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Entry version 154 (12 Aug 2020)
Sequence version 4 (12 Sep 2018)
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Protein

Ankyrin repeat domain-containing protein 26

Gene

ANKRD26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UPS8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 26Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKRD26Imported
Synonyms:KIAA1074
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000107890.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29186, ANKRD26

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610855, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UPS8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Thrombocytopenia 2 (THC2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionThrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
22852

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
ANKRD26

MalaCards human disease database

More...
MalaCardsi
ANKRD26
MIMi188000, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000107890

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
71290, Familial platelet disorder with associated myeloid malignancy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134926710

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UPS8, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKRD26

Domain mapping of disease mutations (DMDM)

More...
DMDMi
109940217

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002408431 – 1710Ankyrin repeat domain-containing protein 26Add BLAST1710

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei241PhosphoserineBy similarity1
Modified residuei261PhosphoserineCombined sources1
Modified residuei489PhosphoserineCombined sources1
Modified residuei530PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UPS8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UPS8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UPS8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UPS8

PeptideAtlas

More...
PeptideAtlasi
Q9UPS8

PRoteomics IDEntifications database

More...
PRIDEi
Q9UPS8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85431 [Q9UPS8-1]
85432 [Q9UPS8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UPS8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UPS8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000107890, Expressed in frontal cortex and 173 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UPS8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UPS8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000107890, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRIO (PubMed:22666460).

Interacts with GPS2 (PubMed:22666460).

Interacts with CCDC85B (PubMed:22666460).

Interacts with HMMR (PubMed:22666460).

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116523, 21 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UPS8, 18 interactors

Molecular INTeraction database

More...
MINTi
Q9UPS8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365255

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UPS8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UPS8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati45 – 75ANK 1Add BLAST31
Repeati79 – 108ANK 2Add BLAST30
Repeati112 – 141ANK 3Add BLAST30
Repeati145 – 174ANK 4Add BLAST30
Repeati178 – 207ANK 5Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili529 – 566Sequence analysisAdd BLAST38
Coiled coili743 – 873Sequence analysisAdd BLAST131
Coiled coili905 – 1472Sequence analysisAdd BLAST568
Coiled coili1517 – 1587Sequence analysisAdd BLAST71
Coiled coili1649 – 1674Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi25 – 28Poly-Gly4
Compositional biasi574 – 579Poly-Asp6

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QR0R, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162459

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001111_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UPS8

Database of Orthologous Groups

More...
OrthoDBi
305292at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UPS8

TreeFam database of animal gene trees

More...
TreeFami
TF333496

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR039497, CC144C-like_CC_dom
IPR021885, DUF3496

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 1 hit
PF14915, CCDC144C, 1 hit
PF12001, DUF3496, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKIFSKKGE SPLGSFARRQ RSSAGGGGEP GEGAYSQPGY HVRDRDLGKI
60 70 80 90 100
HKAASAGNVA KVQQILLLRK NGLNDRDKMN RTALHLACAN GHPEVVTLLV
110 120 130 140 150
DRKCQLNVCD NENRTALMKA VQCQEEKCAT ILLEHGADPN LADVHGNTAL
160 170 180 190 200
HYAVYNEDIS VATKLLLYDA NIEAKNKDDL TPLLLAVSGK KQQMVEFLIK
210 220 230 240 250
KKANVNAVDK LESSHQLISE YKEERIPKHS SQNSNSVDES SEDSLSRLSG
260 270 280 290 300
KPGVDDSWPT SDDEDLNFDT KNVPKPSLAK LMTASQQSRK NLEATYGTVR
310 320 330 340 350
TGNRTLFEDR DSDSQDEVVV ESLPTTSIKV QCFSHPTYQS PDLLPKPSHK
360 370 380 390 400
SLANPGLMKE EPTKPGIAKK ENGIDIIESA PLEQTNNDNL TYVDEVHKNN
410 420 430 440 450
RSDMMSALGL GQEEDIESPW DSESISENFP QKYVDPLAGA ADGKEKNIGN
460 470 480 490 500
EQAEDVFYIP SCMSGSRNFK MAKLEDTRNV GMPVAHMESP ERYLHLKPTI
510 520 530 540 550
EMKDSVPNKA GGMKDVQTSK AAEHDLEVAS EEEQEREGSE NNQPQVEEER
560 570 580 590 600
KKHRNNEMEV SANIHDGATD DAEDDDDDDG LIQKRKSGET DHQQFPRKEN
610 620 630 640 650
KEYASSGPAL QMKEVKSTEK EKRTSKESVN SPVFGKASLL TGGLLQVDDD
660 670 680 690 700
SSLSEIDEDE GRPTKKTSNE KNKVKNQIQS MDDVDDLTQS SETASEDCEL
710 720 730 740 750
PHSSYKNFML LIEQLGMECK DSVSLLKIQD AALSCERLLE LKKNHCELLT
760 770 780 790 800
VKIKKMEDKV NVLQRELSET KEIKSQLEHQ KVEWERELCS LRFSLNQEEE
810 820 830 840 850
KRRNADTLYE KIREQLRRKE EQYRKEVEVK QQLELSLQTL EMELRTVKSN
860 870 880 890 900
LNQVVQERND AQRQLSREQN ARMLQDGILT NHLSKQKEIE MAQKKMNSEN
910 920 930 940 950
SHSHEEEKDL SHKNSMLQEE IAMLRLEIDT IKNQNQEKEK KCFEDLKIVK
960 970 980 990 1000
EKNEDLQKTI KQNEETLTQT ISQYNGRLSV LTAENAMLNS KLENEKQSKE
1010 1020 1030 1040 1050
RLEAEVESYH SRLAAAIHDR DQSETSKREL ELAFQRARDE CSRLQDKMNF
1060 1070 1080 1090 1100
DVSNLKDNNE ILSQQLFKTE SKLNSLEIEF HHTRDALREK TLGLERVQKD
1110 1120 1130 1140 1150
LSQTQCQMKE MEQKYQNEQV KVNKYIGKQE SVEERLSQLQ SENMLLRQQL
1160 1170 1180 1190 1200
DDAHNKADNK EKTVINIQDQ FHAIVQKLQA ESEKQSLLLE ERNKELISEC
1210 1220 1230 1240 1250
NHLKERQYQY ENEKAEREVV VRQLQQELAD TLKKQSMSEA SLEVTSRYRI
1260 1270 1280 1290 1300
NLEDETQDLK KKLGQIRNQL QEAQDRHTEA VRCAEKMQDH KQKLEKDNAK
1310 1320 1330 1340 1350
LKVTVKKQMD KIEELQKNLL NANLSEDEKE QLKKLMELKQ SLECNLDQEM
1360 1370 1380 1390 1400
KKNVELEREI TGFKNLLKMT RKKLNEYENG EFSFHGDLKT SQFEMDIQIN
1410 1420 1430 1440 1450
KLKHKIDDLT AELETAGSKC LHLDTKNQIL QEELLSMKTV QKKCEKLQKN
1460 1470 1480 1490 1500
KKKLEQEVIN LRSHIERNMV ELGQVKQYKQ EIEERARQEI AEKLKEVNLF
1510 1520 1530 1540 1550
LQAQAASQEN LEQFRENNFA SMKSQMELRI KDLESELSKI KTSQEDFNKT
1560 1570 1580 1590 1600
ELEKYKQLYL EELKVRKSLS SKLTKTNERL AEVNTKLLVE KQQSRSLFTT
1610 1620 1630 1640 1650
LTTRPVMEPP CVGNLNNSLD LNRKLIPREN LVISTSNPRA SNNSMENYLS
1660 1670 1680 1690 1700
KMQQELEKNI TRELKEAAAE LESGSIASPL GSTDESNLNQ DLVWKASREY
1710
VQVLKKNYMI
Length:1,710
Mass (Da):196,411
Last modified:September 12, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01CBF9BADB894872
GO
Isoform 2 (identifier: Q9UPS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-443: Missing.
     444-545: KEKNIGNEQA...REGSENNQPQ → MNHMFHIKRH...EKEKVQLQKE

Show »
Length:1,267
Mass (Da):148,309
Checksum:i3F635BC067B3CBDE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ESJ3E7ESJ3_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD26
1,726Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4T9H0Y4T9_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD26
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83026 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1347D → G in BAC87508 (PubMed:14702039).Curated1
Sequence conflicti1517 – 1523NNFASMK → KQDLPDS in BAC87508 (PubMed:14702039).Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02683320Q → R2 PublicationsCorresponds to variant dbSNP:rs7897309EnsemblClinVar.1
Natural variantiVAR_055513425I → V. Corresponds to variant dbSNP:rs12359281EnsemblClinVar.1
Natural variantiVAR_080646606Missing 1 PublicationCorresponds to variant dbSNP:rs564681878Ensembl.1
Natural variantiVAR_0555141220V → L. Corresponds to variant dbSNP:rs12572862EnsemblClinVar.1
Natural variantiVAR_0268341305V → I1 PublicationCorresponds to variant dbSNP:rs10829163EnsemblClinVar.1
Natural variantiVAR_0268351514F → L1 PublicationCorresponds to variant dbSNP:rs2274741EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0194341 – 443Missing in isoform 2. 1 PublicationAdd BLAST443
Alternative sequenceiVSP_019435444 – 545KEKNI…NNQPQ → MNHMFHIKRHSISAGTDAYK KTKPIQNLFQKPLYDHCSAN NYKSMEPELENVRSSPPRGD RTSKVSLKEELQQDMQRFKN EIGMLKVEFQALEKEKVQLQ KE in isoform 2. 1 PublicationAdd BLAST102

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB028997 mRNA Translation: BAA83026.2 Different initiation.
AL162272 Genomic DNA No translation available.
AK001137 mRNA Translation: BAA91516.1
AK128577 mRNA Translation: BAC87508.1
AL137351 mRNA Translation: CAB70706.1
AL162063 mRNA Translation: CAB82401.1
BC110646 mRNA Translation: AAI10647.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41499.1 [Q9UPS8-1]

Protein sequence database of the Protein Information Resource

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PIRi
T46425
T47167

NCBI Reference Sequences

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RefSeqi
NP_001242982.1, NM_001256053.1
NP_055730.2, NM_014915.2 [Q9UPS8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000376087; ENSP00000365255; ENSG00000107890 [Q9UPS8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22852

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22852

UCSC genome browser

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UCSCi
uc009xku.2, human [Q9UPS8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028997 mRNA Translation: BAA83026.2 Different initiation.
AL162272 Genomic DNA No translation available.
AK001137 mRNA Translation: BAA91516.1
AK128577 mRNA Translation: BAC87508.1
AL137351 mRNA Translation: CAB70706.1
AL162063 mRNA Translation: CAB82401.1
BC110646 mRNA Translation: AAI10647.1
CCDSiCCDS41499.1 [Q9UPS8-1]
PIRiT46425
T47167
RefSeqiNP_001242982.1, NM_001256053.1
NP_055730.2, NM_014915.2 [Q9UPS8-1]

3D structure databases

SMRiQ9UPS8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116523, 21 interactors
IntActiQ9UPS8, 18 interactors
MINTiQ9UPS8
STRINGi9606.ENSP00000365255

PTM databases

iPTMnetiQ9UPS8
PhosphoSitePlusiQ9UPS8

Polymorphism and mutation databases

BioMutaiANKRD26
DMDMi109940217

Proteomic databases

EPDiQ9UPS8
jPOSTiQ9UPS8
MassIVEiQ9UPS8
PaxDbiQ9UPS8
PeptideAtlasiQ9UPS8
PRIDEiQ9UPS8
ProteomicsDBi85431 [Q9UPS8-1]
85432 [Q9UPS8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
25959, 118 antibodies

Genome annotation databases

EnsembliENST00000376087; ENSP00000365255; ENSG00000107890 [Q9UPS8-1]
GeneIDi22852
KEGGihsa:22852
UCSCiuc009xku.2, human [Q9UPS8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22852
DisGeNETi22852
EuPathDBiHostDB:ENSG00000107890.16

GeneCards: human genes, protein and diseases

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GeneCardsi
ANKRD26
GeneReviewsiANKRD26
HGNCiHGNC:29186, ANKRD26
HPAiENSG00000107890, Low tissue specificity
MalaCardsiANKRD26
MIMi188000, phenotype
610855, gene
neXtProtiNX_Q9UPS8
OpenTargetsiENSG00000107890
Orphaneti71290, Familial platelet disorder with associated myeloid malignancy
PharmGKBiPA134926710

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QR0R, Eukaryota
GeneTreeiENSGT00940000162459
HOGENOMiCLU_001111_0_0_1
InParanoidiQ9UPS8
OrthoDBi305292at2759
PhylomeDBiQ9UPS8
TreeFamiTF333496

Enzyme and pathway databases

PathwayCommonsiQ9UPS8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
22852, 2 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ANKRD26, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ANKRD26

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22852
PharosiQ9UPS8, Tbio

Protein Ontology

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PROi
PR:Q9UPS8
RNActiQ9UPS8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000107890, Expressed in frontal cortex and 173 other tissues
ExpressionAtlasiQ9UPS8, baseline and differential
GenevisibleiQ9UPS8, HS

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR039497, CC144C-like_CC_dom
IPR021885, DUF3496
PfamiView protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 1 hit
PF14915, CCDC144C, 1 hit
PF12001, DUF3496, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 4 hits
SUPFAMiSSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANR26_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPS8
Secondary accession number(s): A6NH29
, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: September 12, 2018
Last modified: August 12, 2020
This is version 154 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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