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UniProtKB - Q9UPT8 (ZC3H4_HUMAN)

Entry version 170 (25 May 2022)
Sequence version 3 (02 May 2006)
Previous versions | rss
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Protein

Zinc finger CCCH domain-containing protein 4

Gene

ZC3H4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that suppresses transcription of long non-coding RNAs (lncRNAs) (PubMed:33913806, PubMed:33767452).

LncRNAs are defined as transcripts more than 200 nucleotides that are not translated into protein (PubMed:33913806, PubMed:33767452).

Together with WDR82, part of a transcription termination checkpoint that promotes transcription termination of lncRNAs and their subsequent degradation by the exosome (PubMed:33913806, PubMed:33767452).

The transcription termination checkpoint is activated by the inefficiently spliced first exon of lncRNAs (PubMed:33767452).

2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri390 – 417C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri419 – 446C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri447 – 470C3H1-type 3PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processTranscription, Transcription regulation, Transcription termination
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UPT8

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UPT8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 4Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZC3H41 PublicationImported
Synonyms:C19orf7Imported, KIAA10641 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17808, ZC3H4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		619498, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UPT8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000130749

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23211

Open Targets

More...OpenTargetsi		ENSG00000130749

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162409534

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UPT8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZC3H4

Domain mapping of disease mutations (DMDM)

More...DMDMi		94707996

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002340681 – 1303Zinc finger CCCH domain-containing protein 4Add BLAST1303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei72PhosphothreonineCombined sources1
Modified residuei75PhosphothreonineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei155PhosphotyrosineCombined sources1
Modified residuei601Asymmetric dimethylarginineBy similarity1
Modified residuei807PhosphoserineCombined sources1
Modified residuei808PhosphoserineCombined sources1
Modified residuei904PhosphoserineCombined sources1
Modified residuei907PhosphoserineCombined sources1
Modified residuei908PhosphoserineCombined sources1
Modified residuei1104PhosphoserineCombined sources1
Modified residuei1106PhosphothreonineCombined sources1
Modified residuei1108PhosphoserineCombined sources1
Modified residuei1110PhosphoserineCombined sources1
Modified residuei1114PhosphoserineCombined sources1
Modified residuei1118PhosphothreonineBy similarity1
Modified residuei1269PhosphoserineCombined sources1
Modified residuei1275PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UPT8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UPT8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UPT8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UPT8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UPT8

PeptideAtlas

More...PeptideAtlasi		Q9UPT8

PRoteomics IDEntifications database

More...PRIDEi		Q9UPT8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85442

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9UPT8, 5 sites, 2 O-linked glycans (5 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UPT8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UPT8

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9UPT8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000130749, Expressed in forebrain and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UPT8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UPT8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000130749, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with WDR82.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116818, 114 interactors

Protein interaction database and analysis system

More...IntActi		Q9UPT8, 26 interactors

Molecular INTeraction database

More...MINTi		Q9UPT8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000253048

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UPT8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9UPT8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UPT8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9UPT8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 388DisorderedSequence analysisAdd BLAST388
Regioni486 – 571DisorderedSequence analysisAdd BLAST86
Regioni605 – 685DisorderedSequence analysisAdd BLAST81
Regioni710 – 955DisorderedSequence analysisAdd BLAST246
Regioni996 – 1288DisorderedSequence analysisAdd BLAST293

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili95 – 128Sequence analysisAdd BLAST34
Coiled coili767 – 800Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 37Pro residuesSequence analysisAdd BLAST37
Compositional biasi40 – 54Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi55 – 73Acidic residuesSequence analysisAdd BLAST19
Compositional biasi74 – 100Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi101 – 128Basic residuesSequence analysisAdd BLAST28
Compositional biasi143 – 159Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi198 – 216Acidic residuesSequence analysisAdd BLAST19
Compositional biasi217 – 239Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi279 – 303Acidic residuesSequence analysisAdd BLAST25
Compositional biasi304 – 325Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi326 – 342Basic residuesSequence analysisAdd BLAST17
Compositional biasi372 – 388Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi486 – 502Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi505 – 562Pro residuesSequence analysisAdd BLAST58
Compositional biasi605 – 628Pro residuesSequence analysisAdd BLAST24
Compositional biasi632 – 648Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi656 – 685Pro residuesSequence analysisAdd BLAST30
Compositional biasi713 – 738Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi774 – 802Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi808 – 837Polar residuesSequence analysisAdd BLAST30
Compositional biasi901 – 920Polar residuesSequence analysisAdd BLAST20
Compositional biasi922 – 936Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1024 – 1041Polar residuesSequence analysisAdd BLAST18
Compositional biasi1051 – 1065Polar residuesSequence analysisAdd BLAST15
Compositional biasi1235 – 1249Pro residuesSequence analysisAdd BLAST15
Compositional biasi1255 – 1272Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the suppressor of sable family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri390 – 417C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri419 – 446C3H1-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri447 – 470C3H1-type 3PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1040, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160011

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UPT8

Identification of Orthologs from Complete Genome Data

More...OMAi		MFSHEEL

Database of Orthologous Groups

More...OrthoDBi		145192at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UPT8

TreeFam database of animal gene trees

More...TreeFami		TF321641

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR045124, Su(sable)-like
IPR041367, Znf-CCCH_4
IPR000571, Znf_CCCH
IPR036855, Znf_CCCH_sf

The PANTHER Classification System

More...PANTHERi		PTHR13119, PTHR13119, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00642, zf-CCCH, 1 hit
PF18044, zf-CCCH_4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00356, ZnF_C3H1, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF90229, SSF90229, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50103, ZF_C3H1, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UPT8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAAPGTPPP PPSESPPPPS PPPPSTPSPP PCSPDARPAT PHLLHHRLPL 
        60         70         80         90        100
PDDREDGELE EGELEDDGAE ETQDTSGGPE RSRKEKGEKH HSDSDEEKSH 
       110        120        130        140        150
RRLKRKRKKE REKEKRRSKK RRKSKHKRHA SSSDDFSDFS DDSDFSPSEK 
       160        170        180        190        200
GHRKYREYSP PYAPSHQQYP PSHATPLPKK AYSKMDSKSY GMYEDYENEQ 
       210        220        230        240        250
YGEYEGDEEE DMGKEDYDDF TKELNQYRRA KEGSSRGRGS RGRGRGYRGR 
       260        270        280        290        300
GSRGGSRGRG MGRGSRGRGR GSMGGDHPED EEDFYEEEMD YGESEEPMGD 
       310        320        330        340        350
DDYDEYSKEL NQYRRSKDSR GRGLSRGRGR GSRGRGKGMG RGRGRGGSRG 
       360        370        380        390        400
GMNKGGMNDD EDFYDEDMGD GGGGSYRSRD HDKPHQQSDK KGKVICKYFV 
       410        420        430        440        450
EGRCTWGDHC NFSHDIELPK KRELCKFYIT GFCARAENCP YMHGDFPCKL 
       460        470        480        490        500
YHTTGNCING DDCMFSHDPL TEETRELLDK MLADDAEAGA EDEKEVEELK 
       510        520        530        540        550
KQGINPLPKP PPGVGLLPTP PRPPGPQAPT SPNGRPMQGG PPPPPPPPPP 
       560        570        580        590        600
PPGPPQMPMP VHEPLSPQQL QQQDMYNKKI PSLFEIVVRP TGQLAEKLGV 
       610        620        630        640        650
RFPGPGGPPG PMGPGPNMGP PGPMGGPMHP DMHPDMHPDM HPDMHADMHA 
       660        670        680        690        700
DMPMGPGMNP GPPMGPGGPP MMPYGPGDSP HSGMMPPIPP AQNFYENFYQ 
       710        720        730        740        750
QQEGMEMEPG LLGDAEDYGH YEELPGEPGE HLFPEHPLEP DSFSEGGPPG 
       760        770        780        790        800
RPKPGAGVPD FLPSAQRALY LRIQQKQQEE EERARRLAES SKQDRENEEG 
       810        820        830        840        850
DTGNWYSSDE DEGGSSVTSI LKTLRQQTSS RPPASVGELS SSGLGDPRLQ 
       860        870        880        890        900
KGHPTGSRLA DPRLSRDPRL TRHVEASGGS GPGDSGPSDP RLARALPTSK 
       910        920        930        940        950
PEGSLHSSPV GPSSSKGSGP PPTEEEEGER ALREKAVNIP LDPLPGHPLR 
       960        970        980        990       1000
DPRSQLQQFS HIKKDVTLSK PSFARTVLWN PEDLIPLPIP KQDAVPPVPA 
      1010       1020       1030       1040       1050
ALQSMPTLDP RLHRAATAGP PNARQRPGAS TDSSTQGANL PDFELLSRIL 
      1060       1070       1080       1090       1100
KTVNATGSSA APGSSDKPSD PRVRKAPTDP RLQKPTDSTA SSRAAKPGPA 
      1110       1120       1130       1140       1150
EAPSPTASPS GDASPPATAP YDPRVLAAGG LGQGGGGGQS SVLSGISLYD 
      1160       1170       1180       1190       1200
PRTPNAGGKA TEPAADTGAQ PKGAEGNGKS SASKAKEPPF VRKSALEQPE 
      1210       1220       1230       1240       1250
TGKAGADGGT PTDRYNSYNR PRPKAAAAPA ATTATPPPEG APPQPGVHNL 
      1260       1270       1280       1290       1300
PVPTLFGTVK QTPKTGSGSP FAGNSPAREG EQDAASLKDV FKGFDPTASP 

FCQ
Length:1,303
Mass (Da):140,257
Last modified:May 2, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6DAE368F543FF4D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QY97M0QY97_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H4
910Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83016 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052964287E → K. Corresponds to variant dbSNP:rs192824Ensembl.1
Natural variantiVAR_052965464M → V. Corresponds to variant dbSNP:rs402833Ensembl.1
Natural variantiVAR_0529661228A → G. Corresponds to variant dbSNP:rs309195Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB028987 mRNA Translation: BAA83016.2 Different initiation.
AL050155 mRNA Translation: CAB43296.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42582.1

Protein sequence database of the Protein Information Resource

More...PIRi		T08781

NCBI Reference Sequences

More...RefSeqi		NP_055983.1, NM_015168.1
XP_006723176.1, XM_006723113.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000253048.10; ENSP00000253048.4; ENSG00000130749.10

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23211

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23211

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000253048.10; ENSP00000253048.4; NM_015168.2; NP_055983.1

UCSC genome browser

More...UCSCi		uc002pga.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028987 mRNA Translation: BAA83016.2 Different initiation.
AL050155 mRNA Translation: CAB43296.1
CCDSiCCDS42582.1
PIRiT08781
RefSeqiNP_055983.1, NM_015168.1
XP_006723176.1, XM_006723113.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQENMR-A417-501[»]
AlphaFoldDBiQ9UPT8
SMRiQ9UPT8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116818, 114 interactors
IntActiQ9UPT8, 26 interactors
MINTiQ9UPT8
STRINGi9606.ENSP00000253048

PTM databases

GlyGeniQ9UPT8, 5 sites, 2 O-linked glycans (5 sites)
iPTMnetiQ9UPT8
PhosphoSitePlusiQ9UPT8
SwissPalmiQ9UPT8

Genetic variation databases

BioMutaiZC3H4
DMDMi94707996

Proteomic databases

EPDiQ9UPT8
jPOSTiQ9UPT8
MassIVEiQ9UPT8
MaxQBiQ9UPT8
PaxDbiQ9UPT8
PeptideAtlasiQ9UPT8
PRIDEiQ9UPT8
ProteomicsDBi85442

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		45692, 86 antibodies from 24 providers

The DNASU plasmid repository

More...DNASUi		23211

Genome annotation databases

EnsembliENST00000253048.10; ENSP00000253048.4; ENSG00000130749.10
GeneIDi23211
KEGGihsa:23211
MANE-SelectiENST00000253048.10; ENSP00000253048.4; NM_015168.2; NP_055983.1
UCSCiuc002pga.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23211
DisGeNETi23211

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZC3H4
HGNCiHGNC:17808, ZC3H4
HPAiENSG00000130749, Low tissue specificity
MIMi619498, gene
neXtProtiNX_Q9UPT8
OpenTargetsiENSG00000130749
PharmGKBiPA162409534
VEuPathDBiHostDB:ENSG00000130749

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1040, Eukaryota
GeneTreeiENSGT00940000160011
InParanoidiQ9UPT8
OMAiMFSHEEL
OrthoDBi145192at2759
PhylomeDBiQ9UPT8
TreeFamiTF321641

Enzyme and pathway databases

PathwayCommonsiQ9UPT8
SignaLinkiQ9UPT8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23211, 82 hits in 1081 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZC3H4, human
EvolutionaryTraceiQ9UPT8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23211
PharosiQ9UPT8, Tbio

Protein Ontology

More...PROi		PR:Q9UPT8
RNActiQ9UPT8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000130749, Expressed in forebrain and 249 other tissues
ExpressionAtlasiQ9UPT8, baseline and differential
GenevisibleiQ9UPT8, HS

Family and domain databases

InterProiView protein in InterPro
IPR045124, Su(sable)-like
IPR041367, Znf-CCCH_4
IPR000571, Znf_CCCH
IPR036855, Znf_CCCH_sf
PANTHERiPTHR13119, PTHR13119, 1 hit
PfamiView protein in Pfam
PF00642, zf-CCCH, 1 hit
PF18044, zf-CCCH_4, 1 hit
SMARTiView protein in SMART
SM00356, ZnF_C3H1, 3 hits
SUPFAMiSSF90229, SSF90229, 3 hits
PROSITEiView protein in PROSITE
PS50103, ZF_C3H1, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZC3H4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPT8
Secondary accession number(s): Q9Y420
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: May 25, 2022
This is version 170 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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