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Protein

Tripartite motif-containing protein 35

Gene

TRIM35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). Involved in the cell death mechanism (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri21 – 61RING-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri96 – 137B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 35
Alternative name(s):
Hemopoietic lineage switch protein 5
Gene namesi
Name:TRIM35
Synonyms:HLS5, KIAA1098
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104228.12
HGNCiHGNC:16285 TRIM35
MIMi617007 gene
neXtProtiNX_Q9UPQ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23087
OpenTargetsiENSG00000104228
PharmGKBiPA38115

Polymorphism and mutation databases

BioMutaiTRIM35
DMDMi56404980

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562501 – 493Tripartite motif-containing protein 35Add BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei8PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9UPQ4
PeptideAtlasiQ9UPQ4
PRIDEiQ9UPQ4
ProteomicsDBi85414
85415 [Q9UPQ4-2]

PTM databases

iPTMnetiQ9UPQ4
PhosphoSitePlusiQ9UPQ4

Expressioni

Gene expression databases

BgeeiENSG00000104228 Expressed in 170 organ(s), highest expression level in skin of abdomen
CleanExiHS_TRIM35
ExpressionAtlasiQ9UPQ4 baseline and differential
GenevisibleiQ9UPQ4 HS

Organism-specific databases

HPAiHPA019647

Interactioni

Subunit structurei

Interacts with PKM isoform M2, but not isoform M1; this interaction may compete with that between PKM and FGFR1, and hence reduces FGFR1-dependent tyrosine phosphorylation of PKM.1 Publication

Protein-protein interaction databases

BioGridi116716, 35 interactors
IntActiQ9UPQ4, 36 interactors
STRINGi9606.ENSP00000301924

Structurei

3D structure databases

ProteinModelPortaliQ9UPQ4
SMRiQ9UPQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini284 – 487B30.2/SPRYPROSITE-ProRule annotationAdd BLAST204

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili210 – 251Sequence analysisAdd BLAST42

Domaini

The RING finger domain and the coiled-coil region are required for the apoptosis-inducing activity.By similarity

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri21 – 61RING-typePROSITE-ProRule annotationAdd BLAST41
Zinc fingeri96 – 137B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ITFW Eukaryota
ENOG410YB4K LUCA
GeneTreeiENSGT00760000118838
HOGENOMiHOG000124586
HOVERGENiHBG098569
InParanoidiQ9UPQ4
KOiK12012
OMAiQVAPTCP
OrthoDBiEOG091G0AKN
PhylomeDBiQ9UPQ4
TreeFamiTF334286

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPQ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERSPDVSPG PSRSFKEELL CAVCYDPFRD AVTLRCGHNF CRGCVSRCWE
60 70 80 90 100
VQVSPTCPVC KDRASPADLR TNHTLNNLVE KLLREEAEGA RWTSYRFSRV
110 120 130 140 150
CRLHRGQLSL FCLEDKELLC CSCQADPRHQ GHRVQPVKDT AHDFRAKCRN
160 170 180 190 200
MEHALREKAK AFWAMRRSYE AIAKHNQVEA AWLEGRIRQE FDKLREFLRV
210 220 230 240 250
EEQAILDAMA EETRQKQLLA DEKMKQLTEE TEVLAHEIER LQMEMKEDDV
260 270 280 290 300
SFLMKHKSRK RRLFCTMEPE PVQPGMLIDV CKYLGSLQYR VWKKMLASVE
310 320 330 340 350
SVPFSFDPNT AAGWLSVSDD LTSVTNHGYR VQVENPERFS SAPCLLGSRV
360 370 380 390 400
FSQGSHAWEV ALGGLQSWRV GVVRVRQDSG AEGHSHSCYH DTRSGFWYVC
410 420 430 440 450
RTQGVEGDHC VTSDPATSPL VLAIPRRLRV ELECEEGELS FYDAERHCHL
460 470 480 490
YTFHARFGEV RPYFYLGGAR GAGPPEPLRI CPLHISVKEE LDG
Length:493
Mass (Da):56,540
Last modified:December 7, 2004 - v2
Checksum:iBFB7E5BFD3AD7E2D
GO
Isoform 2 (identifier: Q9UPQ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-206: AKCRNMEHAL...FLRVEEQAIL → VRSLIAEERR...QGLLGHAALL

Note: No experimental confirmation available.
Show »
Length:493
Mass (Da):55,914
Checksum:i2DB3305B868B67F8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RGB3E5RGB3_HUMAN
Tripartite motif-containing protein...
TRIM35
266Annotation score:
H0YBF3H0YBF3_HUMAN
Tripartite motif-containing protein...
TRIM35
100Annotation score:

Sequence cautioni

The sequence BAA83050 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012061146 – 206AKCRN…EQAIL → VRSLIAEERRNFLPTHQWIV TKTRLQTSSPNLQSRRQGQV QEHGACTAGEGQGLLGHAAL L in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492463 mRNA Translation: AAO85480.1
AB029021 mRNA Translation: BAA83050.1 Different initiation.
BC018337 mRNA Translation: AAH18337.1
BC069226 mRNA Translation: AAH69226.1
CCDSiCCDS6056.2 [Q9UPQ4-1]
RefSeqiNP_741983.2, NM_171982.4 [Q9UPQ4-1]
UniGeneiHs.104223

Genome annotation databases

EnsembliENST00000305364; ENSP00000301924; ENSG00000104228 [Q9UPQ4-1]
GeneIDi23087
KEGGihsa:23087
UCSCiuc003xfl.2 human [Q9UPQ4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492463 mRNA Translation: AAO85480.1
AB029021 mRNA Translation: BAA83050.1 Different initiation.
BC018337 mRNA Translation: AAH18337.1
BC069226 mRNA Translation: AAH69226.1
CCDSiCCDS6056.2 [Q9UPQ4-1]
RefSeqiNP_741983.2, NM_171982.4 [Q9UPQ4-1]
UniGeneiHs.104223

3D structure databases

ProteinModelPortaliQ9UPQ4
SMRiQ9UPQ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116716, 35 interactors
IntActiQ9UPQ4, 36 interactors
STRINGi9606.ENSP00000301924

PTM databases

iPTMnetiQ9UPQ4
PhosphoSitePlusiQ9UPQ4

Polymorphism and mutation databases

BioMutaiTRIM35
DMDMi56404980

Proteomic databases

PaxDbiQ9UPQ4
PeptideAtlasiQ9UPQ4
PRIDEiQ9UPQ4
ProteomicsDBi85414
85415 [Q9UPQ4-2]

Protocols and materials databases

DNASUi23087
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305364; ENSP00000301924; ENSG00000104228 [Q9UPQ4-1]
GeneIDi23087
KEGGihsa:23087
UCSCiuc003xfl.2 human [Q9UPQ4-1]

Organism-specific databases

CTDi23087
DisGeNETi23087
EuPathDBiHostDB:ENSG00000104228.12
GeneCardsiTRIM35
HGNCiHGNC:16285 TRIM35
HPAiHPA019647
MIMi617007 gene
neXtProtiNX_Q9UPQ4
OpenTargetsiENSG00000104228
PharmGKBiPA38115
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITFW Eukaryota
ENOG410YB4K LUCA
GeneTreeiENSGT00760000118838
HOGENOMiHOG000124586
HOVERGENiHBG098569
InParanoidiQ9UPQ4
KOiK12012
OMAiQVAPTCP
OrthoDBiEOG091G0AKN
PhylomeDBiQ9UPQ4
TreeFamiTF334286

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling

Miscellaneous databases

GenomeRNAii23087
PROiPR:Q9UPQ4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104228 Expressed in 170 organ(s), highest expression level in skin of abdomen
CleanExiHS_TRIM35
ExpressionAtlasiQ9UPQ4 baseline and differential
GenevisibleiQ9UPQ4 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRI35_HUMAN
AccessioniPrimary (citable) accession number: Q9UPQ4
Secondary accession number(s): Q86XQ0, Q8WVA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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