 1070 1080 1090 1100
CGSGVKVRSK WLREKPYNGG RPCPKLDHVN QAQVYEVVPC HSDCNQYLWV
1110 1120 1130 1140 1150
TEPWSICKVT FVNMRENCGE GVQTRKVRCM QNTADGPSEH VEDYLCDPEE
1160 1170 1180 1190 1200
MPLGSRVCKL PCPEDCVISE WGPWTQCVLP CNQSSFRQRS ADPIRQPADE
1210 1220 1230 1240 1250
GRSCPNAVEK EPCNLNKNCY HYDYNVTDWS TCQLSEKAVC GNGIKTRMLD
1260 1270 1280 1290 1300
CVRSDGKSVD LKYCEALGLE KNWQMNTSCM VECPVNCQLS DWSPWSECSQ
1310 1320 1330 1340 1350
TCGLTGKMIR RRTVTQPFQG DGRPCPSLMD QSKPCPVKPC YRWQYGQWSP
1360 1370 1380 1390 1400
CQVQEAQCGE GTRTRNISCV VSDGSADDFS KVVDEEFCAD IELIIDGNKN
1410 1420 1430 1440 1450
MVLEESCSQP CPGDCYLKDW SSWSLCQLTC VNGEDLGFGG IQVRSRPVII
1460 1470 1480 1490 1500
QELENQHLCP EQMLETKSCY DGQCYEYKWM ASAWKGSSRT VWCQRSDGIN
1510 1520 1530 1540 1550
VTGGCLVMSQ PDADRSCNPP CSQPHSYCSE TKTCHCEEGY TEVMSSNSTL
1560 1570 1580 1590 1600
EQCTLIPVVV LPTMEDKRGD VKTSRAVHPT QPSSNPAGRG RTWFLQPFGP
1610 1620 1630 1640 1650
DGRLKTWVYG VAAGAFVLLI FIVSMIYLAC KKPKKPQRRQ NNRLKPLTLA

YDGDADM
Length:1,657
Mass (Da):185,363
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4CF0FC4EDA26E516
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WY08A0A087WY08_HUMAN
Thrombospondin type-1 domain-contai...
THSD7A
1,657Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti131Q → R in AK092252 (PubMed:14702039).Curated1
Sequence conflicti583N → D in BAA76804 (PubMed:10231032).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057366238F → L. Corresponds to variant dbSNP:rs2074599Ensembl.1
Natural variantiVAR_068676583N → H. Corresponds to variant dbSNP:rs47Ensembl.1
Natural variantiVAR_057367771D → E. Corresponds to variant dbSNP:rs2285744Ensembl.1
Natural variantiVAR_068677906D → E. Corresponds to variant dbSNP:rs1432Ensembl.1
Natural variantiVAR_0686781652D → E. Corresponds to variant dbSNP:rs56264449Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC004141 Genomic DNA No translation available.
AC004160 Genomic DNA No translation available.
AC004614 Genomic DNA No translation available.
AC010908 Genomic DNA No translation available.
AC073109 Genomic DNA No translation available.
AK092252 mRNA No translation available.
AB023177 mRNA Translation: BAA76804.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS47543.1

NCBI Reference Sequences

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RefSeqi
NP_056019.1, NM_015204.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.120855

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000423059; ENSP00000406482; ENSG00000005108

Database of genes from NCBI RefSeq genomes

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GeneIDi
221981

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:221981

UCSC genome browser

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UCSCi
uc064bok.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004141 Genomic DNA No translation available.
AC004160 Genomic DNA No translation available.
AC004614 Genomic DNA No translation available.
AC010908 Genomic DNA No translation available.
AC073109 Genomic DNA No translation available.
AK092252 mRNA No translation available.
AB023177 mRNA Translation: BAA76804.2
CCDSiCCDS47543.1
RefSeqiNP_056019.1, NM_015204.2
UniGeneiHs.120855

3D structure databases

ProteinModelPortaliQ9UPZ6
SMRiQ9UPZ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128774, 3 interactors
IntActiQ9UPZ6, 11 interactors
MINTiQ9UPZ6
STRINGi9606.ENSP00000406482

PTM databases

CarbonylDBiQ9UPZ6
iPTMnetiQ9UPZ6
PhosphoSitePlusiQ9UPZ6

Polymorphism and mutation databases

BioMutaiTHSD7A
DMDMi296453024

Proteomic databases

MaxQBiQ9UPZ6
PaxDbiQ9UPZ6
PeptideAtlasiQ9UPZ6
PRIDEiQ9UPZ6
ProteomicsDBi85479

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423059; ENSP00000406482; ENSG00000005108
GeneIDi221981
KEGGihsa:221981
UCSCiuc064bok.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
221981
DisGeNETi221981
EuPathDBiHostDB:ENSG00000005108.15

GeneCards: human genes, protein and diseases

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GeneCardsi
THSD7A

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0167868
HGNCiHGNC:22207 THSD7A
HPAiHPA000923
MIMi612249 gene
neXtProtiNX_Q9UPZ6
OpenTargetsiENSG00000005108
PharmGKBiPA162405715

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410INDB Eukaryota
ENOG410XR0P LUCA
GeneTreeiENSGT00940000155427
HOGENOMiHOG000154569
HOVERGENiHBG094038
InParanoidiQ9UPZ6
OMAiCVLSMWS
PhylomeDBiQ9UPZ6
TreeFamiTF329791

Enzyme and pathway databases

ReactomeiR-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
THSD7A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
221981

Protein Ontology

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PROi
PR:Q9UPZ6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000005108 Expressed in 198 organ(s), highest expression level in chorionic villus
CleanExiHS_THSD7A
ExpressionAtlasiQ9UPZ6 baseline and differential
GenevisibleiQ9UPZ6 HS

Family and domain databases

Gene3Di2.20.100.10, 11 hits
InterProiView protein in InterPro
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF00090 TSP_1, 11 hits
SMARTiView protein in SMART
SM00209 TSP1, 16 hits
SUPFAMiSSF82895 SSF82895, 13 hits
PROSITEiView protein in PROSITE
PS50092 TSP1, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHS7A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPZ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 126 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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