Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA-binding protein SATB2

Gene

SATB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi350 – 437CUT 1PROSITE-ProRule annotationAdd BLAST88
DNA bindingi473 – 560CUT 2PROSITE-ProRule annotationAdd BLAST88
DNA bindingi615 – 674HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Developmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-8940973 RUNX2 regulates osteoblast differentiation
SIGNORiQ9UPW6

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein SATB2
Alternative name(s):
Special AT-rich sequence-binding protein 2
Gene namesi
Name:SATB2
Synonyms:KIAA1034
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000119042.16
HGNCiHGNC:21637 SATB2
MIMi608148 gene
neXtProtiNX_Q9UPW6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11).1 Publication
Cleft palate isolated (CPI)2 Publications
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis.
See also OMIM:119540
A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi233K → R: Reduced sumoylation, impaired nuclear localization, but enhanced transcription factor activity. 1 Publication1
Mutagenesisi350K → R: Reduced sumoylation, impaired nuclear localization, but enhanced transcription factor activity. 1 Publication1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi23314
MalaCardsiSATB2
MIMi119540 phenotype
OpenTargetsiENSG00000119042
Orphaneti251019 2q32q33 microdeletion syndrome
251028 2q33.1 microdeletion syndrome
PharmGKBiPA128394624

Polymorphism and mutation databases

BioMutaiSATB2
DMDMi13634020

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002024001 – 733DNA-binding protein SATB2Add BLAST733

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineCombined sources1
Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki30Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei39PhosphoserineCombined sources1
Cross-linki161Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki233Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)Curated
Cross-linki350Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateCurated
Cross-linki350Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei454PhosphoserineCombined sources1
Modified residuei467PhosphothreonineCombined sources1
Cross-linki475Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei594PhosphoserineCombined sources1
Cross-linki724Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Sumoylated by PIAS1. Sumoylation promotes nuclear localization, but represses transcription factor activity.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9UPW6
PaxDbiQ9UPW6
PeptideAtlasiQ9UPW6
PRIDEiQ9UPW6
ProteomicsDBi85463

PTM databases

iPTMnetiQ9UPW6
PhosphoSitePlusiQ9UPW6

Expressioni

Tissue specificityi

High expression in adult brain, moderate expression in fetal brain, and weak expression in adult liver, kidney, and spinal cord and in select brain regions, including amygdala, corpus callosum, caudate nucleus, and hippocampus.1 Publication

Gene expression databases

BgeeiENSG00000119042 Expressed in 179 organ(s), highest expression level in neocortex
CleanExiHS_SATB2
ExpressionAtlasiQ9UPW6 baseline and differential
GenevisibleiQ9UPW6 HS

Organism-specific databases

HPAiCAB023669
CAB062562
CAB067751
CAB068229
CAB068230
CAB068231
HPA001042
HPA029543

Interactioni

Subunit structurei

Interacts with ATF4 and RUNX2; resulting in enhanced DNA binding and transactivation by these transcription factors (By similarity). Interacts with PIAS1.By similarity1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi116905, 53 interactors
DIPiDIP-60551N
ELMiQ9UPW6
IntActiQ9UPW6, 29 interactors
MINTiQ9UPW6
STRINGi9606.ENSP00000260926

Structurei

Secondary structure

1733
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9UPW6
SMRiQ9UPW6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9UPW6

Family & Domainsi

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiENOG410ISJ9 Eukaryota
ENOG41113K2 LUCA
GeneTreeiENSGT00390000008096
HOGENOMiHOG000004805
HOVERGENiHBG054240
InParanoidiQ9UPW6
OMAiQHVVQLT
OrthoDBiEOG091G02HV
PhylomeDBiQ9UPW6
TreeFamiTF332714

