UniProtKB - Q9UPV9 (TRAK1_HUMAN)
Trafficking kinesin-binding protein 1
TRAK1
Functioni
Miscellaneous
GO - Molecular functioni
- GABA receptor binding Source: GO_Central
- myosin binding Source: GO_Central
- signaling receptor binding Source: GO_Central
GO - Biological processi
- anterograde axonal transport Source: GO_Central
- anterograde axonal transport of mitochondrion Source: GO_Central
- endosome to lysosome transport Source: UniProtKB
- mitochondrion distribution Source: GO_Central
- neurogenesis Source: GO_Central
- protein localization Source: GO_Central
- protein O-linked glycosylation Source: UniProtKB
- protein targeting Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: UniProtKB
- vesicle transport along microtubule Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9UPV9 |
Reactomei | R-HSA-6802952, Signaling by BRAF and RAF fusions |
Names & Taxonomyi
Protein namesi | Recommended name: Trafficking kinesin-binding protein 1Alternative name(s): 106 kDa O-GlcNAc transferase-interacting protein Protein Milton1 Publication |
Gene namesi | Name:TRAK1 Synonyms:KIAA1042, OIP106 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29947, TRAK1 |
MIMi | 608112, gene |
neXtProti | NX_Q9UPV9 |
VEuPathDBi | HostDB:ENSG00000182606.14 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Mitochondrion
- Mitochondrion 4 Publications
- Mitochondrion membrane 1 Publication
Endosome
- Early endosome 1 Publication
- Endosome 1 Publication
Other locations
- Cytoplasm 1 Publication
- cell cortex By similarity
Note: Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HGS/HRS (PubMed:18675823). Colocalizes with MGARP at the mitochondria (PubMed:19528298).2 Publications
Endosome
- early endosome Source: UniProtKB
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
- mitochondrion Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- axon cytoplasm Source: GOC
- cell cortex Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
- cytoplasmic vesicle Source: GO_Central
- dendrite Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Endosome, Membrane, Mitochondrion, NucleusPathology & Biotechi
Involvement in diseasei
Epileptic encephalopathy, early infantile, 68 (EIEE68)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081639 | 329 | L → P in EIEE68; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs770281448EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 447 | S → A: Reduced O-glycosylation of this protein. 1 Publication | 1 | |
Mutagenesisi | 658 – 672 | Missing : Loss of interaction with OGT, but interacts with KIF5B and RHOT1/2 and is able to localize to mitochondria. Increased O-glycosylation of this protein by OGT. 1 PublicationAdd BLAST | 15 | |
Mutagenesisi | 829 | S → A: Reduced O-glycosylation of this protein; when associated with A-830. 1 Publication | 1 | |
Mutagenesisi | 830 | S → A: Reduced O-glycosylation of this protein; when associated with A-829. 1 Publication | 1 | |
Mutagenesisi | 938 | S → A: Reduced O-glycosylation of this protein. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, EpilepsyOrganism-specific databases
DisGeNETi | 22906 |
MalaCardsi | TRAK1 |
MIMi | 618201, phenotype |
OpenTargetsi | ENSG00000182606 |
Orphaneti | 442835, Undetermined early-onset epileptic encephalopathy |
PharmGKBi | PA128394593 |
Miscellaneous databases
Pharosi | Q9UPV9, Tbio |
Genetic variation databases
BioMutai | TRAK1 |
DMDMi | 13124654 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058037 | 1 – 953 | Trafficking kinesin-binding protein 1Add BLAST | 953 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 447 | O-linked (GlcNAc) serine1 Publication | 1 | |
Modified residuei | 537 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 680 | O-linked (GlcNAc) serine1 Publication | 1 | |
Modified residuei | 719 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 719 | O-linked (GlcNAc) serine1 Publication | 1 | |
Modified residuei | 919 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 935 | O-linked (GlcNAc) threonine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9UPV9 |
jPOSTi | Q9UPV9 |
MassIVEi | Q9UPV9 |
PaxDbi | Q9UPV9 |
PeptideAtlasi | Q9UPV9 |
PRIDEi | Q9UPV9 |
ProteomicsDBi | 19736 85456 [Q9UPV9-1] 85457 [Q9UPV9-2] |
PTM databases
GlyGeni | Q9UPV9, 4 sites |
iPTMneti | Q9UPV9 |
PhosphoSitePlusi | Q9UPV9 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000182606, Expressed in secondary oocyte and 247 other tissues |
ExpressionAtlasi | Q9UPV9, baseline and differential |
Genevisiblei | Q9UPV9, HS |
Organism-specific databases
HPAi | ENSG00000182606, Tissue enhanced (heart muscle, skeletal muscle) |
Interactioni
Subunit structurei
Interacts with RHOT1 and RHOT2 (PubMed:16630562).
