UniProtKB - Q9UPR6 (ZFR2_HUMAN)
Protein
Zinc finger RNA-binding protein 2
Gene
ZFR2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- double-stranded RNA binding Source: GO_Central
- single-stranded RNA binding Source: GO_Central
- zinc ion binding Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q9UPR6 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger RNA-binding protein 2 |
Gene namesi | Name:ZFR2 Synonyms:KIAA1086 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29189, ZFR2 |
neXtProti | NX_Q9UPR6 |
VEuPathDBi | HostDB:ENSG00000105278.10 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 23217 |
OpenTargetsi | ENSG00000105278 |
PharmGKBi | PA162409746 |
Miscellaneous databases
Pharosi | Q9UPR6, Tdark |
Genetic variation databases
BioMutai | ZFR2 |
DMDMi | 296453074 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000308958 | 1 – 939 | Zinc finger RNA-binding protein 2Add BLAST | 939 |
Proteomic databases
MassIVEi | Q9UPR6 |
PaxDbi | Q9UPR6 |
PeptideAtlasi | Q9UPR6 |
PRIDEi | Q9UPR6 |
ProteomicsDBi | 4210 85428 [Q9UPR6-1] 85429 [Q9UPR6-2] |
PTM databases
iPTMneti | Q9UPR6 |
PhosphoSitePlusi | Q9UPR6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105278, Expressed in pituitary gland and 137 other tissues |
ExpressionAtlasi | Q9UPR6, baseline and differential |
Genevisiblei | Q9UPR6, HS |
Organism-specific databases
HPAi | ENSG00000105278, Tissue enhanced (brain, pituitary gland, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 116824, 3 interactors |
STRINGi | 9606.ENSP00000262961 |
Miscellaneous databases
RNActi | Q9UPR6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 570 – 935 | DZFPROSITE-ProRule annotationAdd BLAST | 366 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 516 – 549 | Sequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 187 – 265 | Pro-richAdd BLAST | 79 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3792, Eukaryota |
GeneTreei | ENSGT00940000162148 |
HOGENOMi | CLU_012026_1_0_1 |
InParanoidi | Q9UPR6 |
OMAi | MTATDSC |
OrthoDBi | 612611at2759 |
PhylomeDBi | Q9UPR6 |
TreeFami | TF320194 |
Family and domain databases
Gene3Di | 3.30.460.10, 1 hit |
InterProi | View protein in InterPro IPR006561, DZF_dom IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR043519, NT_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF07528, DZF, 1 hit |
SMARTi | View protein in SMART SM00572, DZF, 1 hit SM00355, ZnF_C2H2, 3 hits SM00451, ZnF_U1, 3 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS51703, DZF, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UPR6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATSQYFDFA QGGGPQYSAQ PPTLPLPTVG ASYTAQPTPG MDPAVNPAFP
60 70 80 90 100
PAAPAGYGGY QPHSGQDFAY GSRPQEPVPT ATTMATYQDS YSYGQSAAAR
110 120 130 140 150
SYEDRPYFQS AALQSGRMTA ADSGQPGTQE ACGQPSPHGS HSHAQPPQQA
160 170 180 190 200
PIVESGQPAS TLSSGYTYPT ATGVQPESSA SIVTSYPPPS YNPTCTAYTA
210 220 230 240 250
PSYPNYDASV YSAASPFYPP AQPPPPPGPP QQLPPPPAPA GSGSSPRADS
260 270 280 290 300
KPPLPSKLPR PKAGPRQLQL HYCDICKISC AGPQTYREHL GGQKHRKKEA
310 320 330 340 350
AQKTGVQPNG SPRGVQAQLH CDLCAVSCTG ADAYAAHIRG SKHQKVFKLH
360 370 380 390 400
AKLGKPIPTL EPALATESPP GAEAKPTSPT GPSVCASSRP ALAKRPVASK
410 420 430 440 450
ALCEGPPEPQ AAGCRPQWGK PAQPKLEGPG APTQGGSKEA PAGCSDAQPV
460 470 480 490 500
GPEYVEEVFS DEGRVLRFHC KLCECSFNDL NAKDLHVRGR RHRLQYRKKV
510 520 530 540 550
NPDLPIATEP SSRARKVLEE RMRKQRHLAE ERLEQLRRWH AERRRLEEEP
560 570 580 590 600
PQDVPPHAPP DWAQPLLMGR PESPASAPLQ PGRRPASSDD RHVMCKHATI
610 620 630 640 650
YPTEQELLAV QRAVSHAERA LKLVSDTLAE EDRGRREEEG DKRSSVAPQT
660 670 680 690 700
RVLKGVMRVG ILAKGLLLRG DRNVRLALLC SEKPTHSLLR RIAQQLPRQL
710 720 730 740 750
QMVTEDEYEV SSDPEANIVI SSCEEPRMQV TISVTSPLMR EDPSTDPGVE
760 770 780 790 800
EPQADAGDVL SPKKCLESLA ALRHARWFQA RASGLQPCVI VIRVLRDLCR
810 820 830 840 850
RVPTWGALPA WAMELLVEKA VSSAAGPLGP GDAVRRVLEC VATGTLLTDG
860 870 880 890 900
PGLQDPCERD QTDALEPMTL QEREDVTASA QHALRMLAFR QTHKVLGMDL
910 920 930
LPPRHRLGAR FRKRQRGPGE GEEGAGEKKR GRRGGEGLV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6I8PRF6 | A0A6I8PRF6_HUMAN | Zinc finger RNA-binding protein 2 | ZFR2 | 25 | Annotation score: | ||
K7EQC0 | K7EQC0_HUMAN | Zinc finger RNA-binding protein 2 | ZFR2 | 68 | Annotation score: | ||
K7EPY6 | K7EPY6_HUMAN | Zinc finger RNA-binding protein 2 | ZFR2 | 44 | Annotation score: | ||
K7EKD7 | K7EKD7_HUMAN | Zinc finger RNA-binding protein 2 | ZFR2 | 44 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 181 | S → F in DA237746 (PubMed:10470851).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036886 | 164 | S → L. Corresponds to variant dbSNP:rs2240235Ensembl. | 1 | |
Natural variantiVAR_036887 | 183 | V → M1 PublicationCorresponds to variant dbSNP:rs2240234Ensembl. | 1 | |
Natural variantiVAR_036888 | 210 | V → L. Corresponds to variant dbSNP:rs2240233Ensembl. | 1 | |
Natural variantiVAR_036889 | 235 | P → L. Corresponds to variant dbSNP:rs2240232Ensembl. | 1 | |
Natural variantiVAR_036890 | 577 | A → T. Corresponds to variant dbSNP:rs2301843Ensembl. | 1 | |
Natural variantiVAR_036891 | 589 | D → N. Corresponds to variant dbSNP:rs2301839Ensembl. | 1 | |
Natural variantiVAR_061730 | 718 | I → M. Corresponds to variant dbSNP:rs45465594Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040635 | 19 – 70 | AQPPT…QDFAY → PEVETTPPALASGLPCALPW TVGCSGSDAVTALCPSLRGL ACICSILWDPAW in isoform 2. 1 PublicationAdd BLAST | 52 | |
Alternative sequenceiVSP_040636 | 71 – 939 | Missing in isoform 2. 1 PublicationAdd BLAST | 869 | |
Alternative sequenceiVSP_057301 | 346 – 366 | VFKLH…PALAT → GLLSHRQQAADPSGGNQPNL N in isoform 3. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_057302 | 367 – 939 | Missing in isoform 3. 1 PublicationAdd BLAST | 573 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK295037 mRNA Translation: BAG58091.1 DA237746 mRNA No translation available. AC004598 Genomic DNA No translation available. AC005777 Genomic DNA No translation available. AC093078 Genomic DNA No translation available. BC034005 mRNA No translation available. AB029009 mRNA Translation: BAA83038.1 |
CCDSi | CCDS45921.1 [Q9UPR6-1] CCDS45922.1 [Q9UPR6-2] |
RefSeqi | NP_001139112.1, NM_001145640.1 [Q9UPR6-2] NP_055989.1, NM_015174.1 [Q9UPR6-1] |
Genome annotation databases
Ensembli | ENST00000262961; ENSP00000262961; ENSG00000105278 [Q9UPR6-1] ENST00000438164; ENSP00000388974; ENSG00000105278 [Q9UPR6-3] ENST00000439086; ENSP00000388567; ENSG00000105278 [Q9UPR6-2] |
GeneIDi | 23217 |
KEGGi | hsa:23217 |
UCSCi | uc002lyw.3, human [Q9UPR6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK295037 mRNA Translation: BAG58091.1 DA237746 mRNA No translation available. AC004598 Genomic DNA No translation available. AC005777 Genomic DNA No translation available. AC093078 Genomic DNA No translation available. BC034005 mRNA No translation available. AB029009 mRNA Translation: BAA83038.1 |
CCDSi | CCDS45921.1 [Q9UPR6-1] CCDS45922.1 [Q9UPR6-2] |
RefSeqi | NP_001139112.1, NM_001145640.1 [Q9UPR6-2] NP_055989.1, NM_015174.1 [Q9UPR6-1] |
3D structure databases
SMRi | Q9UPR6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116824, 3 interactors |
STRINGi | 9606.ENSP00000262961 |
PTM databases
iPTMneti | Q9UPR6 |
PhosphoSitePlusi | Q9UPR6 |
Genetic variation databases
BioMutai | ZFR2 |
DMDMi | 296453074 |
Proteomic databases
MassIVEi | Q9UPR6 |
PaxDbi | Q9UPR6 |
PeptideAtlasi | Q9UPR6 |
PRIDEi | Q9UPR6 |
ProteomicsDBi | 4210 85428 [Q9UPR6-1] 85429 [Q9UPR6-2] |
Protocols and materials databases
Antibodypediai | 52596, 7 antibodies |
Genome annotation databases
Ensembli | ENST00000262961; ENSP00000262961; ENSG00000105278 [Q9UPR6-1] ENST00000438164; ENSP00000388974; ENSG00000105278 [Q9UPR6-3] ENST00000439086; ENSP00000388567; ENSG00000105278 [Q9UPR6-2] |
GeneIDi | 23217 |
KEGGi | hsa:23217 |
UCSCi | uc002lyw.3, human [Q9UPR6-1] |
Organism-specific databases
CTDi | 23217 |
DisGeNETi | 23217 |
GeneCardsi | ZFR2 |
HGNCi | HGNC:29189, ZFR2 |
HPAi | ENSG00000105278, Tissue enhanced (brain, pituitary gland, testis) |
neXtProti | NX_Q9UPR6 |
OpenTargetsi | ENSG00000105278 |
PharmGKBi | PA162409746 |
VEuPathDBi | HostDB:ENSG00000105278.10 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3792, Eukaryota |
GeneTreei | ENSGT00940000162148 |
HOGENOMi | CLU_012026_1_0_1 |
InParanoidi | Q9UPR6 |
OMAi | MTATDSC |
OrthoDBi | 612611at2759 |
PhylomeDBi | Q9UPR6 |
TreeFami | TF320194 |
Enzyme and pathway databases
PathwayCommonsi | Q9UPR6 |
Miscellaneous databases
BioGRID-ORCSi | 23217, 8 hits in 993 CRISPR screens |
ChiTaRSi | ZFR2, human |
GenomeRNAii | 23217 |
Pharosi | Q9UPR6, Tdark |
PROi | PR:Q9UPR6 |
RNActi | Q9UPR6, protein |
Gene expression databases
Bgeei | ENSG00000105278, Expressed in pituitary gland and 137 other tissues |
ExpressionAtlasi | Q9UPR6, baseline and differential |
Genevisiblei | Q9UPR6, HS |
Family and domain databases
Gene3Di | 3.30.460.10, 1 hit |
InterProi | View protein in InterPro IPR006561, DZF_dom IPR003604, Matrin/U1-like-C_Znf_C2H2 IPR043519, NT_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF07528, DZF, 1 hit |
SMARTi | View protein in SMART SM00572, DZF, 1 hit SM00355, ZnF_C2H2, 3 hits SM00451, ZnF_U1, 3 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS51703, DZF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFR2_HUMAN | |
Accessioni | Q9UPR6Primary (citable) accession number: Q9UPR6 Secondary accession number(s): B4DHD0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 133 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports