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Entry version 144 (31 Jul 2019)
Sequence version 2 (02 Oct 2007)
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Protein

Protein turtle homolog B

Gene

IGSF9B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Neurogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein turtle homolog B
Alternative name(s):
Immunoglobulin superfamily member 9B
Short name:
IgSF9B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGSF9B
Synonyms:KIAA1030
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:32326 IGSF9B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613773 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UPX0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 722ExtracellularSequence analysisAdd BLAST702
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei723 – 743HelicalSequence analysisAdd BLAST21
Topological domaini744 – 1349CytoplasmicSequence analysisAdd BLAST606

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22997

Open Targets

More...
OpenTargetsi
ENSG00000080854

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671660

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IGSF9B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
158706512

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030611021 – 1349Protein turtle homolog BAdd BLAST1329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi45 ↔ 113PROSITE-ProRule annotation
Disulfide bondi161 ↔ 208PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi250 ↔ 303PROSITE-ProRule annotation
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi346 ↔ 397PROSITE-ProRule annotation
Disulfide bondi442 ↔ 488PROSITE-ProRule annotation
Glycosylationi624N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei775PhosphoserineBy similarity1
Modified residuei783PhosphoserineBy similarity1
Modified residuei794PhosphoserineBy similarity1
Modified residuei1136Omega-N-methylarginineBy similarity1
Modified residuei1207PhosphoserineBy similarity1
Modified residuei1215PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated and sialylated. Not significantly O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UPX0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UPX0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UPX0

PeptideAtlas

More...
PeptideAtlasi
Q9UPX0

PRoteomics IDEntifications database

More...
PRIDEi
Q9UPX0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
34118
85465 [Q9UPX0-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UPX0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UPX0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000080854 Expressed in 89 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UPX0 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA010744
HPA010802

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a complex with MAGI2 and NLGN2, where it interacts with MAGI2 (via PDZ 5 and PDZ 6 domains).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116644, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UPX0, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9UPX0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000436552

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UPX0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 129Ig-like 1Add BLAST106
Domaini139 – 226Ig-like 2Add BLAST88
Domaini228 – 320Ig-like 3Add BLAST93
Domaini324 – 415Ig-like 4Add BLAST92
Domaini420 – 504Ig-like 5Add BLAST85
Domaini512 – 604Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST93
Domaini614 – 708Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi924 – 1342Pro-richAdd BLAST419

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3510 Eukaryota
KOG4222 Eukaryota
ENOG410XNZS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155900

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154717

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UPX0

KEGG Orthology (KO)

More...
KOi
K22656

Identification of Orthologs from Complete Genome Data

More...
OMAi
SAKWQDR

Database of Orthologous Groups

More...
OrthoDBi
291729at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UPX0

TreeFam database of animal gene trees

More...
TreeFami
TF326128

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13895 Ig_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SM00406 IGv, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPX0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIWYVATFIA SVIGTRGLAA EGAHGLREEP EFVTARAGES VVLRCDVIHP
60 70 80 90 100
VTGQPPPYVV EWFKFGVPIP IFIKFGYYPP HVDPEYAGRA SLHDKASLRL
110 120 130 140 150
EQVRSEDQGW YECKVLMLDQ QYDTFHNGSW VHLTINAPPT FTETPPQYIE
160 170 180 190 200
AKEGGSITMT CTAFGNPKPI VTWLKEGTLL GASGKYQVSD GSLTVTSVSR
210 220 230 240 250
EDRGAYTCRA YSIQGEAVHT THLLVQGPPF IVSPPENITV NISQDALLTC
260 270 280 290 300
RAEAYPGNLT YTWYWQDENV YFQNDLKLRV RILIDGTLII FRVKPEDSGK
310 320 330 340 350
YTCVPSNSLG RSPSASAYLT VQYPARVLNM PPVIYVPVGI HGYIRCPVDA
360 370 380 390 400
EPPATVVKWN KDGRPLQVEK NLGWTLMEDG SIRIEEATEE ALGTYTCVPY
410 420 430 440 450
NTLGTMGQSA PARLVLKDPP YFTVLPGWEY RQEAGRELLI PCAAAGDPFP
460 470 480 490 500
VITWRKVGKP SRSKHSALPS GSLQFRALSK EDHGEWECVA TNVVTSITAS
510 520 530 540 550
THLTVIGTSP HAPGSVRVQV SMTTANVSWE PGYDGGYEQT FSVWMKRAQF
560 570 580 590 600
GPHDWLSLPV PPGPSWLLVD TLEPETAYQF SVLAQNKLGT SAFSEVVTVN
610 620 630 640 650
TLAFPITTPE PLVLVTPPRC LIANRTQQGV LLSWLPPANH SFPIDRYIME
660 670 680 690 700
FRVAERWELL DDGIPGTEGE FFAKDLSQDT WYEFRVLAVM QDLISEPSNI
710 720 730 740 750
AGVSSTDIFP QPDLTEDGLA RPVLAGIVAT ICFLAAAILF STLAACFVNK
760 770 780 790 800
QRKRKLKRKK DPPLSITHCR KSLESPLSSG KVSPESIRTL RAPSESSDDQ
810 820 830 840 850
GQPAAKRMLS PTREKELSLY KKTKRAISSK KYSVAKAEAE AEATTPIELI
860 870 880 890 900
SRGPDGRFVM DPAEMEPSLK SRRIEGFPFA EETDMYPEFR QSDEENEDPL
910 920 930 940 950
VPTSVAALKS QLTPLSSSQE SYLPPPAYSP RFQPRGLEGP GGLEGRLQAT
960 970 980 990 1000
GQARPPAPRP FHHGQYYGYL SSSSPGEVEP PPFYVPEVGS PLSSVMSSPP
1010 1020 1030 1040 1050
LPTEGPFGHP TIPEENGENA SNSTLPLTQT PTGGRSPEPW GRPEFPFGGL
1060 1070 1080 1090 1100
ETPAMMFPHQ LPPCDVPESL QPKAGLPRGL PPTSLQVPAA YPGILSLEAP
1110 1120 1130 1140 1150
KGWAGKSPGR GPVPAPPAAK WQDRPMQPLV SQGQLRHTSQ GMGIPVLPYP
1160 1170 1180 1190 1200
EPAEPGAHGG PSTFGLDTRW YEPQPRPRPS PRQARRAEPS LHQVVLQPSR
1210 1220 1230 1240 1250
LSPLTQSPLS SRTGSPELAA RARPRPGLLQ QAEMSEITLQ PPAAVSFSRK
1260 1270 1280 1290 1300
STPSTGSPSQ SSRSGSPSYR PAMGFTTLAT GYPSPPPGPA PAGPGDSLDV
1310 1320 1330 1340
FGQTPSPRRT GEELLRPETP PPTLPTSGKL QRDRPAPATS PPERALSKL
Length:1,349
Mass (Da):147,089
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC8A15ED782EB3893
GO
Isoform 2 (identifier: Q9UPX0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1329-1349: KLQRDRPAPATSPPERALSKL → TLPPAPGNAA...HDDPGHATLL

Note: Gene prediction based on EST data.
Show »
Length:1,437
Mass (Da):156,887
Checksum:i11BBEEFCCCE12A62
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YDP1H0YDP1_HUMAN
Protein turtle homolog B
IGSF9B
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRP3E9PRP3_HUMAN
Protein turtle homolog B
IGSF9B
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1331Q → R in BAA82982 (PubMed:10470851).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076999178T → M1 PublicationCorresponds to variant dbSNP:rs77432041Ensembl.1
Natural variantiVAR_077000268E → K1 PublicationCorresponds to variant dbSNP:rs369063193Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0547301329 – 1349KLQRD…ALSKL → TLPPAPGNAAAPERLEALKY QRIKKPKKSSKGSSKSKKRS DDSASQTQQLPNSQVLWPDE AVCLRKKKRHSRPDPFARLS DLCHRQLPEDQTAILNSVDH DDPGHATLL in isoform 2. CuratedAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AP000911 Genomic DNA No translation available.
AP001979 Genomic DNA No translation available.
AB028953 mRNA Translation: BAA82982.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS61010.1 [Q9UPX0-2]

NCBI Reference Sequences

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RefSeqi
NP_001264214.1, NM_001277285.1 [Q9UPX0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000321016; ENSP00000317980; ENSG00000080854 [Q9UPX0-1]
ENST00000533871; ENSP00000436552; ENSG00000080854 [Q9UPX0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22997

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22997

UCSC genome browser

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UCSCi
uc031qfh.2 human [Q9UPX0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000911 Genomic DNA No translation available.
AP001979 Genomic DNA No translation available.
AB028953 mRNA Translation: BAA82982.1
CCDSiCCDS61010.1 [Q9UPX0-2]
RefSeqiNP_001264214.1, NM_001277285.1 [Q9UPX0-2]

3D structure databases

SMRiQ9UPX0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116644, 2 interactors
IntActiQ9UPX0, 2 interactors
MINTiQ9UPX0
STRINGi9606.ENSP00000436552

PTM databases

iPTMnetiQ9UPX0
PhosphoSitePlusiQ9UPX0

Polymorphism and mutation databases

BioMutaiIGSF9B
DMDMi158706512

Proteomic databases

EPDiQ9UPX0
jPOSTiQ9UPX0
PaxDbiQ9UPX0
PeptideAtlasiQ9UPX0
PRIDEiQ9UPX0
ProteomicsDBi34118
85465 [Q9UPX0-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321016; ENSP00000317980; ENSG00000080854 [Q9UPX0-1]
ENST00000533871; ENSP00000436552; ENSG00000080854 [Q9UPX0-2]
GeneIDi22997
KEGGihsa:22997
UCSCiuc031qfh.2 human [Q9UPX0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22997
DisGeNETi22997

GeneCards: human genes, protein and diseases

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GeneCardsi
IGSF9B
HGNCiHGNC:32326 IGSF9B
HPAiHPA010744
HPA010802
MIMi613773 gene
neXtProtiNX_Q9UPX0
OpenTargetsiENSG00000080854
PharmGKBiPA142671660

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3510 Eukaryota
KOG4222 Eukaryota
ENOG410XNZS LUCA
GeneTreeiENSGT00940000155900
HOGENOMiHOG000154717
InParanoidiQ9UPX0
KOiK22656
OMAiSAKWQDR
OrthoDBi291729at2759
PhylomeDBiQ9UPX0
TreeFamiTF326128

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IGSF9B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22997

Protein Ontology

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PROi
PR:Q9UPX0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000080854 Expressed in 89 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ9UPX0 baseline and differential

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SM00406 IGv, 3 hits
SUPFAMiSSF48726 SSF48726, 5 hits
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTUTLB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPX0
Secondary accession number(s): G5EA26
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 31, 2019
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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