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Entry version 152 (12 Aug 2020)
Sequence version 3 (19 Mar 2014)
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Protein

Histone-lysine N-methyltransferase SETD1B

Gene

SETD1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1943S-adenosyl-L-methioninePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, Methyltransferase, RNA-binding, Transferase
Biological processTranscription, Transcription regulation
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UPS6

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3214841, PKMTs methylate histone lysines
R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SETD1B (EC:2.1.1.3541 Publication)
Alternative name(s):
Lysine N-methyltransferase 2G
SET domain-containing protein 1B
Short name:
hSET1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SETD1B
Synonyms:KIAA1076, KMT2G, SET1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000139718.10

Human Gene Nomenclature Database

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HGNCi
HGNC:29187, SETD1B

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611055, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UPS6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi577L → A: Abolishes interaction with RBM15. 1 Publication1
Mutagenesisi579D → A: Abolishes interaction with RBM15. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
23067

Open Targets

More...
OpenTargetsi
ENSG00000139718

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485611

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UPS6, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105837

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SETD1B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166977692

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003169931 – 1966Histone-lysine N-methyltransferase SETD1BAdd BLAST1966

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei986PhosphoserineCombined sources1
Modified residuei994PhosphoserineCombined sources1
Modified residuei1031PhosphoserineCombined sources1
Modified residuei1265PhosphoserineBy similarity1
Modified residuei1283PhosphoserineBy similarity1
Modified residuei1335PhosphoserineCombined sources1
Modified residuei1659PhosphoserineCombined sources1
Modified residuei1663PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UPS6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UPS6

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9UPS6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UPS6

PeptideAtlas

More...
PeptideAtlasi
Q9UPS6

PRoteomics IDEntifications database

More...
PRIDEi
Q9UPS6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85430 [Q9UPS6-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UPS6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UPS6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000139718, Expressed in endometrium and 254 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UPS6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UPS6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000139718, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30.

Interacts with HCFC1 and ASH2L/ASH2.

Interacts (via the RRM domain) with WDR82.

Interacts (via the RRM domain) with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A) only in the presence of WDR82. Binds specifically to CTD heptad repeats phosphorylated on 'Ser-5' of each heptad.

Interacts with RBM15.

Interacts (via WIN motif) with WDR5 (PubMed:22665483, PubMed:22266653).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116702, 31 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9UPS6

Database of interacting proteins

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DIPi
DIP-61947N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9UPS6

Protein interaction database and analysis system

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IntActi
Q9UPS6, 17 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000442924

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q9UPS6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11966
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UPS6

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini93 – 181RRMPROSITE-ProRule annotationAdd BLAST89
Domaini1827 – 1944SETPROSITE-ProRule annotationAdd BLAST118
Domaini1950 – 1966Post-SETPROSITE-ProRule annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1173 – 1204Sequence analysisAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1745 – 1750WDR5 interaction motif (WIN)2 Publications6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi366 – 1671Pro-richAdd BLAST1306
Compositional biasi1040 – 1175Ser-richAdd BLAST136
Compositional biasi1068 – 1312Glu-richAdd BLAST245
Compositional biasi1103 – 1138Asp-richAdd BLAST36

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1080, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154575

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001226_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9UPS6

Identification of Orthologs from Complete Genome Data

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OMAi
RIWTRLE

Database of Orthologous Groups

More...
OrthoDBi
1234689at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106436

Family and domain databases

Conserved Domains Database

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CDDi
cd12549, RRM_Set1B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

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IDEALi
IID00402

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024657, COMPASS_Set1_N-SET
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR003616, Post-SET_dom
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034468, Set1B_RRM
IPR001214, SET_dom
IPR037842, SETD1B

The PANTHER Classification System

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PANTHERi
PTHR45814:SF1, PTHR45814:SF1, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF11764, N-SET, 1 hit
PF00076, RRM_1, 1 hit
PF00856, SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01291, N-SET, 1 hit
SM00508, PostSET, 1 hit
SM00360, RRM, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50868, POST_SET, 1 hit
PS50102, RRM, 1 hit
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPS6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENSHPPHHH HQQPPPQPGP SGERRNHHWR SYKLMIDPAL KKGHHKLYRY
60 70 80 90 100
DGQHFSLAMS SNRPVEIVED PRVVGIWTKN KELELSVPKF KIDEFYVGPV
110 120 130 140 150
PPKQVTFAKL NDNIRENFLR DMCKKYGEVE EVEILYNPKT KKHLGIAKVV
160 170 180 190 200
FATVRGAKDA VQHLHSTSVM GNIIHVELDT KGETRMRFYE LLVTGRYTPQ
210 220 230 240 250
TLPVGELDAV SPIVNETLQL SDALKRLKDG GLSAGCGSGS SSVTPNSGGT
260 270 280 290 300
PFSQDTAYSS CRLDTPNSYG QGTPLTPRLG TPFSQDSSYS SRQPTPSYLF
310 320 330 340 350
SQDPAVTFKA RRHESKFTDA YNRRHEHHYV HNSPAVTAVA GATAAFRGSS
360 370 380 390 400
DLPFGAVGGT GGSSGPPFKA QPQDSATFAH TPPPAQATPA PGFKSAFSPY
410 420 430 440 450
QTPVAHFPPP PEEPTATAAF GARDSGEFRR APAPPPLPPA EPLAKEKPGT
460 470 480 490 500
PPGPPPPDTN SMELGGRPTF GWSPEPCDSP GTPTLESSPA GPEKPHDSLD
510 520 530 540 550
SRIEMLLKEQ RTKLLFLREP DSDTELQMEG SPISSSSSQL SPLAPFGTNS
560 570 580 590 600
QPGFRGPTPP SSRPSSTGLE DISPTPLPDS DEDEELDLGL GPRPPPEPGP
610 620 630 640 650
PDPAGLLSQT AEVALDLVGD RTPTSEKMDE GQQSSGEDME ISDDEMPSAP
660 670 680 690 700
ITSADCPKPM VVTPGAAAVA APSVLAPTLP LPPPPGFPPL PPPPPPPPPQ
710 720 730 740 750
PGFPMPPPLP PPPPPPPPAH PAVTVPPPPL PAPPGVPPPP ILPPLPPFPP
760 770 780 790 800
GLFPVMQVDM SHVLGGQWGG MPMSFQMQTQ VLSRLMTGQG ACPYPPFMAA
810 820 830 840 850
AAAAASAGLQ FVNLPPYRGP FSLSNSGPGR GQHWPPLPKF DPSVPPPGYM
860 870 880 890 900
PRQEDPHKAT VDGVLLVVLK ELKAIMKRDL NRKMVEVVAF RAFDEWWDKK
910 920 930 940 950
ERMAKASLTP VKSGEHKDED RPKPKDRIAS CLLESWGKGE GLGYEGLGLG
960 970 980 990 1000
IGLRGAIRLP SFKVKRKEPP DTTSSGDQKR LRPSTSVDEE DEESERERDR
1010 1020 1030 1040 1050
DMADTPCELA KRDPKGVGVR RRPARPLELD SGGEEDEKES LSASSSSSAS
1060 1070 1080 1090 1100
SSSGSSTTSP SSSASDKEEE QESTEEEEEA EEEEEEEVPR SQLSSSSTSS
1110 1120 1130 1140 1150
TSDKDDDDDD SDDRDESEND DEDTALSEAS EKDEGDSDEE ETVSIVTSKA
1160 1170 1180 1190 1200
EATSSSESSE SSEFESSSES SPSSSEDEEE VVAREEEEEE EEEEMVAEES
1210 1220 1230 1240 1250
MASAGPEDFE QDGEEAALAP GAPAVDSLGM EEEVDIETEA VAPEERPSML
1260 1270 1280 1290 1300
DEPPLPVGVE EPADSREPPE EPGLSQEGAM LLSPEPPAKE VEARPPLSPE
1310 1320 1330 1340 1350
RAPEHDLEVE PEPPMMLPLP LQPPLPPPRP PRPPSPPPEP ETTDASHPSV
1360 1370 1380 1390 1400
PPEPLAEDHP PHTPGLCGSL AKSQSTETVP ATPGGEPPLS GGSSGLSLSS
1410 1420 1430 1440 1450
PQVPGSPFSY PAPSPSLSSG GLPRTPGRDF SFTPTFSEPS GPLLLPVCPL
1460 1470 1480 1490 1500
PTGRRDERSG PLASPVLLET GLPLPLPLPL PLPLALPAVL RAQARAPTPL
1510 1520 1530 1540 1550
PPLLPAPLAS CPPPMKRKPG RPRRSPPSML SLDGPLVRPP AGAALGRELL
1560 1570 1580 1590 1600
LLPGQPQTPV FPSTHDPRTV TLDFRNAGIP APPPPLPPQP PPPPPPPPVE
1610 1620 1630 1640 1650
PTKLPFKELD NQWPSEAIPP GPRGRDEVTE EYMELAKSRG PWRRPPKKRH
1660 1670 1680 1690 1700
EDLVPPAGSP ELSPPQPLFR PRSEFEEMTI LYDIWNGGID EEDIRFLCVT
1710 1720 1730 1740 1750
YERLLQQDNG MDWLNDTLWV YHPSTSLSSA KKKKRDDGIR EHVTGCARSE
1760 1770 1780 1790 1800
GFYTIDKKDK LRYLNSSRAS TDEPPADTQG MSIPAQPHAS TRAGSERRSE
1810 1820 1830 1840 1850
QRRLLSSFTG SCDSDLLKFN QLKFRKKKLK FCKSHIHDWG LFAMEPIAAD
1860 1870 1880 1890 1900
EMVIEYVGQN IRQVIADMRE KRYEDEGIGS SYMFRVDHDT IIDATKCGNF
1910 1920 1930 1940 1950
ARFINHSCNP NCYAKVITVE SQKKIVIYSK QHINVNEEIT YDYKFPIEDV
1960
KIPCLCGSEN CRGTLN
Length:1,966
Mass (Da):212,803
Last modified:March 19, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i164F81BC84EAD2C2
GO
Isoform 2 (identifier: Q9UPS6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1043-1068: Missing.
     1088-1104: Missing.

Show »
Length:1,923
Mass (Da):208,732
Checksum:i057CD0948D670243
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQV9A0A0A0MQV9_HUMAN
Histone-lysine N-methyltransferase ...
SETD1B
1,923Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0538751043 – 1068Missing in isoform 2. CuratedAdd BLAST26
Alternative sequenceiVSP_0538761088 – 1104Missing in isoform 2. CuratedAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
JF813787 mRNA Translation: AEG67286.1
AC079360 Genomic DNA No translation available.
AC084018 Genomic DNA No translation available.
AB028999 mRNA Translation: BAA83028.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS86338.1 [Q9UPS6-1]

NCBI Reference Sequences

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RefSeqi
NP_055863.1, NM_015048.1
XP_005253915.1, XM_005253858.4 [Q9UPS6-1]
XP_006719359.1, XM_006719296.3 [Q9UPS6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000542440; ENSP00000442924; ENSG00000139718 [Q9UPS6-2]
ENST00000604567; ENSP00000474253; ENSG00000139718 [Q9UPS6-1]
ENST00000619791; ENSP00000481531; ENSG00000139718 [Q9UPS6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23067

UCSC genome browser

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UCSCi
uc021rfg.2, human [Q9UPS6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JF813787 mRNA Translation: AEG67286.1
AC079360 Genomic DNA No translation available.
AC084018 Genomic DNA No translation available.
AB028999 mRNA Translation: BAA83028.1
CCDSiCCDS86338.1 [Q9UPS6-1]
RefSeqiNP_055863.1, NM_015048.1
XP_005253915.1, XM_005253858.4 [Q9UPS6-1]
XP_006719359.1, XM_006719296.3 [Q9UPS6-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UVOX-ray2.20B1745-1755[»]
4ES0X-ray1.82C1741-1754[»]
SMRiQ9UPS6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116702, 31 interactors
CORUMiQ9UPS6
DIPiDIP-61947N
ELMiQ9UPS6
IntActiQ9UPS6, 17 interactors
STRINGi9606.ENSP00000442924

Chemistry databases

ChEMBLiCHEMBL4105837

PTM databases

iPTMnetiQ9UPS6
PhosphoSitePlusiQ9UPS6

Polymorphism and mutation databases

BioMutaiSETD1B
DMDMi166977692

Proteomic databases

EPDiQ9UPS6
jPOSTiQ9UPS6
MassIVEiQ9UPS6
PaxDbiQ9UPS6
PeptideAtlasiQ9UPS6
PRIDEiQ9UPS6
ProteomicsDBi85430 [Q9UPS6-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
9774, 109 antibodies

Genome annotation databases

EnsembliENST00000542440; ENSP00000442924; ENSG00000139718 [Q9UPS6-2]
ENST00000604567; ENSP00000474253; ENSG00000139718 [Q9UPS6-1]
ENST00000619791; ENSP00000481531; ENSG00000139718 [Q9UPS6-1]
GeneIDi23067
UCSCiuc021rfg.2, human [Q9UPS6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23067
DisGeNETi23067
EuPathDBiHostDB:ENSG00000139718.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SETD1B
HGNCiHGNC:29187, SETD1B
HPAiENSG00000139718, Low tissue specificity
MIMi611055, gene
neXtProtiNX_Q9UPS6
OpenTargetsiENSG00000139718
PharmGKBiPA143485611

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1080, Eukaryota
GeneTreeiENSGT00940000154575
HOGENOMiCLU_001226_0_0_1
InParanoidiQ9UPS6
OMAiRIWTRLE
OrthoDBi1234689at2759
TreeFamiTF106436

Enzyme and pathway databases

PathwayCommonsiQ9UPS6
ReactomeiR-HSA-3214841, PKMTs methylate histone lysines
R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
23067, 72 hits in 876 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23067
PharosiQ9UPS6, Tbio

Protein Ontology

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PROi
PR:Q9UPS6
RNActiQ9UPS6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000139718, Expressed in endometrium and 254 other tissues
ExpressionAtlasiQ9UPS6, baseline and differential
GenevisibleiQ9UPS6, HS

Family and domain databases

CDDicd12549, RRM_Set1B, 1 hit
Gene3Di3.30.70.330, 1 hit
IDEALiIID00402
InterProiView protein in InterPro
IPR024657, COMPASS_Set1_N-SET
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR003616, Post-SET_dom
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034468, Set1B_RRM
IPR001214, SET_dom
IPR037842, SETD1B
PANTHERiPTHR45814:SF1, PTHR45814:SF1, 1 hit
PfamiView protein in Pfam
PF11764, N-SET, 1 hit
PF00076, RRM_1, 1 hit
PF00856, SET, 1 hit
SMARTiView protein in SMART
SM01291, N-SET, 1 hit
SM00508, PostSET, 1 hit
SM00360, RRM, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50868, POST_SET, 1 hit
PS50102, RRM, 1 hit
PS50280, SET, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSET1B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPS6
Secondary accession number(s): F6MFW1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 19, 2014
Last modified: August 12, 2020
This is version 152 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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