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Entry version 163 (18 Sep 2019)
Sequence version 2 (29 May 2007)
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Protein

Inactive phospholipase C-like protein 2

Gene

PLCL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.By similarity

Caution

In the PI-PLC X-box Thr-486 is present instead of the conserved His which is one of the active site residues. It is therefore expected that this protein lacks catalytic activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive phospholipase C-like protein 2
Short name:
PLC-L(2)
Short name:
PLC-L2
Short name:
Phospholipase C-L2
Alternative name(s):
Phospholipase C-epsilon-2
Short name:
PLC-epsilon-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLCL2
Synonyms:KIAA1092, PLCE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:9064 PLCL2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614276 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UPR0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23228

Open Targets

More...
OpenTargetsi
ENSG00000154822

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33395

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLCL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
148880116

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002888512 – 1127Inactive phospholipase C-like protein 2Add BLAST1126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei84PhosphothreonineBy similarity1
Modified residuei584PhosphothreonineCombined sources1
Modified residuei1113PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UPR0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9UPR0

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9UPR0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UPR0

PeptideAtlas

More...
PeptideAtlasi
Q9UPR0

PRoteomics IDEntifications database

More...
PRIDEi
Q9UPR0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85423 [Q9UPR0-1]
85424 [Q9UPR0-2]
85425 [Q9UPR0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UPR0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UPR0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154822 Expressed in 223 organ(s), highest expression level in chorionic villus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UPR0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UPR0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047616

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116833, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UPR0, 7 interactors

Molecular INTeraction database

More...
MINTi
Q9UPR0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000478458

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9UPR0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini141 – 251PHPROSITE-ProRule annotationAdd BLAST111
Domaini426 – 570PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST145
Domaini618 – 734PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST117
Domaini741 – 846C2PROSITE-ProRule annotationAdd BLAST106

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5 – 65Gly-richAdd BLAST61

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0169 Eukaryota
ENOG410XPSW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155660

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006871

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UPR0

KEGG Orthology (KO)

More...
KOi
K15370

Identification of Orthologs from Complete Genome Data

More...
OMAi
EPYPTME

Database of Orthologous Groups

More...
OrthoDBi
368239at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UPR0

TreeFam database of animal gene trees

More...
TreeFami
TF313216

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001192 PI-PLC_fam
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR015359 PLC_EF-hand-like
IPR028382 PLCL2
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y

The PANTHER Classification System

More...
PANTHERi
PTHR10336 PTHR10336, 1 hit
PTHR10336:SF84 PTHR10336:SF84, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 1 hit
PF09279 EF-hand_like, 1 hit
PF16457 PH_12, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00390 PHPHLIPASEC

