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Protein

VPS10 domain-containing receptor SorCS3

Gene

SORCS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • neuropeptide receptor activity Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
VPS10 domain-containing receptor SorCS3
Gene namesi
Name:SORCS3
Synonyms:KIAA1059
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000156395.12
HGNCiHGNC:16699 SORCS3
MIMi606285 gene
neXtProtiNX_Q9UPU3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 1125LumenalSequence analysisAdd BLAST1092
Transmembranei1126 – 1146HelicalSequence analysisAdd BLAST21
Topological domaini1147 – 1222CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi22986
OpenTargetsiENSG00000156395
PharmGKBiPA134949387

Polymorphism and mutation databases

BioMutaiSORCS3
DMDMi27151703

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000003317434 – 1222VPS10 domain-containing receptor SorCS3Add BLAST1189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi789N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi800N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi840N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi932N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi953N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1065N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9UPU3
PaxDbiQ9UPU3
PeptideAtlasiQ9UPU3
PRIDEiQ9UPU3
ProteomicsDBi85445

PTM databases

iPTMnetiQ9UPU3
PhosphoSitePlusiQ9UPU3

Expressioni

Tissue specificityi

Highly expressed in brain.

Gene expression databases

BgeeiENSG00000156395 Expressed in 79 organ(s), highest expression level in caudate nucleus
CleanExiHS_SORCS3
ExpressionAtlasiQ9UPU3 baseline and differential
GenevisibleiQ9UPU3 HS

Interactioni

Protein-protein interaction databases

BioGridi116635, 2 interactors
IntActiQ9UPU3, 1 interactor
MINTiQ9UPU3
STRINGi9606.ENSP00000358715

Structurei

3D structure databases

ProteinModelPortaliQ9UPU3
SMRiQ9UPU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati231 – 242BNR 1Add BLAST12
Repeati279 – 290BNR 2Add BLAST12
Repeati320 – 331BNR 3Add BLAST12
Repeati515 – 526BNR 4Add BLAST12
Repeati592 – 603BNR 5Add BLAST12
Repeati634 – 645BNR 6Add BLAST12
Domaini827 – 917PKDPROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ISX9 Eukaryota
ENOG410XNN6 LUCA
GeneTreeiENSGT00510000046443
HOGENOMiHOG000236260
HOVERGENiHBG059252
InParanoidiQ9UPU3
OMAiVWFLDWG
OrthoDBiEOG091G00JR
PhylomeDBiQ9UPU3
TreeFamiTF324918

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
IPR031777 Sortilin_C
IPR031778 Sortilin_N
IPR006581 VPS10
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF00801 PKD, 1 hit
PF15902 Sortilin-Vps10, 1 hit
PF15901 Sortilin_C, 1 hit
SMARTiView protein in SMART
SM00602 VPS10, 1 hit
SUPFAMiSSF49299 SSF49299, 2 hits
PROSITEiView protein in PROSITE
PS50093 PKD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9UPU3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAARTERPA GRPGAPLVRT GLLLLSTWVL AGAEITWDAT GGPGRPAAPA
60 70 80 90 100
SRPPALSPLS PRAVASQWPE ELASARRAAV LGRRAGPELL PQQGGGRGGE
110 120 130 140 150
MQVEAGGTSP AGERRGRGIP APAKLGGARR SRRAQPPITQ ERGDAWATAP
160 170 180 190 200
ADGSRGSRPL AKGSREEVKA PRAGGSAAED LRLPSTSFAL TGDSAHNQAM
210 220 230 240 250
VHWSGHNSSV ILILTKLYDF NLGSVTESSL WRSTDYGTTY EKLNDKVGLK
260 270 280 290 300
TVLSYLYVNP TNKRKIMLLS DPEMESSILI SSDEGATYQK YRLTFYIQSL
310 320 330 340 350
LFHPKQEDWV LAYSLDQKLY SSMDFGRRWQ LMHERITPNR FYWSVAGLDK
360 370 380 390 400
EADLVHMEVR TTDGYAHYLT CRIQECAETT RSGPFARSID ISSLVVQDEY
410 420 430 440 450
IFIQVTTSGR ASYYVSYRRE AFAQIKLPKY SLPKDMHIIS TDENQVFAAV
460 470 480 490 500
QEWNQNDTYN LYISDTRGIY FTLAMENIKS SRGLMGNIII ELYEVAGIKG
510 520 530 540 550
IFLANKKVDD QVKTYITYNK GRDWRLLQAP DVDLRGSPVH CLLPFCSLHL
560 570 580 590 600
HLQLSENPYS SGRISSKETA PGLVVATGNI GPELSYTDIG VFISSDGGNT
610 620 630 640 650
WRQIFDEEYN VWFLDWGGAL VAMKHTPLPV RHLWVSFDEG HSWDKYGFTS
660 670 680 690 700
VPLFVDGALV EAGMETHIMT VFGHFSLRSE WQLVKVDYKS IFSRHCTKED
710 720 730 740 750
YQTWHLLNQG EPCVMGERKI FKKRKPGAQC ALGRDHSGSV VSEPCVCANW
760 770 780 790 800
DFECDYGYER HGESQCVPAF WYNPASPSKD CSLGQSYLNS TGYRRIVSNN
810 820 830 840 850
CTDGLREKYT AKAQMCPGKA PRGLHVVTTD GRLVAEQGHN ATFIILMEEG
860 870 880 890 900
DLQRTNIQLD FGDGIAVSYA NFSPIEDGIK HVYKSAGIFQ VTAYAENNLG
910 920 930 940 950
SDTAVLFLHV VCPVEHVHLR VPFVAIRNKE VNISAVVWPS QLGTLTYFWW
960 970 980 990 1000
FGNSTKPLIT LDSSISFTFL AEGTDTITVQ VAAGNALIQD TKEIAVHEYF
1010 1020 1030 1040 1050
QSQLLSFSPN LDYHNPDIPE WRKDIGNVIK RALVKVTSVP EDQILIAVFP
1060 1070 1080 1090 1100
GLPTSAELFI LPPKNLTERR KGNEGDLEQI VETLFNALNQ NLVQFELKPG
1110 1120 1130 1140 1150
VQVIVYVTQL TLAPLVDSSA GHSSSAMLML LSVVFVGLAV FLIYKFKRKI
1160 1170 1180 1190 1200
PWINIYAQVQ HDKEQEMIGS VSQSENAPKI TLSDFTEPEE LLDKELDTRV
1210 1220
IGGIATIANS ESTKEIPNCT SV
Length:1,222
Mass (Da):135,755
Last modified:March 1, 2002 - v2
Checksum:i57671F993B09D597
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5CAJ2Q5CAJ2_HUMAN
VPS10 domain-containing receptor So...
SORCS3
152Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028982 mRNA Translation: BAA83011.2
AL161646 Genomic DNA No translation available.
AL353900 Genomic DNA No translation available.
AL358949 Genomic DNA No translation available.
AL365449 Genomic DNA No translation available.
AL445492 Genomic DNA No translation available.
AL596118 Genomic DNA No translation available.
CCDSiCCDS7558.1
RefSeqiNP_055793.1, NM_014978.2
UniGeneiHs.671950

Genome annotation databases

EnsembliENST00000369699; ENSP00000358713; ENSG00000156395
ENST00000369701; ENSP00000358715; ENSG00000156395
GeneIDi22986
KEGGihsa:22986
UCSCiuc001kyi.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028982 mRNA Translation: BAA83011.2
AL161646 Genomic DNA No translation available.
AL353900 Genomic DNA No translation available.
AL358949 Genomic DNA No translation available.
AL365449 Genomic DNA No translation available.
AL445492 Genomic DNA No translation available.
AL596118 Genomic DNA No translation available.
CCDSiCCDS7558.1
RefSeqiNP_055793.1, NM_014978.2
UniGeneiHs.671950

3D structure databases

ProteinModelPortaliQ9UPU3
SMRiQ9UPU3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116635, 2 interactors
IntActiQ9UPU3, 1 interactor
MINTiQ9UPU3
STRINGi9606.ENSP00000358715

PTM databases

iPTMnetiQ9UPU3
PhosphoSitePlusiQ9UPU3

Polymorphism and mutation databases

BioMutaiSORCS3
DMDMi27151703

Proteomic databases

EPDiQ9UPU3
PaxDbiQ9UPU3
PeptideAtlasiQ9UPU3
PRIDEiQ9UPU3
ProteomicsDBi85445

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369699; ENSP00000358713; ENSG00000156395
ENST00000369701; ENSP00000358715; ENSG00000156395
GeneIDi22986
KEGGihsa:22986
UCSCiuc001kyi.1 human

Organism-specific databases

CTDi22986
DisGeNETi22986
EuPathDBiHostDB:ENSG00000156395.12
GeneCardsiSORCS3
HGNCiHGNC:16699 SORCS3
MIMi606285 gene
neXtProtiNX_Q9UPU3
OpenTargetsiENSG00000156395
PharmGKBiPA134949387
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISX9 Eukaryota
ENOG410XNN6 LUCA
GeneTreeiENSGT00510000046443
HOGENOMiHOG000236260
HOVERGENiHBG059252
InParanoidiQ9UPU3
OMAiVWFLDWG
OrthoDBiEOG091G00JR
PhylomeDBiQ9UPU3
TreeFamiTF324918

Miscellaneous databases

ChiTaRSiSORCS3 human
GenomeRNAii22986
PROiPR:Q9UPU3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156395 Expressed in 79 organ(s), highest expression level in caudate nucleus
CleanExiHS_SORCS3
ExpressionAtlasiQ9UPU3 baseline and differential
GenevisibleiQ9UPU3 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
IPR031777 Sortilin_C
IPR031778 Sortilin_N
IPR006581 VPS10
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF00801 PKD, 1 hit
PF15902 Sortilin-Vps10, 1 hit
PF15901 Sortilin_C, 1 hit
SMARTiView protein in SMART
SM00602 VPS10, 1 hit
SUPFAMiSSF49299 SSF49299, 2 hits
PROSITEiView protein in PROSITE
PS50093 PKD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSORC3_HUMAN
AccessioniPrimary (citable) accession number: Q9UPU3
Secondary accession number(s): Q5VXF9, Q9NQJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: March 1, 2002
Last modified: September 12, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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