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UniProtKB - Q9UPR0 (PLCL2_HUMAN)

Entry version 178 (25 May 2022)
Sequence version 2 (29 May 2007)
Previous versions | rss
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Protein

Inactive phospholipase C-like protein 2

Gene

PLCL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.

By similarity

Caution

In the PI-PLC X-box Thr-486 is present instead of the conserved His which is one of the active site residues. It is therefore expected that this protein lacks catalytic activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UPR0

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9UPR0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive phospholipase C-like protein 2
Short name:
PLC-L(2)
Short name:
PLC-L2
Short name:
Phospholipase C-L2
Alternative name(s):
Phospholipase C-epsilon-2
Short name:
PLC-epsilon-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLCL2
Synonyms:KIAA1092, PLCE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9064, PLCL2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614276, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UPR0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000154822

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23228

Open Targets

More...OpenTargetsi		ENSG00000154822

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33395

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UPR0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PLCL2

Domain mapping of disease mutations (DMDM)

More...DMDMi		148880116

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002888512 – 1127Inactive phospholipase C-like protein 2Add BLAST1126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei84PhosphothreonineBy similarity1
Modified residuei584PhosphothreonineCombined sources1
Modified residuei1113PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UPR0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UPR0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UPR0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9UPR0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UPR0

PeptideAtlas

More...PeptideAtlasi		Q9UPR0

PRoteomics IDEntifications database

More...PRIDEi		Q9UPR0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85423 [Q9UPR0-1]
85424 [Q9UPR0-2]
85425 [Q9UPR0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UPR0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UPR0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000154822, Expressed in chorionic villus and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UPR0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UPR0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000154822, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116833, 15 interactors

Protein interaction database and analysis system

More...IntActi		Q9UPR0, 11 interactors

Molecular INTeraction database

More...MINTi		Q9UPR0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000478458

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UPR0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9UPR0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UPR0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini141 – 251PHPROSITE-ProRule annotationAdd BLAST111
Domaini426 – 570PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST145
Domaini618 – 734PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST117
Domaini734 – 863C2PROSITE-ProRule annotationAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 128DisorderedSequence analysisAdd BLAST128
Regioni1101 – 1127DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi108 – 125Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1105 – 1127Basic and acidic residuesSequence analysisAdd BLAST23

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0169, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155660

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UPR0

Identification of Orthologs from Complete Genome Data

More...OMAi		NTDSLYE

Database of Orthologous Groups

More...OrthoDBi		368239at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UPR0

TreeFam database of animal gene trees

More...TreeFami		TF313216

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011992, EF-hand-dom_pair
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR001192, PI-PLC_fam
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR015359, PLC_EF-hand-like
IPR028382, PLCL2
IPR000909, PLipase_C_PInositol-sp_X_dom
IPR001711, PLipase_C_Pinositol-sp_Y

The PANTHER Classification System

More...PANTHERi		PTHR10336, PTHR10336, 1 hit
PTHR10336:SF84, PTHR10336:SF84, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 1 hit
PF09279, EF-hand_like, 1 hit
PF16457, PH_12, 1 hit
PF00388, PI-PLC-X, 1 hit
PF00387, PI-PLC-Y, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00390, PHPHLIPASEC