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd11585 SATB1_N, 1 hit
Gene3Di1.10.260.70, 1 hit
3.10.20.710, 1 hit
InterProiView protein in InterPro
IPR003350 CUT_dom
IPR032355 CUTL
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR039673 SATB1/SATB2
IPR038216 SATB_CUTL_sf
IPR038224 SATB_ULD_sf
IPR032392 ULD
PANTHERiPTHR15116 PTHR15116, 1 hit
PfamiView protein in Pfam
PF02376 CUT, 2 hits
PF16557 CUTL, 1 hit
PF00046 Homeobox, 1 hit
PF16534 ULD, 1 hit
SMARTiView protein in SMART
SM01109 CUT, 2 hits
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 2 hits
PROSITEiView protein in PROSITE
PS51042 CUT, 2 hits
PS50071 HOMEOBOX_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPW6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERRSESPCL RDSPDRRSGS PDVKGPPPVK VARLEQNGSP MGARGRPNGA
60 70 80 90 100
VAKAVGGLMI PVFCVVEQLD GSLEYDNREE HAEFVLVRKD VLFSQLVETA
110 120 130 140 150
LLALGYSHSS AAQAQGIIKL GRWNPLPLSY VTDAPDATVA DMLQDVYHVV
160 170 180 190 200
TLKIQLQSCS KLEDLPAEQW NHATVRNALK ELLKEMNQST LAKECPLSQS
210 220 230 240 250
MISSIVNSTY YANVSATKCQ EFGRWYKKYK KIKVERVERE NLSDYCVLGQ
260 270 280 290 300
RPMHLPNMNQ LASLGKTNEQ SPHSQIHHST PIRNQVPALQ PIMSPGLLSP
310 320 330 340 350
QLSPQLVRQQ IAMAHLINQQ IAVSRLLAHQ HPQAINQQFL NHPPIPRAVK
360 370 380 390 400
PEPTNSSVEV SPDIYQQVRD ELKRASVSQA VFARVAFNRT QGLLSEILRK
410 420 430 440 450
EEDPRTASQS LLVNLRAMQN FLNLPEVERD RIYQDERERS MNPNVSMVSS
460 470 480 490 500
ASSSPSSSRT PQAKTSTPTT DLPIKVDGAN INITAAIYDE IQQEMKRAKV
510 520 530 540 550
SQALFAKVAA NKSQGWLCEL LRWKENPSPE NRTLWENLCT IRRFLNLPQH
560 570 580 590 600
ERDVIYEEES RHHHSERMQH VVQLPPEPVQ VLHRQQSQPA KESSPPREEA
610 620 630 640 650
PPPPPPTEDS CAKKPRSRTK ISLEALGILQ SFIHDVGLYP DQEAIHTLSA
660 670 680 690 700
QLDLPKHTII KFFQNQRYHV KHHGKLKEHL GSAVDVAEYK DEELLTESEE
710 720 730
NDSEEGSEEM YKVEAEEENA DKSKAAPAEI DQR
Length:733
Mass (Da):82,555
Last modified:April 27, 2001 - v2
Checksum:i1FE1FCBD34F11E9E
GO
Isoform 2 (identifier: Q9UPW6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-233: Missing.

Note: No experimental confirmation available.
Show »
Length:615
Mass (Da):69,137
Checksum:i8A4F3998CF207015
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JR56C9JR56_HUMAN
DNA-binding protein SATB
SATB2
674Annotation score:
F8WCV6F8WCV6_HUMAN
DNA-binding protein SATB2
SATB2
126Annotation score:

Sequence cautioni

The sequence BAA82986 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059320263S → P. Corresponds to variant dbSNP:rs12619995Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054416116 – 233Missing in isoform 2. 1 PublicationAdd BLAST118

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028957 mRNA Translation: BAA82986.1 Different initiation.
AK291463 mRNA Translation: BAF84152.1
AC016746 Genomic DNA No translation available.
AC017096 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70180.1
BC098136 mRNA Translation: AAH98136.1
BC099723 mRNA Translation: AAH99723.1
BC103492 mRNA Translation: AAI03493.1
BC103500 mRNA Translation: AAI03501.1
CCDSiCCDS2327.1 [Q9UPW6-1]
RefSeqiNP_001165980.1, NM_001172509.1 [Q9UPW6-1]
NP_001165988.1, NM_001172517.1 [Q9UPW6-1]
NP_056080.1, NM_015265.3 [Q9UPW6-1]
XP_006712435.1, XM_006712372.2
XP_011509142.1, XM_011510840.2 [Q9UPW6-1]
UniGeneiHs.516617

Genome annotation databases

EnsembliENST00000260926; ENSP00000260926; ENSG00000119042 [Q9UPW6-1]
ENST00000417098; ENSP00000401112; ENSG00000119042 [Q9UPW6-1]
ENST00000428695; ENSP00000388581; ENSG00000119042 [Q9UPW6-2]
ENST00000457245; ENSP00000405420; ENSG00000119042 [Q9UPW6-1]
ENST00000614512; ENSP00000483287; ENSG00000119042 [Q9UPW6-2]
GeneIDi23314
KEGGihsa:23314
UCSCiuc002uuy.2 human [Q9UPW6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028957 mRNA Translation: BAA82986.1 Different initiation.
AK291463 mRNA Translation: BAF84152.1
AC016746 Genomic DNA No translation available.
AC017096 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70180.1
BC098136 mRNA Translation: AAH98136.1
BC099723 mRNA Translation: AAH99723.1
BC103492 mRNA Translation: AAI03493.1
BC103500 mRNA Translation: AAI03501.1
CCDSiCCDS2327.1 [Q9UPW6-1]
RefSeqiNP_001165980.1, NM_001172509.1 [Q9UPW6-1]
NP_001165988.1, NM_001172517.1 [Q9UPW6-1]
NP_056080.1, NM_015265.3 [Q9UPW6-1]
XP_006712435.1, XM_006712372.2
XP_011509142.1, XM_011510840.2 [Q9UPW6-1]
UniGeneiHs.516617

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WI3NMR-A615-672[»]
1WIZNMR-A350-437[»]
2CSFNMR-A473-560[»]
ProteinModelPortaliQ9UPW6
SMRiQ9UPW6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116905, 53 interactors
DIPiDIP-60551N
ELMiQ9UPW6
IntActiQ9UPW6, 29 interactors
MINTiQ9UPW6
STRINGi9606.ENSP00000260926

PTM databases

iPTMnetiQ9UPW6
PhosphoSitePlusiQ9UPW6

Polymorphism and mutation databases

BioMutaiSATB2
DMDMi13634020

Proteomic databases

EPDiQ9UPW6
PaxDbiQ9UPW6
PeptideAtlasiQ9UPW6
PRIDEiQ9UPW6
ProteomicsDBi85463

Protocols and materials databases

DNASUi23314
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260926; ENSP00000260926; ENSG00000119042 [Q9UPW6-1]
ENST00000417098; ENSP00000401112; ENSG00000119042 [Q9UPW6-1]
ENST00000428695; ENSP00000388581; ENSG00000119042 [Q9UPW6-2]
ENST00000457245; ENSP00000405420; ENSG00000119042 [Q9UPW6-1]
ENST00000614512; ENSP00000483287; ENSG00000119042 [Q9UPW6-2]
GeneIDi23314
KEGGihsa:23314
UCSCiuc002uuy.2 human [Q9UPW6-1]

Organism-specific databases

CTDi23314
DisGeNETi23314
EuPathDBiHostDB:ENSG00000119042.16
GeneCardsiSATB2
HGNCiHGNC:21637 SATB2
HPAiCAB023669
CAB062562
CAB067751
CAB068229
CAB068230
CAB068231
HPA001042
HPA029543
MalaCardsiSATB2
MIMi119540 phenotype
608148 gene
neXtProtiNX_Q9UPW6
OpenTargetsiENSG00000119042
Orphaneti251019 2q32q33 microdeletion syndrome
251028 2q33.1 microdeletion syndrome
PharmGKBiPA128394624
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISJ9 Eukaryota
ENOG41113K2 LUCA
GeneTreeiENSGT00390000008096
HOGENOMiHOG000004805
HOVERGENiHBG054240
InParanoidiQ9UPW6
OMAiQHVVQLT
OrthoDBiEOG091G02HV
PhylomeDBiQ9UPW6
TreeFamiTF332714

Enzyme and pathway databases

ReactomeiR-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-8940973 RUNX2 regulates osteoblast differentiation
SIGNORiQ9UPW6

Miscellaneous databases

ChiTaRSiSATB2 human
EvolutionaryTraceiQ9UPW6
GeneWikiiSATB2
GenomeRNAii23314
PROiPR:Q9UPW6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119042 Expressed in 179 organ(s), highest expression level in neocortex
CleanExiHS_SATB2
ExpressionAtlasiQ9UPW6 baseline and differential
GenevisibleiQ9UPW6 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd11585 SATB1_N, 1 hit
Gene3Di1.10.260.70, 1 hit
3.10.20.710, 1 hit
InterProiView protein in InterPro
IPR003350 CUT_dom
IPR032355 CUTL
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR039673 SATB1/SATB2
IPR038216 SATB_CUTL_sf
IPR038224 SATB_ULD_sf
IPR032392 ULD
PANTHERiPTHR15116 PTHR15116, 1 hit
PfamiView protein in Pfam
PF02376 CUT, 2 hits
PF16557 CUTL, 1 hit
PF00046 Homeobox, 1 hit
PF16534 ULD, 1 hit
SMARTiView protein in SMART
SM01109 CUT, 2 hits
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 2 hits
PROSITEiView protein in PROSITE
PS51042 CUT, 2 hits
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSATB2_HUMAN
AccessioniPrimary (citable) accession number: Q9UPW6
Secondary accession number(s): A8K5Z8, Q3ZB87, Q4V763
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 7, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again