UniProtKB - Q9UPW6 (SATB2_HUMAN)

BLAST

>sp|Q9UPW6|SATB2_HUMAN DNA-binding protein SATB2 OS=Homo sapiens OX=9606 GN=SATB2 PE=1 SV=2
MERRSESPCLRDSPDRRSGSPDVKGPPPVKVARLEQNGSPMGARGRPNGAVAKAVGGLMI
PVFCVVEQLDGSLEYDNREEHAEFVLVRKDVLFSQLVETALLALGYSHSSAAQAQGIIKL
GRWNPLPLSYVTDAPDATVADMLQDVYHVVTLKIQLQSCSKLEDLPAEQWNHATVRNALK
ELLKEMNQSTLAKECPLSQSMISSIVNSTYYANVSATKCQEFGRWYKKYKKIKVERVERE
NLSDYCVLGQRPMHLPNMNQLASLGKTNEQSPHSQIHHSTPIRNQVPALQPIMSPGLLSP
QLSPQLVRQQIAMAHLINQQIAVSRLLAHQHPQAINQQFLNHPPIPRAVKPEPTNSSVEV
SPDIYQQVRDELKRASVSQAVFARVAFNRTQGLLSEILRKEEDPRTASQSLLVNLRAMQN
FLNLPEVERDRIYQDERERSMNPNVSMVSSASSSPSSSRTPQAKTSTPTTDLPIKVDGAN
INITAAIYDEIQQEMKRAKVSQALFAKVAANKSQGWLCELLRWKENPSPENRTLWENLCT
IRRFLNLPQHERDVIYEEESRHHHSERMQHVVQLPPEPVQVLHRQQSQPAKESSPPREEA
PPPPPPTEDSCAKKPRSRTKISLEALGILQSFIHDVGLYPDQEAIHTLSAQLDLPKHTII
KFFQNQRYHVKHHGKLKEHLGSAVDVAEYKDEELLTESEENDSEEGSEEMYKVEAEEENA
DKSKAAPAEIDQR

Align

Format
Add to basket Added to basket
History
Entry version 171 (07 Nov 2018)
Sequence version 2 (27 Apr 2001)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

DNA-binding protein SATB2

Gene

SATB2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	350 – 437	CUT 1PROSITE-ProRule annotationAdd BLAST	88
DNA bindingⁱ	473 – 560	CUT 2PROSITE-ProRule annotationAdd BLAST	88
DNA bindingⁱ	615 – 674	HomeoboxPROSITE-ProRule annotationAdd BLAST	60

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cartilage development Source: Ensembl
cellular response to organic substance Source: Ensembl
chromatin remodeling Source: Ensembl
commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
embryonic pattern specification Source: Ensembl
embryonic skeletal system morphogenesis Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
neuron migration Source: Ensembl
osteoblast development Source: Ensembl
roof of mouth development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, Developmental protein, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-4551638 SUMOylation of chromatin organization proteins R-HSA-8940973 RUNX2 regulates osteoblast differentiation
SIGNORⁱ	Q9UPW6

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA-binding protein SATB2 Alternative name(s): Special AT-rich sequence-binding protein 2
Gene namesⁱ	Name:SATB2 Synonyms:KIAA1034
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000119042.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21637 SATB2
MIMⁱ	608148 gene
neXtProtⁱ	NX_Q9UPW6

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11).1 Publication

Cleft palate isolated (CPI)2 Publications

The disease may be caused by mutations affecting the gene represented in this entry.

Disease descriptionA congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	233	K → R: Reduced sumoylation, impaired nuclear localization, but enhanced transcription factor activity. 1 Publication		1
Mutagenesisⁱ	350	K → R: Reduced sumoylation, impaired nuclear localization, but enhanced transcription factor activity. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23314
MalaCards human disease database More...MalaCardsⁱ	SATB2
MIMⁱ	119540 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000119042
Orphanetⁱ	251019 2q32q33 microdeletion syndrome 251028 2q33.1 microdeletion syndrome
PharmGKBⁱ	PA128394624

Polymorphism and mutation databases

BioMutaⁱ	SATB2
DMDMⁱ	13634020

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000202400	1 – 733	DNA-binding protein SATB2Add BLAST		733

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	20	PhosphoserineCombined sources	1
Cross-linkⁱ	24	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	30	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	39	PhosphoserineCombined sources	1
Cross-linkⁱ	161	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	233	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)Curated
Cross-linkⁱ	350	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateCurated
Cross-linkⁱ	350	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	454	PhosphoserineCombined sources	1
Modified residueⁱ	467	PhosphothreonineCombined sources	1
Cross-linkⁱ	475	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	594	PhosphoserineCombined sources	1
Cross-linkⁱ	724	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Sumoylated by PIAS1. Sumoylation promotes nuclear localization, but represses transcription factor activity.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9UPW6
PaxDbⁱ	Q9UPW6
PeptideAtlas More...PeptideAtlasⁱ	Q9UPW6
PRIDEⁱ	Q9UPW6
ProteomicsDBⁱ	85463

PTM databases

iPTMnetⁱ	Q9UPW6
PhosphoSitePlusⁱ	Q9UPW6

Expressionⁱ

Tissue specificityⁱ

High expression in adult brain, moderate expression in fetal brain, and weak expression in adult liver, kidney, and spinal cord and in select brain regions, including amygdala, corpus callosum, caudate nucleus, and hippocampus.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000119042 Expressed in 179 organ(s), highest expression level in neocortex
CleanExⁱ	HS_SATB2
ExpressionAtlasⁱ	Q9UPW6 baseline and differential
Genevisibleⁱ	Q9UPW6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB023669 CAB062562 CAB067751 CAB068229 CAB068230 CAB068231 HPA001042 HPA029543

HPAⁱ

CAB023669
CAB062562
CAB067751
CAB068229
CAB068230
CAB068231
HPA001042
HPA029543

Interactionⁱ

Subunit structureⁱ

Interacts with ATF4 and RUNX2; resulting in enhanced DNA binding and transactivation by these transcription factors (By similarity). Interacts with PIAS1.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
RAB3IL1	Q8TBN0	3	EBI-8298169,EBI-743796
TP63	Q9H3D4-2	5	EBI-8298169,EBI-6481107

Protein-protein interaction databases

BioGridⁱ	116905, 53 interactors
Database of interacting proteins More...DIPⁱ	DIP-60551N
ELMⁱ	Q9UPW6
IntActⁱ	Q9UPW6, 29 interactors
Molecular INTeraction database More...MINTⁱ	Q9UPW6
STRINGⁱ	9606.ENSP00000260926

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	364 – 375	Combined sources	12
Helixⁱ	379 – 387	Combined sources	9
Helixⁱ	391 – 399	Combined sources	9
Turnⁱ	404 – 406	Combined sources	3
Helixⁱ	409 – 421	Combined sources	13
Helixⁱ	426 – 437	Combined sources	12
Helixⁱ	486 – 498	Combined sources	13
Helixⁱ	502 – 508	Combined sources	7
Helixⁱ	514 – 523	Combined sources	10
Helixⁱ	532 – 545	Combined sources	14
Helixⁱ	549 – 559	Combined sources	11
Helixⁱ	624 – 636	Combined sources	13
Helixⁱ	642 – 651	Combined sources	10
Helixⁱ	656 – 669	Combined sources	14

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UPW6
SMRⁱ	Q9UPW6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UPW6

EvolutionaryTraceⁱ

Q9UPW6

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CUT homeobox family.Curated

Keywords - Domainⁱ

Homeobox, Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410ISJ9 Eukaryota ENOG41113K2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008096
HOGENOMⁱ	HOG000004805
HOVERGENⁱ	HBG054240
InParanoidⁱ	Q9UPW6
OMAⁱ	QHVVQLT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02HV
PhylomeDBⁱ	Q9UPW6
TreeFamⁱ	TF332714

