UniProtKB - Q9UPR3 (SMG5_HUMAN)

BLAST

>sp|Q9UPR3|SMG5_HUMAN Protein SMG5 OS=Homo sapiens OX=9606 GN=SMG5 PE=1 SV=3
MSQGPPTGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLR
ELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAGIG
FYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGD
LSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQ
SEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQP
KSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVI
ICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDE
PESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFES
DSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLE
PPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHT
SASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKV
FLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELP
DLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQ
GSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQL
EGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHP
GARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQG
AGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG

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History
Entry version 148 (07 Nov 2018)
Sequence version 3 (20 Dec 2005)
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Protein

Protein SMG5

Gene

SMG5

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.1 Publication

GO - Molecular functionⁱ

histone deacetylase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16809764
protein phosphatase 2A binding
Source: HGNC
Inferred from direct assayⁱ
- 14636577
ribonuclease activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ribonucleoprotein complex binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
telomerase RNA binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15857955
telomeric DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 17916692
ubiquitin protein ligase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16809764

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA export from nucleus
Source: HGNC
Traceable author statementⁱ
- 16488880
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of dephosphorylation
Source: HGNC
Inferred from mutant phenotypeⁱ
- 14636577
regulation of RNA stability
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of telomere maintenance
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16809764
regulation of telomere maintenance via telomerase
Source: BHF-UCL
Traceable author statementⁱ
- 16507993
telomere maintenance via telomerase
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Nonsense-mediated mRNA decay

Biological process

Nonsense-mediated mRNA decay

Enzyme and pathway databases

Reactomeⁱ	R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein SMG5 Alternative name(s): EST1-like protein B LPTS-RP1 LPTS-interacting protein SMG-5 homolog Short name: hSMG-5
Gene namesⁱ	Name:SMG5 Synonyms:EST1B, KIAA1089
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198952.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24644 SMG5
MIMⁱ	610962 gene
neXtProtⁱ	NX_Q9UPR3

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	860	D → A: Abolishes stimulation of RENT1 dephosphorylation. 1 Publication		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000198952
PharmGKBⁱ	PA143485617

Polymorphism and mutation databases

BioMutaⁱ	SMG5
DMDMⁱ	84029494

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000076322	2 – 1016	Protein SMG5Add BLAST		1015

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	2	PhosphoserineCombined sources	1
Modified residueⁱ	423	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9UPR3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9UPR3
PaxDbⁱ	Q9UPR3
PeptideAtlas More...PeptideAtlasⁱ	Q9UPR3
PRIDEⁱ	Q9UPR3
ProteomicsDBⁱ	85426

PTM databases

iPTMnetⁱ	Q9UPR3
PhosphoSitePlusⁱ	Q9UPR3

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000198952 Expressed in 222 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_SMG5
Genevisibleⁱ	Q9UPR3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA072651

HPAⁱ

HPA072651

Interactionⁱ

Subunit structureⁱ

Interacts with TERT, PPP2CA and SMG1. Part of a complex that contains SMG1, SMG5, SMG7, PPP2CA, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated UPF1. Not detected in complexes that contain unphosphorylated UPF1.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SMG7	Q92540	5	EBI-3400861,EBI-719830
UPF1	Q92900-2	2	EBI-3400861,EBI-373492

GO - Molecular functionⁱ

histone deacetylase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16809764
protein phosphatase 2A binding
Source: HGNC
Inferred from direct assayⁱ
- 14636577
ubiquitin protein ligase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16809764

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116957, 17 interactors
IntActⁱ	Q9UPR3, 8 interactors
Molecular INTeraction database More...MINTⁱ	Q9UPR3
STRINGⁱ	9606.ENSP00000355261

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	856 – 859	Combined sources	4
Helixⁱ	861 – 866	Combined sources	6
Helixⁱ	868 – 877	Combined sources	10
Beta strandⁱ	878 – 884	Combined sources	7
Helixⁱ	886 – 895	Combined sources	10
Helixⁱ	900 – 915	Combined sources	16
Beta strandⁱ	918 – 922	Combined sources	5
Helixⁱ	946 – 955	Combined sources	10
Beta strandⁱ	977 – 980	Combined sources	4
Helixⁱ	992 – 996	Combined sources	5
Beta strandⁱ	1000 – 1002	Combined sources	3
Helixⁱ	1005 – 1011	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9UPR3
SMRⁱ	Q9UPR3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9UPR3

EvolutionaryTraceⁱ

Q9UPR3

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	872 – 995	PINcAdd BLAST		124

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	798 – 841	Sequence analysisAdd BLAST		44

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	460 – 463	Poly-Arg		4
Compositional biasⁱ	529 – 532	Poly-Glu		4

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410INQY Eukaryota ENOG410XPF4 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00560000077120
HOVERGENⁱ	HBG082268
InParanoidⁱ	Q9UPR3
KEGG Orthology (KO) More...KOⁱ	K11125
OMAⁱ	GMAQNQL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0188
PhylomeDBⁱ	Q9UPR3
TreeFamⁱ	TF327119

