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Entry version 145 (13 Feb 2019)
Sequence version 1 (01 May 2000)
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Protein

Dolichol kinase

Gene

DOLK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors.By similarity

Miscellaneous

Complements the defects in growth, dolichol kinase activity and protein N-glycosylation at the restrictive temperature in yeast sec59 mutant cells.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • dolichol kinase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-446199 Synthesis of Dolichyl-phosphate
R-HSA-4755583 Defective DOLK causes DOLK-CDG (CDG-1m)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dolichol kinase (EC:2.7.1.108)
Alternative name(s):
Transmembrane protein 15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DOLK
Synonyms:KIAA1094, TMEM15
ORF Names:UNQ2422/PRO4980
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000175283.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23406 DOLK

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610746 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UPQ8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13LumenalSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 74CytoplasmicSequence analysisAdd BLAST40
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 111LumenalSequence analysisAdd BLAST16
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 134CytoplasmicSequence analysis2
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 163LumenalSequence analysis8
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 188CytoplasmicSequence analysis4
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 224LumenalSequence analysisAdd BLAST15
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 254CytoplasmicSequence analysis9
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 297LumenalSequence analysisAdd BLAST22
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 337CytoplasmicSequence analysisAdd BLAST19
Transmembranei338 – 354HelicalSequence analysisAdd BLAST17
Topological domaini355 – 359LumenalSequence analysis5
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Topological domaini381 – 401CytoplasmicSequence analysisAdd BLAST21
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21
Topological domaini423 – 436LumenalSequence analysisAdd BLAST14
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Topological domaini458 – 472CytoplasmicSequence analysisAdd BLAST15
Transmembranei473 – 493HelicalSequence analysisAdd BLAST21
Topological domaini494 – 495LumenalSequence analysis2
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21
Topological domaini517 – 538CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Congenital disorder of glycosylation 1M (CDG1M)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. CDG1M is a very severe disease with death occurring in early life.
See also OMIM:610768
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03285199C → S in CDG1M; 2% residual activity; fails to complement the temperature-sensitive phenotype of DK1-deficient yeast cells. 1 PublicationCorresponds to variant dbSNP:rs137853109EnsemblClinVar.1
Natural variantiVAR_032852441Y → S in CDG1M; 4% residual activity; fails to complement the temperature-sensitive phenotype of DK1-deficient yeast cells. 1 PublicationCorresponds to variant dbSNP:rs137853110EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi443G → D: Abolishes kinase activity. 1 Publication1
Mutagenesisi451D → A: Reduces kinase activity. 1 Publication1
Mutagenesisi470K → A: Reduces kinase activity. Significant reduction in binding affinity for CTP; when associated with A-471. 1 Publication1
Mutagenesisi471K → A: Reduces kinase activity. Significant reduction in binding affinity for CTP. 1 Publication1
Mutagenesisi472T → A: Reduces kinase activity. Significant reduction in binding affinity for CTP. 1 Publication1
Mutagenesisi474E → A: No effect on kinase activity. 1 Publication1
Mutagenesisi475G → A: No effect on kinase activity. 1 Publication1

Keywords - Diseasei

Congenital disorder of glycosylation, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
22845

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
DOLK

MalaCards human disease database

More...
MalaCardsi
DOLK
MIMi610768 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000175283

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
91131 DK1-CDG
154 Familial isolated dilated cardiomyopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162384054

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DOLK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20140913

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000725951 – 538Dolichol kinaseAdd BLAST538

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UPQ8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UPQ8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UPQ8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UPQ8

PeptideAtlas

More...
PeptideAtlasi
Q9UPQ8

PRoteomics IDEntifications database

More...
PRIDEi
Q9UPQ8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85419

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UPQ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UPQ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175283 Expressed in 199 organ(s), highest expression level in right adrenal gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9UPQ8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UPQ8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA066767
HPA068706

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116517, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UPQ8, 20 interactors

Molecular INTeraction database

More...
MINTi
Q9UPQ8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361667

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UPQ8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni459 – 474CTP-bindingAdd BLAST16

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polyprenol kinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2468 Eukaryota
COG0170 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004067

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000036052

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054655

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UPQ8

KEGG Orthology (KO)

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KOi
K00902

Identification of Orthologs from Complete Genome Data

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OMAi
RKYFHFI

Database of Orthologous Groups

More...
OrthoDBi
614199at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UPQ8

TreeFam database of animal gene trees

More...
TreeFami
TF323379

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026566 DOLK
IPR032974 Polypren_kinase

The PANTHER Classification System

More...
PANTHERi
PTHR13205 PTHR13205, 1 hit
PTHR13205:SF15 PTHR13205:SF15, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9UPQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRECPSPAP GPGAPLSGSV LAEAAVVFAV VLSIHATVWD RYSWCAVALA
60 70 80 90 100
VQAFYVQYKW DRLLQQGSAV FQFRMSANSG LLPASMVMPL LGLVMKERCQ
110 120 130 140 150
TAGNPFFERF GIVVAATGMA VALFSSVLAL GITRPVPTNT CVILGLAGGV
160 170 180 190 200
IIYIMKHSLS VGEVIEVLEV LLIFVYLNMI LLYLLPRCFT PGEALLVLGG
210 220 230 240 250
ISFVLNQLIK RSLTLVESQG DPVDFFLLVV VVGMVLMGIF FSTLFVFMDS
260 270 280 290 300
GTWASSIFFH LMTCVLSLGV VLPWLHRLIR RNPLLWLLQF LFQTDTRIYL
310 320 330 340 350
LAYWSLLATL ACLVVLYQNA KRSSSESKKH QAPTIARKYF HLIVVATYIP
360 370 380 390 400
GIIFDRPLLY VAATVCLAVF IFLEYVRYFR IKPLGHTLRS FLSLFLDERD
410 420 430 440 450
SGPLILTHIY LLLGMSLPIW LIPRPCTQKG SLGGARALVP YAGVLAVGVG
460 470 480 490 500
DTVASIFGST MGEIRWPGTK KTFEGTMTSI FAQIISVALI LIFDSGVDLN
510 520 530
YSYAWILGSI STVSLLEAYT TQIDNLLLPL YLLILLMA
Length:538
Mass (Da):59,268
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB7D1BABD45362AD
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83046 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03285199C → S in CDG1M; 2% residual activity; fails to complement the temperature-sensitive phenotype of DK1-deficient yeast cells. 1 PublicationCorresponds to variant dbSNP:rs137853109EnsemblClinVar.1
Natural variantiVAR_049709224D → V. Corresponds to variant dbSNP:rs17485436EnsemblClinVar.1
Natural variantiVAR_032852441Y → S in CDG1M; 4% residual activity; fails to complement the temperature-sensitive phenotype of DK1-deficient yeast cells. 1 PublicationCorresponds to variant dbSNP:rs137853110EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB029017 mRNA Translation: BAA83046.2 Different initiation.
AY358759 mRNA Translation: AAQ89119.1
AL672142 Genomic DNA No translation available.
BC035556 mRNA Translation: AAH35556.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6915.1

NCBI Reference Sequences

More...
RefSeqi
NP_055723.1, NM_014908.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.531563

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372586; ENSP00000361667; ENSG00000175283

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22845

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22845

UCSC genome browser

More...
UCSCi
uc004bwr.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029017 mRNA Translation: BAA83046.2 Different initiation.
AY358759 mRNA Translation: AAQ89119.1
AL672142 Genomic DNA No translation available.
BC035556 mRNA Translation: AAH35556.1
CCDSiCCDS6915.1
RefSeqiNP_055723.1, NM_014908.3
UniGeneiHs.531563

3D structure databases

ProteinModelPortaliQ9UPQ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116517, 20 interactors
IntActiQ9UPQ8, 20 interactors
MINTiQ9UPQ8
STRINGi9606.ENSP00000361667

PTM databases

iPTMnetiQ9UPQ8
PhosphoSitePlusiQ9UPQ8

Polymorphism and mutation databases

BioMutaiDOLK
DMDMi20140913

Proteomic databases

EPDiQ9UPQ8
jPOSTiQ9UPQ8
MaxQBiQ9UPQ8
PaxDbiQ9UPQ8
PeptideAtlasiQ9UPQ8
PRIDEiQ9UPQ8
ProteomicsDBi85419

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
22845
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372586; ENSP00000361667; ENSG00000175283
GeneIDi22845
KEGGihsa:22845
UCSCiuc004bwr.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22845
DisGeNETi22845
EuPathDBiHostDB:ENSG00000175283.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DOLK
GeneReviewsiDOLK
HGNCiHGNC:23406 DOLK
HPAiHPA066767
HPA068706
MalaCardsiDOLK
MIMi610746 gene
610768 phenotype
neXtProtiNX_Q9UPQ8
OpenTargetsiENSG00000175283
Orphaneti91131 DK1-CDG
154 Familial isolated dilated cardiomyopathy
PharmGKBiPA162384054

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2468 Eukaryota
COG0170 LUCA
GeneTreeiENSGT00390000004067
HOGENOMiHOG000036052
HOVERGENiHBG054655
InParanoidiQ9UPQ8
KOiK00902
OMAiRKYFHFI
OrthoDBi614199at2759
PhylomeDBiQ9UPQ8
TreeFamiTF323379

Enzyme and pathway databases

ReactomeiR-HSA-446199 Synthesis of Dolichyl-phosphate
R-HSA-4755583 Defective DOLK causes DOLK-CDG (CDG-1m)

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Dolichol_kinase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22845

Protein Ontology

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PROi
PR:Q9UPQ8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000175283 Expressed in 199 organ(s), highest expression level in right adrenal gland
ExpressionAtlasiQ9UPQ8 baseline and differential
GenevisibleiQ9UPQ8 HS

Family and domain databases

InterProiView protein in InterPro
IPR026566 DOLK
IPR032974 Polypren_kinase
PANTHERiPTHR13205 PTHR13205, 1 hit
PTHR13205:SF15 PTHR13205:SF15, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOLK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPQ8
Secondary accession number(s): Q5SRE6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 2000
Last modified: February 13, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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