UniProtKB - Q9UPV9 (TRAK1_HUMAN)

BLAST

>sp|Q9UPV9|TRAK1_HUMAN Trafficking kinesin-binding protein 1 OS=Homo sapiens OX=9606 GN=TRAK1 PE=1 SV=1
MALVFQFGQPVRAQPLPGLCHGKLIRTNACDVCNSTDLPEVEIISLLEEQLPHYKLRADT
IYGYDHDDWLHTPLISPDANIDLTTEQIEETLKYFLLCAERVGQMTKTYNDIDAVTRLLE
EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS
AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT
YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA
CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS
RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTP
SPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDER
SKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSLTP
TESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLGGI
LDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSAHHPGK
CMSQTNSTFTFTTCRILHPSDELTRVTPSLNSAPTPACGSTSHLKSTPVATPCTPRRLSL
AESFTNTRESTTTMSTSLGLVWLLKERGISAAVYDPQSWDRAGRGSLLHSYTPKMAVIPS
TPPNSPMQTPTSSPPSFEFKCTSPPYDNFLASKPASSILREVREKNVRSSESQTDVSVSN
LNLVDKVRRFGVAKVVNSGRAHVPTLTEEQGPLLCGPPGPAPALVPRGLVPEGLPLRCPT
VTSAIGGLQLNSGIRRNRSFPTMVGSSMQMKAPVTLTSGILMGAKLSKQTSLR

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History
Entry version 146 (07 Nov 2018)
Sequence version 1 (01 May 2000)
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Protein

Trafficking kinesin-binding protein 1

Gene

TRAK1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity).By similarity2 Publications

Miscellaneous

Over-expressed in all investigated carcinomas, especially in gastric adenocarcinoma and signet-ring carcinoma and may serve as a marker of gastric cancer.

GO - Molecular functionⁱ

GABA receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
myosin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signaling receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
TPR domain binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterograde axonal transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
anterograde axonal transport of mitochondrion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
dendrite morphogenesis Source: Ensembl
endosome to lysosome transport
Source: UniProtKB
Inferred from direct assayⁱ
- 18675823
mitochondrion distribution
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neurogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of axonogenesis Source: Ensembl
protein localization
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein O-linked glycosylation Source: UniProtKB
protein targeting Source: UniProtKB
regulation of transcription by RNA polymerase II Source: UniProtKB
vesicle transport along microtubule
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6802952 Signaling by BRAF and RAF fusions

Reactomeⁱ

R-HSA-6802952 Signaling by BRAF and RAF fusions

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Trafficking kinesin-binding protein 1 Alternative name(s): 106 kDa O-GlcNAc transferase-interacting protein Protein Milton1 Publication
Gene namesⁱ	Name:TRAK1 Synonyms:KIAA1042, OIP106
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000182606.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29947 TRAK1
MIMⁱ	608112 gene
neXtProtⁱ	NX_Q9UPV9

Keywords - Cellular componentⁱ

Cytoplasm, Endosome, Membrane, Mitochondrion, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	447	S → A: Reduced O-glycosylation of this protein. 1 Publication	1
Mutagenesisⁱ	658 – 672	Missing : Loss of interaction with OGT, but interacts with KIF5B and RHOT1/2 and is able to localize to mitochondria. Increased O-glycosylation of this protein by OGT. 1 PublicationAdd BLAST	15
Mutagenesisⁱ	829	S → A: Reduced O-glycosylation of this protein; when associated with A-830. 1 Publication	1
Mutagenesisⁱ	830	S → A: Reduced O-glycosylation of this protein; when associated with A-829. 1 Publication	1
Mutagenesisⁱ	938	S → A: Reduced O-glycosylation of this protein. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	22906
MalaCards human disease database More...MalaCardsⁱ	TRAK1
Open Targets More...OpenTargetsⁱ	ENSG00000182606
Orphanetⁱ	442835 Undetermined early-onset epileptic encephalopathy
PharmGKBⁱ	PA128394593

Polymorphism and mutation databases

BioMutaⁱ	TRAK1
DMDMⁱ	13124654

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000058037	1 – 953	Trafficking kinesin-binding protein 1Add BLAST		953

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	447	O-linked (GlcNAc) serine1 Publication	1
Modified residueⁱ	537	PhosphoserineBy similarity	1
Glycosylationⁱ	680	O-linked (GlcNAc) serine1 Publication	1
Modified residueⁱ	719	PhosphoserineBy similarity	1
Glycosylationⁱ	719	O-linked (GlcNAc) serine1 Publication	1
Modified residueⁱ	919	PhosphoserineCombined sources	1
Glycosylationⁱ	935	O-linked (GalNAc) threonine1 Publication	1

Post-translational modificationⁱ

O-glycosylated (PubMed:24995978, PubMed:12435728). Glycosylated by OGT; glycosylation in response to increased extracellular glucose levels is required for and leads to regulation of mitochondrial motility by OGT (PubMed:24995978).2 Publications

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9UPV9
PaxDbⁱ	Q9UPV9
PeptideAtlas More...PeptideAtlasⁱ	Q9UPV9
PRIDEⁱ	Q9UPV9
ProteomicsDBⁱ	85456 85457 [Q9UPV9-2]

PTM databases

iPTMnetⁱ	Q9UPV9
PhosphoSitePlusⁱ	Q9UPV9

Expressionⁱ

Tissue specificityⁱ

High expression in spinal cord and moderate expression in all other tissues and specific brain regions examined. Expressed in all cell lines examined.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000182606 Expressed in 236 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_TRAK1
ExpressionAtlasⁱ	Q9UPV9 baseline and differential
Genevisibleⁱ	Q9UPV9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA005853 HPA011367

HPAⁱ

HPA005853
HPA011367

Interactionⁱ

Subunit structureⁱ

Interacts with RHOT1 and RHOT2 (PubMed:16630562). Found in a complex with KIF5B, OGT, RHOT1 and RHOT2 (PubMed:24995978). Interacts with HGS (PubMed:18675823). Interacts with GABRA1 (By similarity). Interacts with KIF5C (PubMed:15644324). Interacts with OGT; stable interaction is not required for glycosylation of this protein by OGT. Isoform 1 interacts with OGT (PubMed:24995978, PubMed:12435728).By similarity5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Kif5b	Q2PQA9	3	EBI-1105048,EBI-920191	From Rattus norvegicus.
OGT	O15294	3	EBI-1105048,EBI-539828
Ogt	P56558	6	EBI-1105048,EBI-7614183	From Rattus norvegicus.
RHOT1	Q8IXI2	5	EBI-1105048,EBI-1396430
RHOT2	Q8IXI1	3	EBI-1105048,EBI-1396563

GO - Molecular functionⁱ

GABA receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
myosin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signaling receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
TPR domain binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116570, 10 interactors
CORUMⁱ	Q9UPV9
IntActⁱ	Q9UPV9, 16 interactors
Molecular INTeraction database More...MINTⁱ	Q9UPV9
STRINGⁱ	9606.ENSP00000328998

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UPV9
SMRⁱ	Q9UPV9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	47 – 354	HAP1 N-terminalAdd BLAST		308

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	359 – 509	Interaction with HGS1 PublicationAdd BLAST		151
Regionⁱ	658 – 672	Interaction with OGT1 PublicationAdd BLAST		15

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	104 – 356	Sequence analysisAdd BLAST		253
Coiled coilⁱ	492 – 532	Sequence analysisAdd BLAST		41

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	200 – 203	Poly-Ser		4

Domainⁱ

The C-terminal region is required for the early endosomal and mitochondrial localization.