Family and domain databases

InterProⁱ	View protein in InterPro IPR018834 DNA/RNA-bd_Est1-type IPR019458 EST1 IPR002716 PIN_dom IPR011990 TPR-like_helical_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10374 EST1, 1 hit PF10373 EST1_DNA_bind, 2 hits PF13638 PIN_4, 1 hit
SMARTⁱ	View protein in SMART SM00670 PINc, 1 hit
SUPFAMⁱ	SSF48452 SSF48452, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9UPR3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSQGPPTGES SEPEAKVLHT KRLYRAVVEA VHRLDLILCN KTAYQEVFKP 
        60         70         80         90        100
ENISLRNKLR ELCVKLMFLH PVDYGRKAEE LLWRKVYYEV IQLIKTNKKH 
       110        120        130        140        150
IHSRSTLECA YRTHLVAGIG FYQHLLLYIQ SHYQLELQCC IDWTHVTDPL 
       160        170        180        190        200
IGCKKPVSAS GKEMDWAQMA CHRCLVYLGD LSRYQNELAG VDTELLAERF 
       210        220        230        240        250
YYQALSVAPQ IGMPFNQLGT LAGSKYYNVE AMYCYLRCIQ SEVSFEGAYG 
       260        270        280        290        300
NLKRLYDKAA KMYHQLKKCE TRKLSPGKKR CKDIKRLLVN FMYLQSLLQP 
       310        320        330        340        350
KSSSVDSELT SLCQSVLEDF NLCLFYLPSS PNLSLASEDE EEYESGYAFL 
       360        370        380        390        400
PDLLIFQMVI ICLMCVHSLE RAGSKQYSAA IAFTLALFSH LVNHVNIRLQ 
       410        420        430        440        450
AELEEGENPV PAFQSDGTDE PESKEPVEKE EEPDPEPPPV TPQVGEGRKS 
       460        470        480        490        500
RKFSRLSCLR RRRHPPKVGD DSDLSEGFES DSSHDSARAS EGSDSGSDKS 
       510        520        530        540        550
LEGGGTAFDA ETDSEMNSQE SRSDLEDMEE EEGTRSPTLE PPRGRSEAPD 
       560        570        580        590        600
SLNGPLGPSE ASIASNLQAM STQMFQTKRC FRLAPTFSNL LLQPTTNPHT 
       610        620        630        640        650
SASHRPCVNG DVDKPSEPAS EEGSESEGSE SSGRSCRNER SIQEKLQVLM 
       660        670        680        690        700
AEGLLPAVKV FLDWLRTNPD LIIVCAQSSQ SLWNRLSVLL NLLPAAGELQ 
       710        720        730        740        750
ESGLALCPEV QDLLEGCELP DLPSSLLLPE DMALRNLPPL RAAHRRFNFD 
       760        770        780        790        800
TDRPLLSTLE ESVVRICCIR SFGHFIARLQ GSILQFNPEV GIFVSIAQSE 
       810        820        830        840        850
QESLLQQAQA QFRMAQEEAR RNRLMRDMAQ LRLQLEVSQL EGSLQQPKAQ 
       860        870        880        890        900
SAMSPYLVPD TQALCHHLPV IRQLATSGRF IVIIPRTVID GLDLLKKEHP 
       910        920        930        940        950
GARDGIRYLE AEFKKGNRYI RCQKEVGKSF ERHKLKRQDA DAWTLYKILD 
       960        970        980        990       1000
SCKQLTLAQG AGEEDPSGMV TIITGLPLDN PSVLSGPMQA ALQAAAHASV 
      1010 
DIKNVLDFYK QWKEIG

Length:1,016

Mass (Da):113,928

Last modified:December 20, 2005 - v3

Checksum:ⁱB6F8F9B53CF42195

Sequence cautionⁱ

The sequence BAA83041 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	372	A → S in AAQ84301 (Ref. 3) Curated	1
Sequence conflictⁱ	384	T → A in AAQ84301 (Ref. 3) Curated	1
Sequence conflictⁱ	496	G → R in AAQ84301 (Ref. 3) Curated	1
Sequence conflictⁱ	915	K → KK in CAH56374 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_030828	1004	N → D1 PublicationCorresponds to variant dbSNP:rs17853821Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB085691 mRNA Translation: BAC53623.1 AY168922 mRNA Translation: AAO17582.1 AY336728 mRNA Translation: AAQ84301.1 AB029012 mRNA Translation: BAA83041.2 Different initiation. AL589685 Genomic DNA No translation available. AL135927 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52973.1 CH471121 Genomic DNA Translation: EAW52974.1 BC007453 mRNA Translation: AAH07453.2 BC038296 mRNA Translation: AAH38296.1 AL137738 mRNA Translation: CAH56374.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1137.1
NCBI Reference Sequences More...RefSeqⁱ	NP_056142.2, NM_015327.2
UniGeneⁱ	Hs.516837

Genome annotation databases

Ensemblⁱ	ENST00000361813; ENSP00000355261; ENSG00000198952
GeneIDⁱ	23381
KEGGⁱ	hsa:23381
UCSC genome browser More...UCSCⁱ	uc001foc.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9UPR3	Protein SMG5		MOUSE		1017	UniRef90_Q9UPR3
protein SMG5		PHYCD		1138
protein SMG5 isoform X1		DIPOR		1025
Protein SMG5		wild yak		1025
Uncharacterized protein		CAVPO		1018
+181

Protein	Similar proteins		Species	Score	Length	Source
Q9UPR3	Protein SMG5		MOUSE		1017	UniRef50_Q9UPR3
protein SMG5		PHYCD		1138
Protein SMG5		wild yak		1025
protein SMG5 isoform X1		DIPOR		1025
protein SMG5 isoform X1		ERIEU		1018
+279

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB085691 mRNA Translation: BAC53623.1 AY168922 mRNA Translation: AAO17582.1 AY336728 mRNA Translation: AAQ84301.1 AB029012 mRNA Translation: BAA83041.2 Different initiation. AL589685 Genomic DNA No translation available. AL135927 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52973.1 CH471121 Genomic DNA Translation: EAW52974.1 BC007453 mRNA Translation: AAH07453.2 BC038296 mRNA Translation: AAH38296.1 AL137738 mRNA Translation: CAH56374.1
CCDSⁱ	CCDS1137.1
RefSeqⁱ	NP_056142.2, NM_015327.2
UniGeneⁱ	Hs.516837

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2HWY	X-ray	2.75	A/B	853-1016	[»]
ProteinModelPortalⁱ	Q9UPR3
SMRⁱ	Q9UPR3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116957, 17 interactors
IntActⁱ	Q9UPR3, 8 interactors
MINTⁱ	Q9UPR3
STRINGⁱ	9606.ENSP00000355261

PTM databases

iPTMnetⁱ	Q9UPR3
PhosphoSitePlusⁱ	Q9UPR3

Polymorphism and mutation databases

BioMutaⁱ	SMG5
DMDMⁱ	84029494

Proteomic databases

EPDⁱ	Q9UPR3
MaxQBⁱ	Q9UPR3
PaxDbⁱ	Q9UPR3
PeptideAtlasⁱ	Q9UPR3
PRIDEⁱ	Q9UPR3
ProteomicsDBⁱ	85426

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000361813; ENSP00000355261; ENSG00000198952
GeneIDⁱ	23381
KEGGⁱ	hsa:23381
UCSCⁱ	uc001foc.5 human

Organism-specific databases

CTDⁱ	23381
EuPathDBⁱ	HostDB:ENSG00000198952.8
GeneCardsⁱ	SMG5
HGNCⁱ	HGNC:24644 SMG5
HPAⁱ	HPA072651
MIMⁱ	610962 gene
neXtProtⁱ	NX_Q9UPR3
OpenTargetsⁱ	ENSG00000198952
PharmGKBⁱ	PA143485617
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410INQY Eukaryota ENOG410XPF4 LUCA
GeneTreeⁱ	ENSGT00560000077120
HOVERGENⁱ	HBG082268
InParanoidⁱ	Q9UPR3
KOⁱ	K11125
OMAⁱ	GMAQNQL
OrthoDBⁱ	EOG091G0188
PhylomeDBⁱ	Q9UPR3
TreeFamⁱ	TF327119

Enzyme and pathway databases

Reactomeⁱ	R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Reactomeⁱ

R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSⁱ	SMG5 human
EvolutionaryTraceⁱ	Q9UPR3
GeneWikiⁱ	SMG5
GenomeRNAiⁱ	23381
Protein Ontology More...PROⁱ	PR:Q9UPR3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000198952 Expressed in 222 organ(s), highest expression level in apex of heart
CleanExⁱ	HS_SMG5
Genevisibleⁱ	Q9UPR3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR018834 DNA/RNA-bd_Est1-type IPR019458 EST1 IPR002716 PIN_dom IPR011990 TPR-like_helical_dom_sf
Pfamⁱ	View protein in Pfam PF10374 EST1, 1 hit PF10373 EST1_DNA_bind, 2 hits PF13638 PIN_4, 1 hit
SMARTⁱ	View protein in SMART SM00670 PINc, 1 hit
SUPFAMⁱ	SSF48452 SSF48452, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SMG5_HUMAN
Accessionⁱ	Q9UPR3Primary (citable) accession number: Q9UPR3 Secondary accession number(s): D3DVB7 , Q5QJE7, Q659C7, Q8IXC0, Q8IY09, Q96IJ7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
	Last sequence update:	December 20, 2005
	Last modified:	November 7, 2018
	This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9UPR3 (SMG5_HUMAN)

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Protein SMG5

SMG5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