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UniProtKB - Q9UPT5 (EXOC7_HUMAN)

Protein

Exocyst complex component 7

Gene

EXOC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).By similarity

GO - Biological processi

  • exocytosis Source: UniProtKB-KW
  • protein transport Source: UniProtKB-KW
  • regulation of entry of bacterium into host cell Source: AgBase
  • regulation of macroautophagy Source: ParkinsonsUK-UCL
View the complete GO annotation on QuickGO ...

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium
SIGNORiQ9UPT5

Protein family/group databases

TCDBi1.F.2.1.2 the octameric exocyst (exocyst) family

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 7
Alternative name(s):
Exocyst complex component Exo70
Gene namesi
Name:EXOC7
Synonyms:EXO70, KIAA1067
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000182473.21
HGNCiHGNC:23214 EXOC7
MIMi608163 gene
neXtProtiNX_Q9UPT5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23265
OpenTargetsiENSG00000182473
PharmGKBiPA134988420

Polymorphism and mutation databases

BioMutaiEXOC7
DMDMi38372889

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189601 – 735Exocyst complex component 7Add BLAST735

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei133PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9UPT5
MaxQBiQ9UPT5
PaxDbiQ9UPT5
PeptideAtlasiQ9UPT5
PRIDEiQ9UPT5
ProteomicsDBi85434
85435 [Q9UPT5-1]
85436 [Q9UPT5-2]
85437 [Q9UPT5-4]
85438 [Q9UPT5-5]
85439 [Q9UPT5-6]

PTM databases

iPTMnetiQ9UPT5
PhosphoSitePlusiQ9UPT5

Expressioni

Gene expression databases

BgeeiENSG00000182473 Expressed in 227 organ(s), highest expression level in right uterine tube
CleanExiHS_EXOC7
ExpressionAtlasiQ9UPT5 baseline and differential
GenevisibleiQ9UPT5 HS

Organism-specific databases

HPAiHPA022840
HPA022842

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with ARHQ in a GTP-dependent manner. Interacts with RAB11FIP3 (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi116867, 62 interactors
CORUMiQ9UPT5
DIPiDIP-37604N
IntActiQ9UPT5, 44 interactors
MINTiQ9UPT5
STRINGi9606.ENSP00000334100

Structurei

3D structure databases

ProteinModelPortaliQ9UPT5
SMRiQ9UPT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili5 – 42Sequence analysisAdd BLAST38
Coiled coili63 – 85Sequence analysisAdd BLAST23

Domaini

The N-terminus is involved in SEC8 and ARHQ binding.By similarity
The C-terminus is required for translocation to the plasma membrane.By similarity

Sequence similaritiesi

Belongs to the EXO70 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2344 Eukaryota
ENOG410YIGI LUCA
GeneTreeiENSGT00390000003595
HOVERGENiHBG051515
InParanoidiQ9UPT5
KOiK07195
OMAiKDRVDKY
OrthoDBiEOG091G02QC
PhylomeDBiQ9UPT5
TreeFamiTF324243

Family and domain databases

InterProiView protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR004140 Exo70
PANTHERiPTHR12542 PTHR12542, 1 hit
PfamiView protein in Pfam
PF03081 Exo70, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q9UPT5-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIPPQEASAR RREIEDKLKQ EEETLSFIRD SLEKSDQLTK NMVSILSSFE 
        60         70         80         90        100
SRLMKLENSI IPVHKQTENL QRLQENVEKT LSCLDHVISY YHVASDTEKI 
       110        120        130        140        150
IREGPTGRLE EYLGSMAKIQ KAVEYFQDNS PDSPELNKVK LLFERGKEAL 
       160        170        180        190        200
ESEFRSLMTR HSKVVSPVLI LDLISGDDDL EAQEDVTLEH LPESVLQDVI 
       210        220        230        240        250
RISRWLVEYG RNQDFMNVYY QIRSSQLDRS IKGLKEHFHK SSSSSGVPYS 
       260        270        280        290        300
PAIPNKRKDT PTKKPVKRPG TIRKAQNLLK QYSQHGLDGK KGGSNLIPLE 
       310        320        330        340        350
GLLPCTPRGG LPGPWINAAC VCAADISPGH EHDFRVKHLS EALNDKHGPL 
       360        370        380        390        400
AGRDDMLDVE TDAYIHCVSA FVKLAQSEYQ LLADIIPEHH QKKTFDSLIQ 
       410        420        430        440        450
DALDGLMLEG ENIVSAARKA IVRHDFSTVL TVFPILRHLK QTKPEFDQVL 
       460        470        480        490        500
QGTAASTKNK LPGLITSMET IGAKALEDFA DNIKNDPDKE YNMPKDGTVH 
       510        520        530        540        550
ELTSNAILFL QQLLDFQETA GAMLASQETS SSATSYSSEF SKRLLSTYIC 
       560        570        580        590        600
KVLGNLQLNL LSKSKVYEDP ALSAIFLHNN YNYILKSLEK SELIQLVAVT 
       610        620        630        640        650
QKTAERSYRE HIEQQIQTYQ RSWLKVTDYI AEKNLPVFQP GVKLRDKERQ 
       660        670        680        690        700
IIKERFKGFN DGLEELCKIQ KAWAIPDTEQ RDRIRQAQKT IVKETYGAFL 
       710        720        730 
QKFGSVPFTK NPEKYIKYGV EQVGDMIDRL FDTSA
Note: No experimental confirmation available.
Length:735
Mass (Da):83,382
Last modified:November 14, 2003 - v3
Checksum:i6B929762542854B6
GO
Isoform 1 (identifier: Q9UPT5-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     302-352: Missing.

Show »
Length:684
Mass (Da):78,060
Checksum:i6E25C7BAB9017D9E
GO
Isoform 2 (identifier: Q9UPT5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-352: Missing.

Show »
Length:653
Mass (Da):74,713
Checksum:iD70DC752161DDE68
GO
Isoform 4 (identifier: Q9UPT5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-283: TIRKAQNLLKQYS → EPPSWPISATARG
     284-735: Missing.

Note: May be due to intron retention. No experimental confirmation available.
Show »
Length:283
Mass (Da):32,451
Checksum:i93885953F51F60E1
GO
Isoform 5 (identifier: Q9UPT5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-327: Missing.

Show »
Length:676
Mass (Da):77,303
Checksum:i2CBC61E2A6578A8A
GO
Isoform 6 (identifier: Q9UPT5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-328: Missing.

Show »
Length:707
Mass (Da):80,650
Checksum:i3EF94FEE3F52C8E9
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSB8A0A0A0MSB8_HUMAN
Exocyst complex component 7
EXOC7
693Annotation score:
B4DJ07B4DJ07_HUMAN
Exocyst complex component 7
EXOC7
656Annotation score:
A0A0A0MRE1A0A0A0MRE1_HUMAN
Exocyst complex component 7
EXOC7
617Annotation score:
B5MCY9B5MCY9_HUMAN
Exocyst complex component 7, isofor...
EXOC7 hCG_40887
159Annotation score:
K7ERQ5K7ERQ5_HUMAN
Exocyst complex component 7
EXOC7
168Annotation score:
C9JKC2C9JKC2_HUMAN
Exocyst complex component 7
EXOC7
122Annotation score:
C9JME6C9JME6_HUMAN
Exocyst complex component 7
EXOC7
121Annotation score:
K7ENP8K7ENP8_HUMAN
Exocyst complex component 7
EXOC7
33Annotation score:

Sequence cautioni

The sequence BAA83019 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB14095 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234L → Q in BAB14694 (PubMed:14702039).Curated1
Sequence conflicti362D → N in BAB14694 (PubMed:14702039).Curated1
Sequence conflicti459N → I in AAH18466 (PubMed:15489334).Curated1
Sequence conflicti646D → G in BAB14694 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041098269 – 327Missing in isoform 5. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_001483271 – 352Missing in isoform 2. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_008876271 – 283TIRKA…LKQYS → EPPSWPISATARG in isoform 4. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_008877284 – 735Missing in isoform 4. 1 PublicationAdd BLAST452
Alternative sequenceiVSP_041099301 – 328Missing in isoform 6. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_008878302 – 352Missing in isoform 1. 3 PublicationsAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ457119 mRNA Translation: ACK36853.1
FJ457120 mRNA Translation: ACK36854.1
AB028990 mRNA Translation: BAA83019.1 Different initiation.
AK022397 mRNA Translation: BAB14026.1
AK022552 mRNA Translation: BAB14095.1 Different initiation.
AK023832 mRNA Translation: BAB14694.1
AL834324 mRNA Translation: CAD38992.2
AC018665 Genomic DNA No translation available.
BC011045 mRNA Translation: AAH11045.1
BC018466 mRNA Translation: AAH18466.1
CCDSiCCDS11741.1 [Q9UPT5-2]
CCDS32738.1 [Q9UPT5-1]
CCDS45781.1 [Q9UPT5-5]
CCDS45782.1 [Q9UPT5-3]
CCDS45783.1 [Q9UPT5-6]
RefSeqiNP_001013861.1, NM_001013839.3 [Q9UPT5-1]
NP_001138769.1, NM_001145297.3 [Q9UPT5-3]
NP_001138770.1, NM_001145298.3 [Q9UPT5-5]
NP_001138771.1, NM_001145299.3 [Q9UPT5-6]
NP_001269242.1, NM_001282313.1
NP_056034.2, NM_015219.4 [Q9UPT5-2]
UniGeneiHs.514496

Genome annotation databases

EnsembliENST00000332065; ENSP00000333806; ENSG00000182473 [Q9UPT5-2]
ENST00000335146; ENSP00000334100; ENSG00000182473 [Q9UPT5-3]
ENST00000411744; ENSP00000404322; ENSG00000182473 [Q9UPT5-5]
ENST00000589210; ENSP00000468404; ENSG00000182473 [Q9UPT5-1]
ENST00000634349; ENSP00000489266; ENSG00000182473 [Q9UPT5-6]
GeneIDi23265
KEGGihsa:23265
UCSCiuc002jqq.5 human [Q9UPT5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ457119 mRNA Translation: ACK36853.1
FJ457120 mRNA Translation: ACK36854.1
AB028990 mRNA Translation: BAA83019.1 Different initiation.
AK022397 mRNA Translation: BAB14026.1
AK022552 mRNA Translation: BAB14095.1 Different initiation.
AK023832 mRNA Translation: BAB14694.1
AL834324 mRNA Translation: CAD38992.2
AC018665 Genomic DNA No translation available.
BC011045 mRNA Translation: AAH11045.1
BC018466 mRNA Translation: AAH18466.1
CCDSiCCDS11741.1 [Q9UPT5-2]
CCDS32738.1 [Q9UPT5-1]
CCDS45781.1 [Q9UPT5-5]
CCDS45782.1 [Q9UPT5-3]
CCDS45783.1 [Q9UPT5-6]
RefSeqiNP_001013861.1, NM_001013839.3 [Q9UPT5-1]
NP_001138769.1, NM_001145297.3 [Q9UPT5-3]
NP_001138770.1, NM_001145298.3 [Q9UPT5-5]
NP_001138771.1, NM_001145299.3 [Q9UPT5-6]
NP_001269242.1, NM_001282313.1
NP_056034.2, NM_015219.4 [Q9UPT5-2]
UniGeneiHs.514496

3D structure databases

ProteinModelPortaliQ9UPT5
SMRiQ9UPT5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116867, 62 interactors
CORUMiQ9UPT5
DIPiDIP-37604N
IntActiQ9UPT5, 44 interactors
MINTiQ9UPT5
STRINGi9606.ENSP00000334100

Protein family/group databases

TCDBi1.F.2.1.2 the octameric exocyst (exocyst) family

PTM databases

iPTMnetiQ9UPT5
PhosphoSitePlusiQ9UPT5

Polymorphism and mutation databases

BioMutaiEXOC7
DMDMi38372889

Proteomic databases

EPDiQ9UPT5
MaxQBiQ9UPT5
PaxDbiQ9UPT5
PeptideAtlasiQ9UPT5
PRIDEiQ9UPT5
ProteomicsDBi85434
85435 [Q9UPT5-1]
85436 [Q9UPT5-2]
85437 [Q9UPT5-4]
85438 [Q9UPT5-5]
85439 [Q9UPT5-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332065; ENSP00000333806; ENSG00000182473 [Q9UPT5-2]
ENST00000335146; ENSP00000334100; ENSG00000182473 [Q9UPT5-3]
ENST00000411744; ENSP00000404322; ENSG00000182473 [Q9UPT5-5]
ENST00000589210; ENSP00000468404; ENSG00000182473 [Q9UPT5-1]
ENST00000634349; ENSP00000489266; ENSG00000182473 [Q9UPT5-6]
GeneIDi23265
KEGGihsa:23265
UCSCiuc002jqq.5 human [Q9UPT5-3]

Organism-specific databases

CTDi23265
DisGeNETi23265
EuPathDBiHostDB:ENSG00000182473.21
GeneCardsiEXOC7
HGNCiHGNC:23214 EXOC7
HPAiHPA022840
HPA022842
MIMi608163 gene
neXtProtiNX_Q9UPT5
OpenTargetsiENSG00000182473
PharmGKBiPA134988420
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2344 Eukaryota
ENOG410YIGI LUCA
GeneTreeiENSGT00390000003595
HOVERGENiHBG051515
InParanoidiQ9UPT5
KOiK07195
OMAiKDRVDKY
OrthoDBiEOG091G02QC
PhylomeDBiQ9UPT5
TreeFamiTF324243

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium
SIGNORiQ9UPT5

Miscellaneous databases

ChiTaRSiEXOC7 human
GeneWikiiEXOC7
GenomeRNAii23265
PROiPR:Q9UPT5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182473 Expressed in 227 organ(s), highest expression level in right uterine tube
CleanExiHS_EXOC7
ExpressionAtlasiQ9UPT5 baseline and differential
GenevisibleiQ9UPT5 HS

Family and domain databases

InterProiView protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR004140 Exo70
PANTHERiPTHR12542 PTHR12542, 1 hit
PfamiView protein in Pfam
PF03081 Exo70, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC7_HUMAN
AccessioniPrimary (citable) accession number: Q9UPT5
Secondary accession number(s): B5MC69
, B8XXP2, Q8ND93, Q8WV91, Q96FF0, Q9H8C3, Q9H9X3, Q9HA32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 14, 2003
Last modified: November 7, 2018
This is version 171 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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