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Protein

Major intrinsically disordered Notch2-binding receptor 1

Gene

MINAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR (PubMed:30080879). Negatively regulates angiogenesis (PubMed:29329397). Negatively regulates cell growth (PubMed:29329397, PubMed:30080879). Negatively regulates neurite outgrowth in hippocampal neurons (By similarity).By similarity2 Publications

Caution

MINAR1 topology is a matter of debate, some authors think the N-terminus is extracellular, while preliminary experimental results suggest a cytosolic location.2 Publications

GO - Biological processi

Keywordsi

Biological processAngiogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Major intrinsically disordered Notch2-binding receptor 11 Publication
Alternative name(s):
Membrane integral NOTCH2-associated receptor 1
Ubiquitination and mTOR signaling protein1 Publication
Gene namesi
Name:MINAR11 Publication
Synonyms:KIAA1024, UBTOR1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000169330.8
HGNCiHGNC:29172 MINAR1
MIMi618054 gene
neXtProtiNX_Q9UPX6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 891Cytoplasmic1 PublicationAdd BLAST891
Transmembranei892 – 912HelicalSequence analysisAdd BLAST21
Topological domaini913 – 916Extracellular1 Publication4

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169330
PharmGKBiPA162393036

Polymorphism and mutation databases

BioMutaiKIAA1024
DMDMi32699623

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001571331 – 916Major intrinsically disordered Notch2-binding receptor 1Add BLAST916

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei711PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UPX6
PaxDbiQ9UPX6
PeptideAtlasiQ9UPX6
PRIDEiQ9UPX6
ProteomicsDBi85466

PTM databases

iPTMnetiQ9UPX6
PhosphoSitePlusiQ9UPX6

Expressioni

Tissue specificityi

Widely expressed, including in breast epithelial cells and endothelial cells (at protein level). Expression is down-regulated in advanced breast tumors (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000169330 Expressed in 113 organ(s), highest expression level in vastus lateralis
CleanExiHS_KIAA1024
ExpressionAtlasiQ9UPX6 baseline and differential
GenevisibleiQ9UPX6 HS

Organism-specific databases

HPAiHPA011545

Interactioni

Subunit structurei

Interacts with NOTCH2; this interaction increases MINAR1 stability (PubMed:29329397). Interacts (via N-terminus) with DEPTOR (via PDZ domain); this interaction may stabilize DEPTOR protein by impairing its ubiquitination (PubMed:30080879).2 Publications

Protein-protein interaction databases

IntActiQ9UPX6, 7 interactors
STRINGi9606.ENSP00000307461

Structurei

3D structure databases

ProteinModelPortaliQ9UPX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MINAR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFF3 Eukaryota
ENOG410ZD1X LUCA
GeneTreeiENSGT00530000063851
HOGENOMiHOG000004865
HOVERGENiHBG052193
InParanoidiQ9UPX6
OMAiCEMQSTY
OrthoDBiEOG091G014I
PhylomeDBiQ9UPX6
TreeFamiTF350677

Family and domain databases

InterProiView protein in InterPro
IPR039706 MINAR1-like
IPR009626 MINAR1-like_C
PANTHERiPTHR31530 PTHR31530, 1 hit
PfamiView protein in Pfam
PF06789 UPF0258, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UPX6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METSQETSLF LVKILEELDS KQNTVSYQDL CKSLCARFDL SQLAKLRSVL
60 70 80 90 100
FYTACLDPNF PATLFKDKMK CTVNNQQSKK IMVAADIVTI FNLIQMNGGA
110 120 130 140 150
AKEKLPTGRQ KVRKKEASFE SCRSDTEICN AAECEPLNCE LSERSFSRGY
160 170 180 190 200
PIRQSSKCRK MDCKDCPQFV PASEPNFLLG VSKEVKNRAA SLDRLQALAP
210 220 230 240 250
YSVTSPQPCE MQRTYFPMNI ENESISDQDS LPINQSIKET FISNEEPFVV
260 270 280 290 300
QSCVQKRNIF KEDFHNLMAV SPSLVGPISK AENEHREPQS RKEPHKPPFF
310 320 330 340 350
NHSFEMPYNS QYLNPVYSPV PDKRRAKHES LDDLQASTYF GPTPVMGTQE
360 370 380 390 400
ARRCLGKPNK QTPWPAKSWS LNTEEVPDFE RSFFNRNPSE EKLHYPNASS
410 420 430 440 450
QTPNFPAPER RPTYLVPKDQ QPILPIAYAA KQNGLKSKEI SSPVDLEKHE
460 470 480 490 500
PVKKFKDKSI NCTSGQLSSD TSSVGTQTEH VLEPKKCRDL CTSGQGKYSD
510 520 530 540 550
RHTMKHSDDD SEIVSDDISD IFRFLDDMSI SGSTGVIQSS CYNSTGSLSQ
560 570 580 590 600
LHKSDCDSSP EHNLTKIANG VPNSKGDKGN RPENTHHSEE ELKTSVCKLV
610 620 630 640 650
LRIGEIERKL ESLSGVRDEI SQVLGKLNKL DQKMQQPEKV SVQIDLNSLT
660 670 680 690 700
SEGPSDDSAS PRMFHAHSGS HGPKLENNPD WCCSDASGSN SESLRVKALK
710 720 730 740 750
KSLFTRPSSR SLTEENSATE SKIASISNSP RDWRTITYTN RVGLNEEEIK
760 770 780 790 800
DTGPGDNKDW HRKSKEADRQ YDIPPQHRLP KQPKDGFLVE QVFSPHPYPA
810 820 830 840 850
SLKAHMKSNP LYTDMRLTEL AEVKRGQPSW TIEEYARNAG DKGKLTALDL
860 870 880 890 900
QTQESLNPNN LEYWMEDIYT PGYDSLLKRK EAEFRRAKVC KIAALIAAAA
910
CTVILVIVVP ICTMKS
Length:916
Mass (Da):102,993
Last modified:July 11, 2003 - v3
Checksum:i8A7831FA765197AF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YNN7H0YNN7_HUMAN
Major intrinsically disordered Notc...
MINAR1
854Annotation score:

Sequence cautioni

The sequence BAA82976 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034044320V → F. Corresponds to variant dbSNP:rs11634652Ensembl.1
Natural variantiVAR_022042832I → V. Corresponds to variant dbSNP:rs2297773Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028947 mRNA Translation: BAA82976.2 Different initiation.
CH471136 Genomic DNA Translation: EAW99137.1
BC152466 mRNA Translation: AAI52467.1
CCDSiCCDS32306.1
RefSeqiNP_056021.1, NM_015206.2
XP_011519694.1, XM_011521392.1
XP_011519695.1, XM_011521393.2
XP_011519697.1, XM_011521395.2
XP_011519698.1, XM_011521396.2
XP_016877516.1, XM_017022027.1
UniGeneiHs.301654

Genome annotation databases

EnsembliENST00000305428; ENSP00000307461; ENSG00000169330
GeneIDi23251
KEGGihsa:23251
UCSCiuc002bew.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028947 mRNA Translation: BAA82976.2 Different initiation.
CH471136 Genomic DNA Translation: EAW99137.1
BC152466 mRNA Translation: AAI52467.1
CCDSiCCDS32306.1
RefSeqiNP_056021.1, NM_015206.2
XP_011519694.1, XM_011521392.1
XP_011519695.1, XM_011521393.2
XP_011519697.1, XM_011521395.2
XP_011519698.1, XM_011521396.2
XP_016877516.1, XM_017022027.1
UniGeneiHs.301654

3D structure databases

ProteinModelPortaliQ9UPX6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9UPX6, 7 interactors
STRINGi9606.ENSP00000307461

PTM databases

iPTMnetiQ9UPX6
PhosphoSitePlusiQ9UPX6

Polymorphism and mutation databases

BioMutaiKIAA1024
DMDMi32699623

Proteomic databases

EPDiQ9UPX6
PaxDbiQ9UPX6
PeptideAtlasiQ9UPX6
PRIDEiQ9UPX6
ProteomicsDBi85466

Protocols and materials databases

DNASUi23251
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305428; ENSP00000307461; ENSG00000169330
GeneIDi23251
KEGGihsa:23251
UCSCiuc002bew.2 human

Organism-specific databases

CTDi23251
EuPathDBiHostDB:ENSG00000169330.8
GeneCardsiKIAA1024
HGNCiHGNC:29172 MINAR1
HPAiHPA011545
MIMi618054 gene
neXtProtiNX_Q9UPX6
OpenTargetsiENSG00000169330
PharmGKBiPA162393036
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFF3 Eukaryota
ENOG410ZD1X LUCA
GeneTreeiENSGT00530000063851
HOGENOMiHOG000004865
HOVERGENiHBG052193
InParanoidiQ9UPX6
OMAiCEMQSTY
OrthoDBiEOG091G014I
PhylomeDBiQ9UPX6
TreeFamiTF350677

Miscellaneous databases

GenomeRNAii23251
PROiPR:Q9UPX6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169330 Expressed in 113 organ(s), highest expression level in vastus lateralis
CleanExiHS_KIAA1024
ExpressionAtlasiQ9UPX6 baseline and differential
GenevisibleiQ9UPX6 HS

Family and domain databases

InterProiView protein in InterPro
IPR039706 MINAR1-like
IPR009626 MINAR1-like_C
PANTHERiPTHR31530 PTHR31530, 1 hit
PfamiView protein in Pfam
PF06789 UPF0258, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMNAR1_HUMAN
AccessioniPrimary (citable) accession number: Q9UPX6
Secondary accession number(s): A7MD43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 11, 2003
Last modified: November 7, 2018
This is version 112 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  6. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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