Found in a complex with KIF5B, OGT, RHOT1 and RHOT2 (PubMed:24995978).
Interacts with HGS (PubMed:18675823).
Interacts with GABRA1 (By similarity).
Interacts with KIF5C (PubMed:15644324).
Interacts with OGT; stable interaction is not required for glycosylation of this protein by OGT.
Isoform 1 interacts with OGT (PubMed:24995978, PubMed:12435728).
By similarity5 PublicationsBinary interactionsi
Hide detailsQ9UPV9
GO - Molecular functioni
- GABA receptor binding Source: GO_Central
- myosin binding Source: GO_Central
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 116570, 22 interactors |
CORUMi | Q9UPV9 |
IntActi | Q9UPV9, 18 interactors |
MINTi | Q9UPV9 |
STRINGi | 9606.ENSP00000328998 |
Miscellaneous databases
RNActi | Q9UPV9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 354 | HAP1 N-terminalAdd BLAST | 308 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 359 – 509 | Interaction with HGS1 PublicationAdd BLAST | 151 | |
Regioni | 658 – 672 | Interaction with OGT1 PublicationAdd BLAST | 15 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 104 – 356 | Sequence analysisAdd BLAST | 253 | |
Coiled coili | 492 – 532 | Sequence analysisAdd BLAST | 41 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 200 – 203 | Poly-Ser | 4 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4360, Eukaryota |
GeneTreei | ENSGT00940000155697 |
HOGENOMi | CLU_013450_0_0_1 |
InParanoidi | Q9UPV9 |
OMAi | RRTFSYE |
OrthoDBi | 1003820at2759 |
PhylomeDBi | Q9UPV9 |
TreeFami | TF323495 |
Family and domain databases
InterProi | View protein in InterPro IPR006933, HAP1_N IPR022154, TRAK1/2_C |
Pfami | View protein in Pfam PF04849, HAP1_N, 1 hit PF12448, Milton, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALVFQFGQP VRAQPLPGLC HGKLIRTNAC DVCNSTDLPE VEIISLLEEQ
60 70 80 90 100
LPHYKLRADT IYGYDHDDWL HTPLISPDAN IDLTTEQIEE TLKYFLLCAE
110 120 130 140 150
RVGQMTKTYN DIDAVTRLLE EKERDLELAA RIGQSLLKKN KTLTERNELL
160 170 180 190 200
EEQVEHIREE VSQLRHELSM KDELLQFYTS AAEESEPESV CSTPLKRNES
210 220 230 240 250
SSSVQNYFHL DSLQKKLKDL EEENVVLRSE ASQLKTETIT YEEKEQQLVN
260 270 280 290 300
DCVKELRDAN VQIASISEEL AKKTEDAARQ QEEITHLLSQ IVDLQKKAKA
310 320 330 340 350
CAVENEELVQ HLGAAKDAQR QLTAELRELE DKYAECMEML HEAQEELKNL
360 370 380 390 400
RNKTMPNTTS RRYHSLGLFP MDSLAAEIEG TMRKELQLEE AESPDITHQK
410 420 430 440 450
RVFETVRNIN QVVKQRSLTP SPMNIPGSNQ SSAMNSLLSS CVSTPRSSFY
460 470 480 490 500
GSDIGNVVLD NKTNSIILET EAADLGNDER SKKPGTPGTP GSHDLETALR
510 520 530 540 550
RLSLRRENYL SERRFFEEEQ ERKLQELAEK GELRSGSLTP TESIMSLGTH
560 570 580 590 600
SRFSEFTGFS GMSFSSRSYL PEKLQIVKPL EGSATLHHWQ QLAQPHLGGI
610 620 630 640 650
LDPRPGVVTK GFRTLDVDLD EVYCLNDFEE DDTGDHISLP RLATSTPVQH
660 670 680 690 700
PETSAHHPGK CMSQTNSTFT FTTCRILHPS DELTRVTPSL NSAPTPACGS
710 720 730 740 750
TSHLKSTPVA TPCTPRRLSL AESFTNTRES TTTMSTSLGL VWLLKERGIS
760 770 780 790 800
AAVYDPQSWD RAGRGSLLHS YTPKMAVIPS TPPNSPMQTP TSSPPSFEFK
810 820 830 840 850
CTSPPYDNFL ASKPASSILR EVREKNVRSS ESQTDVSVSN LNLVDKVRRF
860 870 880 890 900
GVAKVVNSGR AHVPTLTEEQ GPLLCGPPGP APALVPRGLV PEGLPLRCPT
910 920 930 940 950
VTSAIGGLQL NSGIRRNRSF PTMVGSSMQM KAPVTLTSGI LMGAKLSKQT
SLR
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F9ZI06 | A0A5F9ZI06_HUMAN | Trafficking kinesin-binding protein... | TRAK1 | 981 | Annotation score: | ||
A0A087X0N0 | A0A087X0N0_HUMAN | Trafficking kinesin-binding protein... | TRAK1 | 670 | Annotation score: | ||
C9JC32 | C9JC32_HUMAN | Trafficking kinesin-binding protein... | TRAK1 hCG_2000014 | 895 | Annotation score: | ||
H7C3T3 | H7C3T3_HUMAN | Trafficking kinesin-binding protein... | TRAK1 | 300 | Annotation score: | ||
A0A0D9SFL5 | A0A0D9SFL5_HUMAN | Trafficking kinesin-binding protein... | TRAK1 | 849 | Annotation score: | ||
A0A0D9SGH2 | A0A0D9SGH2_HUMAN | Trafficking kinesin-binding protein... | TRAK1 | 526 | Annotation score: | ||
A0A5F9ZH95 | A0A5F9ZH95_HUMAN | Trafficking kinesin-binding protein... | TRAK1 | 608 | Annotation score: | ||
F8WDH2 | F8WDH2_HUMAN | Trafficking kinesin-binding protein... | TRAK1 | 44 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 503 | S → P in CAH56169 (PubMed:17974005).Curated | 1 | ||
Sequence conflicti | 638 | S → F in CAH56169 (PubMed:17974005).Curated | 1 | ||
Isoform 2 (identifier: Q9UPV9-2) | |||||
Sequence conflicti | 631 | E → EE in CAH56169 (PubMed:17974005).Curated | 1 | ||
Sequence conflicti | 631 | E → EEE in AAH15922 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081639 | 329 | L → P in EIEE68; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs770281448EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045558 | 1 – 97 | MALVF…KYFLL → MQKFIEADYYELDWYYEECS DVL in isoform 3. 1 PublicationAdd BLAST | 97 | |
Alternative sequenceiVSP_010839 | 1 – 96 | MALVF…LKYFL → MSLRDKGGEEECFEYDCQDE ERKPTHRQHDTQDLLEEV in isoform 2. 2 PublicationsAdd BLAST | 96 | |
Alternative sequenceiVSP_045559 | 583 – 630 | SATLH…NDFEE → DHAGPRPLSVLLGDSLWSLI HLRKAGHLCHAYSFFFRDSH PRCWFEFL in isoform 3. 1 PublicationAdd BLAST | 48 | |
Alternative sequenceiVSP_045560 | 631 – 953 | Missing in isoform 3. 1 PublicationAdd BLAST | 323 | |
Alternative sequenceiVSP_010840 | 655 – 744 | AHHPG…LVWLL → GERSQARVTVSGSRSYPSRP QASPEEMQEPPAATEEEEEE EEEEGSGEGTTISPVNLAPF PEAEFWAILTSVPGTIRSGS LSVASARLCG in isoform 2. 2 PublicationsAdd BLAST | 90 | |
Alternative sequenceiVSP_010841 | 745 – 953 | Missing in isoform 2. 2 PublicationsAdd BLAST | 209 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB028965 mRNA Translation: BAA82994.2 Different initiation. BX647199 mRNA Translation: CAH56169.1 AL713787 mRNA Translation: CAH56394.1 AC018358 Genomic DNA No translation available. AC093414 Genomic DNA No translation available. AC137935 Genomic DNA No translation available. BC015922 mRNA Translation: AAH15922.1 |
CCDSi | CCDS2695.1 [Q9UPV9-2] CCDS43072.1 [Q9UPV9-1] CCDS58826.1 [Q9UPV9-3] |
RefSeqi | NP_001036111.1, NM_001042646.2 [Q9UPV9-1] NP_001252537.1, NM_001265608.1 NP_001252539.1, NM_001265610.1 [Q9UPV9-3] NP_055780.2, NM_014965.4 [Q9UPV9-2] |
Genome annotation databases
Ensembli | ENST00000327628; ENSP00000328998; ENSG00000182606 [Q9UPV9-1] ENST00000341421; ENSP00000340702; ENSG00000182606 [Q9UPV9-2] ENST00000449246; ENSP00000410717; ENSG00000182606 [Q9UPV9-3] |
GeneIDi | 22906 |
KEGGi | hsa:22906 |
UCSCi | uc003cky.5, human [Q9UPV9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB028965 mRNA Translation: BAA82994.2 Different initiation. BX647199 mRNA Translation: CAH56169.1 AL713787 mRNA Translation: CAH56394.1 AC018358 Genomic DNA No translation available. AC093414 Genomic DNA No translation available. AC137935 Genomic DNA No translation available. BC015922 mRNA Translation: AAH15922.1 |
CCDSi | CCDS2695.1 [Q9UPV9-2] CCDS43072.1 [Q9UPV9-1] CCDS58826.1 [Q9UPV9-3] |
RefSeqi | NP_001036111.1, NM_001042646.2 [Q9UPV9-1] NP_001252537.1, NM_001265608.1 NP_001252539.1, NM_001265610.1 [Q9UPV9-3] NP_055780.2, NM_014965.4 [Q9UPV9-2] |
3D structure databases
SMRi | Q9UPV9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116570, 22 interactors |
CORUMi | Q9UPV9 |
IntActi | Q9UPV9, 18 interactors |
MINTi | Q9UPV9 |
STRINGi | 9606.ENSP00000328998 |
PTM databases
GlyGeni | Q9UPV9, 4 sites |
iPTMneti | Q9UPV9 |
PhosphoSitePlusi | Q9UPV9 |
Genetic variation databases
BioMutai | TRAK1 |
DMDMi | 13124654 |
Proteomic databases
EPDi | Q9UPV9 |
jPOSTi | Q9UPV9 |
MassIVEi | Q9UPV9 |
PaxDbi | Q9UPV9 |
PeptideAtlasi | Q9UPV9 |
PRIDEi | Q9UPV9 |
ProteomicsDBi | 19736 85456 [Q9UPV9-1] 85457 [Q9UPV9-2] |
Protocols and materials databases
ABCDi | Q9UPV9, 1 sequenced antibody |
Antibodypediai | 1603, 185 antibodies |
DNASUi | 22906 |
Genome annotation databases
Ensembli | ENST00000327628; ENSP00000328998; ENSG00000182606 [Q9UPV9-1] ENST00000341421; ENSP00000340702; ENSG00000182606 [Q9UPV9-2] ENST00000449246; ENSP00000410717; ENSG00000182606 [Q9UPV9-3] |
GeneIDi | 22906 |
KEGGi | hsa:22906 |
UCSCi | uc003cky.5, human [Q9UPV9-1] |
Organism-specific databases
CTDi | 22906 |
DisGeNETi | 22906 |
GeneCardsi | TRAK1 |
HGNCi | HGNC:29947, TRAK1 |
HPAi | ENSG00000182606, Tissue enhanced (heart muscle, skeletal muscle) |
MalaCardsi | TRAK1 |
MIMi | 608112, gene 618201, phenotype |
neXtProti | NX_Q9UPV9 |
OpenTargetsi | ENSG00000182606 |
Orphaneti | 442835, Undetermined early-onset epileptic encephalopathy |
PharmGKBi | PA128394593 |
VEuPathDBi | HostDB:ENSG00000182606.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4360, Eukaryota |
GeneTreei | ENSGT00940000155697 |
HOGENOMi | CLU_013450_0_0_1 |
InParanoidi | Q9UPV9 |
OMAi | RRTFSYE |
OrthoDBi | 1003820at2759 |
PhylomeDBi | Q9UPV9 |
TreeFami | TF323495 |
Enzyme and pathway databases
PathwayCommonsi | Q9UPV9 |
Reactomei | R-HSA-6802952, Signaling by BRAF and RAF fusions |
Miscellaneous databases
BioGRID-ORCSi | 22906, 5 hits in 877 CRISPR screens |
ChiTaRSi | TRAK1, human |
GeneWikii | TRAK1 |
GenomeRNAii | 22906 |
Pharosi | Q9UPV9, Tbio |
PROi | PR:Q9UPV9 |
RNActi | Q9UPV9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182606, Expressed in secondary oocyte and 247 other tissues |
ExpressionAtlasi | Q9UPV9, baseline and differential |
Genevisiblei | Q9UPV9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006933, HAP1_N IPR022154, TRAK1/2_C |
Pfami | View protein in Pfam PF04849, HAP1_N, 1 hit PF12448, Milton, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRAK1_HUMAN | |
Accessioni | Q9UPV9Primary (citable) accession number: Q9UPV9 Secondary accession number(s): E9PDS2 Q96B69 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants