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Entry version 176 (12 Aug 2020)
Sequence version 2 (01 Feb 2005)
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Protein

E3 ubiquitin-protein ligase PDZRN3

Gene

PDZRN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri18 – 56RING-type; degeneratePROSITE-ProRule annotationAdd BLAST39
Zinc fingeri100 – 158TRAF-typePROSITE-ProRule annotationAdd BLAST59

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9UPQ7

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase PDZRN3 (EC:2.3.2.27)
Alternative name(s):
Ligand of Numb protein X 3
PDZ domain-containing RING finger protein 3
RING-type E3 ubiquitin transferase PDZRN3Curated
Semaphorin cytoplasmic domain-associated protein 3
Short name:
Protein SEMACAP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDZRN3
Synonyms:KIAA1095, LNX3, SEMCAP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000121440.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17704, PDZRN3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609729, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UPQ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cytoplasm, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23024

Open Targets

More...
OpenTargetsi
ENSG00000121440

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134931098

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UPQ7, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PDZRN3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62288903

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000559171 – 1066E3 ubiquitin-protein ligase PDZRN3Add BLAST1066

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei427PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Auto-ubiquitinated.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UPQ7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UPQ7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UPQ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UPQ7

PeptideAtlas

More...
PeptideAtlasi
Q9UPQ7

PRoteomics IDEntifications database

More...
PRIDEi
Q9UPQ7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85416 [Q9UPQ7-1]
85417 [Q9UPQ7-2]
85418 [Q9UPQ7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UPQ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UPQ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000121440, Expressed in esophagus and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UPQ7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UPQ7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000121440, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NLGN1 and EFNB2.

Interacts with UBE2D2 and with MUSK via the first PDZ domain.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116664, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UPQ7, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000263666

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9UPQ7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11066
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UPQ7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9UPQ7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini249 – 339PDZ 1PROSITE-ProRule annotationAdd BLAST91
Domaini419 – 503PDZ 2PROSITE-ProRule annotationAdd BLAST85

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili679 – 704Sequence analysisAdd BLAST26
Coiled coili975 – 1025Sequence analysisAdd BLAST51

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RING-type zinc finger domain is required for E3 ligase activity.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 56RING-type; degeneratePROSITE-ProRule annotationAdd BLAST39
Zinc fingeri100 – 158TRAF-typePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0297, Eukaryota
KOG0312, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183062

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_058306_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UPQ7

KEGG Orthology (KO)

More...
KOi
K15682

Identification of Orthologs from Complete Genome Data

More...
OMAi
NDYMGDI

Database of Orthologous Groups

More...
OrthoDBi
631580at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UPQ7

TreeFam database of animal gene trees

More...
TreeFami
TF315909

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 2 hits
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR008974, TRAF-like
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
IPR001293, Znf_TRAF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595, PDZ, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 2 hits
SM00184, RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49599, SSF49599, 1 hit
SSF50156, SSF50156, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106, PDZ, 2 hits
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit
PS50145, ZF_TRAF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGFELDRFDG DVDPDLKCAL CHKVLEDPLT TPCGHVFCAG CVLPWVVQEG
60 70 80 90 100
SCPARCRGRL SAKELNHVLP LKRLILKLDI KCAYATRGCG RVVKLQQLPE
110 120 130 140 150
HLERCDFAPA RCRHAGCGQV LLRRDVEAHM RDACDARPVG RCQEGCGLPL
160 170 180 190 200
THGEQRAGGH CCARALRAHN GALQARLGAL HKALKKEALR AGKREKSLVA
210 220 230 240 250
QLAAAQLELQ MTALRYQKKF TEYSARLDSL SRCVAAPPGG KGEETKSLTL
260 270 280 290 300
VLHRDSGSLG FNIIGGRPSV DNHDGSSSEG IFVSKIVDSG PAAKEGGLQI
310 320 330 340 350
HDRIIEVNGR DLSRATHDQA VEAFKTAKEP IVVQVLRRTP RTKMFTPPSE
360 370 380 390 400
SQLVDTGTQT DITFEHIMAL TKMSSPSPPV LDPYLLPEEH PSAHEYYDPN
410 420 430 440 450
DYIGDIHQEM DREELELEEV DLYRMNSQDK LGLTVCYRTD DEDDIGIYIS
460 470 480 490 500
EIDPNSIAAK DGRIREGDRI IQINGIEVQN REEAVALLTS EENKNFSLLI
510 520 530 540 550
ARPELQLDEG WMDDDRNDFL DDLHMDMLEE QHHQAMQFTA SVLQQKKHDE
560 570 580 590 600
DGGTTDTATI LSNQHEKDSG VGRTDESTRN DESSEQENNG DDATASSNPL
610 620 630 640 650
AGQRKLTCSQ DTLGSGDLPF SNESFISADC TDADYLGIPV DECERFRELL
660 670 680 690 700
ELKCQVKSAT PYGLYYPSGP LDAGKSDPES VDKELELLNE ELRSIELECL
710 720 730 740 750
SIVRAHKMQQ LKEQYRESWM LHNSGFRNYN TSIDVRRHEL SDITELPEKS
760 770 780 790 800
DKDSSSAYNT GESCRSTPLT LEISPDNSLR RAAEGISCPS SEGAVGTTEA
810 820 830 840 850
YGPASKNLLS ITEDPEVGTP TYSPSLKELD PNQPLESKER RASDGSRSPT
860 870 880 890 900
PSQKLGSAYL PSYHHSPYKH AHIPAHAQHY QSYMQLIQQK SAVEYAQSQM
910 920 930 940 950
SLVSMCKDLS SPTPSEPRME WKVKIRSDGT RYITKRPVRD RLLRERALKI
960 970 980 990 1000
REERSGMTTD DDAVSEMKMG RYWSKEERKQ HLVKAKEQRR RREFMMQSRL
1010 1020 1030 1040 1050
DCLKEQQAAD DRKEMNILEL SHKKMMKKRN KKIFDNWMTI QELLTHGTKS
1060
PDGTRVYNSF LSVTTV
Length:1,066
Mass (Da):119,596
Last modified:February 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE837EF3B5B0C808
GO
Isoform 2 (identifier: Q9UPQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     307-360: VNGRDLSRAT...SQLVDTGTQT → MRKLELRTVK...ACGGAYLNCI
     361-1066: Missing.

Show »
Length:360
Mass (Da):38,931
Checksum:i451BC8AF39408341
GO
Isoform 3 (identifier: Q9UPQ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     641-729: DECERFRELL...MLHNSGFRNY → EGEDPQRRDA...GLSQGAASSR
     730-1066: Missing.

Show »
Length:729
Mass (Da):80,006
Checksum:i24509433F18C9CFA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZAG0B7ZAG0_HUMAN
E3 ubiquitin-protein ligase PDZRN3
PDZRN3
783Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ENB6E7ENB6_HUMAN
E3 ubiquitin-protein ligase PDZRN3
PDZRN3
723Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWE6C9JWE6_HUMAN
E3 ubiquitin-protein ligase PDZRN3
PDZRN3
492Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C566H7C566_HUMAN
E3 ubiquitin-protein ligase PDZRN3
PDZRN3
382Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83047 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11068 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020965783A → V1 PublicationCorresponds to variant dbSNP:rs3205537Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012606307 – 360VNGRD…TGTQT → MRKLELRTVKLPKAHSQDSN AGFIPQLLSLHTPPLSCEKG GGHLACGGAYLNCI in isoform 2. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_012607361 – 1066Missing in isoform 2. 1 PublicationAdd BLAST706
Alternative sequenceiVSP_012608641 – 729DECER…GFRNY → EGEDPQRRDALHHQEARAGP PAAGARPEDPGRAQRHDHRR RRGERDEDGALLEQGGEEAA PGEGQGAAAAARVHDAEQVG LSQGAASSR in isoform 3. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_012609730 – 1066Missing in isoform 3. 1 PublicationAdd BLAST337

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB029018 mRNA Translation: BAA83047.1 Different initiation.
BC014432 mRNA Translation: AAH14432.1
BC152417 mRNA Translation: AAI52418.1
AK074573 mRNA Translation: BAC11068.1 Different initiation.
AL157498 mRNA Translation: CAB75679.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33789.1 [Q9UPQ7-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46925

NCBI Reference Sequences

More...
RefSeqi
NP_001290068.1, NM_001303139.1
NP_001290069.1, NM_001303140.1
NP_001290070.1, NM_001303141.1
NP_001290071.1, NM_001303142.1
NP_055824.1, NM_015009.2 [Q9UPQ7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263666; ENSP00000263666; ENSG00000121440 [Q9UPQ7-1]
ENST00000308537; ENSP00000308831; ENSG00000121440 [Q9UPQ7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23024

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23024

UCSC genome browser

More...
UCSCi
uc003dpl.2, human [Q9UPQ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029018 mRNA Translation: BAA83047.1 Different initiation.
BC014432 mRNA Translation: AAH14432.1
BC152417 mRNA Translation: AAI52418.1
AK074573 mRNA Translation: BAC11068.1 Different initiation.
AL157498 mRNA Translation: CAB75679.1
CCDSiCCDS33789.1 [Q9UPQ7-1]
PIRiT46925
RefSeqiNP_001290068.1, NM_001303139.1
NP_001290069.1, NM_001303140.1
NP_001290070.1, NM_001303141.1
NP_001290071.1, NM_001303142.1
NP_055824.1, NM_015009.2 [Q9UPQ7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UHPNMR-A246-339[»]
1WH1NMR-A405-515[»]
SMRiQ9UPQ7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116664, 22 interactors
IntActiQ9UPQ7, 8 interactors
STRINGi9606.ENSP00000263666

PTM databases

iPTMnetiQ9UPQ7
PhosphoSitePlusiQ9UPQ7

Polymorphism and mutation databases

BioMutaiPDZRN3
DMDMi62288903

Proteomic databases

EPDiQ9UPQ7
jPOSTiQ9UPQ7
MassIVEiQ9UPQ7
PaxDbiQ9UPQ7
PeptideAtlasiQ9UPQ7
PRIDEiQ9UPQ7
ProteomicsDBi85416 [Q9UPQ7-1]
85417 [Q9UPQ7-2]
85418 [Q9UPQ7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31945, 99 antibodies

Genome annotation databases

EnsembliENST00000263666; ENSP00000263666; ENSG00000121440 [Q9UPQ7-1]
ENST00000308537; ENSP00000308831; ENSG00000121440 [Q9UPQ7-2]
GeneIDi23024
KEGGihsa:23024
UCSCiuc003dpl.2, human [Q9UPQ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23024
DisGeNETi23024
EuPathDBiHostDB:ENSG00000121440.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PDZRN3
HGNCiHGNC:17704, PDZRN3
HPAiENSG00000121440, Low tissue specificity
MIMi609729, gene
neXtProtiNX_Q9UPQ7
OpenTargetsiENSG00000121440
PharmGKBiPA134931098

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0297, Eukaryota
KOG0312, Eukaryota
GeneTreeiENSGT00950000183062
HOGENOMiCLU_058306_0_0_1
InParanoidiQ9UPQ7
KOiK15682
OMAiNDYMGDI
OrthoDBi631580at2759
PhylomeDBiQ9UPQ7
TreeFamiTF315909

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ9UPQ7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
23024, 3 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PDZRN3, human
EvolutionaryTraceiQ9UPQ7

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PDZRN3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23024
PharosiQ9UPQ7, Tbio

Protein Ontology

More...
PROi
PR:Q9UPQ7
RNActiQ9UPQ7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000121440, Expressed in esophagus and 243 other tissues
ExpressionAtlasiQ9UPQ7, baseline and differential
GenevisibleiQ9UPQ7, HS

Family and domain databases

Gene3Di2.30.42.10, 2 hits
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR008974, TRAF-like
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
IPR001293, Znf_TRAF
PfamiView protein in Pfam
PF00595, PDZ, 2 hits
SMARTiView protein in SMART
SM00228, PDZ, 2 hits
SM00184, RING, 1 hit
SUPFAMiSSF49599, SSF49599, 1 hit
SSF50156, SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106, PDZ, 2 hits
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit
PS50145, ZF_TRAF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPZRN3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPQ7
Secondary accession number(s): A7MCZ6
, Q8N2N7, Q96CC2, Q9NSQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: August 12, 2020
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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