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 1 hit
SM00233, PH, 1 hit
SM00148, PLCXc, 1 hit
SM00149, PLCYc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit
SSF49562, SSF49562, 1 hit
SSF51695, SSF51695, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50007, PIPLC_X_DOMAIN, 1 hit
PS50008, PIPLC_Y_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAECGRGGAA GGALPTSPGP ALGAKGALKA GVGEGGGGGG RLGHGRARYD 
        60         70         80         90        100
SGGVSNGDCS LGVSGDEARA SPTRGPRGVA LAPTPSAVVC TLPRESKPGG 
       110        120        130        140        150
LPRRSSIIKD GTKQKRERKK TVSFSSMPTE KKISSASDCI NSMVEGSELK 
       160        170        180        190        200
KVRSNSRIYH RYFLLDADMQ SLRWEPSKKD SEKAKIDIKS IKEVRTGKNT 
       210        220        230        240        250
DIFRSNGISD QISEDCAFSV IYGENYESLD LVANSADVAN IWVTGLRYLI 
       260        270        280        290        300
SYGKHTLDML ESSQDNMRTS WVSQMFSEID VDNLGHITLC NAVQCIRNLN 
       310        320        330        340        350
PGLKTSKIEL KFKELHKSKD KAGTEVTKEE FIEVFHELCT RPEIYFLLVQ 
       360        370        380        390        400
FSSNKEFLDT KDLMMFLEAE QGVAHINEEI SLEIIHKYEP SKEGQEKGWL 
       410        420        430        440        450
SIDGFTNYLM SPDCYIFDPE HKKVCQDMKQ PLSHYFINSS HNTYLIEDQF 
       460        470        480        490        500
RGPSDITGYI RALKMGCRSV ELDVWDGPDN EPVIYTGHTM TSQIVFRSVI 
       510        520        530        540        550
DIINKYAFFA SEYPLILCLE NHCSIKQQKV MVQHMKKLLG DKLYTTSPNV 
       560        570        580        590        600
EESYLPSPDV LKGKILIKAK KLSSNCSGVE GDVTDEDEGA EMSQRMGKEN 
       610        620        630        640        650
MEQPNNVPVK RFQLCKELSE LVSICKSVQF KEFQVSFQVQ KYWEVCSFNE 
       660        670        680        690        700
VLASKYANEN PGDFVNYNKR FLARVFPSPM RIDSSNMNPQ DFWKCGCQIV 
       710        720        730        740        750
AMNFQTPGLM MDLNIGWFRQ NGNCGYVLRP AIMREEVSFF SANTKDSVPG 
       760        770        780        790        800
VSPQLLHIKI ISGQNFPKPK GSGAKGDVVD PYVYVEIHGI PADCAEQRTK 
       810        820        830        840        850
TVHQNGDAPI FDESFEFQIN LPELAMVRFV VLDDDYIGDE FIGQYTIPFE 
       860        870        880        890        900
CLQTGYRHVP LQSLTGEVLA HASLFVHVAI TNRRGGGKPH KRGLSVRKGK 
       910        920        930        940        950
KSREYASLRT LWIKTVDEVF KNAQPPIRDA TDLRENMQNA VVSFKELCGL 
       960        970        980        990       1000
SSVANLMQCM LAVSPRFLGP DNTPLVVLNL SEQYPTMELQ GIVPEVLKKI 
      1010       1020       1030       1040       1050
VTTYDMMIQS LKALIENADA VYEKIVHCQK AAMEFHEHLH SIGTKEGLKE 
      1060       1070       1080       1090       1100
RKLQKAVESF TWNITILKGQ ADLLKYAKNE TLENLKQIHF AAVSCGLNKP 
      1110       1120 
GTENADVQKP RRSLEVIPEK ANDETGE
Length:1,127
Mass (Da):125,866
Last modified:May 29, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF75F774DAE18EC5F
GO
Isoform 2 (identifier: Q9UPR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.
     1069-1086: GQADLLKYAKNETLENLK → IRKTGRRSIFVPQTPIMV
     1087-1127: Missing.

Show »
Length:960
Mass (Da):109,221
Checksum:iDD532227D68B5986
GO
Isoform 3 (identifier: Q9UPR0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Show »
Length:1,001
Mass (Da):113,602
Checksum:i7208D87B3EA88134
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C276H7C276_HUMAN
Phosphoinositide phospholipase C
PLCL2
704Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83044 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14606 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032507211Q → R1 PublicationCorresponds to variant dbSNP:rs17853614Ensembl.1
Natural variantiVAR_032508635V → M1 PublicationCorresponds to variant dbSNP:rs17857109Ensembl.1
Natural variantiVAR_032509742A → V1 PublicationCorresponds to variant dbSNP:rs17857110Ensembl.1
Natural variantiVAR_032510809P → H1 PublicationCorresponds to variant dbSNP:rs17853612Ensembl.1
Natural variantiVAR_032511890H → R1 PublicationCorresponds to variant dbSNP:rs17853613Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0257901 – 126Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST126
Alternative sequenceiVSP_0257911069 – 1086GQADL…LENLK → IRKTGRRSIFVPQTPIMV in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0257921087 – 1127Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB029015 mRNA Translation: BAA83044.1 Different initiation.
AK023546 mRNA Translation: BAB14606.1 Different initiation.
AK291419 mRNA Translation: BAF84108.1
BC036392 mRNA Translation: AAH36392.1
AL117515 mRNA Translation: CAB55974.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33713.1 [Q9UPR0-3]
CCDS74911.1 [Q9UPR0-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T17284

NCBI Reference Sequences

More...RefSeqi		NP_001137854.1, NM_001144382.1 [Q9UPR0-1]
NP_055999.2, NM_015184.5 [Q9UPR0-3]
XP_016861511.1, XM_017006022.1 [Q9UPR0-1]
XP_016861512.1, XM_017006023.1 [Q9UPR0-1]
XP_016861513.1, XM_017006024.1 [Q9UPR0-1]
XP_016861514.1, XM_017006025.1 [Q9UPR0-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000432376.5; ENSP00000412836.1; ENSG00000154822.18 [Q9UPR0-3]
ENST00000615277.5; ENSP00000478458.1; ENSG00000154822.18
ENST00000638327.1; ENSP00000491897.1; ENSG00000284017.2 [Q9UPR0-3]
ENST00000638466.2; ENSP00000492839.1; ENSG00000284017.2

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23228

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23228

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000615277.5; ENSP00000478458.1; NM_001144382.2; NP_001137854.1

UCSC genome browser

More...UCSCi		uc011awd.3, human [Q9UPR0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029015 mRNA Translation: BAA83044.1 Different initiation.
AK023546 mRNA Translation: BAB14606.1 Different initiation.
AK291419 mRNA Translation: BAF84108.1
BC036392 mRNA Translation: AAH36392.1
AL117515 mRNA Translation: CAB55974.1
CCDSiCCDS33713.1 [Q9UPR0-3]
CCDS74911.1 [Q9UPR0-1]
PIRiT17284
RefSeqiNP_001137854.1, NM_001144382.1 [Q9UPR0-1]
NP_055999.2, NM_015184.5 [Q9UPR0-3]
XP_016861511.1, XM_017006022.1 [Q9UPR0-1]
XP_016861512.1, XM_017006023.1 [Q9UPR0-1]
XP_016861513.1, XM_017006024.1 [Q9UPR0-1]
XP_016861514.1, XM_017006025.1 [Q9UPR0-3]

3D structure databases

AlphaFoldDBiQ9UPR0
SMRiQ9UPR0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116833, 15 interactors
IntActiQ9UPR0, 11 interactors
MINTiQ9UPR0
STRINGi9606.ENSP00000478458

PTM databases

iPTMnetiQ9UPR0
PhosphoSitePlusiQ9UPR0

Genetic variation databases

BioMutaiPLCL2
DMDMi148880116

Proteomic databases

EPDiQ9UPR0
jPOSTiQ9UPR0
MassIVEiQ9UPR0
MaxQBiQ9UPR0
PaxDbiQ9UPR0
PeptideAtlasiQ9UPR0
PRIDEiQ9UPR0
ProteomicsDBi85423 [Q9UPR0-1]
85424 [Q9UPR0-2]
85425 [Q9UPR0-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26950, 148 antibodies from 28 providers

The DNASU plasmid repository

More...DNASUi		23228

Genome annotation databases

EnsembliENST00000432376.5; ENSP00000412836.1; ENSG00000154822.18 [Q9UPR0-3]
ENST00000615277.5; ENSP00000478458.1; ENSG00000154822.18
ENST00000638327.1; ENSP00000491897.1; ENSG00000284017.2 [Q9UPR0-3]
ENST00000638466.2; ENSP00000492839.1; ENSG00000284017.2
GeneIDi23228
KEGGihsa:23228
MANE-SelectiENST00000615277.5; ENSP00000478458.1; NM_001144382.2; NP_001137854.1
UCSCiuc011awd.3, human [Q9UPR0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23228
DisGeNETi23228

GeneCards: human genes, protein and diseases

More...GeneCardsi		PLCL2
HGNCiHGNC:9064, PLCL2
HPAiENSG00000154822, Tissue enhanced (skeletal)
MIMi614276, gene
neXtProtiNX_Q9UPR0
OpenTargetsiENSG00000154822
PharmGKBiPA33395
VEuPathDBiHostDB:ENSG00000154822

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0169, Eukaryota
GeneTreeiENSGT00940000155660
InParanoidiQ9UPR0
OMAiNTDSLYE
OrthoDBi368239at2759
PhylomeDBiQ9UPR0
TreeFamiTF313216

Enzyme and pathway databases

PathwayCommonsiQ9UPR0
SignaLinkiQ9UPR0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23228, 11 hits in 1073 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PLCL2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23228
PharosiQ9UPR0, Tbio

Protein Ontology

More...PROi		PR:Q9UPR0
RNActiQ9UPR0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000154822, Expressed in chorionic villus and 236 other tissues
ExpressionAtlasiQ9UPR0, baseline and differential
GenevisibleiQ9UPR0, HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011992, EF-hand-dom_pair
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR001192, PI-PLC_fam
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR015359, PLC_EF-hand-like
IPR028382, PLCL2
IPR000909, PLipase_C_PInositol-sp_X_dom
IPR001711, PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336, PTHR10336, 1 hit
PTHR10336:SF84, PTHR10336:SF84, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF09279, EF-hand_like, 1 hit
PF16457, PH_12, 1 hit
PF00388, PI-PLC-X, 1 hit
PF00387, PI-PLC-Y, 1 hit
PRINTSiPR00390, PHPHLIPASEC
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00233, PH, 1 hit
SM00148, PLCXc, 1 hit
SM00149, PLCYc, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
SSF49562, SSF49562, 1 hit
SSF51695, SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50007, PIPLC_X_DOMAIN, 1 hit
PS50008, PIPLC_Y_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLCL2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPR0
Secondary accession number(s): A8K5V4
, Q8N498, Q9H8L0, Q9UFP9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: May 25, 2022
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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