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UniProtKB - Q9UPR5 (NAC2_HUMAN)

Entry version 157 (12 Aug 2020)
Sequence version 2 (01 Dec 2000)
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Protein

Sodium/calcium exchanger 2

Gene

SLC8A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the electrogenic exchange of Ca2+ against Na+ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca2+ levels and Ca2+-dependent cellular processes. Contributes to cellular Ca2+ homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca2+ levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca2+ and Na+ excretion.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Calcium transport is down-regulated by Na+ and stimulated by Ca2+.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi407Calcium 1By similarity1
Metal bindingi407Calcium 2By similarity1
Metal bindingi407Calcium 3By similarity1
Metal bindingi443Calcium 1By similarity1
Metal bindingi443Calcium 4By similarity1
Metal bindingi468Calcium 2By similarity1
Metal bindingi469Calcium 1By similarity1
Metal bindingi469Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi469Calcium 3By similarity1
Metal bindingi469Calcium 4By similarity1
Metal bindingi471Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi473Calcium 1By similarity1
Metal bindingi473Calcium 3By similarity1
Metal bindingi473Calcium 4By similarity1
Metal bindingi476Calcium 4By similarity1
Metal bindingi518Calcium 3By similarity1
Metal bindingi519Calcium 2By similarity1
Metal bindingi520Calcium 2By similarity1
Metal bindingi520Calcium 3By similarity1
Metal bindingi536Calcium 5By similarity1
Metal bindingi598Calcium 5By similarity1
Metal bindingi598Calcium 6By similarity1
Metal bindingi599Calcium 6By similarity1
Metal bindingi600Calcium 5; via carbonyl oxygenBy similarity1
Metal bindingi600Calcium 6By similarity1
Metal bindingi665Calcium 5By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding
Biological processAntiport, Calcium transport, Ion transport, Sodium transport, Transport
LigandCalcium, Metal-binding, Sodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UPR5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-418359, Reduction of cytosolic Ca++ levels
R-HSA-425561, Sodium/Calcium exchangers
R-HSA-5578775, Ion homeostasis

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.19.3.5, the ca(2+):cation antiporter (caca) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/calcium exchanger 2
Alternative name(s):
Na(+)/Ca(2+)-exchange protein 2
Solute carrier family 8 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC8A2
Synonyms:KIAA1087, NCX2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000118160.13

Human Gene Nomenclature Database

More...HGNCi		HGNC:11069, SLC8A2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601901, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UPR5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 68ExtracellularSequence analysisAdd BLAST48
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei69 – 90HelicalSequence analysisAdd BLAST22
Topological domaini91 – 130CytoplasmicSequence analysisAdd BLAST40
Transmembranei131 – 152HelicalSequence analysisAdd BLAST22
Topological domaini153 – 164ExtracellularSequence analysisAdd BLAST12
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Topological domaini186 – 196CytoplasmicSequence analysisAdd BLAST11
Transmembranei197 – 219HelicalSequence analysisAdd BLAST23
Topological domaini220 – 222ExtracellularSequence analysis3
Transmembranei223 – 246HelicalSequence analysisAdd BLAST24
Topological domaini247 – 720CytoplasmicSequence analysisAdd BLAST474
Transmembranei721 – 740HelicalSequence analysisAdd BLAST20
Topological domaini741 – 747ExtracellularSequence analysis7
Transmembranei748 – 770HelicalSequence analysisAdd BLAST23
Topological domaini771 – 772CytoplasmicSequence analysis2
Transmembranei773 – 791HelicalSequence analysisAdd BLAST19
Topological domaini792 – 822ExtracellularSequence analysisAdd BLAST31
Transmembranei823 – 843HelicalSequence analysisAdd BLAST21
Topological domaini844 – 854CytoplasmicSequence analysisAdd BLAST11
Transmembranei855 – 875HelicalSequence analysisAdd BLAST21
Topological domaini876 – 892ExtracellularSequence analysisAdd BLAST17
Transmembranei893 – 909HelicalSequence analysisAdd BLAST17
Topological domaini910 – 921CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6543

Open Targets

More...OpenTargetsi		ENSG00000118160

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA313

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UPR5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC8A2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001938221 – 921Sodium/calcium exchanger 2Add BLAST901

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei622PhosphoserineBy similarity1
Glycosylationi817N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UPR5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UPR5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UPR5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UPR5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UPR5