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit cd11585 SATB1_N, 1 hit
Gene3Dⁱ	1.10.260.70, 1 hit 3.10.20.710, 1 hit
InterProⁱ	View protein in InterPro IPR003350 CUT_dom IPR032355 CUTL IPR009057 Homeobox-like_sf IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf IPR039673 SATB1/SATB2 IPR038216 SATB_CUTL_sf IPR038224 SATB_ULD_sf IPR032392 ULD
PANTHERⁱ	PTHR15116 PTHR15116, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02376 CUT, 2 hits PF16557 CUTL, 1 hit PF00046 Homeobox, 1 hit PF16534 ULD, 1 hit
SMARTⁱ	View protein in SMART SM01109 CUT, 2 hits SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 2 hits
PROSITEⁱ	View protein in PROSITE PS51042 CUT, 2 hits PS50071 HOMEOBOX_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UPW6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERRSESPCL RDSPDRRSGS PDVKGPPPVK VARLEQNGSP MGARGRPNGA 
        60         70         80         90        100
VAKAVGGLMI PVFCVVEQLD GSLEYDNREE HAEFVLVRKD VLFSQLVETA 
       110        120        130        140        150
LLALGYSHSS AAQAQGIIKL GRWNPLPLSY VTDAPDATVA DMLQDVYHVV 
       160        170        180        190        200
TLKIQLQSCS KLEDLPAEQW NHATVRNALK ELLKEMNQST LAKECPLSQS 
       210        220        230        240        250
MISSIVNSTY YANVSATKCQ EFGRWYKKYK KIKVERVERE NLSDYCVLGQ 
       260        270        280        290        300
RPMHLPNMNQ LASLGKTNEQ SPHSQIHHST PIRNQVPALQ PIMSPGLLSP 
       310        320        330        340        350
QLSPQLVRQQ IAMAHLINQQ IAVSRLLAHQ HPQAINQQFL NHPPIPRAVK 
       360        370        380        390        400
PEPTNSSVEV SPDIYQQVRD ELKRASVSQA VFARVAFNRT QGLLSEILRK 
       410        420        430        440        450
EEDPRTASQS LLVNLRAMQN FLNLPEVERD RIYQDERERS MNPNVSMVSS 
       460        470        480        490        500
ASSSPSSSRT PQAKTSTPTT DLPIKVDGAN INITAAIYDE IQQEMKRAKV 
       510        520        530        540        550
SQALFAKVAA NKSQGWLCEL LRWKENPSPE NRTLWENLCT IRRFLNLPQH 
       560        570        580        590        600
ERDVIYEEES RHHHSERMQH VVQLPPEPVQ VLHRQQSQPA KESSPPREEA 
       610        620        630        640        650
PPPPPPTEDS CAKKPRSRTK ISLEALGILQ SFIHDVGLYP DQEAIHTLSA 
       660        670        680        690        700
QLDLPKHTII KFFQNQRYHV KHHGKLKEHL GSAVDVAEYK DEELLTESEE 
       710        720        730 
NDSEEGSEEM YKVEAEEENA DKSKAAPAEI DQR

Length:733

Mass (Da):82,555

Last modified:April 27, 2001 - v2

Checksum:ⁱ1FE1FCBD34F11E9E

Isoform 2 (identifier: Q9UPW6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
116-233: Missing.