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPR0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAECGRGGAA GGALPTSPGP ALGAKGALKA GVGEGGGGGG RLGHGRARYD
60 70 80 90 100
SGGVSNGDCS LGVSGDEARA SPTRGPRGVA LAPTPSAVVC TLPRESKPGG
110 120 130 140 150
LPRRSSIIKD GTKQKRERKK TVSFSSMPTE KKISSASDCI NSMVEGSELK
160 170 180 190 200
KVRSNSRIYH RYFLLDADMQ SLRWEPSKKD SEKAKIDIKS IKEVRTGKNT
210 220 230 240 250
DIFRSNGISD QISEDCAFSV IYGENYESLD LVANSADVAN IWVTGLRYLI
260 270 280 290 300
SYGKHTLDML ESSQDNMRTS WVSQMFSEID VDNLGHITLC NAVQCIRNLN
310 320 330 340 350
PGLKTSKIEL KFKELHKSKD KAGTEVTKEE FIEVFHELCT RPEIYFLLVQ
360 370 380 390 400
FSSNKEFLDT KDLMMFLEAE QGVAHINEEI SLEIIHKYEP SKEGQEKGWL
410 420 430 440 450
SIDGFTNYLM SPDCYIFDPE HKKVCQDMKQ PLSHYFINSS HNTYLIEDQF
460 470 480 490 500
RGPSDITGYI RALKMGCRSV ELDVWDGPDN EPVIYTGHTM TSQIVFRSVI
510 520 530 540 550
DIINKYAFFA SEYPLILCLE NHCSIKQQKV MVQHMKKLLG DKLYTTSPNV
560 570 580 590 600
EESYLPSPDV LKGKILIKAK KLSSNCSGVE GDVTDEDEGA EMSQRMGKEN
610 620 630 640 650
MEQPNNVPVK RFQLCKELSE LVSICKSVQF KEFQVSFQVQ KYWEVCSFNE
660 670 680 690 700
VLASKYANEN PGDFVNYNKR FLARVFPSPM RIDSSNMNPQ DFWKCGCQIV
710 720 730 740 750
AMNFQTPGLM MDLNIGWFRQ NGNCGYVLRP AIMREEVSFF SANTKDSVPG
760 770 780 790 800
VSPQLLHIKI ISGQNFPKPK GSGAKGDVVD PYVYVEIHGI PADCAEQRTK
810 820 830 840 850
TVHQNGDAPI FDESFEFQIN LPELAMVRFV VLDDDYIGDE FIGQYTIPFE
860 870 880 890 900
CLQTGYRHVP LQSLTGEVLA HASLFVHVAI TNRRGGGKPH KRGLSVRKGK
910 920 930 940 950
KSREYASLRT LWIKTVDEVF KNAQPPIRDA TDLRENMQNA VVSFKELCGL
960 970 980 990 1000
SSVANLMQCM LAVSPRFLGP DNTPLVVLNL SEQYPTMELQ GIVPEVLKKI
1010 1020 1030 1040 1050
VTTYDMMIQS LKALIENADA VYEKIVHCQK AAMEFHEHLH SIGTKEGLKE
1060 1070 1080 1090 1100
RKLQKAVESF TWNITILKGQ ADLLKYAKNE TLENLKQIHF AAVSCGLNKP
1110 1120
GTENADVQKP RRSLEVIPEK ANDETGE
Length:1,127
Mass (Da):125,866
Last modified:May 29, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF75F774DAE18EC5F
GO
Isoform 2 (identifier: Q9UPR0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.
     1069-1086: GQADLLKYAKNETLENLK → IRKTGRRSIFVPQTPIMV
     1087-1127: Missing.

Note: No experimental confirmation available.
Show »
Length:960
Mass (Da):109,221
Checksum:iDD532227D68B5986
GO
Isoform 3 (identifier: Q9UPR0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Show »
Length:1,001
Mass (Da):113,602
Checksum:i7208D87B3EA88134
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C276H7C276_HUMAN
Phosphoinositide phospholipase C
PLCL2
704Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83044 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14606 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032507211Q → R1 PublicationCorresponds to variant dbSNP:rs17853614Ensembl.1
Natural variantiVAR_032508635V → M1 PublicationCorresponds to variant dbSNP:rs17857109Ensembl.1
Natural variantiVAR_032509742A → V1 PublicationCorresponds to variant dbSNP:rs17857110Ensembl.1
Natural variantiVAR_032510809P → H1 PublicationCorresponds to variant dbSNP:rs17853612Ensembl.1
Natural variantiVAR_032511890H → R1 PublicationCorresponds to variant dbSNP:rs17853613Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0257901 – 126Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST126
Alternative sequenceiVSP_0257911069 – 1086GQADL…LENLK → IRKTGRRSIFVPQTPIMV in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0257921087 – 1127Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB029015 mRNA Translation: BAA83044.1 Different initiation.
AK023546 mRNA Translation: BAB14606.1 Different initiation.
AK291419 mRNA Translation: BAF84108.1
BC036392 mRNA Translation: AAH36392.1
AL117515 mRNA Translation: CAB55974.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33713.1 [Q9UPR0-3]
CCDS74911.1 [Q9UPR0-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T17284

