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Protein

C-Jun-amino-terminal kinase-interacting protein 3

Gene

MAPK8IP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:21775604).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • JUN kinase binding Source: GO_Central
  • kinesin binding Source: UniProtKB
  • MAP-kinase scaffold activity Source: UniProtKB
  • receptor signaling complex scaffold activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9UPT6

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9UPT6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-Jun-amino-terminal kinase-interacting protein 3
Short name:
JIP-3
Short name:
JNK-interacting protein 3
Alternative name(s):
JNK MAP kinase scaffold protein 3
Mitogen-activated protein kinase 8-interacting protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAPK8IP3
Synonyms:JIP3, KIAA1066
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138834.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6884 MAPK8IP3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605431 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UPT6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23162

Open Targets

More...
OpenTargetsi
ENSG00000138834

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30628

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAPK8IP3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145559484

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002206331 – 1336C-Jun-amino-terminal kinase-interacting protein 3Add BLAST1336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei265Phosphothreonine; by MAPKBy similarity1
Modified residuei275Phosphothreonine; by MAPKBy similarity1
Modified residuei286Phosphothreonine; by MAPKBy similarity1
Modified residuei314Phosphoserine; by ROCK11 Publication1
Modified residuei364Phosphoserine; by ROCK11 Publication1
Modified residuei365Phosphoserine; by ROCK11 Publication1
Modified residuei602PhosphoserineBy similarity1
Modified residuei676PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by ROCK1 is crucial for the recruitment of JNK.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UPT6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UPT6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UPT6

PeptideAtlas

More...
PeptideAtlasi
Q9UPT6

PRoteomics IDEntifications database

More...
PRIDEi
Q9UPT6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85440
85441 [Q9UPT6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UPT6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UPT6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000138834 Expressed in 219 organ(s), highest expression level in right hemisphere of cerebellum

CleanEx database of gene expression profiles

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CleanExi
HS_MAPK8IP3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UPT6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UPT6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005580
HPA041785
HPA069311

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homo- or heterooligomeric complexes. The central region of MAPK8IP3 interacts with the C-terminal of MAPK8IP2 but not MAPK8IP1. Binds specific components of the JNK signaling pathway namely MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 to the N-terminal region, MAP2K4/MKK4 and MAP2K7/MKK7 to the central region and MAP3K11 to the C-terminal region. Binds the TPR motif-containing C-terminal of kinesin light chain, KLC1. Pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Interacts with ROCK1 and this interaction is enhanced by ultraviolet-B (UVB) radiation. Interacts with SH3RF2 (By similarity). Interacts with NTRK2/TRKB and NTRK3/TRKC (By similarity).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
LDLRAP1Q5SW964EBI-717887,EBI-747813

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116774, 35 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9UPT6

Protein interaction database and analysis system

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IntActi
Q9UPT6, 9 interactors

Molecular INTeraction database

More...
MINTi
Q9UPT6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000250894

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11336
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PXJX-ray2.06A/B/C433-486[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9UPT6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UPT6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 100RH1PROSITE-ProRule annotationAdd BLAST89
Domaini520 – 594RH2PROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni50 – 80Kinesin-binding domain (KBD); essential for its function in axon elongationBy similarityAdd BLAST31
Regioni209 – 225JNK-binding domain (JBD); essential for its function in axon elongationBy similarityAdd BLAST17
Regioni423 – 458Leucine zipper-like domain (LZ); essential for its function in axon elongationBy similarityAdd BLAST36
Regioni458 – 514Interaction with NTRK2By similarityAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili58 – 177Sequence analysisAdd BLAST120
Coiled coili440 – 554Sequence analysisAdd BLAST115

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JIP scaffold family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2077 Eukaryota
ENOG410XQ19 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153496

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG024110

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UPT6

KEGG Orthology (KO)

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KOi
K04436

Database of Orthologous Groups

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OrthoDBi
324912at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9UPT6

TreeFam database of animal gene trees

More...
TreeFami
TF313096

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039911 JIP3/JIP4
IPR032486 JIP_LZII
IPR019143 JNK/Rab-associated_protein-1_N
IPR034743 RH1
IPR034744 RH2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13886 PTHR13886, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16471 JIP_LZII, 1 hit
PF09744 Jnk-SapK_ap_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51776 RH1, 1 hit
PS51777 RH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPT6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMEIQMDEGG GVVVYQDDYC SGSVMSERVS GLAGSIYREF ERLIHCYDEE
60 70 80 90 100
VVKELMPLVV NVLENLDSVL SENQEHEVEL ELLREDNEQL LTQYEREKAL
110 120 130 140 150
RRQAEEKFIE FEDALEQEKK ELQIQVEHYE FQTRQLELKA KNYADQISRL
160 170 180 190 200
EERESEMKKE YNALHQRHTE MIQTYVEHIE RSKMQQVGGN SQTESSLPGR
210 220 230 240 250
RKERPTSLNV FPLADGTVRA QIGGKLVPAG DHWHLSDLGQ LQSSSSYQCP
260 270 280 290 300
QDEMSESGQS SAAATPSTTG TKSNTPTSSV PSAAVTPLNE SLQPLGDYGV
310 320 330 340 350
GSKNSKRARE KRDSRNMEVQ VTQEMRNVSI GMGSSDEWSD VQDIIDSTPE
360 370 380 390 400
LDMCPETRLD RTGSSPTQGI VNKAFGINTD SLYHELSTAG SEVIGDVDEG
410 420 430 440 450
ADLLGEFSVR DDFFGMGKEV GNLLLENSQL LETKNALNVV KNDLIAKVDQ
460 470 480 490 500
LSGEQEVLRG ELEAAKQAKV KLENRIKELE EELKRVKSEA IIARREPKEE
510 520 530 540 550
AEDVSSYLCT ESDKIPMAQR RRFTRVEMAR VLMERNQYKE RLMELQEAVR
560 570 580 590 600
WTEMIRASRE HPSVQEKKKS TIWQFFSRLF SSSSSPPPAK RPYPSVNIHY
610 620 630 640 650
KSPTTAGFSQ RRNHAMCPIS AGSRPLEFFP DDDCTSSARR EQKREQYRQV
660 670 680 690 700
REHVRNDDGR LQACGWSLPA KYKQLSPNGG QEDTRMKNVP VPVYCRPLVE
710 720 730 740 750
KDPTMKLWCA AGVNLSGWRP NEDDAGNGVK PAPGRDPLTC DREGDGEPKS
760 770 780 790 800
AHTSPEKKKA KELPEMDATS SRVWILTSTL TTSKVVIIDA NQPGTVVDQF
810 820 830 840 850
TVCNAHVLCI SSIPAASDSD YPPGEMFLDS DVNPEDPGAD GVLAGITLVG
860 870 880 890 900
CATRCNVPRS NCSSRGDTPV LDKGQGEVAT IANGKVNPSQ STEEATEATE
910 920 930 940 950
VPDPGPSEPE TATLRPGPLT EHVFTDPAPT PSSGPQPGSE NGPEPDSSST
960 970 980 990 1000
RPEPEPSGDP TGAGSSAAPT MWLGAQNGWL YVHSAVANWK KCLHSIKLKD
1010 1020 1030 1040 1050
SVLSLVHVKG RVLVALADGT LAIFHRGEDG QWDLSNYHLM DLGHPHHSIR
1060 1070 1080 1090 1100
CMAVVYDRVW CGYKNKVHVI QPKTMQIEKS FDAHPRRESQ VRQLAWIGDG
1110 1120 1130 1140 1150
VWVSIRLDST LRLYHAHTHQ HLQDVDIEPY VSKMLGTGKL GFSFVRITAL
1160 1170 1180 1190 1200
LVAGSRLWVG TGNGVVISIP LTETVVLHRG QLLGLRANKT SPTSGEGARP
1210 1220 1230 1240 1250
GGIIHVYGDD SSDRAASSFI PYCSMAQAQL CFHGHRDAVK FFVSVPGNVL
1260 1270 1280 1290 1300
ATLNGSVLDS PAEGPGPAAP ASEVEGQKLR NVLVLSGGEG YIDFRIGDGE
1310 1320 1330
DDETEEGAGD MSQVKPVLSK AERSHIIVWQ VSYTPE
Length:1,336
Mass (Da):147,457
Last modified:April 17, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84166F5725D74B25
GO
Isoform 2 (identifier: Q9UPT6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     249-250: CP → VL
     251-1336: Missing.

Show »
Length:250
Mass (Da):29,052
Checksum:iE7C2A9B0793A810E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYG2A0A087WYG2_HUMAN
C-Jun-amino-terminal kinase-interac...
MAPK8IP3
1,337Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PFH7E9PFH7_HUMAN
C-Jun-amino-terminal kinase-interac...
MAPK8IP3
1,330Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN91H3BN91_HUMAN
C-Jun-amino-terminal kinase-interac...
MAPK8IP3
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK61290 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA83018 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB15727 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAB72318 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049667753T → A. Corresponds to variant dbSNP:rs2294619Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024430249 – 250CP → VL in isoform 2. 1 Publication2
Alternative sequenceiVSP_024431251 – 1336Missing in isoform 2. 1 PublicationAdd BLAST1086

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB028989 mRNA Translation: BAA83018.2 Different initiation.
AK024437 mRNA Translation: BAB15727.1 Different initiation.
AE006639 Genomic DNA Translation: AAK61290.1 Sequence problems.
AL031718 Genomic DNA Translation: CAB72318.1 Sequence problems.
AC012180 Genomic DNA No translation available.
AL031710 Genomic DNA No translation available.
AL031717 Genomic DNA No translation available.
BC137123 mRNA Translation: AAI37124.1
BC137124 mRNA Translation: AAI37125.1
BC150266 mRNA Translation: AAI50267.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10442.2 [Q9UPT6-1]

NCBI Reference Sequences

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RefSeqi
NP_001035529.1, NM_001040439.1
NP_001305781.1, NM_001318852.1
NP_055948.2, NM_015133.4 [Q9UPT6-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.207763

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000250894; ENSP00000250894; ENSG00000138834 [Q9UPT6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23162

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23162

UCSC genome browser

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UCSCi
uc002cmk.4 human [Q9UPT6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028989 mRNA Translation: BAA83018.2 Different initiation.
AK024437 mRNA Translation: BAB15727.1 Different initiation.
AE006639 Genomic DNA Translation: AAK61290.1 Sequence problems.
AL031718 Genomic DNA Translation: CAB72318.1 Sequence problems.
AC012180 Genomic DNA No translation available.
AL031710 Genomic DNA No translation available.
AL031717 Genomic DNA No translation available.
BC137123 mRNA Translation: AAI37124.1
BC137124 mRNA Translation: AAI37125.1
BC150266 mRNA Translation: AAI50267.1
CCDSiCCDS10442.2 [Q9UPT6-1]
RefSeqiNP_001035529.1, NM_001040439.1
NP_001305781.1, NM_001318852.1
NP_055948.2, NM_015133.4 [Q9UPT6-1]
UniGeneiHs.207763

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4PXJX-ray2.06A/B/C433-486[»]
ProteinModelPortaliQ9UPT6
SMRiQ9UPT6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116774, 35 interactors
ELMiQ9UPT6
IntActiQ9UPT6, 9 interactors
MINTiQ9UPT6
STRINGi9606.ENSP00000250894

PTM databases

iPTMnetiQ9UPT6
PhosphoSitePlusiQ9UPT6

Polymorphism and mutation databases

BioMutaiMAPK8IP3
DMDMi145559484

Proteomic databases

EPDiQ9UPT6
jPOSTiQ9UPT6
PaxDbiQ9UPT6
PeptideAtlasiQ9UPT6
PRIDEiQ9UPT6
ProteomicsDBi85440
85441 [Q9UPT6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250894; ENSP00000250894; ENSG00000138834 [Q9UPT6-1]
GeneIDi23162
KEGGihsa:23162
UCSCiuc002cmk.4 human [Q9UPT6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23162
DisGeNETi23162
EuPathDBiHostDB:ENSG00000138834.12

GeneCards: human genes, protein and diseases

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GeneCardsi
MAPK8IP3
HGNCiHGNC:6884 MAPK8IP3
HPAiCAB005580
HPA041785
HPA069311
MIMi605431 gene
neXtProtiNX_Q9UPT6
OpenTargetsiENSG00000138834
PharmGKBiPA30628

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2077 Eukaryota
ENOG410XQ19 LUCA
GeneTreeiENSGT00940000153496
HOVERGENiHBG024110
InParanoidiQ9UPT6
KOiK04436
OrthoDBi324912at2759
PhylomeDBiQ9UPT6
TreeFamiTF313096

Enzyme and pathway databases

SignaLinkiQ9UPT6
SIGNORiQ9UPT6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MAPK8IP3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MAPK8IP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23162

Protein Ontology

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PROi
PR:Q9UPT6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138834 Expressed in 219 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_MAPK8IP3
ExpressionAtlasiQ9UPT6 baseline and differential
GenevisibleiQ9UPT6 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR039911 JIP3/JIP4
IPR032486 JIP_LZII
IPR019143 JNK/Rab-associated_protein-1_N
IPR034743 RH1
IPR034744 RH2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13886 PTHR13886, 1 hit
PfamiView protein in Pfam
PF16471 JIP_LZII, 1 hit
PF09744 Jnk-SapK_ap_N, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS51776 RH1, 1 hit
PS51777 RH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJIP3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPT6
Secondary accession number(s): A2A2B3
, A7E2B3, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: April 17, 2007
Last modified: January 16, 2019
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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