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UniProtKB - Q9UPT5 (EXOC7_HUMAN)

Entry version 182 (17 Jun 2020)
Sequence version 3 (14 Nov 2003)
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Protein

Exocyst complex component 7

Gene

EXOC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9UPT5

Protein family/group databases

Transport Classification Database

More...TCDBi		1.F.2.1.2 the octameric exocyst (exocyst) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component 7
Alternative name(s):
Exocyst complex component Exo70
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EXOC7
Synonyms:EXO70, KIAA1067
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000182473.21

Human Gene Nomenclature Database

More...HGNCi		HGNC:23214 EXOC7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608163 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UPT5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23265

Open Targets

More...OpenTargetsi		ENSG00000182473

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134988420

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UPT5 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		EXOC7

Domain mapping of disease mutations (DMDM)

More...DMDMi		38372889

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001189601 – 735Exocyst complex component 7Add BLAST735

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei133PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UPT5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UPT5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UPT5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UPT5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UPT5

PeptideAtlas

More...PeptideAtlasi		Q9UPT5

PRoteomics IDEntifications database

More...PRIDEi		Q9UPT5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85434 [Q9UPT5-3]
85435 [Q9UPT5-1]
85436 [Q9UPT5-2]
85437 [Q9UPT5-4]
85438 [Q9UPT5-5]
85439 [Q9UPT5-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UPT5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UPT5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000182473 Expressed in right uterine tube and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UPT5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UPT5 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000182473 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8.

Interacts with ARHQ in a GTP-dependent manner.

Interacts with RAB11FIP3 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116867, 71 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4943 Exocyst, EXOC6 variant
CPX-4944 Exocyst, EXOC6B variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9UPT5

Database of interacting proteins

More...DIPi		DIP-37604N

Protein interaction database and analysis system

More...IntActi		Q9UPT5, 67 interactors

Molecular INTeraction database

More...MINTi		Q9UPT5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000334100

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UPT5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UPT5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili5 – 42Sequence analysisAdd BLAST38
Coiled coili63 – 85Sequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus is involved in SEC8 and ARHQ binding.By similarity
The C-terminus is required for translocation to the plasma membrane.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EXO70 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2344 Eukaryota
ENOG410YIGI LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003595

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UPT5

KEGG Orthology (KO)

More...KOi		K07195

Identification of Orthologs from Complete Genome Data

More...OMAi		YHDLSTQ

Database of Orthologous Groups

More...OrthoDBi		410847at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UPT5

TreeFam database of animal gene trees

More...TreeFami		TF324243

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR004140 Exo70

The PANTHER Classification System

More...PANTHERi		PTHR12542 PTHR12542, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03081 Exo70, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF74788 SSF74788, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q9UPT5-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIPPQEASAR RREIEDKLKQ EEETLSFIRD SLEKSDQLTK NMVSILSSFE 
        60         70         80         90        100
SRLMKLENSI IPVHKQTENL QRLQENVEKT LSCLDHVISY YHVASDTEKI 
       110        120        130        140        150
IREGPTGRLE EYLGSMAKIQ KAVEYFQDNS PDSPELNKVK LLFERGKEAL 
       160        170        180        190        200
ESEFRSLMTR HSKVVSPVLI LDLISGDDDL EAQEDVTLEH LPESVLQDVI 
       210        220        230        240        250
RISRWLVEYG RNQDFMNVYY QIRSSQLDRS IKGLKEHFHK SSSSSGVPYS 
       260        270        280        290        300
PAIPNKRKDT PTKKPVKRPG TIRKAQNLLK QYSQHGLDGK KGGSNLIPLE 
       310        320        330        340        350
GLLPCTPRGG LPGPWINAAC VCAADISPGH EHDFRVKHLS EALNDKHGPL 
       360        370        380        390        400
AGRDDMLDVE TDAYIHCVSA FVKLAQSEYQ LLADIIPEHH QKKTFDSLIQ 
       410        420        430        440        450
DALDGLMLEG ENIVSAARKA IVRHDFSTVL TVFPILRHLK QTKPEFDQVL 
       460        470        480        490        500
QGTAASTKNK LPGLITSMET IGAKALEDFA DNIKNDPDKE YNMPKDGTVH 
       510        520        530        540        550
ELTSNAILFL QQLLDFQETA GAMLASQETS SSATSYSSEF SKRLLSTYIC 
       560        570        580        590        600
KVLGNLQLNL LSKSKVYEDP ALSAIFLHNN YNYILKSLEK SELIQLVAVT 
       610        620        630        640        650
QKTAERSYRE HIEQQIQTYQ RSWLKVTDYI AEKNLPVFQP GVKLRDKERQ 
       660        670        680        690        700
IIKERFKGFN DGLEELCKIQ KAWAIPDTEQ RDRIRQAQKT IVKETYGAFL 
       710        720        730 
QKFGSVPFTK NPEKYIKYGV EQVGDMIDRL FDTSA
Length:735
Mass (Da):83,382
Last modified:November 14, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B929762542854B6
GO
Isoform 1 (identifier: Q9UPT5-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-352: Missing.