« Hide

        10         20         30         40         50
MERRSESPCL RDSPDRRSGS PDVKGPPPVK VARLEQNGSP MGARGRPNGA 
        60         70         80         90        100
VAKAVGGLMI PVFCVVEQLD GSLEYDNREE HAEFVLVRKD VLFSQLVETA 
       110        120        130        140        150
LLALGYSHSS AAQAQVERVE RENLSDYCVL GQRPMHLPNM NQLASLGKTN 
       160        170        180        190        200
EQSPHSQIHH STPIRNQVPA LQPIMSPGLL SPQLSPQLVR QQIAMAHLIN 
       210        220        230        240        250
QQIAVSRLLA HQHPQAINQQ FLNHPPIPRA VKPEPTNSSV EVSPDIYQQV 
       260        270        280        290        300
RDELKRASVS QAVFARVAFN RTQGLLSEIL RKEEDPRTAS QSLLVNLRAM 
       310        320        330        340        350
QNFLNLPEVE RDRIYQDERE RSMNPNVSMV SSASSSPSSS RTPQAKTSTP 
       360        370        380        390        400
TTDLPIKVDG ANINITAAIY DEIQQEMKRA KVSQALFAKV AANKSQGWLC 
       410        420        430        440        450
ELLRWKENPS PENRTLWENL CTIRRFLNLP QHERDVIYEE ESRHHHSERM 
       460        470        480        490        500
QHVVQLPPEP VQVLHRQQSQ PAKESSPPRE EAPPPPPPTE DSCAKKPRSR 
       510        520        530        540        550
TKISLEALGI LQSFIHDVGL YPDQEAIHTL SAQLDLPKHT IIKFFQNQRY 
       560        570        580        590        600
HVKHHGKLKE HLGSAVDVAE YKDEELLTES EENDSEEGSE EMYKVEAEEE 
       610 
NADKSKAAPA EIDQR

Note: No experimental confirmation available.

Show »

Length:615

Mass (Da):69,137

Checksum:ⁱ8A4F3998CF207015

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JR56	C9JR56_HUMAN	DNA-binding protein SATB DNA-binding protein SATB (Special AT-rich sequence-binding protein)	SATB2	674	Annotation score:
F8WCV6	F8WCV6_HUMAN	DNA-binding protein SATB2 DNA-binding protein SATB2	SATB2	126	Annotation score:

Sequence cautionⁱ

The sequence BAA82986 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_059320	263	S → P. Corresponds to variant dbSNP:rs12619995Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054416	116 – 233	Missing in isoform 2. 1 PublicationAdd BLAST		118

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB028957 mRNA Translation: BAA82986.1 Different initiation. AK291463 mRNA Translation: BAF84152.1 AC016746 Genomic DNA No translation available. AC017096 Genomic DNA No translation available. CH471063 Genomic DNA Translation: EAW70180.1 BC098136 mRNA Translation: AAH98136.1 BC099723 mRNA Translation: AAH99723.1 BC103492 mRNA Translation: AAI03493.1 BC103500 mRNA Translation: AAI03501.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2327.1 [Q9UPW6-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001165980.1, NM_001172509.1 [Q9UPW6-1] NP_001165988.1, NM_001172517.1 [Q9UPW6-1] NP_056080.1, NM_015265.3 [Q9UPW6-1] XP_006712435.1, XM_006712372.2 XP_011509142.1, XM_011510840.2 [Q9UPW6-1]
UniGeneⁱ	Hs.516617

Genome annotation databases

Ensemblⁱ	ENST00000260926; ENSP00000260926; ENSG00000119042 [Q9UPW6-1] ENST00000417098; ENSP00000401112; ENSG00000119042 [Q9UPW6-1] ENST00000428695; ENSP00000388581; ENSG00000119042 [Q9UPW6-2] ENST00000457245; ENSP00000405420; ENSG00000119042 [Q9UPW6-1] ENST00000614512; ENSP00000483287; ENSG00000119042 [Q9UPW6-2]
GeneIDⁱ	23314
KEGGⁱ	hsa:23314
UCSC genome browser More...UCSCⁱ	uc002uuy.2 human [Q9UPW6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UPW6	SATB family member 2 variant (Fragment)		HUMAN		763	UniRef100_Q9UPW6
DNA-binding protein SATB		PANTR		733
DNA-binding protein SATB		PANPA		733
DNA-binding protein SATB		PONAB		733
DNA-binding protein SATB		GORGO		733
+3
Q9UPW6-2	DNA-binding protein SATB		PANTR		615	UniRef100_A0A2J8N4U9
DNA-binding protein SATB		PONAB		615
DNA-binding protein SATB		PANPA		615
DNA-binding protein SATB		GORGO		615

Protein	Similar proteins		Species	Score	Length	Source
Q9UPW6	DNA-binding protein SATB2		MOUSE		733	UniRef90_Q8VI24
DNA-binding protein SATB		ALLMI		803
DNA-binding protein SATB		BOVIN		765
DNA-binding protein SATB		OTOGA		763
DNA-binding protein SATB		CANLF		763
+249
Q9UPW6-2	DNA-binding protein SATB		MOUSE		615	UniRef90_H3BKH3
DNA-binding protein SATB		PANTR		615
DNA-binding protein SATB		PONAB		615
DNA-binding protein SATB		PANPA		615
DNA-binding protein SATB		GORGO		615
+27

Protein	Similar proteins		Species	Score	Length	Source
Q9UPW6	DNA-binding protein SATB2		MOUSE		733	UniRef50_Q8VI24
DNA-binding protein SATB		ALLMI		803
DNA-binding protein SATB		BOVIN		765
DNA-binding protein SATB		OTOGA		763
DNA-binding protein SATB		CANLF		763
+285
Q9UPW6-2	DNA-binding protein SATB		MOUSE		615	UniRef50_H3BKH3
DNA-binding protein SATB		ODORO		615
DNA-binding protein SATB		CALJA		615
DNA-binding protein SATB		SAIBB		615
DNA-binding protein SATB		Cebus capucinus imitator		615
+33

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB028957 mRNA Translation: BAA82986.1 Different initiation. AK291463 mRNA Translation: BAF84152.1 AC016746 Genomic DNA No translation available. AC017096 Genomic DNA No translation available. CH471063 Genomic DNA Translation: EAW70180.1 BC098136 mRNA Translation: AAH98136.1 BC099723 mRNA Translation: AAH99723.1 BC103492 mRNA Translation: AAI03493.1 BC103500 mRNA Translation: AAI03501.1
CCDSⁱ	CCDS2327.1 [Q9UPW6-1]
RefSeqⁱ	NP_001165980.1, NM_001172509.1 [Q9UPW6-1] NP_001165988.1, NM_001172517.1 [Q9UPW6-1] NP_056080.1, NM_015265.3 [Q9UPW6-1] XP_006712435.1, XM_006712372.2 XP_011509142.1, XM_011510840.2 [Q9UPW6-1]
UniGeneⁱ	Hs.516617

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1WI3	NMR	-	A	615-672	[»]
	1WIZ	NMR	-	A	350-437	[»]
	2CSF	NMR	-	A	473-560	[»]
ProteinModelPortalⁱ	Q9UPW6
SMRⁱ	Q9UPW6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116905, 53 interactors
DIPⁱ	DIP-60551N
ELMⁱ	Q9UPW6
IntActⁱ	Q9UPW6, 29 interactors
MINTⁱ	Q9UPW6
STRINGⁱ	9606.ENSP00000260926

PTM databases

iPTMnetⁱ	Q9UPW6
PhosphoSitePlusⁱ	Q9UPW6

Polymorphism and mutation databases

BioMutaⁱ	SATB2
DMDMⁱ	13634020

Proteomic databases

EPDⁱ	Q9UPW6
PaxDbⁱ	Q9UPW6
PeptideAtlasⁱ	Q9UPW6
PRIDEⁱ	Q9UPW6
ProteomicsDBⁱ	85463

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23314
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000260926; ENSP00000260926; ENSG00000119042 [Q9UPW6-1] ENST00000417098; ENSP00000401112; ENSG00000119042 [Q9UPW6-1] ENST00000428695; ENSP00000388581; ENSG00000119042 [Q9UPW6-2] ENST00000457245; ENSP00000405420; ENSG00000119042 [Q9UPW6-1] ENST00000614512; ENSP00000483287; ENSG00000119042 [Q9UPW6-2]
GeneIDⁱ	23314
KEGGⁱ	hsa:23314
UCSCⁱ	uc002uuy.2 human [Q9UPW6-1]

Organism-specific databases

CTDⁱ	23314
DisGeNETⁱ	23314
EuPathDBⁱ	HostDB:ENSG00000119042.16
GeneCardsⁱ	SATB2
HGNCⁱ	HGNC:21637 SATB2
HPAⁱ	CAB023669 CAB062562 CAB067751 CAB068229 CAB068230 CAB068231 HPA001042 HPA029543
MalaCardsⁱ	SATB2
MIMⁱ	119540 phenotype 608148 gene
neXtProtⁱ	NX_Q9UPW6
OpenTargetsⁱ	ENSG00000119042
Orphanetⁱ	251019 2q32q33 microdeletion syndrome 251028 2q33.1 microdeletion syndrome
PharmGKBⁱ	PA128394624
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410ISJ9 Eukaryota ENOG41113K2 LUCA
GeneTreeⁱ	ENSGT00390000008096
HOGENOMⁱ	HOG000004805
HOVERGENⁱ	HBG054240
InParanoidⁱ	Q9UPW6
OMAⁱ	QHVVQLT
OrthoDBⁱ	EOG091G02HV
PhylomeDBⁱ	Q9UPW6
TreeFamⁱ	TF332714

Enzyme and pathway databases

Reactomeⁱ	R-HSA-4551638 SUMOylation of chromatin organization proteins R-HSA-8940973 RUNX2 regulates osteoblast differentiation
SIGNORⁱ	Q9UPW6

Miscellaneous databases

ChiTaRSⁱ	SATB2 human
EvolutionaryTraceⁱ	Q9UPW6
GeneWikiⁱ	SATB2
GenomeRNAiⁱ	23314
Protein Ontology More...PROⁱ	PR:Q9UPW6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000119042 Expressed in 179 organ(s), highest expression level in neocortex
CleanExⁱ	HS_SATB2
ExpressionAtlasⁱ	Q9UPW6 baseline and differential
Genevisibleⁱ	Q9UPW6 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit cd11585 SATB1_N, 1 hit
Gene3Dⁱ	1.10.260.70, 1 hit 3.10.20.710, 1 hit
InterProⁱ	View protein in InterPro IPR003350 CUT_dom IPR032355 CUTL IPR009057 Homeobox-like_sf IPR001356 Homeobox_dom IPR010982 Lambda_DNA-bd_dom_sf IPR039673 SATB1/SATB2 IPR038216 SATB_CUTL_sf IPR038224 SATB_ULD_sf IPR032392 ULD
PANTHERⁱ	PTHR15116 PTHR15116, 1 hit
Pfamⁱ	View protein in Pfam PF02376 CUT, 2 hits PF16557 CUTL, 1 hit PF00046 Homeobox, 1 hit PF16534 ULD, 1 hit
SMARTⁱ	View protein in SMART SM01109 CUT, 2 hits SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF47413 SSF47413, 2 hits
PROSITEⁱ	View protein in PROSITE PS51042 CUT, 2 hits PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SATB2_HUMAN
Accessionⁱ	Q9UPW6Primary (citable) accession number: Q9UPW6 Secondary accession number(s): A8K5Z8, Q3ZB87, Q4V763
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	April 27, 2001
	Last modified:	November 7, 2018
	This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UPW6 (SATB2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

DNA-binding protein SATB2

SATB2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