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UniProtKB - Q9UPU3 (SORC3_HUMAN)

Entry version 160 (07 Apr 2021)
Sequence version 2 (01 Mar 2002)
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Protein

VPS10 domain-containing receptor SorCS3

Gene

SORCS3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UPU3

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.63.1.4, the retromer-dependent vacuolar protein sorting (r-vps) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
VPS10 domain-containing receptor SorCS3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SORCS3
Synonyms:KIAA1059
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16699, SORCS3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606285, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UPU3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000156395.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini34 – 1125LumenalSequence analysisAdd BLAST1092
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1126 – 1146HelicalSequence analysisAdd BLAST21
Topological domaini1147 – 1222CytoplasmicSequence analysisAdd BLAST76

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		22986

Open Targets

More...OpenTargetsi		ENSG00000156395

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134949387

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UPU3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SORCS3

Domain mapping of disease mutations (DMDM)

More...DMDMi		27151703

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003317434 – 1222VPS10 domain-containing receptor SorCS3Add BLAST1189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi789N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi800N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi840N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi932N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi953N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1065N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UPU3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UPU3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UPU3

PeptideAtlas

More...PeptideAtlasi		Q9UPU3

PRoteomics IDEntifications database

More...PRIDEi		Q9UPU3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85445

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9UPU3, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UPU3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UPU3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000156395, Expressed in prefrontal cortex and 95 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UPU3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UPU3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000156395, Group enriched (adrenal gland, brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116635, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q9UPU3, 3 interactors

Molecular INTeraction database

More...MINTi		Q9UPU3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358715

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UPU3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UPU3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati231 – 242BNR 1Add BLAST12
Repeati279 – 290BNR 2Add BLAST12
Repeati320 – 331BNR 3Add BLAST12
Repeati515 – 526BNR 4Add BLAST12
Repeati592 – 603BNR 5Add BLAST12
Repeati634 – 645BNR 6Add BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini827 – 917PKDPROSITE-ProRule annotationAdd BLAST91

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS10-related sortilin family. SORCS subfamily.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3511, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00990000203581

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010702_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UPU3

Identification of Orthologs from Complete Genome Data

More...OMAi		YVFIQVT

Database of Orthologous Groups

More...OrthoDBi		1046610at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UPU3

TreeFam database of animal gene trees

More...TreeFami		TF324918

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013783, Ig-like_fold
IPR000601, PKD_dom
IPR035986, PKD_dom_sf
IPR031777, Sortilin_C
IPR031778, Sortilin_N
IPR006581, VPS10
IPR015943, WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00801, PKD, 1 hit
PF15902, Sortilin-Vps10, 1 hit
PF15901, Sortilin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00602, VPS10, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49299, SSF49299, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50093, PKD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UPU3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAARTERPA GRPGAPLVRT GLLLLSTWVL AGAEITWDAT GGPGRPAAPA 
        60         70         80         90        100
SRPPALSPLS PRAVASQWPE ELASARRAAV LGRRAGPELL PQQGGGRGGE 
       110        120        130        140        150
MQVEAGGTSP AGERRGRGIP APAKLGGARR SRRAQPPITQ ERGDAWATAP 
       160        170        180        190        200
ADGSRGSRPL AKGSREEVKA PRAGGSAAED LRLPSTSFAL TGDSAHNQAM 
       210        220        230        240        250
VHWSGHNSSV ILILTKLYDF NLGSVTESSL WRSTDYGTTY EKLNDKVGLK 
       260        270        280        290        300
TVLSYLYVNP TNKRKIMLLS DPEMESSILI SSDEGATYQK YRLTFYIQSL 
       310        320        330        340        350
LFHPKQEDWV LAYSLDQKLY SSMDFGRRWQ LMHERITPNR FYWSVAGLDK 
       360        370        380        390        400
EADLVHMEVR TTDGYAHYLT CRIQECAETT RSGPFARSID ISSLVVQDEY 
       410        420        430        440        450
IFIQVTTSGR ASYYVSYRRE AFAQIKLPKY SLPKDMHIIS TDENQVFAAV 
       460        470        480        490        500
QEWNQNDTYN LYISDTRGIY FTLAMENIKS SRGLMGNIII ELYEVAGIKG 
       510        520        530        540        550
IFLANKKVDD QVKTYITYNK GRDWRLLQAP DVDLRGSPVH CLLPFCSLHL 
       560        570        580        590        600
HLQLSENPYS SGRISSKETA PGLVVATGNI GPELSYTDIG VFISSDGGNT 
       610        620        630        640        650
WRQIFDEEYN VWFLDWGGAL VAMKHTPLPV RHLWVSFDEG HSWDKYGFTS 
       660        670        680        690        700
VPLFVDGALV EAGMETHIMT VFGHFSLRSE WQLVKVDYKS IFSRHCTKED 
       710        720        730        740        750
YQTWHLLNQG EPCVMGERKI FKKRKPGAQC ALGRDHSGSV VSEPCVCANW 
       760        770        780        790        800
DFECDYGYER HGESQCVPAF WYNPASPSKD CSLGQSYLNS TGYRRIVSNN 
       810        820        830        840        850
CTDGLREKYT AKAQMCPGKA PRGLHVVTTD GRLVAEQGHN ATFIILMEEG 
       860        870        880        890        900
DLQRTNIQLD FGDGIAVSYA NFSPIEDGIK HVYKSAGIFQ VTAYAENNLG 
       910        920        930        940        950
SDTAVLFLHV VCPVEHVHLR VPFVAIRNKE VNISAVVWPS QLGTLTYFWW 
       960        970        980        990       1000
FGNSTKPLIT LDSSISFTFL AEGTDTITVQ VAAGNALIQD TKEIAVHEYF 
      1010       1020       1030       1040       1050
QSQLLSFSPN LDYHNPDIPE WRKDIGNVIK RALVKVTSVP EDQILIAVFP 
      1060       1070       1080       1090       1100
GLPTSAELFI LPPKNLTERR KGNEGDLEQI VETLFNALNQ NLVQFELKPG 
      1110       1120       1130       1140       1150
VQVIVYVTQL TLAPLVDSSA GHSSSAMLML LSVVFVGLAV FLIYKFKRKI 
      1160       1170       1180       1190       1200
PWINIYAQVQ HDKEQEMIGS VSQSENAPKI TLSDFTEPEE LLDKELDTRV 
      1210       1220 
IGGIATIANS ESTKEIPNCT SV
Length:1,222
Mass (Da):135,755
Last modified:March 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57671F993B09D597
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5CAJ2Q5CAJ2_HUMAN
VPS10 domain-containing receptor So...
SORCS3
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB028982 mRNA Translation: BAA83011.2
AL161646 Genomic DNA No translation available.
AL353900 Genomic DNA No translation available.
AL358949 Genomic DNA No translation available.
AL365449 Genomic DNA No translation available.
AL445492 Genomic DNA No translation available.
AL596118 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7558.1

NCBI Reference Sequences

More...RefSeqi		NP_055793.1, NM_014978.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369699; ENSP00000358713; ENSG00000156395
ENST00000369701; ENSP00000358715; ENSG00000156395

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22986

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:22986

UCSC genome browser

More...UCSCi		uc001kyi.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028982 mRNA Translation: BAA83011.2
AL161646 Genomic DNA No translation available.
AL353900 Genomic DNA No translation available.
AL358949 Genomic DNA No translation available.
AL365449 Genomic DNA No translation available.
AL445492 Genomic DNA No translation available.
AL596118 Genomic DNA No translation available.
CCDSiCCDS7558.1
RefSeqiNP_055793.1, NM_014978.2

3D structure databases

SMRiQ9UPU3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116635, 3 interactors
IntActiQ9UPU3, 3 interactors
MINTiQ9UPU3
STRINGi9606.ENSP00000358715

Protein family/group databases

TCDBi9.A.63.1.4, the retromer-dependent vacuolar protein sorting (r-vps) family

PTM databases

GlyGeniQ9UPU3, 8 sites
iPTMnetiQ9UPU3
PhosphoSitePlusiQ9UPU3

Genetic variation databases

BioMutaiSORCS3
DMDMi27151703

Proteomic databases

EPDiQ9UPU3
MassIVEiQ9UPU3
PaxDbiQ9UPU3
PeptideAtlasiQ9UPU3
PRIDEiQ9UPU3
ProteomicsDBi85445

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31628, 58 antibodies

Genome annotation databases

EnsembliENST00000369699; ENSP00000358713; ENSG00000156395
ENST00000369701; ENSP00000358715; ENSG00000156395
GeneIDi22986
KEGGihsa:22986
UCSCiuc001kyi.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22986
DisGeNETi22986

GeneCards: human genes, protein and diseases

More...GeneCardsi		SORCS3
HGNCiHGNC:16699, SORCS3
HPAiENSG00000156395, Group enriched (adrenal gland, brain)
MIMi606285, gene
neXtProtiNX_Q9UPU3
OpenTargetsiENSG00000156395
PharmGKBiPA134949387
VEuPathDBiHostDB:ENSG00000156395.12

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3511, Eukaryota
GeneTreeiENSGT00990000203581
HOGENOMiCLU_010702_0_0_1
InParanoidiQ9UPU3
OMAiYVFIQVT
OrthoDBi1046610at2759
PhylomeDBiQ9UPU3
TreeFamiTF324918

Enzyme and pathway databases

PathwayCommonsiQ9UPU3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		22986, 6 hits in 985 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SORCS3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		22986
PharosiQ9UPU3, Tbio

Protein Ontology

More...PROi		PR:Q9UPU3
RNActiQ9UPU3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000156395, Expressed in prefrontal cortex and 95 other tissues
ExpressionAtlasiQ9UPU3, baseline and differential
GenevisibleiQ9UPU3, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR000601, PKD_dom
IPR035986, PKD_dom_sf
IPR031777, Sortilin_C
IPR031778, Sortilin_N
IPR006581, VPS10
IPR015943, WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF00801, PKD, 1 hit
PF15902, Sortilin-Vps10, 1 hit
PF15901, Sortilin_C, 1 hit
SMARTiView protein in SMART
SM00602, VPS10, 1 hit
SUPFAMiSSF49299, SSF49299, 2 hits
PROSITEiView protein in PROSITE
PS50093, PKD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSORC3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPU3
Secondary accession number(s): Q5VXF9, Q9NQJ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: March 1, 2002
Last modified: April 7, 2021
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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