Show »
Length:684
Mass (Da):78,060
Checksum:i6E25C7BAB9017D9E
GO
Isoform 2 (identifier: Q9UPT5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-352: Missing.

Show »
Length:653
Mass (Da):74,713
Checksum:iD70DC752161DDE68
GO
Isoform 4 (identifier: Q9UPT5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-283: TIRKAQNLLKQYS → EPPSWPISATARG
     284-735: Missing.

Note: May be due to intron retention.Curated
Show »
Length:283
Mass (Da):32,451
Checksum:i93885953F51F60E1
GO
Isoform 5 (identifier: Q9UPT5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-327: Missing.

Show »
Length:676
Mass (Da):77,303
Checksum:i2CBC61E2A6578A8A
GO
Isoform 6 (identifier: Q9UPT5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-328: Missing.

Show »
Length:707
Mass (Da):80,650
Checksum:i3EF94FEE3F52C8E9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSB8A0A0A0MSB8_HUMAN
Exocyst complex component 7
EXOC7
693Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DJ07B4DJ07_HUMAN
Exocyst complex component 7
EXOC7
656Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRE1A0A0A0MRE1_HUMAN
Exocyst complex component 7
EXOC7
617Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MCY9B5MCY9_HUMAN
Exocyst complex component 7
EXOC7 hCG_40887
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERQ5K7ERQ5_HUMAN
Exocyst complex component 7
EXOC7
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JKC2C9JKC2_HUMAN
Exocyst complex component 7
EXOC7
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JME6C9JME6_HUMAN
Exocyst complex component 7
EXOC7
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENP8K7ENP8_HUMAN
Exocyst complex component 7
EXOC7
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83019 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB14095 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti234L → Q in BAB14694 (PubMed:14702039).Curated1
Sequence conflicti362D → N in BAB14694 (PubMed:14702039).Curated1
Sequence conflicti459N → I in AAH18466 (PubMed:15489334).Curated1
Sequence conflicti646D → G in BAB14694 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041098269 – 327Missing in isoform 5. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_001483271 – 352Missing in isoform 2. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_008876271 – 283TIRKA…LKQYS → EPPSWPISATARG in isoform 4. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_008877284 – 735Missing in isoform 4. 1 PublicationAdd BLAST452
Alternative sequenceiVSP_041099301 – 328Missing in isoform 6. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_008878302 – 352Missing in isoform 1. 3 PublicationsAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
FJ457119 mRNA Translation: ACK36853.1
FJ457120 mRNA Translation: ACK36854.1
AB028990 mRNA Translation: BAA83019.1 Different initiation.
AK022397 mRNA Translation: BAB14026.1
AK022552 mRNA Translation: BAB14095.1 Different initiation.
AK023832 mRNA Translation: BAB14694.1
AL834324 mRNA Translation: CAD38992.2
AC018665 Genomic DNA No translation available.
BC011045 mRNA Translation: AAH11045.1
BC018466 mRNA Translation: AAH18466.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11741.1 [Q9UPT5-2]
CCDS32738.1 [Q9UPT5-1]
CCDS45781.1 [Q9UPT5-5]
CCDS45782.1 [Q9UPT5-3]
CCDS45783.1 [Q9UPT5-6]

NCBI Reference Sequences

More...RefSeqi		NP_001013861.1, NM_001013839.3 [Q9UPT5-1]
NP_001138769.1, NM_001145297.3 [Q9UPT5-3]
NP_001138770.1, NM_001145298.3 [Q9UPT5-5]
NP_001138771.1, NM_001145299.3 [Q9UPT5-6]
NP_001269242.1, NM_001282313.1
NP_056034.2, NM_015219.4 [Q9UPT5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000332065; ENSP00000333806; ENSG00000182473 [Q9UPT5-2]
ENST00000335146; ENSP00000334100; ENSG00000182473 [Q9UPT5-3]
ENST00000411744; ENSP00000404322; ENSG00000182473 [Q9UPT5-5]
ENST00000589210; ENSP00000468404; ENSG00000182473 [Q9UPT5-1]
ENST00000634349; ENSP00000489266; ENSG00000182473 [Q9UPT5-6]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23265

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23265

UCSC genome browser

More...UCSCi		uc002jqq.5 human [Q9UPT5-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ457119 mRNA Translation: ACK36853.1
FJ457120 mRNA Translation: ACK36854.1
AB028990 mRNA Translation: BAA83019.1 Different initiation.
AK022397 mRNA Translation: BAB14026.1
AK022552 mRNA Translation: BAB14095.1 Different initiation.
AK023832 mRNA Translation: BAB14694.1
AL834324 mRNA Translation: CAD38992.2
AC018665 Genomic DNA No translation available.
BC011045 mRNA Translation: AAH11045.1
BC018466 mRNA Translation: AAH18466.1
CCDSiCCDS11741.1 [Q9UPT5-2]
CCDS32738.1 [Q9UPT5-1]
CCDS45781.1 [Q9UPT5-5]
CCDS45782.1 [Q9UPT5-3]
CCDS45783.1 [Q9UPT5-6]
RefSeqiNP_001013861.1, NM_001013839.3 [Q9UPT5-1]
NP_001138769.1, NM_001145297.3 [Q9UPT5-3]
NP_001138770.1, NM_001145298.3 [Q9UPT5-5]
NP_001138771.1, NM_001145299.3 [Q9UPT5-6]
NP_001269242.1, NM_001282313.1
NP_056034.2, NM_015219.4 [Q9UPT5-2]

3D structure databases

SMRiQ9UPT5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116867, 71 interactors
ComplexPortaliCPX-4943 Exocyst, EXOC6 variant
CPX-4944 Exocyst, EXOC6B variant
CORUMiQ9UPT5
DIPiDIP-37604N
IntActiQ9UPT5, 67 interactors
MINTiQ9UPT5
STRINGi9606.ENSP00000334100

Protein family/group databases

TCDBi1.F.2.1.2 the octameric exocyst (exocyst) family

PTM databases

iPTMnetiQ9UPT5
PhosphoSitePlusiQ9UPT5

Polymorphism and mutation databases

BioMutaiEXOC7
DMDMi38372889

Proteomic databases

EPDiQ9UPT5
jPOSTiQ9UPT5
MassIVEiQ9UPT5
MaxQBiQ9UPT5
PaxDbiQ9UPT5
PeptideAtlasiQ9UPT5
PRIDEiQ9UPT5
ProteomicsDBi85434 [Q9UPT5-3]
85435 [Q9UPT5-1]
85436 [Q9UPT5-2]
85437 [Q9UPT5-4]
85438 [Q9UPT5-5]
85439 [Q9UPT5-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19667 183 antibodies

Genome annotation databases

EnsembliENST00000332065; ENSP00000333806; ENSG00000182473 [Q9UPT5-2]
ENST00000335146; ENSP00000334100; ENSG00000182473 [Q9UPT5-3]
ENST00000411744; ENSP00000404322; ENSG00000182473 [Q9UPT5-5]
ENST00000589210; ENSP00000468404; ENSG00000182473 [Q9UPT5-1]
ENST00000634349; ENSP00000489266; ENSG00000182473 [Q9UPT5-6]
GeneIDi23265
KEGGihsa:23265
UCSCiuc002jqq.5 human [Q9UPT5-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23265
DisGeNETi23265
EuPathDBiHostDB:ENSG00000182473.21

GeneCards: human genes, protein and diseases

More...GeneCardsi		EXOC7
HGNCiHGNC:23214 EXOC7
HPAiENSG00000182473 Low tissue specificity
MIMi608163 gene
neXtProtiNX_Q9UPT5
OpenTargetsiENSG00000182473
PharmGKBiPA134988420

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2344 Eukaryota
ENOG410YIGI LUCA
GeneTreeiENSGT00390000003595
InParanoidiQ9UPT5
KOiK07195
OMAiYHDLSTQ
OrthoDBi410847at2759
PhylomeDBiQ9UPT5
TreeFamiTF324243

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium
SIGNORiQ9UPT5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23265 288 hits in 785 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		EXOC7 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		EXOC7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23265
PharosiQ9UPT5 Tbio

Protein Ontology

More...PROi		PR:Q9UPT5
RNActiQ9UPT5 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000182473 Expressed in right uterine tube and 226 other tissues
ExpressionAtlasiQ9UPT5 baseline and differential
GenevisibleiQ9UPT5 HS

Family and domain databases

InterProiView protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR004140 Exo70
PANTHERiPTHR12542 PTHR12542, 1 hit
PfamiView protein in Pfam
PF03081 Exo70, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXOC7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPT5
Secondary accession number(s): B5MC69
, B8XXP2, Q8ND93, Q8WV91, Q96FF0, Q9H8C3, Q9H9X3, Q9HA32
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 14, 2003
Last modified: June 17, 2020
This is version 182 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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