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Protein

Endoribonuclease Dicer

Gene

DICER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.9 Publications

Caution

It is uncertain whether Met-1 or Met-11 is the initiator.Curated
A paper describing truncating mutations of TARBP2 in tumor cells and resultant effects on DICER1 stability and miRNA processing has been retracted, due to concerns of image duplication in some of the figures.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication, Mn2+1 PublicationNote: Binds 2 magnesium or manganese ions per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1316Magnesium or manganese 1By similarity1
Metal bindingi1395Magnesium or manganese 1By similarity1
Metal bindingi1398Magnesium or manganese 1By similarity1
Metal bindingi1705Magnesium or manganese 2Combined sources1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1806Important for activityBy similarity1
Metal bindingi1810Magnesium or manganese 2Combined sources1 Publication1
Metal bindingi1813Magnesium or manganese 2Combined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi64 – 71ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • deoxyribonuclease I activity Source: GO_Central
  • DNA binding Source: InterPro
  • double-stranded RNA binding Source: UniProtKB
  • endoribonuclease activity Source: BHF-UCL
  • helicase activity Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • pre-miRNA binding Source: BHF-UCL
  • protein domain specific binding Source: BHF-UCL
  • ribonuclease III activity Source: BHF-UCL
  • siRNA binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Helicase, Hydrolase, Nuclease, RNA-binding
Biological processRNA-mediated gene silencing
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.26.3 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-203927 MicroRNA (miRNA) biogenesis
R-HSA-426486 Small interfering RNA (siRNA) biogenesis

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9UPY3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endoribonuclease Dicer (EC:3.1.26.3)
Alternative name(s):
Helicase with RNase motif
Short name:
Helicase MOI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DICER1
Synonyms:DICER, HERNA, KIAA0928
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000100697.14

Human Gene Nomenclature Database

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HGNCi
HGNC:17098 DICER1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606241 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9UPY3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pleuropulmonary blastoma (PPB)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare pediatric intrathoracic neoplasm. The tumor arises from the lung, pleura, or both, and appears to be purely mesenchymal in phenotype. It lacks malignant epithelial elements, a feature that distinguishes it from the classic adult-type pulmonary blastoma. It arises during fetal lung development and is often part of an inherited cancer syndrome. The tumor contain both epithelial and mesenchymal cells. Early in tumorigenesis, cysts form in lung airspaces, and these cysts are lined with benign-appearing epithelium. Mesenchymal cells susceptible to malignant transformation reside within the cyst walls and form a dense layer beneath the epithelial lining. In a subset of patients, overgrowth of the mesenchymal cells produces a sarcoma, a transition that is associated with a poorer prognosis. Some patients have multilocular cystic nephroma, a benign kidney tumor.
See also OMIM:601200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0631501583L → R in PPB. 1 PublicationCorresponds to variant dbSNP:rs137852976EnsemblClinVar.1
Goiter multinodular 1, with or without Sertoli-Leydig cell tumors (MNG1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA common disorder characterized by nodular overgrowth of the thyroid gland. Some individuals may also develop Sertoli-Leydig cell tumors, usually of the ovary.
See also OMIM:138800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065301839S → F in MNG1. 1 PublicationCorresponds to variant dbSNP:rs387906934EnsemblClinVar.1
Rhabdomyosarcoma, embryonal, 2 (RMSE2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas.
See also OMIM:180295
DICER1 mutations have been found in uterine cervix embryonal rhabdomyosarcoma, primitive neuroectodermal tumor, Wilms tumor, pulmonary sequestration and juvenile intestinal polyp (PubMed:21882293). Somatic missense mutations affecting the RNase IIIb domain of DICER1 are common in non-epithelial ovarian tumors. These mutations do not abolish DICER1 function but alter it in specific cell types, a novel mechanism through which perturbation of microRNA processing may be oncogenic (PubMed:22187960).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi960F → A: 2-fold decrease in activity. 1
Mutagenesisi971Y → A: 10-fold decrease in activity; when associated with Y-972. 1
Mutagenesisi972Y → A: 10-fold decrease in activity; when associated with Y-971. 1
Mutagenesisi1036E → A: 5-fold decrease in activity. 1
Mutagenesisi1313E → A: No effect on activity. 1 Publication1
Mutagenesisi1320D → A: Decreased activity. Loss of activity; when associated with D-1709. 1 Publication1
Mutagenesisi1340E → A: No effect on activity. 1 Publication1
Mutagenesisi1444E → A: Decreased activity. Loss of activity; when associated with E-1813. 1 Publication1
Mutagenesisi1702Q → A: No effect on activity. 1 Publication1
Mutagenesisi1709D → A: Decreased activity. Loss of activity; when associated with D-1320. 1 Publication1
Mutagenesisi1729P → E: No effect on activity. 1 Publication1
Mutagenesisi1813E → A: Decreased activity. Loss of activity; when associated with E-1444. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
23405

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
DICER1

MalaCards human disease database

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MalaCardsi
DICER1
MIMi138800 phenotype
180295 phenotype
601200 phenotype

Open Targets

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OpenTargetsi
ENSG00000100697

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
276399 Familial multinodular goiter
404476 Global developmental delay-lung cysts-overgrowth-Wilms tumor syndrome
99914 Gynandroblastoma
99915 Maligant granulosa cell tumor of the ovary
99916 Malignant Sertoli-Leydig cell tumor of the ovary
284343 Pleuropulmonary blastoma familial tumor susceptibility syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38437

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2311232

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
DICER1

Domain mapping of disease mutations (DMDM)

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DMDMi
257051056

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001804701 – 1922Endoribonuclease DicerAdd BLAST1922

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei413PhosphoserineCombined sources1
Modified residuei415PhosphoserineCombined sources1
Modified residuei1016PhosphoserineCombined sources1
Modified residuei1160PhosphoserineCombined sources1
Modified residuei1460PhosphoserineCombined sources1
Modified residuei1468PhosphoserineBy similarity1
Modified residuei1470PhosphoserineCombined sources1
Modified residuei1868PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9UPY3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9UPY3

PeptideAtlas

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PeptideAtlasi
Q9UPY3

PRoteomics IDEntifications database

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PRIDEi
Q9UPY3

ProteomicsDB human proteome resource

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ProteomicsDBi
85471
85472 [Q9UPY3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9UPY3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9UPY3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000100697 Expressed in 247 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

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CleanExi
HS_DICER1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UPY3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9UPY3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB068185
HPA000694

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2; DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with DHX9, AGO1, PIWIL1 and PRKRA. Associates with the 60S ribosome. Interacts with BCDIN3D. Interacts with AGO2, TARBP2, EIF6, MOV10 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC) (PubMed:17507929).14 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116978, 94 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1072 RISC-loading complex, PRKRA variant
CPX-134 RISC-loading complex, TARBP2 variant

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9UPY3

Database of interacting proteins

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DIPi
DIP-29664N

Protein interaction database and analysis system

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IntActi
Q9UPY3, 44 interactors

Molecular INTeraction database

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MINTi
Q9UPY3

STRING: functional protein association networks

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STRINGi
9606.ENSP00000343745

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11922
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UPY3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UPY3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q9UPY3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 227Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST177
Domaini433 – 602Helicase C-terminalPROSITE-ProRule annotationAdd BLAST170
Domaini630 – 722Dicer dsRNA-binding foldPROSITE-ProRule annotationAdd BLAST93
Domaini891 – 1042PAZPROSITE-ProRule annotationAdd BLAST152
Domaini1276 – 1403RNase III 1PROSITE-ProRule annotationAdd BLAST128
Domaini1666 – 1824RNase III 2PROSITE-ProRule annotationAdd BLAST159
Domaini1849 – 1914DRBMPROSITE-ProRule annotationAdd BLAST66

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni256 – 595Required for interaction with PRKRA and TARBP2Add BLAST340

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi175 – 178DECH box4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0701 Eukaryota
COG0571 LUCA
COG1111 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156287

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000001567

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG107811

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UPY3

KEGG Orthology (KO)

