UniProtKB - Q9UPU7 (TBD2B_HUMAN)
Protein
TBC1 domain family member 2B
Gene
TBC1D2B
Organism
Homo sapiens (Human)
Status
Functioni
May act as a GTPase-activating protein.By similarity
GO - Molecular functioni
- GTPase activator activity Source: GO_Central
- Rab GTPase binding Source: GO_Central
GO - Biological processi
- activation of GTPase activity Source: GO_Central
- intracellular protein transport Source: GO_Central
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
PathwayCommonsi | Q9UPU7 |
Names & Taxonomyi
Protein namesi | Recommended name: TBC1 domain family member 2B |
Gene namesi | Name:TBC1D2B Synonyms:KIAA1055 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167202.11 |
HGNCi | HGNC:29183, TBC1D2B |
neXtProti | NX_Q9UPU7 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 23102 |
OpenTargetsi | ENSG00000167202 |
PharmGKBi | PA142670832 |
Miscellaneous databases
Pharosi | Q9UPU7, Tdark |
Polymorphism and mutation databases
BioMutai | TBC1D2B |
DMDMi | 166227884 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315713 | 1 – 963 | TBC1 domain family member 2BAdd BLAST | 963 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 155 | PhosphoserineCombined sources | 1 | |
Modified residuei | 317 | PhosphoserineCombined sources | 1 | |
Modified residuei | 473 | PhosphoserineCombined sources | 1 | |
Modified residuei | 957 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UPU7 |
jPOSTi | Q9UPU7 |
MassIVEi | Q9UPU7 |
PaxDbi | Q9UPU7 |
PeptideAtlasi | Q9UPU7 |
PRIDEi | Q9UPU7 |
ProteomicsDBi | 85447 [Q9UPU7-1] 85448 [Q9UPU7-2] 85449 [Q9UPU7-3] |
PTM databases
iPTMneti | Q9UPU7 |
PhosphoSitePlusi | Q9UPU7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167202, Expressed in female gonad and 229 other tissues |
ExpressionAtlasi | Q9UPU7, baseline and differential |
Genevisiblei | Q9UPU7, HS |
Organism-specific databases
HPAi | ENSG00000167202, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9UPU7
GO - Molecular functioni
- Rab GTPase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 116729, 27 interactors |
IntActi | Q9UPU7, 22 interactors |
STRINGi | 9606.ENSP00000300584 |
Miscellaneous databases
RNActi | Q9UPU7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 139 | PHPROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 662 – 856 | Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST | 195 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 337 – 535 | Sequence analysisAdd BLAST | 199 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2058, Eukaryota |
GeneTreei | ENSGT00940000157737 |
HOGENOMi | CLU_011278_0_0_1 |
InParanoidi | Q9UPU7 |
OMAi | EQAFFKP |
PhylomeDBi | Q9UPU7 |
TreeFami | TF317336 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit PS50086, TBC_RABGAP, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UPU7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPGAGARAEE GGGGGEGAAQ GAAAEPGAGP AREPARLCGY LQKLSGKGPL
60 70 80 90 100
RGYRSRWFVF DARRCYLYYF KSPQDALPLG HLDIADACFS YQGPDEAAEP
110 120 130 140 150
GTEPPAHFQV HSAGAVTVLK APNRQLMTYW LQELQQKRWE YCNSLDMVKW
160 170 180 190 200
DSRTSPTPGD FPKGLVARDN TDLIYPHPNA SAEKARNVLA VETVPGELVG
210 220 230 240 250
EQAANQPAPG HPNSINFYSL KQWGNELKNS MSSFRPGRGH NDSRRTVFYT
260 270 280 290 300
NEEWELLDPT PKDLEESIVQ EEKKKLTPEG NKGVTGSGFP FDFGRNPYKG
310 320 330 340 350
KRPLKDIIGS YKNRHSSGDP SSEGTSGSGS VSIRKPASEM QLQVQSQQEE
360 370 380 390 400
LEQLKKDLSS QKELVRLLQQ TVRSSQYDKY FTSSRLCEGV PKDTLELLHQ
410 420 430 440 450
KDDQILGLTS QLERFSLEKE SLQQEVRTLK SKVGELNEQL GMLMETIQAK
460 470 480 490 500
DEVIIKLSEG EGNGPPPTVA PSSPSVVPVA RDQLELDRLK DNLQGYKTQN
510 520 530 540 550
KFLNKEILEL SALRRNAERR ERDLMAKYSS LEAKLCQIES KYLILLQEMK
560 570 580 590 600
TPVCSEDQGP TREVIAQLLE DALQVESQEQ PEQAFVKPHL VSEYDIYGFR
610 620 630 640 650
TVPEDDEEEK LVAKVRALDL KTLYLTENQE VSTGVKWENY FASTVNREMM
660 670 680 690 700
CSPELKNLIR AGIPHEHRSK VWKWCVDRHT RKFKDNTEPG HFQTLLQKAL
710 720 730 740 750
EKQNPASKQI ELDLLRTLPN NKHYSCPTSE GIQKLRNVLL AFSWRNPDIG
760 770 780 790 800
YCQGLNRLVA VALLYLEQED AFWCLVTIVE VFMPRDYYTK TLLGSQVDQR
810 820 830 840 850
VFRDLMSEKL PRLHGHFEQY KVDYTLITFN WFLVVFVDSV VSDILFKIWD
860 870 880 890 900
SFLYEGPKVI FRFALALFKY KEEEILKLQD SMSIFKYLRY FTRTILDARK
910 920 930 940 950
LISISFGDLN PFPLRQIRNR RAYHLEKVRL ELTELEAIRE DFLRERDTSP
960
DKGELVSDEE EDT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JW56 | C9JW56_HUMAN | TBC1 domain family member 2B | TBC1D2B | 291 | Annotation score: | ||
