UniProtKB - Q9UPU3 (SORC3_HUMAN)
Protein
VPS10 domain-containing receptor SorCS3
Gene
SORCS3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- neuropeptide receptor activity Source: UniProtKB
GO - Biological processi
- learning Source: Ensembl
- memory Source: Ensembl
- neuropeptide signaling pathway Source: UniProtKB
- regulation of long-term synaptic depression Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q9UPU3 |
Protein family/group databases
TCDBi | 9.A.63.1.4, the retromer-dependent vacuolar protein sorting (r-vps) family |
Names & Taxonomyi
Protein namesi | Recommended name: VPS10 domain-containing receptor SorCS3 |
Gene namesi | Name:SORCS3 Synonyms:KIAA1059 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16699, SORCS3 |
MIMi | 606285, gene |
neXtProti | NX_Q9UPU3 |
VEuPathDBi | HostDB:ENSG00000156395.12 |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of postsynaptic density membrane Source: GO_Central
Other locations
- glutamatergic synapse Source: Ensembl
- integral component of membrane Source: GO_Central
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 34 – 1125 | LumenalSequence analysisAdd BLAST | 1092 | |
Transmembranei | 1126 – 1146 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1147 – 1222 | CytoplasmicSequence analysisAdd BLAST | 76 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 22986 |
OpenTargetsi | ENSG00000156395 |
PharmGKBi | PA134949387 |
Miscellaneous databases
Pharosi | Q9UPU3, Tbio |
Genetic variation databases
BioMutai | SORCS3 |
DMDMi | 27151703 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | Sequence analysisAdd BLAST | 33 | |
ChainiPRO_0000033174 | 34 – 1222 | VPS10 domain-containing receptor SorCS3Add BLAST | 1189 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 207 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 456 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 789 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 800 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 840 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 932 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 953 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1065 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q9UPU3 |
MassIVEi | Q9UPU3 |
PaxDbi | Q9UPU3 |
PeptideAtlasi | Q9UPU3 |
PRIDEi | Q9UPU3 |
ProteomicsDBi | 85445 |
PTM databases
GlyGeni | Q9UPU3, 8 sites |
iPTMneti | Q9UPU3 |
PhosphoSitePlusi | Q9UPU3 |
Expressioni
Tissue specificityi
Highly expressed in brain.
Gene expression databases
Bgeei | ENSG00000156395, Expressed in prefrontal cortex and 95 other tissues |
ExpressionAtlasi | Q9UPU3, baseline and differential |
Genevisiblei | Q9UPU3, HS |
Organism-specific databases
HPAi | ENSG00000156395, Group enriched (adrenal gland, brain) |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 116635, 3 interactors |
IntActi | Q9UPU3, 3 interactors |
MINTi | Q9UPU3 |
STRINGi | 9606.ENSP00000358715 |
Miscellaneous databases
RNActi | Q9UPU3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 231 – 242 | BNR 1Add BLAST | 12 | |
Repeati | 279 – 290 | BNR 2Add BLAST | 12 | |
Repeati | 320 – 331 | BNR 3Add BLAST | 12 | |
Repeati | 515 – 526 | BNR 4Add BLAST | 12 | |
Repeati | 592 – 603 | BNR 5Add BLAST | 12 | |
Repeati | 634 – 645 | BNR 6Add BLAST | 12 | |
Domaini | 827 – 917 | PKDPROSITE-ProRule annotationAdd BLAST | 91 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3511, Eukaryota |
GeneTreei | ENSGT00990000203581 |
HOGENOMi | CLU_010702_0_0_1 |
InParanoidi | Q9UPU3 |
OMAi | YVFIQVT |
OrthoDBi | 1046610at2759 |
PhylomeDBi | Q9UPU3 |
TreeFami | TF324918 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR000601, PKD_dom IPR035986, PKD_dom_sf IPR031777, Sortilin_C IPR031778, Sortilin_N IPR006581, VPS10 IPR015943, WD40/YVTN_repeat-like_dom_sf |
Pfami | View protein in Pfam PF00801, PKD, 1 hit PF15902, Sortilin-Vps10, 1 hit PF15901, Sortilin_C, 1 hit |
SMARTi | View protein in SMART SM00602, VPS10, 1 hit |
SUPFAMi | SSF49299, SSF49299, 2 hits |
PROSITEi | View protein in PROSITE PS50093, PKD, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9UPU3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEAARTERPA GRPGAPLVRT GLLLLSTWVL AGAEITWDAT GGPGRPAAPA
60 70 80 90 100
SRPPALSPLS PRAVASQWPE ELASARRAAV LGRRAGPELL PQQGGGRGGE
110 120 130 140 150
MQVEAGGTSP AGERRGRGIP APAKLGGARR SRRAQPPITQ ERGDAWATAP
160 170 180 190 200
ADGSRGSRPL AKGSREEVKA PRAGGSAAED LRLPSTSFAL TGDSAHNQAM
210 220 230 240 250
VHWSGHNSSV ILILTKLYDF NLGSVTESSL WRSTDYGTTY EKLNDKVGLK
260 270 280 290 300
TVLSYLYVNP TNKRKIMLLS DPEMESSILI SSDEGATYQK YRLTFYIQSL
310 320 330 340 350
LFHPKQEDWV LAYSLDQKLY SSMDFGRRWQ LMHERITPNR FYWSVAGLDK
360 370 380 390 400
EADLVHMEVR TTDGYAHYLT CRIQECAETT RSGPFARSID ISSLVVQDEY
410 420 430 440 450
IFIQVTTSGR ASYYVSYRRE AFAQIKLPKY SLPKDMHIIS TDENQVFAAV
460 470 480 490 500
QEWNQNDTYN LYISDTRGIY FTLAMENIKS SRGLMGNIII ELYEVAGIKG
510 520 530 540 550
IFLANKKVDD QVKTYITYNK GRDWRLLQAP DVDLRGSPVH CLLPFCSLHL
560 570 580 590 600
HLQLSENPYS SGRISSKETA PGLVVATGNI GPELSYTDIG VFISSDGGNT
610 620 630 640 650
WRQIFDEEYN VWFLDWGGAL VAMKHTPLPV RHLWVSFDEG HSWDKYGFTS
660 670 680 690 700
VPLFVDGALV EAGMETHIMT VFGHFSLRSE WQLVKVDYKS IFSRHCTKED
710 720 730 740 750
YQTWHLLNQG EPCVMGERKI FKKRKPGAQC ALGRDHSGSV VSEPCVCANW
760 770 780 790 800
DFECDYGYER HGESQCVPAF WYNPASPSKD CSLGQSYLNS TGYRRIVSNN
810 820 830 840 850
CTDGLREKYT AKAQMCPGKA PRGLHVVTTD GRLVAEQGHN ATFIILMEEG
860 870 880 890 900
DLQRTNIQLD FGDGIAVSYA NFSPIEDGIK HVYKSAGIFQ VTAYAENNLG
910 920 930 940 950
SDTAVLFLHV VCPVEHVHLR VPFVAIRNKE VNISAVVWPS QLGTLTYFWW
960 970 980 990 1000
FGNSTKPLIT LDSSISFTFL AEGTDTITVQ VAAGNALIQD TKEIAVHEYF
1010 1020 1030 1040 1050
QSQLLSFSPN LDYHNPDIPE WRKDIGNVIK RALVKVTSVP EDQILIAVFP
1060 1070 1080 1090 1100
GLPTSAELFI LPPKNLTERR KGNEGDLEQI VETLFNALNQ NLVQFELKPG
1110 1120 1130 1140 1150
VQVIVYVTQL TLAPLVDSSA GHSSSAMLML LSVVFVGLAV FLIYKFKRKI
1160 1170 1180 1190 1200
PWINIYAQVQ HDKEQEMIGS VSQSENAPKI TLSDFTEPEE LLDKELDTRV
1210 1220
IGGIATIANS ESTKEIPNCT SV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5CAJ2 | Q5CAJ2_HUMAN | VPS10 domain-containing receptor So... | SORCS3 | 152 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB028982 mRNA Translation: BAA83011.2 AL161646 Genomic DNA No translation available. AL353900 Genomic DNA No translation available. AL358949 Genomic DNA No translation available. AL365449 Genomic DNA No translation available. AL445492 Genomic DNA No translation available. AL596118 Genomic DNA No translation available. |
CCDSi | CCDS7558.1 |
RefSeqi | NP_055793.1, NM_014978.2 |
Genome annotation databases
Ensembli | ENST00000369699; ENSP00000358713; ENSG00000156395 ENST00000369701; ENSP00000358715; ENSG00000156395 |
GeneIDi | 22986 |
KEGGi | hsa:22986 |
UCSCi | uc001kyi.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB028982 mRNA Translation: BAA83011.2 AL161646 Genomic DNA No translation available. AL353900 Genomic DNA No translation available. AL358949 Genomic DNA No translation available. AL365449 Genomic DNA No translation available. AL445492 Genomic DNA No translation available. AL596118 Genomic DNA No translation available. |
CCDSi | CCDS7558.1 |
RefSeqi | NP_055793.1, NM_014978.2 |
3D structure databases
SMRi | Q9UPU3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116635, 3 interactors |
IntActi | Q9UPU3, 3 interactors |
MINTi | Q9UPU3 |
STRINGi | 9606.ENSP00000358715 |
Protein family/group databases
TCDBi | 9.A.63.1.4, the retromer-dependent vacuolar protein sorting (r-vps) family |
PTM databases
GlyGeni | Q9UPU3, 8 sites |
iPTMneti | Q9UPU3 |
PhosphoSitePlusi | Q9UPU3 |
Genetic variation databases
BioMutai | SORCS3 |
DMDMi | 27151703 |
Proteomic databases
EPDi | Q9UPU3 |
MassIVEi | Q9UPU3 |
PaxDbi | Q9UPU3 |
PeptideAtlasi | Q9UPU3 |
PRIDEi | Q9UPU3 |
ProteomicsDBi | 85445 |
Protocols and materials databases
Antibodypediai | 31628, 58 antibodies |
Genome annotation databases
Ensembli | ENST00000369699; ENSP00000358713; ENSG00000156395 ENST00000369701; ENSP00000358715; ENSG00000156395 |
GeneIDi | 22986 |
KEGGi | hsa:22986 |
UCSCi | uc001kyi.1, human |
Organism-specific databases
CTDi | 22986 |
DisGeNETi | 22986 |
GeneCardsi | SORCS3 |
HGNCi | HGNC:16699, SORCS3 |
HPAi | ENSG00000156395, Group enriched (adrenal gland, brain) |
MIMi | 606285, gene |
neXtProti | NX_Q9UPU3 |
OpenTargetsi | ENSG00000156395 |
PharmGKBi | PA134949387 |
VEuPathDBi | HostDB:ENSG00000156395.12 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3511, Eukaryota |
GeneTreei | ENSGT00990000203581 |
HOGENOMi | CLU_010702_0_0_1 |
InParanoidi | Q9UPU3 |
OMAi | YVFIQVT |
OrthoDBi | 1046610at2759 |
PhylomeDBi | Q9UPU3 |
TreeFami | TF324918 |
Enzyme and pathway databases
PathwayCommonsi | Q9UPU3 |
Miscellaneous databases
BioGRID-ORCSi | 22986, 6 hits in 985 CRISPR screens |
ChiTaRSi | SORCS3, human |
GenomeRNAii | 22986 |
Pharosi | Q9UPU3, Tbio |
PROi | PR:Q9UPU3 |
RNActi | Q9UPU3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000156395, Expressed in prefrontal cortex and 95 other tissues |
ExpressionAtlasi | Q9UPU3, baseline and differential |
Genevisiblei | Q9UPU3, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR013783, Ig-like_fold IPR000601, PKD_dom IPR035986, PKD_dom_sf IPR031777, Sortilin_C IPR031778, Sortilin_N IPR006581, VPS10 IPR015943, WD40/YVTN_repeat-like_dom_sf |
Pfami | View protein in Pfam PF00801, PKD, 1 hit PF15902, Sortilin-Vps10, 1 hit PF15901, Sortilin_C, 1 hit |
SMARTi | View protein in SMART SM00602, VPS10, 1 hit |
SUPFAMi | SSF49299, SSF49299, 2 hits |
PROSITEi | View protein in PROSITE PS50093, PKD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SORC3_HUMAN | |
Accessioni | Q9UPU3Primary (citable) accession number: Q9UPU3 Secondary accession number(s): Q5VXF9, Q9NQJ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 13, 2002 |
Last sequence update: | March 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families