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KOi
K11592

Identification of Orthologs from Complete Genome Data

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OMAi
PKPDQPC

Database of Orthologous Groups

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OrthoDBi
EOG091G00M8

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UPY3

TreeFam database of animal gene trees

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TreeFami
TF330258

Family and domain databases

Conserved Domains Database

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CDDi
cd00048 DSRM, 1 hit
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1520.10, 1 hit
3.30.160.380, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF04851 ResIII, 1 hit
PF00636 Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00358 DSRM, 1 hit
SM00490 HELICc, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKSPALQPLS MAGLQLMTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE
60 70 80 90 100
LLEAALDHNT IVCLNTGSGK TFIAVLLTKE LSYQIRGDFS RNGKRTVFLV
110 120 130 140 150
NSANQVAQQV SAVRTHSDLK VGEYSNLEVN ASWTKERWNQ EFTKHQVLIM
160 170 180 190 200
TCYVALNVLK NGYLSLSDIN LLVFDECHLA ILDHPYREIM KLCENCPSCP
210 220 230 240 250
RILGLTASIL NGKCDPEELE EKIQKLEKIL KSNAETATDL VVLDRYTSQP
260 270 280 290 300
CEIVVDCGPF TDRSGLYERL LMELEEALNF INDCNISVHS KERDSTLISK
310 320 330 340 350
QILSDCRAVL VVLGPWCADK VAGMMVRELQ KYIKHEQEEL HRKFLLFTDT
360 370 380 390 400
FLRKIHALCE EHFSPASLDL KFVTPKVIKL LEILRKYKPY ERQQFESVEW
410 420 430 440 450
YNNRNQDNYV SWSDSEDDDE DEEIEEKEKP ETNFPSPFTN ILCGIIFVER
460 470 480 490 500
RYTAVVLNRL IKEAGKQDPE LAYISSNFIT GHGIGKNQPR NKQMEAEFRK
510 520 530 540 550
QEEVLRKFRA HETNLLIATS IVEEGVDIPK CNLVVRFDLP TEYRSYVQSK
560 570 580 590 600
GRARAPISNY IMLADTDKIK SFEEDLKTYK AIEKILRNKC SKSVDTGETD
610 620 630 640 650
IDPVMDDDDV FPPYVLRPDD GGPRVTINTA IGHINRYCAR LPSDPFTHLA
660 670 680 690 700
PKCRTRELPD GTFYSTLYLP INSPLRASIV GPPMSCVRLA ERVVALICCE
710 720 730 740 750
KLHKIGELDD HLMPVGKETV KYEEELDLHD EEETSVPGRP GSTKRRQCYP
760 770 780 790 800
KAIPECLRDS YPRPDQPCYL YVIGMVLTTP LPDELNFRRR KLYPPEDTTR
810 820 830 840 850
CFGILTAKPI PQIPHFPVYT RSGEVTISIE LKKSGFMLSL QMLELITRLH
860 870 880 890 900
QYIFSHILRL EKPALEFKPT DADSAYCVLP LNVVNDSSTL DIDFKFMEDI
910 920 930 940 950
EKSEARIGIP STKYTKETPF VFKLEDYQDA VIIPRYRNFD QPHRFYVADV
960 970 980 990 1000
YTDLTPLSKF PSPEYETFAE YYKTKYNLDL TNLNQPLLDV DHTSSRLNLL
1010 1020 1030 1040 1050
TPRHLNQKGK ALPLSSAEKR KAKWESLQNK QILVPELCAI HPIPASLWRK
1060 1070 1080 1090 1100
AVCLPSILYR LHCLLTAEEL RAQTASDAGV GVRSLPADFR YPNLDFGWKK
1110 1120 1130 1140 1150
SIDSKSFISI SNSSSAENDN YCKHSTIVPE NAAHQGANRT SSLENHDQMS
1160 1170 1180 1190 1200
VNCRTLLSES PGKLHVEVSA DLTAINGLSY NQNLANGSYD LANRDFCQGN
1210 1220 1230 1240 1250
QLNYYKQEIP VQPTTSYSIQ NLYSYENQPQ PSDECTLLSN KYLDGNANKS
1260 1270 1280 1290 1300
TSDGSPVMAV MPGTTDTIQV LKGRMDSEQS PSIGYSSRTL GPNPGLILQA
1310 1320 1330 1340 1350
LTLSNASDGF NLERLEMLGD SFLKHAITTY LFCTYPDAHE GRLSYMRSKK
1360 1370 1380 1390 1400
VSNCNLYRLG KKKGLPSRMV VSIFDPPVNW LPPGYVVNQD KSNTDKWEKD
1410 1420 1430 1440 1450
EMTKDCMLAN GKLDEDYEEE DEEEESLMWR APKEEADYED DFLEYDQEHI
1460 1470 1480 1490 1500
RFIDNMLMGS GAFVKKISLS PFSTTDSAYE WKMPKKSSLG SMPFSSDFED
1510 1520 1530 1540 1550
FDYSSWDAMC YLDPSKAVEE DDFVVGFWNP SEENCGVDTG KQSISYDLHT
1560 1570 1580 1590 1600
EQCIADKSIA DCVEALLGCY LTSCGERAAQ LFLCSLGLKV LPVIKRTDRE
1610 1620 1630 1640 1650
KALCPTRENF NSQQKNLSVS CAAASVASSR SSVLKDSEYG CLKIPPRCMF
1660 1670 1680 1690 1700
DHPDADKTLN HLISGFENFE KKINYRFKNK AYLLQAFTHA SYHYNTITDC
1710 1720 1730 1740 1750
YQRLEFLGDA ILDYLITKHL YEDPRQHSPG VLTDLRSALV NNTIFASLAV
1760 1770 1780 1790 1800
KYDYHKYFKA VSPELFHVID DFVQFQLEKN EMQGMDSELR RSEEDEEKEE
1810 1820 1830 1840 1850
DIEVPKAMGD IFESLAGAIY MDSGMSLETV WQVYYPMMRP LIEKFSANVP
1860 1870 1880 1890 1900
RSPVRELLEM EPETAKFSPA ERTYDGKVRV TVEVVGKGKF KGVGRSYRIA
1910 1920
KSAAARRALR SLKANQPQVP NS
Length:1,922
Mass (Da):218,682
Last modified:September 1, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9452B96A601D4551
GO
Isoform 2 (identifier: Q9UPY3-2) [UniParc]FASTAAdd to basket
Also known as: t-Dicer