PeptideAtlas

More...PeptideAtlasi		Q9UPR5

PRoteomics IDEntifications database

More...PRIDEi		Q9UPR5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85427

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9UPR5, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UPR5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UPR5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000118160, Expressed in cerebellum and 128 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UPR5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UPR5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000118160, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112434, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q9UPR5, 4 interactors

Molecular INTeraction database

More...MINTi		Q9UPR5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000236877

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UPR5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UPR5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati135 – 175Alpha-1Add BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini384 – 483Calx-beta 1Add BLAST100
Domaini512 – 612Calx-beta 2Add BLAST101
Repeati790 – 826Alpha-2Add BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni248 – 267Putative calmodulin-binding regionBy similarityAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi29 – 32Poly-Pro4
Compositional biasi638 – 641Poly-Glu4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytoplasmic Calx-beta domains bind the regulatory Ca2+. The first Calx-beta domain can bind up to four Ca2+ ions. The second domain can bind another two Ca2+ ions that are essential for calcium-regulated ion exchange.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1306, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158344

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012872_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UPR5

KEGG Orthology (KO)

More...KOi		K05849

Identification of Orthologs from Complete Genome Data

More...OMAi		ELEKHAM

Database of Orthologous Groups

More...OrthoDBi		490546at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UPR5

TreeFam database of animal gene trees

More...TreeFami		TF314308

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.2030, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR004836, Na_Ca_Ex
IPR032452, Na_Ca_Ex_C-exten
IPR004837, NaCa_Exmemb

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03160, Calx-beta, 2 hits
PF01699, Na_Ca_ex, 2 hits
PF16494, Na_Ca_ex_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01259, NACAEXCHNGR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00237, Calx_beta, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF141072, SSF141072, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00845, caca, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9UPR5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPLALVGVT LLLAAPPCSG AATPTPSLPP PPANDSDTST GGCQGSYRCQ 
        60         70         80         90        100
PGVLLPVWEP DDPSLGDKAA RAVVYFVAMV YMFLGVSIIA DRFMAAIEVI 
       110        120        130        140        150
TSKEKEITIT KANGETSVGT VRIWNETVSN LTLMALGSSA PEILLSVIEV 
       160        170        180        190        200
CGHNFQAGEL GPGTIVGSAA FNMFVVIAVC IYVIPAGESR KIKHLRVFFV 
       210        220        230        240        250
TASWSIFAYV WLYLILAVFS PGVVQVWEAL LTLVFFPVCV VFAWMADKRL 
       260        270        280        290        300
LFYKYVYKRY RTDPRSGIII GAEGDPPKSI ELDGTFVGAE APGELGGLGP 
       310        320        330        340        350
GPAEARELDA SRREVIQILK DLKQKHPDKD LEQLVGIANY YALLHQQKSR 
       360        370        380        390        400
AFYRIQATRL MTGAGNVLRR HAADASRRAA PAEGAGEDED DGASRIFFEP 
       410        420        430        440        450
SLYHCLENCG SVLLSVTCQG GEGNSTFYVD YRTEDGSAKA GSDYEYSEGT 
       460        470        480        490        500
LVFKPGETQK ELRIGIIDDD IFEEDEHFFV RLLNLRVGDA QGMFEPDGGG 
       510        520        530        540        550
RPKGRLVAPL LATVTILDDD HAGIFSFQDR LLHVSECMGT VDVRVVRSSG 
       560        570        580        590        600
ARGTVRLPYR TVDGTARGGG VHYEDACGEL EFGDDETMKT LQVKIVDDEE 
       610        620        630        640        650
YEKKDNFFIE LGQPQWLKRG ISALLLNQGD GDRKLTAEEE EARRIAEMGK 
       660        670        680        690        700
PVLGENCRLE VIIEESYDFK NTVDKLIKKT NLALVIGTHS WREQFLEAIT 
       710        720        730        740        750
VSAGDEEEEE DGSREERLPS CFDYVMHFLT VFWKVLFACV PPTEYCHGWA 
       760        770        780        790        800
CFGVSILVIG LLTALIGDLA SHFGCTVGLK DSVNAVVFVA LGTSIPDTFA 
       810        820        830        840        850
SKVAALQDQC ADASIGNVTG SNAVNVFLGL GVAWSVAAVY WAVQGRPFEV 
       860        870        880        890        900
RTGTLAFSVT LFTVFAFVGI AVLLYRRRPH IGGELGGPRG PKLATTALFL 
       910        920 
GLWLLYILFA SLEAYCHIRG F
Length:921
Mass (Da):100,368
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i798CDF7E32B9410C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H6L7F5H6L7_HUMAN
Sodium/calcium exchanger 2
SLC8A2
677Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1Z4M0R1Z4_HUMAN
Sodium/calcium exchanger 2
SLC8A2
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R211M0R211_HUMAN
Sodium/calcium exchanger 2
SLC8A2
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83039 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07207829P → L Found in a family with atypical autism and severe epilepsy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs201723439Ensembl.1
Natural variantiVAR_050226429V → L. Corresponds to variant dbSNP:rs17759929Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB029010 mRNA Translation: BAA83039.1 Different initiation.
AK302552 mRNA Translation: BAG63821.1
CH471126 Genomic DNA Translation: EAW57485.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33065.1

NCBI Reference Sequences

More...RefSeqi		NP_055878.1, NM_015063.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000236877; ENSP00000236877; ENSG00000118160

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6543

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6543

UCSC genome browser

More...UCSCi		uc002pgx.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029010 mRNA Translation: BAA83039.1 Different initiation.
AK302552 mRNA Translation: BAG63821.1
CH471126 Genomic DNA Translation: EAW57485.1
CCDSiCCDS33065.1
RefSeqiNP_055878.1, NM_015063.2

3D structure databases

SMRiQ9UPR5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112434, 1 interactor
IntActiQ9UPR5, 4 interactors
MINTiQ9UPR5
STRINGi9606.ENSP00000236877

Protein family/group databases

TCDBi2.A.19.3.5, the ca(2+):cation antiporter (caca) family

PTM databases

GlyGeniQ9UPR5, 2 sites
iPTMnetiQ9UPR5
PhosphoSitePlusiQ9UPR5

Polymorphism and mutation databases

BioMutaiSLC8A2

Proteomic databases

EPDiQ9UPR5
jPOSTiQ9UPR5
MassIVEiQ9UPR5
MaxQBiQ9UPR5
PaxDbiQ9UPR5
PeptideAtlasiQ9UPR5
PRIDEiQ9UPR5
ProteomicsDBi85427

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		54559, 76 antibodies

The DNASU plasmid repository

More...DNASUi		6543

Genome annotation databases

EnsembliENST00000236877; ENSP00000236877; ENSG00000118160
GeneIDi6543
KEGGihsa:6543
UCSCiuc002pgx.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6543
DisGeNETi6543
EuPathDBiHostDB:ENSG00000118160.13

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC8A2
HGNCiHGNC:11069, SLC8A2
HPAiENSG00000118160, Tissue enriched (brain)
MIMi601901, gene
neXtProtiNX_Q9UPR5
OpenTargetsiENSG00000118160
PharmGKBiPA313

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1306, Eukaryota
GeneTreeiENSGT00940000158344
HOGENOMiCLU_012872_1_0_1
InParanoidiQ9UPR5
KOiK05849
OMAiELEKHAM
OrthoDBi490546at2759
PhylomeDBiQ9UPR5
TreeFamiTF314308

Enzyme and pathway databases

PathwayCommonsiQ9UPR5
ReactomeiR-HSA-418359, Reduction of cytosolic Ca++ levels
R-HSA-425561, Sodium/Calcium exchangers
R-HSA-5578775, Ion homeostasis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6543, 4 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC8A2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6543
PharosiQ9UPR5, Tbio

Protein Ontology

More...PROi		PR:Q9UPR5
RNActiQ9UPR5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000118160, Expressed in cerebellum and 128 other tissues
ExpressionAtlasiQ9UPR5, baseline and differential
GenevisibleiQ9UPR5, HS

Family and domain databases

Gene3Di2.60.40.2030, 2 hits
InterProiView protein in InterPro
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR004836, Na_Ca_Ex
IPR032452, Na_Ca_Ex_C-exten
IPR004837, NaCa_Exmemb
PfamiView protein in Pfam
PF03160, Calx-beta, 2 hits
PF01699, Na_Ca_ex, 2 hits
PF16494, Na_Ca_ex_C, 1 hit
PRINTSiPR01259, NACAEXCHNGR
SMARTiView protein in SMART
SM00237, Calx_beta, 2 hits
SUPFAMiSSF141072, SSF141072, 2 hits
TIGRFAMsiTIGR00845, caca, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPR5
Secondary accession number(s): B4DYQ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: August 12, 2020
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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