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UniProtKB - Q9UPU7 (TBD2B_HUMAN)

Entry version 138 (18 Sep 2019)
Sequence version 2 (15 Jan 2008)
Previous versions | rss
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Protein

TBC1 domain family member 2B

Gene

TBC1D2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a GTPase-activating protein.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 2B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBC1D2B
Synonyms:KIAA1055
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29183 TBC1D2B

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UPU7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23102

Open Targets

More...OpenTargetsi		ENSG00000167202

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670832

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TBC1D2B

Domain mapping of disease mutations (DMDM)

More...DMDMi		166227884

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003157131 – 963TBC1 domain family member 2BAdd BLAST963

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei155PhosphoserineCombined sources1
Modified residuei317PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei957PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UPU7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UPU7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UPU7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UPU7

PeptideAtlas

More...PeptideAtlasi		Q9UPU7

PRoteomics IDEntifications database

More...PRIDEi		Q9UPU7

ProteomicsDB human proteome resource

More...ProteomicsDBi		85447 [Q9UPU7-1]
85448 [Q9UPU7-2]
85449 [Q9UPU7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UPU7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UPU7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000167202 Expressed in 217 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UPU7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UPU7 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA041833
HPA048174
HPA052663

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		116729, 26 interactors

Protein interaction database and analysis system

More...IntActi		Q9UPU7, 22 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000300584

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UPU7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 139PHPROSITE-ProRule annotationAdd BLAST106
Domaini662 – 856Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST195

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili337 – 535Sequence analysisAdd BLAST199

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2058 Eukaryota
COG5210 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157737

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000049204

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UPU7

KEGG Orthology (KO)

More...KOi		K20166

Identification of Orthologs from Complete Genome Data

More...OMAi		QLMTYWL

Database of Orthologous Groups

More...OrthoDBi		1162786at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UPU7

TreeFam database of animal gene trees

More...TreeFami		TF317336

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00169 PH, 1 hit
PF00566 RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233 PH, 1 hit
SM00164 TBC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47923 SSF47923, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50086 TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPU7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGAGARAEE GGGGGEGAAQ GAAAEPGAGP AREPARLCGY LQKLSGKGPL 
        60         70         80         90        100
RGYRSRWFVF DARRCYLYYF KSPQDALPLG HLDIADACFS YQGPDEAAEP 
       110        120        130        140        150
GTEPPAHFQV HSAGAVTVLK APNRQLMTYW LQELQQKRWE YCNSLDMVKW 
       160        170        180        190        200
DSRTSPTPGD FPKGLVARDN TDLIYPHPNA SAEKARNVLA VETVPGELVG 
       210        220        230        240        250
EQAANQPAPG HPNSINFYSL KQWGNELKNS MSSFRPGRGH NDSRRTVFYT 
       260        270        280        290        300
NEEWELLDPT PKDLEESIVQ EEKKKLTPEG NKGVTGSGFP FDFGRNPYKG 
       310        320        330        340        350
KRPLKDIIGS YKNRHSSGDP SSEGTSGSGS VSIRKPASEM QLQVQSQQEE 
       360        370        380        390        400
LEQLKKDLSS QKELVRLLQQ TVRSSQYDKY FTSSRLCEGV PKDTLELLHQ 
       410        420        430        440        450
KDDQILGLTS QLERFSLEKE SLQQEVRTLK SKVGELNEQL GMLMETIQAK 
       460        470        480        490        500
DEVIIKLSEG EGNGPPPTVA PSSPSVVPVA RDQLELDRLK DNLQGYKTQN 
       510        520        530        540        550
KFLNKEILEL SALRRNAERR ERDLMAKYSS LEAKLCQIES KYLILLQEMK 
       560        570        580        590        600
TPVCSEDQGP TREVIAQLLE DALQVESQEQ PEQAFVKPHL VSEYDIYGFR 
       610        620        630        640        650
TVPEDDEEEK LVAKVRALDL KTLYLTENQE VSTGVKWENY FASTVNREMM 
       660        670        680        690        700
CSPELKNLIR AGIPHEHRSK VWKWCVDRHT RKFKDNTEPG HFQTLLQKAL 
       710        720        730        740        750
EKQNPASKQI ELDLLRTLPN NKHYSCPTSE GIQKLRNVLL AFSWRNPDIG 
       760        770        780        790        800
YCQGLNRLVA VALLYLEQED AFWCLVTIVE VFMPRDYYTK TLLGSQVDQR 
       810        820        830        840        850
VFRDLMSEKL PRLHGHFEQY KVDYTLITFN WFLVVFVDSV VSDILFKIWD 
       860        870        880        890        900
SFLYEGPKVI FRFALALFKY KEEEILKLQD SMSIFKYLRY FTRTILDARK 
       910        920        930        940        950
LISISFGDLN PFPLRQIRNR RAYHLEKVRL ELTELEAIRE DFLRERDTSP 
       960 
DKGELVSDEE EDT
Length:963
Mass (Da):109,880
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1BC9B8FCA5BC2EEF
GO
Isoform 2 (identifier: Q9UPU7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     900-963: KLISISFGDL...ELVSDEEEDT → SGTDAPTTWRKSGWS

Show »
Length:914
Mass (Da):103,917
Checksum:iCCA1D0A2D006D6BF
GO
Isoform 3 (identifier: Q9UPU7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-548: Missing.
     860-860: I → S
     861-963: Missing.

Note: No experimental confirmation available.
Show »
Length:312
Mass (Da):36,457
Checksum:i5873220F1C0E82A6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JW56C9JW56_HUMAN
TBC1 domain family member 2B
TBC1D2B
291Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YL97H0YL97_HUMAN
TBC1 domain family member 2B
TBC1D2B
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH33712 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI52466 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW99190 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0306661 – 548Missing in isoform 3. 1 PublicationAdd BLAST548
Alternative sequenceiVSP_030667860I → S in isoform 3. 1 Publication1
Alternative sequenceiVSP_030668861 – 963Missing in isoform 3. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_030669900 – 963KLISI…EEEDT → SGTDAPTTWRKSGWS in isoform 2. 2 PublicationsAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK000173 mRNA Translation: BAA90990.1
AC104758 Genomic DNA No translation available.
AC090260 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99188.1
CH471136 Genomic DNA Translation: EAW99190.1 Sequence problems.
AB028978 mRNA Translation: BAA83007.1
BC033712 mRNA Translation: AAH33712.1 Different initiation.
BC152465 mRNA Translation: AAI52466.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32301.2 [Q9UPU7-2]
CCDS45314.1 [Q9UPU7-1]

NCBI Reference Sequences

More...RefSeqi		NP_055894.6, NM_015079.5 [Q9UPU7-2]
NP_653173.1, NM_144572.1 [Q9UPU7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000300584; ENSP00000300584; ENSG00000167202 [Q9UPU7-1]
ENST00000409931; ENSP00000387165; ENSG00000167202 [Q9UPU7-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23102

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23102

UCSC genome browser

More...UCSCi		uc002bcy.4 human [Q9UPU7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000173 mRNA Translation: BAA90990.1
AC104758 Genomic DNA No translation available.
AC090260 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99188.1
CH471136 Genomic DNA Translation: EAW99190.1 Sequence problems.
AB028978 mRNA Translation: BAA83007.1
BC033712 mRNA Translation: AAH33712.1 Different initiation.
BC152465 mRNA Translation: AAI52466.1 Different initiation.
CCDSiCCDS32301.2 [Q9UPU7-2]
CCDS45314.1 [Q9UPU7-1]
RefSeqiNP_055894.6, NM_015079.5 [Q9UPU7-2]
NP_653173.1, NM_144572.1 [Q9UPU7-1]

3D structure databases

SMRiQ9UPU7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116729, 26 interactors
IntActiQ9UPU7, 22 interactors
STRINGi9606.ENSP00000300584

PTM databases

iPTMnetiQ9UPU7
PhosphoSitePlusiQ9UPU7

Polymorphism and mutation databases

BioMutaiTBC1D2B
DMDMi166227884

Proteomic databases

EPDiQ9UPU7
jPOSTiQ9UPU7
MassIVEiQ9UPU7
PaxDbiQ9UPU7
PeptideAtlasiQ9UPU7
PRIDEiQ9UPU7
ProteomicsDBi85447 [Q9UPU7-1]
85448 [Q9UPU7-2]
85449 [Q9UPU7-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300584; ENSP00000300584; ENSG00000167202 [Q9UPU7-1]
ENST00000409931; ENSP00000387165; ENSG00000167202 [Q9UPU7-2]
GeneIDi23102
KEGGihsa:23102
UCSCiuc002bcy.4 human [Q9UPU7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23102
DisGeNETi23102

GeneCards: human genes, protein and diseases

More...GeneCardsi		TBC1D2B
HGNCiHGNC:29183 TBC1D2B
HPAiHPA041833
HPA048174
HPA052663
neXtProtiNX_Q9UPU7
OpenTargetsiENSG00000167202
PharmGKBiPA142670832

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2058 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00940000157737
HOGENOMiHOG000049204
InParanoidiQ9UPU7
KOiK20166
OMAiQLMTYWL
OrthoDBi1162786at2759
PhylomeDBiQ9UPU7
TreeFamiTF317336

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TBC1D2B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23102

Pharos

More...Pharosi		Q9UPU7

Protein Ontology

More...PROi		PR:Q9UPU7

Gene expression databases

BgeeiENSG00000167202 Expressed in 217 organ(s), highest expression level in female gonad
ExpressionAtlasiQ9UPU7 baseline and differential
GenevisibleiQ9UPU7 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50086 TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBD2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPU7
Secondary accession number(s): A7MD42, Q8N1F9, Q9NXM0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 18, 2019
This is version 138 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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