H0YL97 | H0YL97_HUMAN | TBC1 domain family member 2B | TBC1D2B | 122 | Annotation score: |
Sequence cautioni
The sequence AAH33712 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI52466 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW99190 differs from that shown. Reason: Erroneous gene model prediction.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030666 | 1 – 548 | Missing in isoform 3. 1 PublicationAdd BLAST | 548 | |
Alternative sequenceiVSP_030667 | 860 | I → S in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_030668 | 861 – 963 | Missing in isoform 3. 1 PublicationAdd BLAST | 103 | |
Alternative sequenceiVSP_030669 | 900 – 963 | KLISI…EEEDT → SGTDAPTTWRKSGWS in isoform 2. 2 PublicationsAdd BLAST | 64 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000173 mRNA Translation: BAA90990.1 AC104758 Genomic DNA No translation available. AC090260 Genomic DNA No translation available. CH471136 Genomic DNA Translation: EAW99188.1 CH471136 Genomic DNA Translation: EAW99190.1 Sequence problems. AB028978 mRNA Translation: BAA83007.1 BC033712 mRNA Translation: AAH33712.1 Different initiation. BC152465 mRNA Translation: AAI52466.1 Different initiation. |
CCDSi | CCDS32301.2 [Q9UPU7-2] CCDS45314.1 [Q9UPU7-1] |
RefSeqi | NP_055894.6, NM_015079.5 [Q9UPU7-2] NP_653173.1, NM_144572.1 [Q9UPU7-1] |
Genome annotation databases
Ensembli | ENST00000300584; ENSP00000300584; ENSG00000167202 [Q9UPU7-1] ENST00000409931; ENSP00000387165; ENSG00000167202 [Q9UPU7-2] |
GeneIDi | 23102 |
KEGGi | hsa:23102 |
UCSCi | uc002bcy.4, human [Q9UPU7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000173 mRNA Translation: BAA90990.1 AC104758 Genomic DNA No translation available. AC090260 Genomic DNA No translation available. CH471136 Genomic DNA Translation: EAW99188.1 CH471136 Genomic DNA Translation: EAW99190.1 Sequence problems. AB028978 mRNA Translation: BAA83007.1 BC033712 mRNA Translation: AAH33712.1 Different initiation. BC152465 mRNA Translation: AAI52466.1 Different initiation. |
CCDSi | CCDS32301.2 [Q9UPU7-2] CCDS45314.1 [Q9UPU7-1] |
RefSeqi | NP_055894.6, NM_015079.5 [Q9UPU7-2] NP_653173.1, NM_144572.1 [Q9UPU7-1] |
3D structure databases
SMRi | Q9UPU7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116729, 27 interactors |
IntActi | Q9UPU7, 22 interactors |
STRINGi | 9606.ENSP00000300584 |
PTM databases
iPTMneti | Q9UPU7 |
PhosphoSitePlusi | Q9UPU7 |
Polymorphism and mutation databases
BioMutai | TBC1D2B |
DMDMi | 166227884 |
Proteomic databases
EPDi | Q9UPU7 |
jPOSTi | Q9UPU7 |
MassIVEi | Q9UPU7 |
PaxDbi | Q9UPU7 |
PeptideAtlasi | Q9UPU7 |
PRIDEi | Q9UPU7 |
ProteomicsDBi | 85447 [Q9UPU7-1] 85448 [Q9UPU7-2] 85449 [Q9UPU7-3] |
Protocols and materials databases
Antibodypediai | 56232, 34 antibodies |
Genome annotation databases
Ensembli | ENST00000300584; ENSP00000300584; ENSG00000167202 [Q9UPU7-1] ENST00000409931; ENSP00000387165; ENSG00000167202 [Q9UPU7-2] |
GeneIDi | 23102 |
KEGGi | hsa:23102 |
UCSCi | uc002bcy.4, human [Q9UPU7-1] |
Organism-specific databases
CTDi | 23102 |
DisGeNETi | 23102 |
EuPathDBi | HostDB:ENSG00000167202.11 |
GeneCardsi | TBC1D2B |
HGNCi | HGNC:29183, TBC1D2B |
HPAi | ENSG00000167202, Low tissue specificity |
neXtProti | NX_Q9UPU7 |
OpenTargetsi | ENSG00000167202 |
PharmGKBi | PA142670832 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2058, Eukaryota |
GeneTreei | ENSGT00940000157737 |
HOGENOMi | CLU_011278_0_0_1 |
InParanoidi | Q9UPU7 |
OMAi | EQAFFKP |
PhylomeDBi | Q9UPU7 |
TreeFami | TF317336 |
Enzyme and pathway databases
PathwayCommonsi | Q9UPU7 |
Miscellaneous databases
BioGRID-ORCSi | 23102, 3 hits in 840 CRISPR screens |
ChiTaRSi | TBC1D2B, human |
GenomeRNAii | 23102 |
Pharosi | Q9UPU7, Tdark |
PROi | PR:Q9UPU7 |
RNActi | Q9UPU7, protein |
Gene expression databases
Bgeei | ENSG00000167202, Expressed in female gonad and 229 other tissues |
ExpressionAtlasi | Q9UPU7, baseline and differential |
Genevisiblei | Q9UPU7, HS |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit PS50086, TBC_RABGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TBD2B_HUMAN | |
Accessioni | Q9UPU7Primary (citable) accession number: Q9UPU7 Secondary accession number(s): A7MD42, Q8N1F9, Q9NXM0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | January 15, 2008 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM