UniProtKB - Q9UPT5 (EXOC7_HUMAN)
Protein
Exocyst complex component 7
Gene
EXOC7
Organism
Homo sapiens (Human)
Status
Functioni
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).By similarity
GO - Biological processi
- cilium assembly Source: Reactome
- exocytosis Source: GO_Central
- protein transport Source: UniProtKB-KW
- regulation of entry of bacterium into host cell Source: AgBase
- regulation of macroautophagy Source: ParkinsonsUK-UCL
Keywordsi
Biological process | Exocytosis, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9UPT5 |
Reactomei | R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-264876, Insulin processing R-HSA-5620916, VxPx cargo-targeting to cilium |
SIGNORi | Q9UPT5 |
Protein family/group databases
TCDBi | 1.F.2.1.2, the octameric exocyst (exocyst) family |
Names & Taxonomyi
Protein namesi | Recommended name: Exocyst complex component 7Alternative name(s): Exocyst complex component Exo70 |
Gene namesi | Name:EXOC7 Synonyms:EXO70, KIAA1067 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23214, EXOC7 |
MIMi | 608163, gene |
neXtProti | NX_Q9UPT5 |
VEuPathDBi | HostDB:ENSG00000182473.21 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein Curated
Cytoplasm and Cytosol
- cytosol By similarity
Other locations
- Midbody ring 1 Publication
Note: Translocates, as a preformed complex with EXOC3/SEC6 and EXOC4/SEC8, to the plasma membrane in response to insulin through the activation of ARHQ (By similarity). Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214).By similarity1 Publication
Cytoskeleton
- centriolar satellite Source: BHF-UCL
- microtubule organizing center Source: BHF-UCL
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- growth cone membrane Source: Ensembl
- plasma membrane Source: Reactome
Other locations
- exocyst Source: GO_Central
- Flemming body Source: UniProtKB-SubCell
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 23265 |
OpenTargetsi | ENSG00000182473 |
PharmGKBi | PA134988420 |
Miscellaneous databases
Pharosi | Q9UPT5, Tbio |
Genetic variation databases
BioMutai | EXOC7 |
DMDMi | 38372889 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118960 | 1 – 735 | Exocyst complex component 7Add BLAST | 735 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 133 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9UPT5 |
jPOSTi | Q9UPT5 |
MassIVEi | Q9UPT5 |
MaxQBi | Q9UPT5 |
PaxDbi | Q9UPT5 |
PeptideAtlasi | Q9UPT5 |
PRIDEi | Q9UPT5 |
ProteomicsDBi | 85434 [Q9UPT5-3] 85435 [Q9UPT5-1] 85436 [Q9UPT5-2] 85437 [Q9UPT5-4] 85438 [Q9UPT5-5] 85439 [Q9UPT5-6] |
PTM databases
iPTMneti | Q9UPT5 |
PhosphoSitePlusi | Q9UPT5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182473, Expressed in right uterine tube and 241 other tissues |
ExpressionAtlasi | Q9UPT5, baseline and differential |
Genevisiblei | Q9UPT5, HS |
Organism-specific databases
HPAi | ENSG00000182473, Low tissue specificity |
Interactioni
Subunit structurei
The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8.
Interacts with ARHQ in a GTP-dependent manner.
Interacts with RAB11FIP3 (By similarity).
By similarityBinary interactionsi
Hide detailsQ9UPT5
Isoform 1 [Q9UPT5-1]
Protein-protein interaction databases
BioGRIDi | 116867, 87 interactors |
ComplexPortali | CPX-4943, Exocyst, EXOC6 variant CPX-4944, Exocyst, EXOC6B variant |
CORUMi | Q9UPT5 |
DIPi | DIP-37604N |
IntActi | Q9UPT5, 69 interactors |
MINTi | Q9UPT5 |
STRINGi | 9606.ENSP00000334100 |
Miscellaneous databases
RNActi | Q9UPT5, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 5 – 42 | Sequence analysisAdd BLAST | 38 | |
Coiled coili | 63 – 85 | Sequence analysisAdd BLAST | 23 |
Domaini
The N-terminus is involved in SEC8 and ARHQ binding.By similarity
The C-terminus is required for translocation to the plasma membrane.By similarity
Sequence similaritiesi
Belongs to the EXO70 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2344, Eukaryota |
GeneTreei | ENSGT00390000003595 |
InParanoidi | Q9UPT5 |
OMAi | YHDLSTQ |
OrthoDBi | 410847at2759 |
PhylomeDBi | Q9UPT5 |
TreeFami | TF324243 |
Family and domain databases
InterProi | View protein in InterPro IPR016159, Cullin_repeat-like_dom_sf IPR004140, Exo70 |
PANTHERi | PTHR12542, PTHR12542, 1 hit |
Pfami | View protein in Pfam PF03081, Exo70, 1 hit |
SUPFAMi | SSF74788, SSF74788, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 3 (identifier: Q9UPT5-3) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MIPPQEASAR RREIEDKLKQ EEETLSFIRD SLEKSDQLTK NMVSILSSFE
60 70 80 90 100
SRLMKLENSI IPVHKQTENL QRLQENVEKT LSCLDHVISY YHVASDTEKI
110 120 130 140 150
IREGPTGRLE EYLGSMAKIQ KAVEYFQDNS PDSPELNKVK LLFERGKEAL
160 170 180 190 200
ESEFRSLMTR HSKVVSPVLI LDLISGDDDL EAQEDVTLEH LPESVLQDVI
210 220 230 240 250
RISRWLVEYG RNQDFMNVYY QIRSSQLDRS IKGLKEHFHK SSSSSGVPYS
260 270 280 290 300
PAIPNKRKDT PTKKPVKRPG TIRKAQNLLK QYSQHGLDGK KGGSNLIPLE
310 320 330 340 350
GLLPCTPRGG LPGPWINAAC VCAADISPGH EHDFRVKHLS EALNDKHGPL
360 370 380 390 400
AGRDDMLDVE TDAYIHCVSA FVKLAQSEYQ LLADIIPEHH QKKTFDSLIQ
410 420 430 440 450
DALDGLMLEG ENIVSAARKA IVRHDFSTVL TVFPILRHLK QTKPEFDQVL
460 470 480 490 500
QGTAASTKNK LPGLITSMET IGAKALEDFA DNIKNDPDKE YNMPKDGTVH
510 520 530 540 550
ELTSNAILFL QQLLDFQETA GAMLASQETS SSATSYSSEF SKRLLSTYIC
560 570 580 590 600
KVLGNLQLNL LSKSKVYEDP ALSAIFLHNN YNYILKSLEK SELIQLVAVT
610 620 630 640 650
QKTAERSYRE HIEQQIQTYQ RSWLKVTDYI AEKNLPVFQP GVKLRDKERQ
660 670 680 690 700
IIKERFKGFN DGLEELCKIQ KAWAIPDTEQ RDRIRQAQKT IVKETYGAFL
710 720 730
QKFGSVPFTK NPEKYIKYGV EQVGDMIDRL FDTSA
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MSB8 | A0A0A0MSB8_HUMAN | Exocyst complex component 7 | EXOC7 | 693 | Annotation score: | ||
B4DJ07 | B4DJ07_HUMAN | Exocyst complex component 7 | EXOC7 | 656 | Annotation score: | ||
A0A0A0MRE1 | A0A0A0MRE1_HUMAN | Exocyst complex component 7 | EXOC7 | 617 | Annotation score: | ||
B5MCY9 | B5MCY9_HUMAN | Exocyst complex component 7 | EXOC7 hCG_40887 | 159 | Annotation score: | ||
K7ERQ5 | K7ERQ5_HUMAN | Exocyst complex component 7 | EXOC7 | 168 | Annotation score: | ||
C9JKC2 | C9JKC2_HUMAN | Exocyst complex component 7 | EXOC7 | 122 | Annotation score: | ||
C9JME6 | C9JME6_HUMAN | Exocyst complex component 7 | EXOC7 | 121 | Annotation score: | ||
K7ENP8 | K7ENP8_HUMAN | Exocyst complex component 7 | EXOC7 | 33 | Annotation score: |
Sequence cautioni
The sequence BAA83019 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB14095 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 234 | L → Q in BAB14694 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 362 | D → N in BAB14694 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 459 | N → I in AAH18466 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 646 | D → G in BAB14694 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041098 | 269 – 327 | Missing in isoform 5. 1 PublicationAdd BLAST | 59 | |
Alternative sequenceiVSP_001483 | 271 – 352 | Missing in isoform 2. 1 PublicationAdd BLAST | 82 | |
Alternative sequenceiVSP_008876 | 271 – 283 | TIRKA…LKQYS → EPPSWPISATARG in isoform 4. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_008877 | 284 – 735 | Missing in isoform 4. 1 PublicationAdd BLAST | 452 | |
Alternative sequenceiVSP_041099 | 301 – 328 | Missing in isoform 6. 1 PublicationAdd BLAST | 28 | |
Alternative sequenceiVSP_008878 | 302 – 352 | Missing in isoform 1. 3 PublicationsAdd BLAST | 51 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ457119 mRNA Translation: ACK36853.1 FJ457120 mRNA Translation: ACK36854.1 AB028990 mRNA Translation: BAA83019.1 Different initiation. AK022397 mRNA Translation: BAB14026.1 AK022552 mRNA Translation: BAB14095.1 Different initiation. AK023832 mRNA Translation: BAB14694.1 AL834324 mRNA Translation: CAD38992.2 AC018665 Genomic DNA No translation available. BC011045 mRNA Translation: AAH11045.1 BC018466 mRNA Translation: AAH18466.1 |
CCDSi | CCDS11741.1 [Q9UPT5-2] CCDS32738.1 [Q9UPT5-1] CCDS45781.1 [Q9UPT5-5] CCDS45782.1 [Q9UPT5-3] CCDS45783.1 [Q9UPT5-6] |
RefSeqi | NP_001013861.1, NM_001013839.3 [Q9UPT5-1] NP_001138769.1, NM_001145297.3 [Q9UPT5-3] NP_001138770.1, NM_001145298.3 [Q9UPT5-5] NP_001138771.1, NM_001145299.3 [Q9UPT5-6] NP_001269242.1, NM_001282313.1 NP_056034.2, NM_015219.4 [Q9UPT5-2] |
Genome annotation databases
Ensembli | ENST00000332065; ENSP00000333806; ENSG00000182473 [Q9UPT5-2] ENST00000335146; ENSP00000334100; ENSG00000182473 [Q9UPT5-3] ENST00000411744; ENSP00000404322; ENSG00000182473 [Q9UPT5-5] ENST00000589210; ENSP00000468404; ENSG00000182473 [Q9UPT5-1] ENST00000634349; ENSP00000489266; ENSG00000182473 [Q9UPT5-6] |
GeneIDi | 23265 |
KEGGi | hsa:23265 |
UCSCi | uc002jqq.5, human [Q9UPT5-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ457119 mRNA Translation: ACK36853.1 FJ457120 mRNA Translation: ACK36854.1 AB028990 mRNA Translation: BAA83019.1 Different initiation. AK022397 mRNA Translation: BAB14026.1 AK022552 mRNA Translation: BAB14095.1 Different initiation. AK023832 mRNA Translation: BAB14694.1 AL834324 mRNA Translation: CAD38992.2 AC018665 Genomic DNA No translation available. BC011045 mRNA Translation: AAH11045.1 BC018466 mRNA Translation: AAH18466.1 |
CCDSi | CCDS11741.1 [Q9UPT5-2] CCDS32738.1 [Q9UPT5-1] CCDS45781.1 [Q9UPT5-5] CCDS45782.1 [Q9UPT5-3] CCDS45783.1 [Q9UPT5-6] |
RefSeqi | NP_001013861.1, NM_001013839.3 [Q9UPT5-1] NP_001138769.1, NM_001145297.3 [Q9UPT5-3] NP_001138770.1, NM_001145298.3 [Q9UPT5-5] NP_001138771.1, NM_001145299.3 [Q9UPT5-6] NP_001269242.1, NM_001282313.1 NP_056034.2, NM_015219.4 [Q9UPT5-2] |
3D structure databases
SMRi | Q9UPT5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116867, 87 interactors |
ComplexPortali | CPX-4943, Exocyst, EXOC6 variant CPX-4944, Exocyst, EXOC6B variant |
CORUMi | Q9UPT5 |
DIPi | DIP-37604N |
IntActi | Q9UPT5, 69 interactors |
MINTi | Q9UPT5 |
STRINGi | 9606.ENSP00000334100 |
Protein family/group databases
TCDBi | 1.F.2.1.2, the octameric exocyst (exocyst) family |
PTM databases
iPTMneti | Q9UPT5 |
PhosphoSitePlusi | Q9UPT5 |
Genetic variation databases
BioMutai | EXOC7 |
DMDMi | 38372889 |
Proteomic databases
EPDi | Q9UPT5 |
jPOSTi | Q9UPT5 |
MassIVEi | Q9UPT5 |
MaxQBi | Q9UPT5 |
PaxDbi | Q9UPT5 |
PeptideAtlasi | Q9UPT5 |
PRIDEi | Q9UPT5 |
ProteomicsDBi | 85434 [Q9UPT5-3] 85435 [Q9UPT5-1] 85436 [Q9UPT5-2] 85437 [Q9UPT5-4] 85438 [Q9UPT5-5] 85439 [Q9UPT5-6] |
Protocols and materials databases
Antibodypediai | 19667, 189 antibodies |
Genome annotation databases
Ensembli | ENST00000332065; ENSP00000333806; ENSG00000182473 [Q9UPT5-2] ENST00000335146; ENSP00000334100; ENSG00000182473 [Q9UPT5-3] ENST00000411744; ENSP00000404322; ENSG00000182473 [Q9UPT5-5] ENST00000589210; ENSP00000468404; ENSG00000182473 [Q9UPT5-1] ENST00000634349; ENSP00000489266; ENSG00000182473 [Q9UPT5-6] |
GeneIDi | 23265 |
KEGGi | hsa:23265 |
UCSCi | uc002jqq.5, human [Q9UPT5-3] |
Organism-specific databases
CTDi | 23265 |
DisGeNETi | 23265 |
GeneCardsi | EXOC7 |
HGNCi | HGNC:23214, EXOC7 |
HPAi | ENSG00000182473, Low tissue specificity |
MIMi | 608163, gene |
neXtProti | NX_Q9UPT5 |
OpenTargetsi | ENSG00000182473 |
PharmGKBi | PA134988420 |
VEuPathDBi | HostDB:ENSG00000182473.21 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2344, Eukaryota |
GeneTreei | ENSGT00390000003595 |
InParanoidi | Q9UPT5 |
OMAi | YHDLSTQ |
OrthoDBi | 410847at2759 |
PhylomeDBi | Q9UPT5 |
TreeFami | TF324243 |
Enzyme and pathway databases
PathwayCommonsi | Q9UPT5 |
Reactomei | R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-264876, Insulin processing R-HSA-5620916, VxPx cargo-targeting to cilium |
SIGNORi | Q9UPT5 |
Miscellaneous databases
BioGRID-ORCSi | 23265, 309 hits in 998 CRISPR screens |
ChiTaRSi | EXOC7, human |
GeneWikii | EXOC7 |
GenomeRNAii | 23265 |
Pharosi | Q9UPT5, Tbio |
PROi | PR:Q9UPT5 |
RNActi | Q9UPT5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182473, Expressed in right uterine tube and 241 other tissues |
ExpressionAtlasi | Q9UPT5, baseline and differential |
Genevisiblei | Q9UPT5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR016159, Cullin_repeat-like_dom_sf IPR004140, Exo70 |
PANTHERi | PTHR12542, PTHR12542, 1 hit |
Pfami | View protein in Pfam PF03081, Exo70, 1 hit |
SUPFAMi | SSF74788, SSF74788, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EXOC7_HUMAN | |
Accessioni | Q9UPT5Primary (citable) accession number: Q9UPT5 Secondary accession number(s): B5MC69 Q9HA32 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2002 |
Last sequence update: | November 14, 2003 | |
Last modified: | April 7, 2021 | |
This is version 187 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families