The sequence of this isoform differs from the canonical sequence as follows:
     1789-1922: LRRSEEDEEK...KANQPQVPNS → KSFLQMYPVP...TTGRSESLWK

Show »
Length:1,829
Mass (Da):208,448
Checksum:i8F52FAB99C876358
GO
Isoform 3 (identifier: Q9UPY3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MKSPALQPLSMAG → MLAWESDHFLRIL
     14-1115: Missing.

Note: No experimental confirmation available.
Show »
Length:820
Mass (Da):92,726
Checksum:i006901B4B9E96382
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJZ6H0YJZ6_HUMAN
Endoribonuclease Dicer
DICER1
394Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5D0K5Q5D0K5_HUMAN
DICER variant 2
DICER1
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB38857 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti75 – 90VLLTK…RGDFS → STTLLKSCLYLDLGETSA in BAA78691 (PubMed:10786632).CuratedAdd BLAST16
Sequence conflicti189I → F in BAA78691 (PubMed:10786632).Curated1
Sequence conflicti195N → I in BAA78691 (PubMed:10786632).Curated1
Sequence conflicti214C → W in BAA78691 (PubMed:10786632).Curated1
Sequence conflicti218E → D in BAA78691 (PubMed:10786632).Curated1
Sequence conflicti223I → F in BAA78691 (PubMed:10786632).Curated1
Sequence conflicti393 – 394QQ → HS in BAA78691 (PubMed:10786632).Curated2
Sequence conflicti492 – 493KQ → NT in BAA78691 (PubMed:10786632).Curated2
Sequence conflicti609D → H in BAA78691 (PubMed:10786632).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065301839S → F in MNG1. 1 PublicationCorresponds to variant dbSNP:rs387906934EnsemblClinVar.1
Natural variantiVAR_0631501583L → R in PPB. 1 PublicationCorresponds to variant dbSNP:rs137852976EnsemblClinVar.1
Natural variantiVAR_0670911705E → K in non-epithelial ovarian tumor; somatic mutation; results in reduced RNase IIIb activity but retention of RNase IIIa activity. 1 Publication1
Natural variantiVAR_0670921709D → E in non-epithelial ovarian tumor; somatic mutation; results in reduced RNase IIIb activity but retention of RNase IIIa activity. 1 Publication1
Natural variantiVAR_0670931709D → G in non-epithelial ovarian tumor; somatic mutation. 1 Publication1
Natural variantiVAR_0670941709D → N in non-epithelial ovarian tumor; somatic mutation; results in reduced RNase IIIb activity but retention of RNase IIIa activity. 1 Publication1
Natural variantiVAR_0670951810D → H in non-epithelial ovarian tumor; somatic mutation. 1 Publication1
Natural variantiVAR_0670961810D → N in non-epithelial ovarian tumor; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs775912475Ensembl.1
Natural variantiVAR_0670971810D → Y in non-epithelial ovarian tumor; somatic mutation. 1 Publication1
Natural variantiVAR_0670981813E → G in non-epithelial ovarian tumor; somatic mutation. 1 Publication1
Natural variantiVAR_0670991813E → K in non-epithelial ovarian tumor; somatic mutation. 1 Publication1
Natural variantiVAR_0671001813E → Q in non-epithelial ovarian tumor; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0553411 – 13MKSPA…LSMAG → MLAWESDHFLRIL in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_05534214 – 1115Missing in isoform 3. 1 PublicationAdd BLAST1102
Alternative sequenceiVSP_0428321789 – 1922LRRSE…QVPNS → KSFLQMYPVPLCENCLKWNQ KLPNLARLRELTTGRSESLW K in isoform 2. 1 PublicationAdd BLAST134

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB028449 mRNA Translation: BAA78691.1
HM595745 mRNA Translation: ADK25182.1
AJ132261 mRNA Translation: CAB38857.2 Different initiation.
AB023145 mRNA Translation: BAA76772.2
AK091513 mRNA Translation: BAG52376.1
AL356017 Genomic DNA No translation available.
AL390254 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81596.1
BC150287 mRNA Translation: AAI50288.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55941.1 [Q9UPY3-2]
CCDS9931.1 [Q9UPY3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001182502.1, NM_001195573.1 [Q9UPY3-2]
NP_001258211.1, NM_001271282.2 [Q9UPY3-1]
NP_001278557.1, NM_001291628.1 [Q9UPY3-1]
NP_085124.2, NM_030621.4 [Q9UPY3-1]
NP_803187.1, NM_177438.2 [Q9UPY3-1]
XP_011534901.1, XM_011536599.1 [Q9UPY3-1]
XP_011534902.1, XM_011536600.2 [Q9UPY3-1]
XP_011534903.1, XM_011536601.2 [Q9UPY3-1]
XP_011534904.1, XM_011536602.2 [Q9UPY3-1]
XP_016876609.1, XM_017021120.1 [Q9UPY3-1]
XP_016876610.1, XM_017021121.1 [Q9UPY3-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.738957
Hs.87889

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343455; ENSP00000343745; ENSG00000100697 [Q9UPY3-1]
ENST00000393063; ENSP00000376783; ENSG00000100697 [Q9UPY3-1]
ENST00000526495; ENSP00000437256; ENSG00000100697 [Q9UPY3-1]
ENST00000527414; ENSP00000435681; ENSG00000100697 [Q9UPY3-1]
ENST00000541352; ENSP00000444719; ENSG00000100697 [Q9UPY3-2]
ENST00000556045; ENSP00000451041; ENSG00000100697 [Q9UPY3-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23405

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23405

UCSC genome browser

More...
UCSCi
uc001ydv.4 human [Q9UPY3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

The dark side of RNA - Issue 87 of October 2007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028449 mRNA Translation: BAA78691.1
HM595745 mRNA Translation: ADK25182.1
AJ132261 mRNA Translation: CAB38857.2 Different initiation.
AB023145 mRNA Translation: BAA76772.2
AK091513 mRNA Translation: BAG52376.1
AL356017 Genomic DNA No translation available.
AL390254 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81596.1
BC150287 mRNA Translation: AAI50288.1
CCDSiCCDS55941.1 [Q9UPY3-2]
CCDS9931.1 [Q9UPY3-1]
RefSeqiNP_001182502.1, NM_001195573.1 [Q9UPY3-2]
NP_001258211.1, NM_001271282.2 [Q9UPY3-1]
NP_001278557.1, NM_001291628.1 [Q9UPY3-1]
NP_085124.2, NM_030621.4 [Q9UPY3-1]
NP_803187.1, NM_177438.2 [Q9UPY3-1]
XP_011534901.1, XM_011536599.1 [Q9UPY3-1]
XP_011534902.1, XM_011536600.2 [Q9UPY3-1]
XP_011534903.1, XM_011536601.2 [Q9UPY3-1]
XP_011534904.1, XM_011536602.2 [Q9UPY3-1]
XP_016876609.1, XM_017021120.1 [Q9UPY3-1]
XP_016876610.1, XM_017021121.1 [Q9UPY3-1]
UniGeneiHs.738957
Hs.87889

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EB1X-ray2.00A/B/C1660-1852[»]
4NGBX-ray2.25A765-1065[»]
4NGCX-ray2.10A765-1065[»]
4NGDX-ray1.96A765-1065[»]
4NGFX-ray3.10A/B/C/D765-1065[»]
4NGGX-ray2.60A765-1065[»]
4NH3X-ray2.62A765-1065[»]
4NH5X-ray2.55A765-1065[»]
4NH6X-ray2.55A765-1065[»]
4NHAX-ray3.40A765-1065[»]
4WYQX-ray3.20A/D267-389[»]
5ZAKelectron microscopy4.40A1-1922[»]
5ZALelectron microscopy4.70A1-1922[»]
5ZAMelectron microscopy5.70A1-1922[»]
ProteinModelPortaliQ9UPY3
SMRiQ9UPY3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116978, 94 interactors
ComplexPortaliCPX-1072 RISC-loading complex, PRKRA variant
CPX-134 RISC-loading complex, TARBP2 variant
CORUMiQ9UPY3
DIPiDIP-29664N
IntActiQ9UPY3, 44 interactors
MINTiQ9UPY3
STRINGi9606.ENSP00000343745

Chemistry databases

ChEMBLiCHEMBL2311232

PTM databases

iPTMnetiQ9UPY3
PhosphoSitePlusiQ9UPY3

Polymorphism and mutation databases

BioMutaiDICER1
DMDMi257051056

Proteomic databases

EPDiQ9UPY3
PaxDbiQ9UPY3
PeptideAtlasiQ9UPY3
PRIDEiQ9UPY3
ProteomicsDBi85471
85472 [Q9UPY3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343455; ENSP00000343745; ENSG00000100697 [Q9UPY3-1]
ENST00000393063; ENSP00000376783; ENSG00000100697 [Q9UPY3-1]
ENST00000526495; ENSP00000437256; ENSG00000100697 [Q9UPY3-1]
ENST00000527414; ENSP00000435681; ENSG00000100697 [Q9UPY3-1]
ENST00000541352; ENSP00000444719; ENSG00000100697 [Q9UPY3-2]
ENST00000556045; ENSP00000451041; ENSG00000100697 [Q9UPY3-3]
GeneIDi23405
KEGGihsa:23405
UCSCiuc001ydv.4 human [Q9UPY3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23405
DisGeNETi23405
EuPathDBiHostDB:ENSG00000100697.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DICER1
GeneReviewsiDICER1
HGNCiHGNC:17098 DICER1
HPAiCAB068185
HPA000694
MalaCardsiDICER1
MIMi138800 phenotype
180295 phenotype
601200 phenotype
606241 gene
neXtProtiNX_Q9UPY3
OpenTargetsiENSG00000100697
Orphaneti276399 Familial multinodular goiter
404476 Global developmental delay-lung cysts-overgrowth-Wilms tumor syndrome
99914 Gynandroblastoma
99915 Maligant granulosa cell tumor of the ovary
99916 Malignant Sertoli-Leydig cell tumor of the ovary
284343 Pleuropulmonary blastoma familial tumor susceptibility syndrome
PharmGKBiPA38437

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0701 Eukaryota
COG0571 LUCA
COG1111 LUCA
GeneTreeiENSGT00940000156287
HOGENOMiHOG000001567
HOVERGENiHBG107811
InParanoidiQ9UPY3
KOiK11592
OMAiPKPDQPC
OrthoDBiEOG091G00M8
PhylomeDBiQ9UPY3
TreeFamiTF330258

Enzyme and pathway databases

BRENDAi3.1.26.3 2681
ReactomeiR-HSA-203927 MicroRNA (miRNA) biogenesis
R-HSA-426486 Small interfering RNA (siRNA) biogenesis
SIGNORiQ9UPY3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DICER1 human
EvolutionaryTraceiQ9UPY3

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DICER1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23405

Protein Ontology

More...
PROi
PR:Q9UPY3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100697 Expressed in 247 organ(s), highest expression level in blood
CleanExiHS_DICER1
ExpressionAtlasiQ9UPY3 baseline and differential
GenevisibleiQ9UPY3 HS

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 1 hit
3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF04851 ResIII, 1 hit
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00358 DSRM, 1 hit
SM00490 HELICc, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits
SUPFAMiSSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDICER_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPY3
Secondary accession number(s): A7E2D3
, B3KRG4, E0AD28, O95943, Q9UQ02
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: September 1, 2009
Last modified: December 5, 2018
This is version 180 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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