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Entry version 186 (22 Apr 2020)
Sequence version 1 (01 May 2000)
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Protein

Microtubule-associated protein RP/EB family member 3

Gene

MAPRE3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). May play a role in cell migration (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9UPY8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein RP/EB family member 3
Alternative name(s):
EB1 protein family member 3
Short name:
EBF3
End-binding protein 3
Short name:
EB3
RP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAPRE3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6892 MAPRE3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605788 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UPY8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi226Y → A: Loss of localization of CAMSAP2 stretches to the Golgi apparatus; when associated with A-234. 1 Publication1
Mutagenesisi234E → A: Loss of localization of CAMSAP2 stretches to the Golgi apparatus; when associated with A-226. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
22924

Open Targets

More...
OpenTargetsi
ENSG00000084764

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30636

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UPY8 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAPRE3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20138791

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002134281 – 281Microtubule-associated protein RP/EB family member 3Add BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei162PhosphoserineCombined sources1
Modified residuei176PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UPY8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UPY8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UPY8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UPY8

PeptideAtlas

More...
PeptideAtlasi
Q9UPY8

PRoteomics IDEntifications database

More...
PRIDEi
Q9UPY8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85475 [Q9UPY8-1]
85476 [Q9UPY8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UPY8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UPY8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in brain and muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000084764 Expressed in Brodmann (1909) area 10 and 227 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UPY8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UPY8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000084764 Tissue enhanced (brain, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with APC2 (PubMed:10644998). Homodimer (PubMed:19255245). Heterodimer with MAPRE1 (PubMed:19255245).

Interacts with DCTN1 and SRCIN1 (PubMed:14514668, PubMed:19146815). Binds to the C-terminal domain of APC (PubMed:14514668). Binds monomeric and polymerized tubulin (PubMed:10188731).

Interacts (via C-terminus) with CLIP1 (PubMed:17563362).

Interacts with SLAIN2 and SLAIN1 (PubMed:21646404).

Interacts with AKAP9 (PubMed:28814570).

Interacts with PDE4DIP (PubMed:28814570).

Interacts with PDE4DIP isoform 13/MMG8/SMYLE; this interaction is required for its recruitment to the Golgi apparatus (PubMed:25217626).

