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UniProtKB - Q9UPR0 (PLCL2_HUMAN)
Protein
Inactive phospholipase C-like protein 2
Gene
PLCL2
Organism
Homo sapiens (Human)
Status
Functioni
May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.
By similarityCaution
In the PI-PLC X-box Thr-486 is present instead of the conserved His which is one of the active site residues. It is therefore expected that this protein lacks catalytic activity.Curated
GO - Molecular functioni
- GABA receptor binding Source: MGI
- inositol 1,4,5 trisphosphate binding Source: InterPro
- phosphatidylinositol phospholipase C activity Source: InterPro
GO - Biological processi
- B-1a B cell differentiation Source: Ensembl
- B cell proliferation involved in immune response Source: Ensembl
- gamma-aminobutyric acid signaling pathway Source: Ensembl
- lipid metabolic process Source: InterPro
- negative regulation of B cell receptor signaling pathway Source: Ensembl
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- phosphatidylinositol-mediated signaling Source: GO_Central
- positive regulation of receptor binding Source: Ensembl
- regulation of peptidyl-serine phosphorylation Source: Ensembl
- regulation of synaptic transmission, GABAergic Source: Ensembl
Keywordsi
Molecular function | Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q9UPR0 |
SignaLinki | Q9UPR0 |
Names & Taxonomyi
Protein namesi | Recommended name: Inactive phospholipase C-like protein 2Short name: PLC-L(2) Short name: PLC-L2 Short name: Phospholipase C-L2 Alternative name(s): Phospholipase C-epsilon-2 Short name: PLC-epsilon-2 |
Gene namesi | Name:PLCL2 Synonyms:KIAA1092, PLCE2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9064, PLCL2 |
MIMi | 614276, gene |
neXtProti | NX_Q9UPR0 |
VEuPathDBi | HostDB:ENSG00000154822 |
Subcellular locationi
Cytoplasm and Cytosol
Note: Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells.By similarity
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 23228 |
OpenTargetsi | ENSG00000154822 |
PharmGKBi | PA33395 |
Miscellaneous databases
Pharosi | Q9UPR0, Tbio |
Genetic variation databases
BioMutai | PLCL2 |
DMDMi | 148880116 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000288851 | 2 – 1127 | Inactive phospholipase C-like protein 2Add BLAST | 1126 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 17 | PhosphoserineCombined sources | 1 | |
Modified residuei | 84 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 584 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1113 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9UPR0 |
jPOSTi | Q9UPR0 |
MassIVEi | Q9UPR0 |
MaxQBi | Q9UPR0 |
PaxDbi | Q9UPR0 |
PeptideAtlasi | Q9UPR0 |
PRIDEi | Q9UPR0 |
ProteomicsDBi | 85423 [Q9UPR0-1] 85424 [Q9UPR0-2] 85425 [Q9UPR0-3] |
PTM databases
iPTMneti | Q9UPR0 |
PhosphoSitePlusi | Q9UPR0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000154822, Expressed in chorionic villus and 236 other tissues |
ExpressionAtlasi | Q9UPR0, baseline and differential |
Genevisiblei | Q9UPR0, HS |
Organism-specific databases
HPAi | ENSG00000154822, Tissue enhanced (skeletal) |
Interactioni
Binary interactionsi
Q9UPR0
With | #Exp. | IntAct |
---|---|---|
FGFR3 [P22607] | 3 | EBI-311059,EBI-348399 |
GSN [P06396] | 3 | EBI-311059,EBI-351506 |
HRAS [P01112] | 3 | EBI-311059,EBI-350145 |
GO - Molecular functioni
- GABA receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 116833, 15 interactors |
IntActi | Q9UPR0, 11 interactors |
MINTi | Q9UPR0 |
STRINGi | 9606.ENSP00000478458 |
Miscellaneous databases
RNActi | Q9UPR0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 141 – 251 | PHPROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 426 – 570 | PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST | 145 | |
Domaini | 618 – 734 | PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST | 117 | |
Domaini | 734 – 863 | C2PROSITE-ProRule annotationAdd BLAST | 130 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 128 | DisorderedSequence analysisAdd BLAST | 128 | |
Regioni | 1101 – 1127 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 108 – 125 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1105 – 1127 | Basic and acidic residuesSequence analysisAdd BLAST | 23 |
Phylogenomic databases
eggNOGi | KOG0169, Eukaryota |
GeneTreei | ENSGT00940000155660 |
InParanoidi | Q9UPR0 |
OMAi | NTDSLYE |
OrthoDBi | 368239at2759 |
PhylomeDBi | Q9UPR0 |
TreeFami | TF313216 |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001192, PI-PLC_fam IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR028382, PLCL2 IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF84, PTHR10336:SF84, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF16457, PH_12, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00233, PH, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49562, SSF49562, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50003, PH_DOMAIN, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9UPR0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAECGRGGAA GGALPTSPGP ALGAKGALKA GVGEGGGGGG RLGHGRARYD
60 70 80 90 100
SGGVSNGDCS LGVSGDEARA SPTRGPRGVA LAPTPSAVVC TLPRESKPGG
110 120 130 140 150
LPRRSSIIKD GTKQKRERKK TVSFSSMPTE KKISSASDCI NSMVEGSELK
160 170 180 190 200
KVRSNSRIYH RYFLLDADMQ SLRWEPSKKD SEKAKIDIKS IKEVRTGKNT
210 220 230 240 250
DIFRSNGISD QISEDCAFSV IYGENYESLD LVANSADVAN IWVTGLRYLI
260 270 280 290 300
SYGKHTLDML ESSQDNMRTS WVSQMFSEID VDNLGHITLC NAVQCIRNLN
310 320 330 340 350
PGLKTSKIEL KFKELHKSKD KAGTEVTKEE FIEVFHELCT RPEIYFLLVQ
360 370 380 390 400
FSSNKEFLDT KDLMMFLEAE QGVAHINEEI SLEIIHKYEP SKEGQEKGWL
410 420 430 440 450
SIDGFTNYLM SPDCYIFDPE HKKVCQDMKQ PLSHYFINSS HNTYLIEDQF
460 470 480 490 500
RGPSDITGYI RALKMGCRSV ELDVWDGPDN EPVIYTGHTM TSQIVFRSVI
510 520 530 540 550
DIINKYAFFA SEYPLILCLE NHCSIKQQKV MVQHMKKLLG DKLYTTSPNV
560 570 580 590 600
EESYLPSPDV LKGKILIKAK KLSSNCSGVE GDVTDEDEGA EMSQRMGKEN
610 620 630 640 650
MEQPNNVPVK RFQLCKELSE LVSICKSVQF KEFQVSFQVQ KYWEVCSFNE
660 670 680 690 700
VLASKYANEN PGDFVNYNKR FLARVFPSPM RIDSSNMNPQ DFWKCGCQIV
710 720 730 740 750
AMNFQTPGLM MDLNIGWFRQ NGNCGYVLRP AIMREEVSFF SANTKDSVPG
760 770 780 790 800
VSPQLLHIKI ISGQNFPKPK GSGAKGDVVD PYVYVEIHGI PADCAEQRTK
810 820 830 840 850
TVHQNGDAPI FDESFEFQIN LPELAMVRFV VLDDDYIGDE FIGQYTIPFE
860 870 880 890 900
CLQTGYRHVP LQSLTGEVLA HASLFVHVAI TNRRGGGKPH KRGLSVRKGK
910 920 930 940 950
KSREYASLRT LWIKTVDEVF KNAQPPIRDA TDLRENMQNA VVSFKELCGL
960 970 980 990 1000
SSVANLMQCM LAVSPRFLGP DNTPLVVLNL SEQYPTMELQ GIVPEVLKKI
1010 1020 1030 1040 1050
VTTYDMMIQS LKALIENADA VYEKIVHCQK AAMEFHEHLH SIGTKEGLKE
1060 1070 1080 1090 1100
RKLQKAVESF TWNITILKGQ ADLLKYAKNE TLENLKQIHF AAVSCGLNKP
1110 1120
GTENADVQKP RRSLEVIPEK ANDETGE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C276 | H7C276_HUMAN | Phosphoinositide phospholipase C | PLCL2 | 704 | Annotation score: |
Sequence cautioni
The sequence BAA83044 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14606 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032507 | 211 | Q → R1 PublicationCorresponds to variant dbSNP:rs17853614Ensembl. | 1 | |
Natural variantiVAR_032508 | 635 | V → M1 PublicationCorresponds to variant dbSNP:rs17857109Ensembl. | 1 | |
Natural variantiVAR_032509 | 742 | A → V1 PublicationCorresponds to variant dbSNP:rs17857110Ensembl. | 1 | |
Natural variantiVAR_032510 | 809 | P → H1 PublicationCorresponds to variant dbSNP:rs17853612Ensembl. | 1 | |
Natural variantiVAR_032511 | 890 | H → R1 PublicationCorresponds to variant dbSNP:rs17853613Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025790 | 1 – 126 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 126 | |
Alternative sequenceiVSP_025791 | 1069 – 1086 | GQADL…LENLK → IRKTGRRSIFVPQTPIMV in isoform 2. 1 PublicationAdd BLAST | 18 | |
Alternative sequenceiVSP_025792 | 1087 – 1127 | Missing in isoform 2. 1 PublicationAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB029015 mRNA Translation: BAA83044.1 Different initiation. AK023546 mRNA Translation: BAB14606.1 Different initiation. AK291419 mRNA Translation: BAF84108.1 BC036392 mRNA Translation: AAH36392.1 AL117515 mRNA Translation: CAB55974.1 |
CCDSi | CCDS33713.1 [Q9UPR0-3] CCDS74911.1 [Q9UPR0-1] |
PIRi | T17284 |
RefSeqi | NP_001137854.1, NM_001144382.1 [Q9UPR0-1] NP_055999.2, NM_015184.5 [Q9UPR0-3] XP_016861511.1, XM_017006022.1 [Q9UPR0-1] XP_016861512.1, XM_017006023.1 [Q9UPR0-1] XP_016861513.1, XM_017006024.1 [Q9UPR0-1] XP_016861514.1, XM_017006025.1 [Q9UPR0-3] |
Genome annotation databases
Ensembli | ENST00000432376.5; ENSP00000412836.1; ENSG00000154822.18 [Q9UPR0-3] ENST00000615277.5; ENSP00000478458.1; ENSG00000154822.18 ENST00000638327.1; ENSP00000491897.1; ENSG00000284017.2 [Q9UPR0-3] ENST00000638466.2; ENSP00000492839.1; ENSG00000284017.2 |
GeneIDi | 23228 |
KEGGi | hsa:23228 |
MANE-Selecti | ENST00000615277.5; ENSP00000478458.1; NM_001144382.2; NP_001137854.1 |
UCSCi | uc011awd.3, human [Q9UPR0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB029015 mRNA Translation: BAA83044.1 Different initiation. AK023546 mRNA Translation: BAB14606.1 Different initiation. AK291419 mRNA Translation: BAF84108.1 BC036392 mRNA Translation: AAH36392.1 AL117515 mRNA Translation: CAB55974.1 |
CCDSi | CCDS33713.1 [Q9UPR0-3] CCDS74911.1 [Q9UPR0-1] |
PIRi | T17284 |
RefSeqi | NP_001137854.1, NM_001144382.1 [Q9UPR0-1] NP_055999.2, NM_015184.5 [Q9UPR0-3] XP_016861511.1, XM_017006022.1 [Q9UPR0-1] XP_016861512.1, XM_017006023.1 [Q9UPR0-1] XP_016861513.1, XM_017006024.1 [Q9UPR0-1] XP_016861514.1, XM_017006025.1 [Q9UPR0-3] |
3D structure databases
AlphaFoldDBi | Q9UPR0 |
SMRi | Q9UPR0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116833, 15 interactors |
IntActi | Q9UPR0, 11 interactors |
MINTi | Q9UPR0 |
STRINGi | 9606.ENSP00000478458 |
PTM databases
iPTMneti | Q9UPR0 |
PhosphoSitePlusi | Q9UPR0 |
Genetic variation databases
BioMutai | PLCL2 |
DMDMi | 148880116 |
Proteomic databases
EPDi | Q9UPR0 |
jPOSTi | Q9UPR0 |
MassIVEi | Q9UPR0 |
MaxQBi | Q9UPR0 |
PaxDbi | Q9UPR0 |
PeptideAtlasi | Q9UPR0 |
PRIDEi | Q9UPR0 |
ProteomicsDBi | 85423 [Q9UPR0-1] 85424 [Q9UPR0-2] 85425 [Q9UPR0-3] |
Protocols and materials databases
Antibodypediai | 26950, 148 antibodies from 28 providers |
DNASUi | 23228 |
Genome annotation databases
Ensembli | ENST00000432376.5; ENSP00000412836.1; ENSG00000154822.18 [Q9UPR0-3] ENST00000615277.5; ENSP00000478458.1; ENSG00000154822.18 ENST00000638327.1; ENSP00000491897.1; ENSG00000284017.2 [Q9UPR0-3] ENST00000638466.2; ENSP00000492839.1; ENSG00000284017.2 |
GeneIDi | 23228 |
KEGGi | hsa:23228 |
MANE-Selecti | ENST00000615277.5; ENSP00000478458.1; NM_001144382.2; NP_001137854.1 |
UCSCi | uc011awd.3, human [Q9UPR0-1] |
Organism-specific databases
CTDi | 23228 |
DisGeNETi | 23228 |
GeneCardsi | PLCL2 |
HGNCi | HGNC:9064, PLCL2 |
HPAi | ENSG00000154822, Tissue enhanced (skeletal) |
MIMi | 614276, gene |
neXtProti | NX_Q9UPR0 |
OpenTargetsi | ENSG00000154822 |
PharmGKBi | PA33395 |
VEuPathDBi | HostDB:ENSG00000154822 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0169, Eukaryota |
GeneTreei | ENSGT00940000155660 |
InParanoidi | Q9UPR0 |
OMAi | NTDSLYE |
OrthoDBi | 368239at2759 |
PhylomeDBi | Q9UPR0 |
TreeFami | TF313216 |
Enzyme and pathway databases
PathwayCommonsi | Q9UPR0 |
SignaLinki | Q9UPR0 |
Miscellaneous databases
BioGRID-ORCSi | 23228, 11 hits in 1073 CRISPR screens |
ChiTaRSi | PLCL2, human |
GenomeRNAii | 23228 |
Pharosi | Q9UPR0, Tbio |
PROi | PR:Q9UPR0 |
RNActi | Q9UPR0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154822, Expressed in chorionic villus and 236 other tissues |
ExpressionAtlasi | Q9UPR0, baseline and differential |
Genevisiblei | Q9UPR0, HS |
Family and domain databases
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001192, PI-PLC_fam IPR017946, PLC-like_Pdiesterase_TIM-brl IPR015359, PLC_EF-hand-like IPR028382, PLCL2 IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF84, PTHR10336:SF84, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF09279, EF-hand_like, 1 hit PF16457, PH_12, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00233, PH, 1 hit SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49562, SSF49562, 1 hit SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50003, PH_DOMAIN, 1 hit PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PLCL2_HUMAN | |
Accessioni | Q9UPR0Primary (citable) accession number: Q9UPR0 Secondary accession number(s): A8K5V4 Q9UFP9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | May 29, 2007 | |
Last modified: | May 25, 2022 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot