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Protein

Forkhead box protein J3

Gene

FOXJ3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi77 – 168Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein J3
Gene namesi
Name:FOXJ3
Synonyms:KIAA1041
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000198815.8
HGNCiHGNC:29178 FOXJ3
MIMi616035 gene
neXtProtiNX_Q9UPW0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22887
OpenTargetsiENSG00000198815
PharmGKBiPA134945417

Polymorphism and mutation databases

BioMutaiFOXJ3
DMDMi296434510

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918551 – 622Forkhead box protein J3Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei223PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei489PhosphoserineCombined sources1
Modified residuei606PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UPW0
PaxDbiQ9UPW0
PeptideAtlasiQ9UPW0
PRIDEiQ9UPW0
ProteomicsDBi85458
85459 [Q9UPW0-2]

PTM databases

iPTMnetiQ9UPW0
PhosphoSitePlusiQ9UPW0

Expressioni

Gene expression databases

BgeeiENSG00000198815
CleanExiHS_FOXJ3
ExpressionAtlasiQ9UPW0 baseline and differential
GenevisibleiQ9UPW0 HS

Organism-specific databases

HPAiHPA067284

Interactioni

Protein-protein interaction databases

BioGridi116553, 17 interactors
IntActiQ9UPW0, 13 interactors
MINTiQ9UPW0
STRINGi9606.ENSP00000354620

Structurei

3D structure databases

ProteinModelPortaliQ9UPW0
SMRiQ9UPW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00920000148974
HOGENOMiHOG000231184
HOVERGENiHBG051648
InParanoidiQ9UPW0
KOiK09403
OMAiAGHHGAM
OrthoDBiEOG091G0U7S
PhylomeDBiQ9UPW0
TreeFamiTF333250

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9UPW0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLYGQACPS VTSLRMTSEL ESSLTSMDWL PQLTMRAAIQ KSDATQNAHG
60 70 80 90 100
TGISKKNALL DPNTTLDQEE VQQHKDGKPP YSYASLITFA INSSPKKKMT
110 120 130 140 150
LSEIYQWICD NFPYYREAGS GWKNSIRHNL SLNKCFLKVP RSKDDPGKGS
160 170 180 190 200
YWAIDTNPKE DVLPTRPKKR ARSVERASTP YSIDSDSLGM ECIISGSASP
210 220 230 240 250
TLAINTVTNK VTLYNTDQDG SDSPRSSLNN SLSDQSLASV NLNSVGSVHS
260 270 280 290 300
YTPVTSHPES VSQSLTPQQQ PQYNLPERDK QLLFSEYNFE DLSASFRSLY
310 320 330 340 350
KSVFEQSLSQ QGLMNIPSES SQQSHTSCTY QHSPSSTVST HPHSNQSSLS
360 370 380 390 400
NSHGSGLNTT GSNSVAQVSL SHPQMHTQPS PHPPHRPHGL PQHPQRSPHP
410 420 430 440 450
APHPQQHSQL QSPHPQHPSP HQHIQHHPNH QHQTLTHQAP PPPQQVSCNS
460 470 480 490 500
GVSNDWYATL DMLKESCRIA SSVNWSDVDL SQFQGLMESM RQADLKNWSL
510 520 530 540 550
DQVQFADLCS SLNQFFTQTG LIHSQSNVQQ NVCHGAMHPT KPSQHIGTGN
560 570 580 590 600
LYIDSRQNLP PSVMPPPGYP HIPQALSTPG TTMAGHHRAM NQQHMMPSQA
610 620
FQMRRSLPPD DIQDDFDWDS IV
Length:622
Mass (Da):68,960
Last modified:May 18, 2010 - v2
Checksum:i2C53E63C76AF057B
GO
Isoform 2 (identifier: Q9UPW0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-210: Missing.

Show »
Length:588
Mass (Da):65,533
Checksum:i73DC52B528BC4CDC
GO

Sequence cautioni

The sequence BAA82993 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti485G → GG in CAB75651 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039104162V → A2 PublicationsCorresponds to variant dbSNP:rs343376Ensembl.1
Natural variantiVAR_039105377T → P2 PublicationsCorresponds to variant dbSNP:rs1139978Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010367177 – 210Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028964 mRNA Translation: BAA82993.2 Different initiation.
AC096540 Genomic DNA No translation available.
AC114492 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07162.1
CH471059 Genomic DNA Translation: EAX07163.1
CH471059 Genomic DNA Translation: EAX07164.1
CH471059 Genomic DNA Translation: EAX07165.1
BC014182 mRNA Translation: AAH14182.1
BC151828 mRNA Translation: AAI51829.1
BC152441 mRNA Translation: AAI52442.1
AL157422 mRNA Translation: CAB75651.2
CCDSiCCDS30689.1 [Q9UPW0-1]
CCDS55594.1 [Q9UPW0-2]
PIRiT46900
RefSeqiNP_001185779.1, NM_001198850.1 [Q9UPW0-1]
NP_001185780.1, NM_001198851.1 [Q9UPW0-1]
NP_001185781.1, NM_001198852.1 [Q9UPW0-2]
NP_055762.3, NM_014947.4 [Q9UPW0-1]
XP_011539328.1, XM_011541026.2 [Q9UPW0-1]
UniGeneiHs.26023

Genome annotation databases

EnsembliENST00000361346; ENSP00000354620; ENSG00000198815 [Q9UPW0-1]
ENST00000361776; ENSP00000354449; ENSG00000198815 [Q9UPW0-2]
ENST00000372572; ENSP00000361653; ENSG00000198815 [Q9UPW0-1]
ENST00000372573; ENSP00000361654; ENSG00000198815 [Q9UPW0-1]
ENST00000545068; ENSP00000439044; ENSG00000198815 [Q9UPW0-1]
GeneIDi22887
KEGGihsa:22887
UCSCiuc001che.3 human [Q9UPW0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFOXJ3_HUMAN
AccessioniPrimary (citable) accession number: Q9UPW0
Secondary accession number(s): A7MBL7
, A7MD18, D3DPW2, Q9NSS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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