Sequence similaritiesⁱ

Belongs to the milton family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG4360 Eukaryota ENOG410XSWD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003132
HOGENOMⁱ	HOG000143414
HOVERGENⁱ	HBG069248
InParanoidⁱ	Q9UPV9
KEGG Orthology (KO) More...KOⁱ	K15369
OMAⁱ	QRKVNTL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LLD
PhylomeDBⁱ	Q9UPV9
TreeFamⁱ	TF323495

Family and domain databases

InterProⁱ	View protein in InterPro IPR006933 HAP1_N IPR022154 Traffickng_kinesin-bd_prot_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04849 HAP1_N, 1 hit PF12448 Milton, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9UPV9-1) [UniParc]FASTA Add to basket

Also known as: Milton11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MALVFQFGQP VRAQPLPGLC HGKLIRTNAC DVCNSTDLPE VEIISLLEEQ 
        60         70         80         90        100
LPHYKLRADT IYGYDHDDWL HTPLISPDAN IDLTTEQIEE TLKYFLLCAE 
       110        120        130        140        150
RVGQMTKTYN DIDAVTRLLE EKERDLELAA RIGQSLLKKN KTLTERNELL 
       160        170        180        190        200
EEQVEHIREE VSQLRHELSM KDELLQFYTS AAEESEPESV CSTPLKRNES 
       210        220        230        240        250
SSSVQNYFHL DSLQKKLKDL EEENVVLRSE ASQLKTETIT YEEKEQQLVN 
       260        270        280        290        300
DCVKELRDAN VQIASISEEL AKKTEDAARQ QEEITHLLSQ IVDLQKKAKA 
       310        320        330        340        350
CAVENEELVQ HLGAAKDAQR QLTAELRELE DKYAECMEML HEAQEELKNL 
       360        370        380        390        400
RNKTMPNTTS RRYHSLGLFP MDSLAAEIEG TMRKELQLEE AESPDITHQK 
       410        420        430        440        450
RVFETVRNIN QVVKQRSLTP SPMNIPGSNQ SSAMNSLLSS CVSTPRSSFY 
       460        470        480        490        500
GSDIGNVVLD NKTNSIILET EAADLGNDER SKKPGTPGTP GSHDLETALR 
       510        520        530        540        550
RLSLRRENYL SERRFFEEEQ ERKLQELAEK GELRSGSLTP TESIMSLGTH 
       560        570        580        590        600
SRFSEFTGFS GMSFSSRSYL PEKLQIVKPL EGSATLHHWQ QLAQPHLGGI 
       610        620        630        640        650
LDPRPGVVTK GFRTLDVDLD EVYCLNDFEE DDTGDHISLP RLATSTPVQH 
       660        670        680        690        700
PETSAHHPGK CMSQTNSTFT FTTCRILHPS DELTRVTPSL NSAPTPACGS 
       710        720        730        740        750
TSHLKSTPVA TPCTPRRLSL AESFTNTRES TTTMSTSLGL VWLLKERGIS 
       760        770        780        790        800
AAVYDPQSWD RAGRGSLLHS YTPKMAVIPS TPPNSPMQTP TSSPPSFEFK 
       810        820        830        840        850
CTSPPYDNFL ASKPASSILR EVREKNVRSS ESQTDVSVSN LNLVDKVRRF 
       860        870        880        890        900
GVAKVVNSGR AHVPTLTEEQ GPLLCGPPGP APALVPRGLV PEGLPLRCPT 
       910        920        930        940        950
VTSAIGGLQL NSGIRRNRSF PTMVGSSMQM KAPVTLTSGI LMGAKLSKQT 

SLR

Length:953

Mass (Da):106,040

Last modified:May 1, 2000 - v1

Checksum:ⁱE834BE07CF41D9A4

Isoform 2 (identifier: Q9UPV9-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: MALVFQFGQP...QIEETLKYFL → MSLRDKGGEE...HDTQDLLEEV
     655-744: AHHPGKCMSQ...STSLGLVWLL → GERSQARVTV...LSVASARLCG
     745-953: Missing.

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        10         20         30         40         50
MSLRDKGGEE ECFEYDCQDE ERKPTHRQHD TQDLLEEVLC AERVGQMTKT 
        60         70         80         90        100
YNDIDAVTRL LEEKERDLEL AARIGQSLLK KNKTLTERNE LLEEQVEHIR 
       110        120        130        140        150
EEVSQLRHEL SMKDELLQFY TSAAEESEPE SVCSTPLKRN ESSSSVQNYF 
       160        170        180        190        200
HLDSLQKKLK DLEEENVVLR SEASQLKTET ITYEEKEQQL VNDCVKELRD 
       210        220        230        240        250
ANVQIASISE ELAKKTEDAA RQQEEITHLL SQIVDLQKKA KACAVENEEL 
       260        270        280        290        300
VQHLGAAKDA QRQLTAELRE LEDKYAECME MLHEAQEELK NLRNKTMPNT 
       310        320        330        340        350
TSRRYHSLGL FPMDSLAAEI EGTMRKELQL EEAESPDITH QKRVFETVRN 
       360        370        380        390        400
INQVVKQRSL TPSPMNIPGS NQSSAMNSLL SSCVSTPRSS FYGSDIGNVV 
       410        420        430        440        450
LDNKTNSIIL ETEAADLGND ERSKKPGTPG TPGSHDLETA LRRLSLRREN 
       460        470        480        490        500
YLSERRFFEE EQERKLQELA EKGELRSGSL TPTESIMSLG THSRFSEFTG 
       510        520        530        540        550
FSGMSFSSRS YLPEKLQIVK PLEGSATLHH WQQLAQPHLG GILDPRPGVV 
       560        570        580        590        600
TKGFRTLDVD LDEVYCLNDF EEDDTGDHIS LPRLATSTPV QHPETSGERS 
       610        620        630        640        650
QARVTVSGSR SYPSRPQASP EEMQEPPAAT EEEEEEEEEE GSGEGTTISP 
       660        670        680 
VNLAPFPEAE FWAILTSVPG TIRSGSLSVA SARLCG

Show »

Length:686

Mass (Da):77,256

Checksum:ⁱE14EC7B6B460E042

Isoform 3 (identifier: Q9UPV9-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: MALVFQFGQP...IEETLKYFLL → MQKFIEADYYELDWYYEECSDVL
     583-630: SATLHHWQQL...EVYCLNDFEE → DHAGPRPLSV...SHPRCWFEFL
     631-953: Missing.

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        10         20         30         40         50
MQKFIEADYY ELDWYYEECS DVLCAERVGQ MTKTYNDIDA VTRLLEEKER 
        60         70         80         90        100
DLELAARIGQ SLLKKNKTLT ERNELLEEQV EHIREEVSQL RHELSMKDEL 
       110        120        130        140        150
LQFYTSAAEE SEPESVCSTP LKRNESSSSV QNYFHLDSLQ KKLKDLEEEN 
       160        170        180        190        200
VVLRSEASQL KTETITYEEK EQQLVNDCVK ELRDANVQIA SISEELAKKT 
       210        220        230        240        250
EDAARQQEEI THLLSQIVDL QKKAKACAVE NEELVQHLGA AKDAQRQLTA 
       260        270        280        290        300
ELRELEDKYA ECMEMLHEAQ EELKNLRNKT MPNTTSRRYH SLGLFPMDSL 
       310        320        330        340        350
AAEIEGTMRK ELQLEEAESP DITHQKRVFE TVRNINQVVK QRSLTPSPMN 
       360        370        380        390        400
IPGSNQSSAM NSLLSSCVST PRSSFYGSDI GNVVLDNKTN SIILETEAAD 
       410        420        430        440        450
LGNDERSKKP GTPGTPGSHD LETALRRLSL RRENYLSERR FFEEEQERKL 
       460        470        480        490        500
QELAEKGELR SGSLTPTESI MSLGTHSRFS EFTGFSGMSF SSRSYLPEKL 
       510        520        530        540        550
QIVKPLEGDH AGPRPLSVLL GDSLWSLIHL RKAGHLCHAY SFFFRDSHPR 

CWFEFL

Note: No experimental confirmation available.

Show »

Length:556

Mass (Da):63,642

Checksum:ⁱ9837FDB279C91758

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JC32	C9JC32_HUMAN	Trafficking kinesin-binding protein... Trafficking kinesin-binding protein 1 (Trafficking protein, kinesin binding 1, isoform CRA_c)	TRAK1 hCG_2000014	895	Annotation score:
A0A087X0N0	A0A087X0N0_HUMAN	Trafficking kinesin-binding protein... Trafficking kinesin-binding protein 1	TRAK1	670	Annotation score:
H7C3T3	H7C3T3_HUMAN	Trafficking kinesin-binding protein... Trafficking kinesin-binding protein 1	TRAK1	300	Annotation score:
A0A0D9SFL5	A0A0D9SFL5_HUMAN	Trafficking kinesin-binding protein... Trafficking kinesin-binding protein 1	TRAK1	849	Annotation score:
A0A0D9SGH2	A0A0D9SGH2_HUMAN	Trafficking kinesin-binding protein... Trafficking kinesin-binding protein 1	TRAK1	526	Annotation score:
F8WDH2	F8WDH2_HUMAN	Trafficking kinesin-binding protein... Trafficking kinesin-binding protein 1	TRAK1	44	Annotation score:

Sequence cautionⁱ

The sequence BAA82994 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	503	S → P in CAH56169 (PubMed:17974005).Curated	1
Sequence conflictⁱ	638	S → F in CAH56169 (PubMed:17974005).Curated	1
Isoform 2 (identifier: Q9UPV9-2)
Sequence conflictⁱ	631	E → EE in CAH56169 (PubMed:17974005).Curated	1
Sequence conflictⁱ	631	E → EEE in AAH15922 (PubMed:15489334).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_045558	1 – 97	MALVF…KYFLL → MQKFIEADYYELDWYYEECS DVL in isoform 3. 1 PublicationAdd BLAST	97
Alternative sequenceⁱVSP_010839	1 – 96	MALVF…LKYFL → MSLRDKGGEEECFEYDCQDE ERKPTHRQHDTQDLLEEV in isoform 2. 2 PublicationsAdd BLAST	96
Alternative sequenceⁱVSP_045559	583 – 630	SATLH…NDFEE → DHAGPRPLSVLLGDSLWSLI HLRKAGHLCHAYSFFFRDSH PRCWFEFL in isoform 3. 1 PublicationAdd BLAST	48
Alternative sequenceⁱVSP_045560	631 – 953	Missing in isoform 3. 1 PublicationAdd BLAST	323
Alternative sequenceⁱVSP_010840	655 – 744	AHHPG…LVWLL → GERSQARVTVSGSRSYPSRP QASPEEMQEPPAATEEEEEE EEEEGSGEGTTISPVNLAPF PEAEFWAILTSVPGTIRSGS LSVASARLCG in isoform 2. 2 PublicationsAdd BLAST	90
Alternative sequenceⁱVSP_010841	745 – 953	Missing in isoform 2. 2 PublicationsAdd BLAST	209

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB028965 mRNA Translation: BAA82994.2 Different initiation. BX647199 mRNA Translation: CAH56169.1 AL713787 mRNA Translation: CAH56394.1 AC018358 Genomic DNA No translation available. AC093414 Genomic DNA No translation available. AC137935 Genomic DNA No translation available. BC015922 mRNA Translation: AAH15922.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2695.1 [Q9UPV9-2] CCDS43072.1 [Q9UPV9-1] CCDS58826.1 [Q9UPV9-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001036111.1, NM_001042646.2 [Q9UPV9-1] NP_001252537.1, NM_001265608.1 NP_001252539.1, NM_001265610.1 [Q9UPV9-3] NP_055780.2, NM_014965.4 [Q9UPV9-2]
UniGeneⁱ	Hs.535711

Genome annotation databases

Ensemblⁱ	ENST00000327628; ENSP00000328998; ENSG00000182606 [Q9UPV9-1] ENST00000341421; ENSP00000340702; ENSG00000182606 [Q9UPV9-2] ENST00000449246; ENSP00000410717; ENSG00000182606 [Q9UPV9-3]
GeneIDⁱ	22906
KEGGⁱ	hsa:22906
UCSC genome browser More...UCSCⁱ	uc003cky.5 human [Q9UPV9-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UPV9	Trafficking protein, kinesin binding 1, isoform CRA_d		HUMAN		953	UniRef100_Q9UPV9
Trafficking kinesin-binding protein 1		HUMAN		849
Q9UPV9-3	Trafficking kinesin-binding protein 1		HUMAN		526	UniRef100_A0A0D9SGH2
TRAK1 isoform 10		PANTR		556
TRAK1 isoform 11		PANTR		526

Protein	Similar proteins		Species	Score	Length	Source
Q9UPV9	Trafficking kinesin-binding protein 1		MOUSE		939	UniRef90_Q9UPV9
Trafficking protein, kinesin binding 1, isoform CRA_d		HUMAN		953
Trafficking kinesin-binding protein 1		PTEAL		1051
Uncharacterized protein		FELCA		1036
Uncharacterized protein		CERAT		957
+198
Q9UPV9-2	Trafficking kinesin protein 1		SAIBB		721	UniRef90_Q9UPV9-2
Uncharacterized protein		MYOLU		711
Trafficking kinesin-binding protein 1 isoform 2		CALJA		686
TRAK1 isoform 7		PONAB		685
trafficking kinesin-binding protein 1 isoform X3		TARSY		683
+89
Q9UPV9-3	Isoform 2 of Trafficking kinesin-binding protein 1		MOUSE		610	UniRef90_Q6PD31-2
trafficking kinesin-binding protein 1 isoform X6		MESAU		580
TRAK1 isoform 9		PONAB		556
Trafficking kinesin-binding protein 1		HUMAN		526
TRAK1 isoform 10		PANTR		556
+7

Protein	Similar proteins		Species	Score	Length	Source
Q9UPV9	Trafficking kinesin-binding protein 1		MOUSE		939	UniRef50_Q9UPV9
Trafficking protein, kinesin binding 1, isoform CRA_d		HUMAN		953
Trafficking kinesin-binding protein 1		PTEAL		1051
Uncharacterized protein		FELCA		1036
Uncharacterized protein		CERAT		957
+798
Q9UPV9-2	Trafficking kinesin protein 1		SAIBB		721	UniRef50_Q9UPV9-2
Uncharacterized protein		MYOLU		711
Trafficking kinesin-binding protein 1 isoform 2		CALJA		686
TRAK1 isoform 7		PONAB		685
trafficking kinesin-binding protein 1 isoform X3		TARSY		683
+292
Q9UPV9-3	Isoform 2 of Trafficking kinesin-binding protein 1		MOUSE		610	UniRef50_Q6PD31-2
trafficking kinesin-binding protein 1 isoform X6		MESAU		580
TRAK1 isoform 9		PONAB		556
Trafficking kinesin-binding protein 1		HUMAN		526
TRAK1 isoform 10		PANTR		556
+65

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB028965 mRNA Translation: BAA82994.2 Different initiation. BX647199 mRNA Translation: CAH56169.1 AL713787 mRNA Translation: CAH56394.1 AC018358 Genomic DNA No translation available. AC093414 Genomic DNA No translation available. AC137935 Genomic DNA No translation available. BC015922 mRNA Translation: AAH15922.1
CCDSⁱ	CCDS2695.1 [Q9UPV9-2] CCDS43072.1 [Q9UPV9-1] CCDS58826.1 [Q9UPV9-3]
RefSeqⁱ	NP_001036111.1, NM_001042646.2 [Q9UPV9-1] NP_001252537.1, NM_001265608.1 NP_001252539.1, NM_001265610.1 [Q9UPV9-3] NP_055780.2, NM_014965.4 [Q9UPV9-2]
UniGeneⁱ	Hs.535711

3D structure databases

ProteinModelPortalⁱ	Q9UPV9
SMRⁱ	Q9UPV9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116570, 10 interactors
CORUMⁱ	Q9UPV9
IntActⁱ	Q9UPV9, 16 interactors
MINTⁱ	Q9UPV9
STRINGⁱ	9606.ENSP00000328998

PTM databases

iPTMnetⁱ	Q9UPV9
PhosphoSitePlusⁱ	Q9UPV9

Polymorphism and mutation databases

BioMutaⁱ	TRAK1
DMDMⁱ	13124654

Proteomic databases

EPDⁱ	Q9UPV9
PaxDbⁱ	Q9UPV9
PeptideAtlasⁱ	Q9UPV9
PRIDEⁱ	Q9UPV9
ProteomicsDBⁱ	85456 85457 [Q9UPV9-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	22906
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000327628; ENSP00000328998; ENSG00000182606 [Q9UPV9-1] ENST00000341421; ENSP00000340702; ENSG00000182606 [Q9UPV9-2] ENST00000449246; ENSP00000410717; ENSG00000182606 [Q9UPV9-3]
GeneIDⁱ	22906
KEGGⁱ	hsa:22906
UCSCⁱ	uc003cky.5 human [Q9UPV9-1]

Organism-specific databases

CTDⁱ	22906
DisGeNETⁱ	22906
EuPathDBⁱ	HostDB:ENSG00000182606.14
GeneCardsⁱ	TRAK1
HGNCⁱ	HGNC:29947 TRAK1
HPAⁱ	HPA005853 HPA011367
MalaCardsⁱ	TRAK1
MIMⁱ	608112 gene
neXtProtⁱ	NX_Q9UPV9
OpenTargetsⁱ	ENSG00000182606
Orphanetⁱ	442835 Undetermined early-onset epileptic encephalopathy
PharmGKBⁱ	PA128394593
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4360 Eukaryota ENOG410XSWD LUCA
GeneTreeⁱ	ENSGT00390000003132
HOGENOMⁱ	HOG000143414
HOVERGENⁱ	HBG069248
InParanoidⁱ	Q9UPV9
KOⁱ	K15369
OMAⁱ	QRKVNTL
OrthoDBⁱ	EOG091G0LLD
PhylomeDBⁱ	Q9UPV9
TreeFamⁱ	TF323495

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6802952 Signaling by BRAF and RAF fusions

Reactomeⁱ

R-HSA-6802952 Signaling by BRAF and RAF fusions

Miscellaneous databases

ChiTaRSⁱ	TRAK1 human
GeneWikiⁱ	TRAK1
GenomeRNAiⁱ	22906
Protein Ontology More...PROⁱ	PR:Q9UPV9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000182606 Expressed in 236 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_TRAK1
ExpressionAtlasⁱ	Q9UPV9 baseline and differential
Genevisibleⁱ	Q9UPV9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR006933 HAP1_N IPR022154 Traffickng_kinesin-bd_prot_dom
Pfamⁱ	View protein in Pfam PF04849 HAP1_N, 1 hit PF12448 Milton, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TRAK1_HUMAN
Accessionⁱ	Q9UPV9Primary (citable) accession number: Q9UPV9 Secondary accession number(s): E9PDS2 , J3KNT7, Q63HR0, Q659B5, Q96B69
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9UPV9 (TRAK1_HUMAN)

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Trafficking kinesin-binding protein 1

TRAK1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

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Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