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9UPY8
With#Exp.IntAct
itself7EBI-726739,EBI-726739
ANKRD1 [Q15327]5EBI-726739,EBI-5653378
APC2 [O95996]7EBI-726739,EBI-1053045
APPL2 [Q8NEU8]3EBI-726739,EBI-741261
C17orf53 - isoform 3 [Q8N3J3-3]3EBI-726739,EBI-11061081
C20orf202 [A1L168]3EBI-726739,EBI-18396958
C4orf45 [Q96LM5]3EBI-726739,EBI-12020542
CCSER1 - isoform 2 [Q9C0I3-2]3EBI-726739,EBI-17793327
CHRDL2 - isoform 2 [Q6WN34-2]3EBI-726739,EBI-12593838
CRTAC1 [Q9NQ79]3EBI-726739,EBI-10205543
DCTN2 [Q13561]3EBI-726739,EBI-715074
DDIT4L [Q96D03]3EBI-726739,EBI-742054
EIF4E2 [O60573]3EBI-726739,EBI-398610
FAM161B [Q96MY7]3EBI-726739,EBI-7225287
FOXD4L1 [Q9NU39]3EBI-726739,EBI-11320806
FOXD4L4 [Q8WXT5]3EBI-726739,EBI-12911102
GAS2L2 [Q8NHY3]3EBI-726739,EBI-7960826
GTF2F2 [P13984]3EBI-726739,EBI-1030560
IKZF1 - isoform Ik7 [Q13422-7]3EBI-726739,EBI-11522367
JUN [P05412]3EBI-726739,EBI-852823
KLHDC7B [Q96G42]3EBI-726739,EBI-9478422
KNSTRN [Q9Y448]3EBI-726739,EBI-373334
LAP3 [P28838]3EBI-726739,EBI-2339312
LHX4 [Q969G2]3EBI-726739,EBI-2865388
LMO2 [P25791]5EBI-726739,EBI-739696
LMO2 - isoform 3 [P25791-3]6EBI-726739,EBI-11959475
Map1b [P14873] from Mus musculus.4EBI-726739,EBI-764653
MAPRE1 [Q15691]18EBI-726739,EBI-1004115
MAPRE2 [Q15555]7EBI-726739,EBI-739717
MAPT [P10636]3EBI-726739,EBI-366182
MARCH7 [Q9H992]5EBI-726739,EBI-949983
MEOX2 [Q6FHY5]3EBI-726739,EBI-16439278
MRPL12 [P52815]3EBI-726739,EBI-358272
PDE4DIP - isoform 2 [Q5VU43-2]3EBI-726739,EBI-9640281
PICK1 [Q9NRD5]3EBI-726739,EBI-79165
POU4F1 [Q01851]3EBI-726739,EBI-17480471
PSMA1 [P25786]4EBI-726739,EBI-359352
PSMB1 [P20618]3EBI-726739,EBI-372273
PSRC1 [Q6PGN9]3EBI-726739,EBI-7392664
REL - isoform 2 [Q04864-2]3EBI-726739,EBI-10829018
SDCBP [O00560]6EBI-726739,EBI-727004
SIAH1 - isoform 2 [Q8IUQ4-2]3EBI-726739,EBI-11522811
SPDYE6 [P0CI01]3EBI-726739,EBI-11960469
Srcin1 - isoform 2 [Q9QWI6-2] from Mus musculus.5EBI-726739,EBI-775607
TAOK2 [Q9UL54]3EBI-726739,EBI-352832
TEX43 [Q6ZNM6]3EBI-726739,EBI-18115728
TLE5 - isoform 2 [Q08117-2]3EBI-726739,EBI-11741437
TRAIP [Q9BWF2]3EBI-726739,EBI-1756205
TRIM14 [Q14142]3EBI-726739,EBI-2820256
TROAP [Q12815]7EBI-726739,EBI-2349743
TXN2 [Q99757]6EBI-726739,EBI-2932492
YAF2 - isoform 2 [Q8IY57-5]3EBI-726739,EBI-12111538
ZC2HC1A [Q96GY0]3EBI-726739,EBI-5458880
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-726739,EBI-14104088
ZNF526 [Q8TF50]3EBI-726739,EBI-11035148
ZNF547 [Q8IVP9]3EBI-726739,EBI-12895421

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116584, 37 interactors

Database of interacting proteins

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DIPi
DIP-56069N

Protein interaction database and analysis system

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IntActi
Q9UPY8, 69 interactors

Molecular INTeraction database

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MINTi
Q9UPY8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000233121

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UPY8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1281
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UPY8

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UPY8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 116Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST103
Domaini194 – 264EB1 C-terminalPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni217 – 281DCTN1-bindingAdd BLAST65
Regioni217 – 260APC-bindingAdd BLAST44

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Composed of two functionally independent domains. The N-terminal domain forms a hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAPRE family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3000 Eukaryota
COG5217 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00490000043329

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_041744_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UPY8

KEGG Orthology (KO)

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KOi
K10436

Identification of Orthologs from Complete Genome Data

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OMAi
AYCQIID

Database of Orthologous Groups

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OrthoDBi
1237523at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UPY8

TreeFam database of animal gene trees

More...
TreeFami
TF313620

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.418.10, 1 hit
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR004953 EB1_C
IPR036133 EB1_C_sf
IPR027738 EB3
IPR042180 IF_rod_dom_coil1B
IPR027328 MAPRE

The PANTHER Classification System

More...
PANTHERi
PTHR10623 PTHR10623, 1 hit
PTHR10623:SF10 PTHR10623:SF10, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00307 CH, 1 hit
PF03271 EB1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140612 SSF140612, 1 hit
SSF47576 SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021 CH, 1 hit
PS51230 EB1_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPY8-1) [UniParc]FASTAAdd to basket
Also known as: EBF3-L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVNVYSTSV TSENLSRHDM LAWVNDSLHL NYTKIEQLCS GAAYCQFMDM
60 70 80 90 100
LFPGCVHLRK VKFQAKLEHE YIHNFKVLQA AFKKMGVDKI IPVEKLVKGK
110 120 130 140 150
FQDNFEFIQW FKKFFDANYD GKDYNPLLAR QGQDVAPPPN PGDQIFNKSK
160 170 180 190 200
KLIGTAVPQR TSPTGPKNMQ TSGRLSNVAP PCILRKNPPS ARNGGHETDA
210 220 230 240 250
QILELNQQLV DLKLTVDGLE KERDFYFSKL RDIELICQEH ESENSPVISG
260 270 280
IIGILYATEE GFAPPEDDEI EEHQQEDQDE Y
Length:281
Mass (Da):31,982
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DA45E89A0B993D3
GO
Isoform 2 (identifier: Q9UPY8-2) [UniParc]FASTAAdd to basket
Also known as: EBF3-S

The sequence of this isoform differs from the canonical sequence as follows:
     142-156: Missing.

Show »
Length:266
Mass (Da):30,380
Checksum:iE66CAD36E28EE645
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JB30C9JB30_HUMAN
Microtubule-associated protein RP/E...
MAPRE3
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK07556 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAK07557 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA72060 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2A → P in CAA72060 (PubMed:9233623).Curated1
Sequence conflicti13E → V in CAA72060 (PubMed:9233623).Curated1
Sequence conflicti123D → G in CAA72060 (PubMed:9233623).Curated1
Sequence conflicti237C → S in CAG38760 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012947142 – 156Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB025186 mRNA Translation: BAA82958.1
AF288787 Genomic DNA Translation: AAK07556.1 Different initiation.
AF288787 Genomic DNA Translation: AAK07557.1 Different initiation.
CR536523 mRNA Translation: CAG38760.1
CR541845 mRNA Translation: CAG46643.1
AC013472 Genomic DNA Translation: AAY14653.1
CH471053 Genomic DNA Translation: EAX00660.1
CH471053 Genomic DNA Translation: EAX00662.1
CH471053 Genomic DNA Translation: EAX00663.1
CH471053 Genomic DNA Translation: EAX00666.1
BC011557 mRNA Translation: AAH11557.1
Y11174 mRNA Translation: CAA72060.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS1731.1 [Q9UPY8-1]

NCBI Reference Sequences

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RefSeqi
NP_001289979.1, NM_001303050.1 [Q9UPY8-1]
NP_036458.2, NM_012326.3 [Q9UPY8-1]
XP_006712030.1, XM_006711967.3 [Q9UPY8-2]
XP_011531002.1, XM_011532700.1 [Q9UPY8-2]
XP_016859086.1, XM_017003597.1 [Q9UPY8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000233121; ENSP00000233121; ENSG00000084764 [Q9UPY8-1]
ENST00000402218; ENSP00000385715; ENSG00000084764 [Q9UPY8-2]
ENST00000405074; ENSP00000383915; ENSG00000084764 [Q9UPY8-2]
ENST00000648289; ENSP00000497057; ENSG00000084764 [Q9UPY8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22924

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22924

UCSC genome browser

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UCSCi
uc002rhw.4 human [Q9UPY8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025186 mRNA Translation: BAA82958.1
AF288787 Genomic DNA Translation: AAK07556.1 Different initiation.
AF288787 Genomic DNA Translation: AAK07557.1 Different initiation.
CR536523 mRNA Translation: CAG38760.1
CR541845 mRNA Translation: CAG46643.1
AC013472 Genomic DNA Translation: AAY14653.1
CH471053 Genomic DNA Translation: EAX00660.1
CH471053 Genomic DNA Translation: EAX00662.1
CH471053 Genomic DNA Translation: EAX00663.1
CH471053 Genomic DNA Translation: EAX00666.1
BC011557 mRNA Translation: AAH11557.1
Y11174 mRNA Translation: CAA72060.1 Frameshift.
CCDSiCCDS1731.1 [Q9UPY8-1]
RefSeqiNP_001289979.1, NM_001303050.1 [Q9UPY8-1]
NP_036458.2, NM_012326.3 [Q9UPY8-1]
XP_006712030.1, XM_006711967.3 [Q9UPY8-2]
XP_011531002.1, XM_011532700.1 [Q9UPY8-2]
XP_016859086.1, XM_017003597.1 [Q9UPY8-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WYONMR-A1-146[»]
3CO1X-ray1.40A1-130[»]
3JAKelectron microscopy3.50M/N1-200[»]
3JALelectron microscopy3.50M/N1-200[»]
3JARelectron microscopy3.50M/N1-200[»]
3TQ7X-ray2.30B200-281[»]
SMRiQ9UPY8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi116584, 37 interactors
DIPiDIP-56069N
IntActiQ9UPY8, 69 interactors
MINTiQ9UPY8
STRINGi9606.ENSP00000233121

PTM databases

iPTMnetiQ9UPY8
PhosphoSitePlusiQ9UPY8

Polymorphism and mutation databases

BioMutaiMAPRE3
DMDMi20138791

Proteomic databases

EPDiQ9UPY8
jPOSTiQ9UPY8
MassIVEiQ9UPY8
PaxDbiQ9UPY8
PeptideAtlasiQ9UPY8
PRIDEiQ9UPY8
ProteomicsDBi85475 [Q9UPY8-1]
85476 [Q9UPY8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1949 240 antibodies

The DNASU plasmid repository

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DNASUi
22924

Genome annotation databases

EnsembliENST00000233121; ENSP00000233121; ENSG00000084764 [Q9UPY8-1]
ENST00000402218; ENSP00000385715; ENSG00000084764 [Q9UPY8-2]
ENST00000405074; ENSP00000383915; ENSG00000084764 [Q9UPY8-2]
ENST00000648289; ENSP00000497057; ENSG00000084764 [Q9UPY8-2]
GeneIDi22924
KEGGihsa:22924
UCSCiuc002rhw.4 human [Q9UPY8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22924
DisGeNETi22924

GeneCards: human genes, protein and diseases

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GeneCardsi
MAPRE3
HGNCiHGNC:6892 MAPRE3
HPAiENSG00000084764 Tissue enhanced (brain, skeletal muscle)
MIMi605788 gene
neXtProtiNX_Q9UPY8
OpenTargetsiENSG00000084764
PharmGKBiPA30636

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3000 Eukaryota
COG5217 LUCA
GeneTreeiENSGT00490000043329
HOGENOMiCLU_041744_1_0_1
InParanoidiQ9UPY8
KOiK10436
OMAiAYCQIID
OrthoDBi1237523at2759
PhylomeDBiQ9UPY8
TreeFamiTF313620

Enzyme and pathway databases

SIGNORiQ9UPY8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MAPRE3 human
EvolutionaryTraceiQ9UPY8

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MAPRE3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22924
PharosiQ9UPY8 Tbio

Protein Ontology

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PROi
PR:Q9UPY8
RNActiQ9UPY8 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000084764 Expressed in Brodmann (1909) area 10 and 227 other tissues
ExpressionAtlasiQ9UPY8 baseline and differential
GenevisibleiQ9UPY8 HS

Family and domain databases

Gene3Di1.10.418.10, 1 hit
1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR004953 EB1_C
IPR036133 EB1_C_sf
IPR027738 EB3
IPR042180 IF_rod_dom_coil1B
IPR027328 MAPRE
PANTHERiPTHR10623 PTHR10623, 1 hit
PTHR10623:SF10 PTHR10623:SF10, 1 hit
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF03271 EB1, 1 hit
SUPFAMiSSF140612 SSF140612, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS51230 EB1_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMARE3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPY8
Secondary accession number(s): B7WPK5
, O00265, Q6FHB0, Q6FI15, Q9BZP7, Q9BZP8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 2000
Last modified: April 22, 2020
This is version 186 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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