NCBI Reference Sequences

More...
RefSeqi
NP_001137854.1, NM_001144382.1 [Q9UPR0-1]
NP_055999.2, NM_015184.5 [Q9UPR0-3]
XP_016861511.1, XM_017006022.1 [Q9UPR0-1]
XP_016861512.1, XM_017006023.1 [Q9UPR0-1]
XP_016861513.1, XM_017006024.1 [Q9UPR0-1]
XP_016861514.1, XM_017006025.1 [Q9UPR0-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000432376; ENSP00000412836; ENSG00000154822 [Q9UPR0-3]
ENST00000615277; ENSP00000478458; ENSG00000154822 [Q9UPR0-1]
ENST00000638327; ENSP00000491897; ENSG00000284017 [Q9UPR0-3]
ENST00000638466; ENSP00000492839; ENSG00000284017 [Q9UPR0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23228

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23228

UCSC genome browser

More...
UCSCi
uc011awd.3 human [Q9UPR0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029015 mRNA Translation: BAA83044.1 Different initiation.
AK023546 mRNA Translation: BAB14606.1 Different initiation.
AK291419 mRNA Translation: BAF84108.1
BC036392 mRNA Translation: AAH36392.1
AL117515 mRNA Translation: CAB55974.1
CCDSiCCDS33713.1 [Q9UPR0-3]
CCDS74911.1 [Q9UPR0-1]
PIRiT17284
RefSeqiNP_001137854.1, NM_001144382.1 [Q9UPR0-1]
NP_055999.2, NM_015184.5 [Q9UPR0-3]
XP_016861511.1, XM_017006022.1 [Q9UPR0-1]
XP_016861512.1, XM_017006023.1 [Q9UPR0-1]
XP_016861513.1, XM_017006024.1 [Q9UPR0-1]
XP_016861514.1, XM_017006025.1 [Q9UPR0-3]

3D structure databases

SMRiQ9UPR0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116833, 12 interactors
IntActiQ9UPR0, 7 interactors
MINTiQ9UPR0
STRINGi9606.ENSP00000478458

PTM databases

iPTMnetiQ9UPR0
PhosphoSitePlusiQ9UPR0

Polymorphism and mutation databases

BioMutaiPLCL2
DMDMi148880116

Proteomic databases

EPDiQ9UPR0
jPOSTiQ9UPR0
MassIVEiQ9UPR0
PaxDbiQ9UPR0
PeptideAtlasiQ9UPR0
PRIDEiQ9UPR0
ProteomicsDBi85423 [Q9UPR0-1]
85424 [Q9UPR0-2]
85425 [Q9UPR0-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23228
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432376; ENSP00000412836; ENSG00000154822 [Q9UPR0-3]
ENST00000615277; ENSP00000478458; ENSG00000154822 [Q9UPR0-1]
ENST00000638327; ENSP00000491897; ENSG00000284017 [Q9UPR0-3]
ENST00000638466; ENSP00000492839; ENSG00000284017 [Q9UPR0-1]
GeneIDi23228
KEGGihsa:23228
UCSCiuc011awd.3 human [Q9UPR0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23228
DisGeNETi23228

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLCL2
HGNCiHGNC:9064 PLCL2
HPAiHPA047616
MIMi614276 gene
neXtProtiNX_Q9UPR0
OpenTargetsiENSG00000154822
PharmGKBiPA33395

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0169 Eukaryota
ENOG410XPSW LUCA
GeneTreeiENSGT00940000155660
HOGENOMiHOG000006871
InParanoidiQ9UPR0
KOiK15370
OMAiEPYPTME
OrthoDBi368239at2759
PhylomeDBiQ9UPR0
TreeFamiTF313216

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PLCL2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23228

Pharos

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Pharosi
Q9UPR0

Protein Ontology

More...
PROi
PR:Q9UPR0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000154822 Expressed in 223 organ(s), highest expression level in chorionic villus
ExpressionAtlasiQ9UPR0 baseline and differential
GenevisibleiQ9UPR0 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001192 PI-PLC_fam
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR015359 PLC_EF-hand-like
IPR028382 PLCL2
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 1 hit
PTHR10336:SF84 PTHR10336:SF84, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF09279 EF-hand_like, 1 hit
PF16457 PH_12, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLCL2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPR0
Secondary accession number(s): A8K5V4
, Q8N498, Q9H8L0, Q9UFP9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: September 18, 2019
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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