SLC8A2

Functionⁱ

Mediates the electrogenic exchange of Ca²⁺ against Na⁺ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca²⁺ levels and Ca²⁺-dependent cellular processes. Contributes to cellular Ca²⁺ homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca²⁺ levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca²⁺ and Na⁺ excretion.By similarity

Enzyme regulationⁱ

Calcium transport is down-regulated by Na⁺ and stimulated by Ca²⁺.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	407	Calcium 1By similarity	1
Metal bindingⁱ	407	Calcium 2By similarity	1
Metal bindingⁱ	407	Calcium 3By similarity	1
Metal bindingⁱ	443	Calcium 1By similarity	1
Metal bindingⁱ	443	Calcium 4By similarity	1
Metal bindingⁱ	468	Calcium 2By similarity	1
Metal bindingⁱ	469	Calcium 1By similarity	1
Metal bindingⁱ	469	Calcium 2; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	469	Calcium 3By similarity	1
Metal bindingⁱ	469	Calcium 4By similarity	1
Metal bindingⁱ	471	Calcium 3; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	473	Calcium 1By similarity	1
Metal bindingⁱ	473	Calcium 3By similarity	1
Metal bindingⁱ	473	Calcium 4By similarity	1
Metal bindingⁱ	476	Calcium 4By similarity	1
Metal bindingⁱ	518	Calcium 3By similarity	1
Metal bindingⁱ	519	Calcium 2By similarity	1
Metal bindingⁱ	520	Calcium 2By similarity	1
Metal bindingⁱ	520	Calcium 3By similarity	1
Metal bindingⁱ	536	Calcium 5By similarity	1
Metal bindingⁱ	598	Calcium 5By similarity	1
Metal bindingⁱ	598	Calcium 6By similarity	1
Metal bindingⁱ	599	Calcium 6By similarity	1
Metal bindingⁱ	600	Calcium 5; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	600	Calcium 6By similarity	1
Metal bindingⁱ	665	Calcium 5By similarity	1

GO - Molecular functionⁱ

calcium:sodium antiporter activity Source: UniProtKB
calmodulin binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium ion transmembrane transport Source: UniProtKB
cell communication Source: InterPro
cellular calcium ion homeostasis Source: UniProtKB
ion transport Source: Reactome
learning Source: UniProtKB
long-term synaptic potentiation Source: UniProtKB
memory Source: UniProtKB
regulation of cardiac conduction Source: Reactome
regulation of short-term neuronal synaptic plasticity Source: UniProtKB
sodium ion transmembrane transport Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Calmodulin-binding
Biological process	Antiport, Calcium transport, Ion transport, Sodium transport, Transport
Ligand	Calcium, Metal-binding, Sodium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418359 Reduction of cytosolic Ca++ levels R-HSA-425561 Sodium/Calcium exchangers R-HSA-5578775 Ion homeostasis

Reactomeⁱ

R-HSA-418359 Reduction of cytosolic Ca++ levels
R-HSA-425561 Sodium/Calcium exchangers
R-HSA-5578775 Ion homeostasis

Protein family/group databases

TCDBⁱ	2.A.19.3.5 the ca(2+):cation antiporter (caca) family

TCDBⁱ

2.A.19.3.5 the ca(2+):cation antiporter (caca) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sodium/calcium exchanger 2 Alternative name(s): Na(+)/Ca(2+)-exchange protein 2 Solute carrier family 8 member 2
Gene namesⁱ	Name:SLC8A2 Synonyms:KIAA1087, NCX2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000118160.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11069 SLC8A2
MIMⁱ	601901 gene
neXtProtⁱ	NX_Q9UPR5

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	21 – 68	ExtracellularSequence analysisAdd BLAST	48
Transmembraneⁱ	69 – 90	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	91 – 130	CytoplasmicSequence analysisAdd BLAST	40
Transmembraneⁱ	131 – 152	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	153 – 164	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	165 – 185	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	186 – 196	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	197 – 219	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	220 – 222	ExtracellularSequence analysis	3
Transmembraneⁱ	223 – 246	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	247 – 720	CytoplasmicSequence analysisAdd BLAST	474
Transmembraneⁱ	721 – 740	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	741 – 747	ExtracellularSequence analysis	7
Transmembraneⁱ	748 – 770	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	771 – 772	CytoplasmicSequence analysis	2
Transmembraneⁱ	773 – 791	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	792 – 822	ExtracellularSequence analysisAdd BLAST	31
Transmembraneⁱ	823 – 843	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	844 – 854	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	855 – 875	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	876 – 892	ExtracellularSequence analysisAdd BLAST	17
Transmembraneⁱ	893 – 909	HelicalSequence analysisAdd BLAST	17
Topological domainⁱ	910 – 921	CytoplasmicSequence analysisAdd BLAST	12

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6543
Open Targets More...OpenTargetsⁱ	ENSG00000118160
PharmGKBⁱ	PA313

Polymorphism and mutation databases

BioMutaⁱ	SLC8A2

BioMutaⁱ

SLC8A2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_0000019382	21 – 921	Sodium/calcium exchanger 2Add BLAST		901

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	34	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	622	PhosphoserineBy similarity	1
Glycosylationⁱ	817	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9UPR5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UPR5
PaxDbⁱ	Q9UPR5
PeptideAtlas More...PeptideAtlasⁱ	Q9UPR5
PRIDEⁱ	Q9UPR5
ProteomicsDBⁱ	85427

PTM databases

iPTMnetⁱ	Q9UPR5
PhosphoSitePlusⁱ	Q9UPR5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000118160
CleanExⁱ	HS_SLC8A2
ExpressionAtlasⁱ	Q9UPR5 baseline and differential
Genevisibleⁱ	Q9UPR5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA050818 HPA054671

HPAⁱ

HPA050818
HPA054671

Interactionⁱ

GO - Molecular functionⁱ

calmodulin binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112434, 1 interactor
STRINGⁱ	9606.ENSP00000236877

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9UPR5
SMRⁱ	Q9UPR5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	135 – 175	Alpha-1Add BLAST	41
Domainⁱ	384 – 483	Calx-beta 1Add BLAST	100
Domainⁱ	512 – 612	Calx-beta 2Add BLAST	101
Repeatⁱ	790 – 826	Alpha-2Add BLAST	37

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	248 – 267	Putative calmodulin-binding regionBy similarityAdd BLAST		20

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	29 – 32	Poly-Pro		4
Compositional biasⁱ	638 – 641	Poly-Glu		4

Domainⁱ

The cytoplasmic Calx-beta domains bind the regulatory Ca²⁺. The first Calx-beta domain can bind up to four Ca²⁺ ions. The second domain can bind another two Ca²⁺ ions that are essential for calcium-regulated ion exchange.By similarity

Sequence similaritiesⁱ

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily. [View classification]Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1306 Eukaryota ENOG410XPJP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110414
HOGENOMⁱ	HOG000266971
HOVERGENⁱ	HBG006441
InParanoidⁱ	Q9UPR5
KEGG Orthology (KO) More...KOⁱ	K05849
OMAⁱ	WAVQGRP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EC1
PhylomeDBⁱ	Q9UPR5
TreeFamⁱ	TF314308

Family and domain databases

Gene3Dⁱ	2.60.40.2030, 2 hits
InterProⁱ	View protein in InterPro IPR038081 CalX-like_sf IPR003644 Calx_beta IPR004836 Na_Ca_Ex IPR032452 Na_Ca_Ex_C-exten IPR004837 NaCa_Exmemb
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03160 Calx-beta, 2 hits PF01699 Na_Ca_ex, 2 hits PF16494 Na_Ca_ex_C, 1 hit
PRINTSⁱ	PR01259 NACAEXCHNGR
SMARTⁱ	View protein in SMART SM00237 Calx_beta, 2 hits
SUPFAMⁱ	SSF141072 SSF141072, 2 hits
TIGRFAMsⁱ	TIGR00845 caca, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9UPR5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPLALVGVT LLLAAPPCSG AATPTPSLPP PPANDSDTST GGCQGSYRCQ 
        60         70         80         90        100
PGVLLPVWEP DDPSLGDKAA RAVVYFVAMV YMFLGVSIIA DRFMAAIEVI 
       110        120        130        140        150
TSKEKEITIT KANGETSVGT VRIWNETVSN LTLMALGSSA PEILLSVIEV 
       160        170        180        190        200
CGHNFQAGEL GPGTIVGSAA FNMFVVIAVC IYVIPAGESR KIKHLRVFFV 
       210        220        230        240        250
TASWSIFAYV WLYLILAVFS PGVVQVWEAL LTLVFFPVCV VFAWMADKRL 
       260        270        280        290        300
LFYKYVYKRY RTDPRSGIII GAEGDPPKSI ELDGTFVGAE APGELGGLGP 
       310        320        330        340        350
GPAEARELDA SRREVIQILK DLKQKHPDKD LEQLVGIANY YALLHQQKSR 
       360        370        380        390        400
AFYRIQATRL MTGAGNVLRR HAADASRRAA PAEGAGEDED DGASRIFFEP 
       410        420        430        440        450
SLYHCLENCG SVLLSVTCQG GEGNSTFYVD YRTEDGSAKA GSDYEYSEGT 
       460        470        480        490        500
LVFKPGETQK ELRIGIIDDD IFEEDEHFFV RLLNLRVGDA QGMFEPDGGG 
       510        520        530        540        550
RPKGRLVAPL LATVTILDDD HAGIFSFQDR LLHVSECMGT VDVRVVRSSG 
       560        570        580        590        600
ARGTVRLPYR TVDGTARGGG VHYEDACGEL EFGDDETMKT LQVKIVDDEE 
       610        620        630        640        650
YEKKDNFFIE LGQPQWLKRG ISALLLNQGD GDRKLTAEEE EARRIAEMGK 
       660        670        680        690        700
PVLGENCRLE VIIEESYDFK NTVDKLIKKT NLALVIGTHS WREQFLEAIT 
       710        720        730        740        750
VSAGDEEEEE DGSREERLPS CFDYVMHFLT VFWKVLFACV PPTEYCHGWA 
       760        770        780        790        800
CFGVSILVIG LLTALIGDLA SHFGCTVGLK DSVNAVVFVA LGTSIPDTFA 
       810        820        830        840        850
SKVAALQDQC ADASIGNVTG SNAVNVFLGL GVAWSVAAVY WAVQGRPFEV 
       860        870        880        890        900
RTGTLAFSVT LFTVFAFVGI AVLLYRRRPH IGGELGGPRG PKLATTALFL 
       910        920 
GLWLLYILFA SLEAYCHIRG F

Length:921

Mass (Da):100,368

Last modified:December 1, 2000 - v2

Checksum:ⁱ798CDF7E32B9410C

GO

Sequence cautionⁱ

The sequence BAA83039 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_072078	29	P → L Found in a family with atypical autism and severe epilepsy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201723439Ensembl.		1
Natural variantⁱVAR_050226	429	V → L. Corresponds to variant dbSNP:rs17759929Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB029010 mRNA Translation: BAA83039.1 Different initiation. AK302552 mRNA Translation: BAG63821.1 CH471126 Genomic DNA Translation: EAW57485.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33065.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055878.1, NM_015063.2
UniGeneⁱ	Hs.172884

Genome annotation databases

Ensemblⁱ	ENST00000236877; ENSP00000236877; ENSG00000118160
GeneIDⁱ	6543
KEGGⁱ	hsa:6543
UCSC genome browser More...UCSCⁱ	uc002pgx.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9UPR5	SLC8A2 isoform 1		PANTR		921
Solute carrier family 8 member A2		GORGO		921
Sodium/calcium exchanger 2		HUMAN		677
SLC8A2 isoform 2		PANTR		677

Protein	Similar proteins		Species	Score	Length
Q9UPR5	Sodium/calcium exchanger 2		RAT		921
Solute carrier family 8 member A2		CANLF		1083
UPI0004ED4F01		NANGA		429
Solute carrier family 8 member A2		PIG		1002
UPI000786DDC3		ROUAE		966
+137

Protein	Similar proteins		Species	Score	Length
Q9UPR5	Sodium/calcium exchanger 2		RAT		921
Solute carrier family 8 member A2		CANLF		1083
UPI0004ED4F01		NANGA		429
Solute carrier family 8 member A2		PIG		1002
UPI000786DDC3		ROUAE		966
+140

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB029010 mRNA Translation: BAA83039.1 Different initiation. AK302552 mRNA Translation: BAG63821.1 CH471126 Genomic DNA Translation: EAW57485.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33065.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055878.1, NM_015063.2
UniGeneⁱ	Hs.172884

3D structure databases

ProteinModelPortalⁱ	Q9UPR5
SMRⁱ	Q9UPR5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112434, 1 interactor
STRINGⁱ	9606.ENSP00000236877

Protein family/group databases

TCDBⁱ	2.A.19.3.5 the ca(2+):cation antiporter (caca) family

TCDBⁱ

2.A.19.3.5 the ca(2+):cation antiporter (caca) family

PTM databases

iPTMnetⁱ	Q9UPR5
PhosphoSitePlusⁱ	Q9UPR5

Polymorphism and mutation databases

BioMutaⁱ	SLC8A2

BioMutaⁱ

SLC8A2

Proteomic databases

EPDⁱ	Q9UPR5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UPR5
PaxDbⁱ	Q9UPR5
PeptideAtlas More...PeptideAtlasⁱ	Q9UPR5
PRIDEⁱ	Q9UPR5
ProteomicsDBⁱ	85427

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6543
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000236877; ENSP00000236877; ENSG00000118160
GeneIDⁱ	6543
KEGGⁱ	hsa:6543
UCSC genome browser More...UCSCⁱ	uc002pgx.4 human

Organism-specific databases

CTDⁱ	6543
DisGeNET More...DisGeNETⁱ	6543
EuPathDBⁱ	HostDB:ENSG00000118160.13
GeneCardsⁱ	SLC8A2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11069 SLC8A2
Human Protein Atlas More...HPAⁱ	HPA050818 HPA054671
MIMⁱ	601901 gene
neXtProtⁱ	NX_Q9UPR5
Open Targets More...OpenTargetsⁱ	ENSG00000118160
PharmGKBⁱ	PA313
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1306 Eukaryota ENOG410XPJP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110414
HOGENOMⁱ	HOG000266971
HOVERGENⁱ	HBG006441
InParanoidⁱ	Q9UPR5
KEGG Orthology (KO) More...KOⁱ	K05849
OMAⁱ	WAVQGRP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EC1
PhylomeDBⁱ	Q9UPR5
TreeFamⁱ	TF314308

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418359 Reduction of cytosolic Ca++ levels R-HSA-425561 Sodium/Calcium exchangers R-HSA-5578775 Ion homeostasis

Reactomeⁱ

R-HSA-418359 Reduction of cytosolic Ca++ levels
R-HSA-425561 Sodium/Calcium exchangers
R-HSA-5578775 Ion homeostasis

Miscellaneous databases

ChiTaRSⁱ	SLC8A2 human
GenomeRNAiⁱ	6543
Protein Ontology More...PROⁱ	PR:Q9UPR5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000118160
CleanExⁱ	HS_SLC8A2
ExpressionAtlasⁱ	Q9UPR5 baseline and differential
Genevisibleⁱ	Q9UPR5 HS

Family and domain databases

Gene3Dⁱ	2.60.40.2030, 2 hits
InterProⁱ	View protein in InterPro IPR038081 CalX-like_sf IPR003644 Calx_beta IPR004836 Na_Ca_Ex IPR032452 Na_Ca_Ex_C-exten IPR004837 NaCa_Exmemb
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03160 Calx-beta, 2 hits PF01699 Na_Ca_ex, 2 hits PF16494 Na_Ca_ex_C, 1 hit
PRINTSⁱ	PR01259 NACAEXCHNGR
SMARTⁱ	View protein in SMART SM00237 Calx_beta, 2 hits
SUPFAMⁱ	SSF141072 SSF141072, 2 hits
TIGRFAMsⁱ	TIGR00845 caca, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NAC2_HUMAN
Accessionⁱ	Q9UPR5Primary (citable) accession number: Q9UPR5 Secondary accession number(s): B4DYQ9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	December 1, 2000
	Last modified:	June 20, 2018
	This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q9UPR5 (NAC2_HUMAN)

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Sodium/calcium exchanger 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Enzyme regulationⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