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UniProtKB - Q9UPQ0 (LIMC1_HUMAN)

Entry version 150 (07 Apr 2021)
Sequence version 4 (18 May 2010)
Previous versions | rss
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Protein

LIM and calponin homology domains-containing protein 1

Gene

LIMCH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9UPQ0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LIM and calponin homology domains-containing protein 1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LIMCH1Imported
Synonyms:KIAA1102Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29191, LIMCH1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617750, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9UPQ0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000064042.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		22998

Open Targets

More...OpenTargetsi		ENSG00000064042

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162393957

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9UPQ0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LIMCH1

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439483

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002936191 – 1083LIM and calponin homology domains-containing protein 1Add BLAST1083

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei169PhosphoserineCombined sources1
Modified residuei177PhosphoserineBy similarity1
Modified residuei192PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei207PhosphoserineCombined sources1
Modified residuei215PhosphothreonineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei226PhosphoserineBy similarity1
Modified residuei231PhosphoserineCombined sources1
Modified residuei233PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei313PhosphotyrosineBy similarity1
Modified residuei377PhosphoserineCombined sources1
Modified residuei402PhosphothreonineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Modified residuei472PhosphothreonineBy similarity1
Modified residuei516PhosphoserineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei529PhosphothreonineCombined sources1
Modified residuei537PhosphothreonineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei670PhosphoserineCombined sources1
Modified residuei681PhosphoserineCombined sources1
Modified residuei718PhosphoserineCombined sources1
Modified residuei724PhosphothreonineCombined sources1
Modified residuei750PhosphoserineBy similarity1
Modified residuei756PhosphoserineBy similarity1
Modified residuei875PhosphoserineCombined sources1
Modified residuei900PhosphothreonineBy similarity1
Modified residuei966PhosphoserineCombined sources1
Modified residuei973PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9UPQ0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9UPQ0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9UPQ0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9UPQ0

PeptideAtlas

More...PeptideAtlasi		Q9UPQ0

PRoteomics IDEntifications database

More...PRIDEi		Q9UPQ0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20568
85402 [Q9UPQ0-1]
85403 [Q9UPQ0-2]
85404 [Q9UPQ0-3]
85405 [Q9UPQ0-4]
85406 [Q9UPQ0-5]
85407 [Q9UPQ0-6]
85408 [Q9UPQ0-7]
85409 [Q9UPQ0-8]
85410 [Q9UPQ0-9]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9UPQ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9UPQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000064042, Expressed in substantia nigra and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9UPQ0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9UPQ0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000064042, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYH9; independently of the integration of MYH9 into the myosin complex.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116645, 65 interactors

Protein interaction database and analysis system

More...IntActi		Q9UPQ0, 33 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000316891

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9UPQ0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9UPQ0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 125Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST105
Domaini1011 – 1077LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni251 – 639Mediates interaction with MYH91 PublicationAdd BLAST389

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili354 – 439Sequence analysisAdd BLAST86
Coiled coili782 – 823Sequence analysisAdd BLAST42

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LIMCH1 family.Curated

Keywords - Domaini

Coiled coil, LIM domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1704, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183159

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9UPQ0

Database of Orthologous Groups

More...OrthoDBi		298177at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9UPQ0

TreeFam database of animal gene trees

More...TreeFami		TF332155

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001997, Calponin/LIMCH1
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR031865, DUF4757
IPR029980, LIMCH1
IPR003096, SM22_calponin
IPR001781, Znf_LIM

The PANTHER Classification System

More...PANTHERi		PTHR15551:SF3, PTHR15551:SF3, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 1 hit
PF15949, DUF4757, 1 hit
PF00412, LIM, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00889, CALPONIN
PR00888, SM22CALPONIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 1 hit
SM00132, LIM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50021, CH, 1 hit
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (10+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 10 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 10 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UPQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACPALGLEA LQPLQPEPPP EPAFSEAQKW IEQVTGRSFG DKDFRTGLEN 
        60         70         80         90        100
GILLCELLNA IKPGLVKKIN RLPTPIAGLD NIILFLRGCK ELGLKESQLF 
       110        120        130        140        150
DPSDLQDTSN RVTVKSLDYS RKLKNVLVTI YWLGKAANSC TSYSGTTLNL 
       160        170        180        190        200
KEFEGLLAQM RKDTDDIESP KRSIRDSGYI DCWDSERSDS LSPPRHGRDD 
       210        220        230        240        250
SFDSLDSFGS RSRQTPSPDV VLRGSSDGRG SDSESDLPHR KLPDVKKDDM 
       260        270        280        290        300
SARRTSHGEP KSAVPFNQYL PNKSNQTAYV PAPLRKKKAE REEYRKSWST 
       310        320        330        340        350
ATSPLGGERP FRYGPRTPVS DDAESTSMFD MRCEEEAAVQ PHSRARQEQL 
       360        370        380        390        400
QLINNQLREE DDKWQDDLAR WKSRRRSVSQ DLIKKEEERK KMEKLLAGED 
       410        420        430        440        450
GTSERRKSIK TYREIVQEKE RRERELHEAY KNARSQEEAE GILQQYIERF 
       460        470        480        490        500
TISEAVLERL EMPKILERSH STEPNLSSFL NDPNPMKYLR QQSLPPPKFT 
       510        520        530        540        550
ATVETTIARA SVLDTSMSAG SGSPSKTVTP KAVPMLTPKP YSQPKNSQDV 
       560        570        580        590        600
LKTFKVDGKV SVNGETVHRE EEKERECPTV APAHSLTKSQ MFEGVARVHG 
       610        620        630        640        650
SPLELKQDNG SIEINIKKPN SVPQELAATT EKTEPNSQED KNDGGKSRKG 
       660        670        680        690        700
NIELASSEPQ HFTTTVTRCS PTVAFVEFPS SPQLKNDVSE EKDQKKPENE 
       710        720        730        740        750
MSGKVELVLS QKVVKPKSPE PEATLTFPFL DKMPEANQLH LPNLNSQVDS 
       760        770        780        790        800
PSSEKSPVMT PQFKFWAWDP EEERRRQEKW QQEQERLLQE RYQKEQDKLK 
       810        820        830        840        850
EEWEKAQKEV EEEERRYYEE ERKIIEDTVV PFTVSSSSAD QLSTSSSMTE 
       860        870        880        890        900
GSGTMNKIDL GNCQDEKQDR RWKKSFQGDD SDLLLKTRES DRLEEKGSLT 
       910        920        930        940        950
EGALAHSGNP VSKGVHEDHQ LDTEAGAPHC GTNPQLAQDP SQNQQTSNPT 
       960        970        980        990       1000
HSSEDVKPKT LPLDKSINHQ IESPSERRKK SPREHFQAGP FSPCSPTPPG 
      1010       1020       1030       1040       1050
QSPNRSISGK KLCSSCGLPL GKGAAMIIET LNLYFHIQCF RCGICKGQLG 
      1060       1070       1080 
DAVSGTDVRI RNGLLNCNDC YMRSRSAGQP TTL
Length:1,083
Mass (Da):121,867
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19C8BA192EDBDC6B
GO
Isoform 2 (identifier: Q9UPQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     980-1005: Missing.

Show »
Length:1,057
Mass (Da):119,078
Checksum:i0941CE1DC5A787A8
GO
Isoform 3 (identifier: Q9UPQ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.
     311-311: F → FSFPETIEEE...SSKGLPMKDQ
     762-762: Missing.

Show »
Length:1,467
Mass (Da):164,440
Checksum:i0D87F5D5CC068B60
GO
Isoform 4 (identifier: Q9UPQ0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-324: Missing.
     747-747: Q → QESPGTASVPLRVQNSWRRSQFFSQS
     762-762: Missing.
     980-1005: Missing.

Show »
Length:1,069
Mass (Da):120,496
Checksum:iDFE247E4E66028D9
GO
Isoform 5 (identifier: Q9UPQ0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.
     313-324: Missing.
     747-747: Q → QESPGTASVPLRVQNSWRRSQFFSQS
     762-762: Missing.
     980-1005: Missing.

Show »
Length:910
Mass (Da):103,010
Checksum:i569E37A38F29AB9A
GO
Isoform 6 (identifier: Q9UPQ0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-154: Missing.
     155-161: GLLAQMR → MDSERQV
     762-762: Missing.
     980-1005: Missing.

Show »
Length:902
Mass (Da):102,022
Checksum:i7584455BA8EAEC5D
GO
Isoform 7 (identifier: Q9UPQ0-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.
     288-297: KAEREEYRKS → NADTMRRSVR
     298-1083: Missing.

Show »
Length:138
Mass (Da):15,551
Checksum:i7829A68BD11C1097
GO
Isoform 8 (identifier: Q9UPQ0-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.
     762-762: Missing.
     980-1005: Missing.

Show »
Length:897
Mass (Da):101,464
Checksum:iE6A5FF8C3D53D2F9
GO
Isoform 9 (identifier: Q9UPQ0-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-154: Missing.
     155-161: GLLAQMR → MDSERQV
     313-324: Missing.
     762-762: Missing.
     980-1005: Missing.

Show »
Length:890
Mass (Da):100,734
Checksum:iD0F8D08238E15CDD
GO
Isoform 10 (identifier: Q9UPQ0-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     762-762: Missing.
     980-1005: Missing.

Show »
Length:1,056
Mass (Da):118,950
Checksum:i69BBB44235180481
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RD46D6RD46_HUMAN
LIM and calponin homology domains-c...
LIMCH1
980Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5EA03G5EA03_HUMAN
LIM and calponin homology domains-c...
LIMCH1 DKFZP686A01247, hCG_33090
1,467Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PDJ9E9PDJ9_HUMAN
LIM and calponin homology domains-c...
LIMCH1
916Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPK0E7EPK0_HUMAN
LIM and calponin homology domains-c...
LIMCH1
897Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8P3H0Y8P3_HUMAN
LIM and calponin homology domains-c...
LIMCH1
917Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R8Y0D6R8Y0_HUMAN
LIM and calponin homology domains-c...
LIMCH1
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6NVB9Q6NVB9_HUMAN
LIM and calponin homology domains-c...
LIMCH1
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJ93D6RJ93_HUMAN
LIM and calponin homology domains-c...
LIMCH1
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGH8D6RGH8_HUMAN
LIM and calponin homology domains-c...
LIMCH1
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83054 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti17E → G in CAI56749 (PubMed:17974005).Curated1
Sequence conflicti142S → P in CR936664 (PubMed:17974005).Curated1
Sequence conflicti207S → F in CAI56749 (PubMed:17974005).Curated1
Sequence conflicti409I → T in CR936664 (PubMed:17974005).Curated1
Sequence conflicti537T → I in CAH18063 (PubMed:17974005).Curated1
Sequence conflicti611S → G in CAD38604 (PubMed:17974005).Curated1
Sequence conflicti622V → I in CR936664 (PubMed:17974005).Curated1
Sequence conflicti706E → G in CAI56754 (PubMed:17974005).Curated1
Sequence conflicti750S → P in CAD38604 (PubMed:17974005).Curated1
Sequence conflicti867K → N in CAH18063 (PubMed:17974005).Curated1
Sequence conflicti1053V → A in CAD38604 (PubMed:17974005).Curated1
Sequence conflicti1059R → G in CAI45946 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033105759M → T3 PublicationsCorresponds to variant dbSNP:rs11734372Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0265411 – 159Missing in isoform 3, isoform 5, isoform 7 and isoform 8. 2 PublicationsAdd BLAST159
Alternative sequenceiVSP_0265421 – 154Missing in isoform 6 and isoform 9. 1 PublicationAdd BLAST154
Alternative sequenceiVSP_026543155 – 161GLLAQMR → MDSERQV in isoform 6 and isoform 9. 1 Publication7
Alternative sequenceiVSP_026544288 – 297KAEREEYRKS → NADTMRRSVR in isoform 7. 1 Publication10
Alternative sequenceiVSP_026545298 – 1083Missing in isoform 7. 1 PublicationAdd BLAST786
Alternative sequenceiVSP_026546311F → FSFPETIEEEGSEVGSAGED NPAGQMNPGWKPSDGGCELP DGSGKEHPSSDGAVVAPAPK SEEKDAAEIQKRERLEQAGI KVMPAAQRFASQKQLSEEKE AIRDIVLRKENSFLTHQHGN DSEAEGEVVCRLPDLEKDDF AARRARMNQTKPMVPLNQLL YGPYPKKGAEKSDGSKQLSK GISKKRSLEYKRNQGHTEEV KLIVTCNMRAQESEPVEGGL RKVPDLHKDDLAQQRIQGSL APHREPPSFITLSNITEADL ETWERLKVSEKARDGDVQHI CASEPSPEIKAETAIRDDFA NRKARASKKASSPRQKFVHF GPVTELDQQKWKRLSIGKAG PREDEEEVICHGSKIQMDSV SPVSAATSSLKGHQIFNRQN DCRTMNCGRGDYCRRASWLA PVPESQEEWVCSLGECPRGT EEVTSKQLPQDGKEETESAP RDSERLSKAERSEDSSQPLV CPLASECEASGTEEKLEKMT APAWSGSGLKGQRKLDDSRK DDMMARRTGMSLRHTGSNPN QFLPVPFAKQQDVEESSKGL PMKDQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_026547313 – 324Missing in isoform 4, isoform 5 and isoform 9. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_026548747Q → QESPGTASVPLRVQNSWRRS QFFSQS in isoform 4 and isoform 5. 1 Publication1
Alternative sequenceiVSP_026549762Missing in isoform 3, isoform 4, isoform 5, isoform 6, isoform 8, isoform 9 and isoform 10. 2 Publications1
Alternative sequenceiVSP_026550980 – 1005Missing in isoform 2, isoform 4, isoform 5, isoform 6, isoform 8, isoform 9 and isoform 10. 2 PublicationsAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB029025 mRNA Translation: BAA83054.2 Different initiation.
AL831962 mRNA Translation: CAD38604.1
BX537916 mRNA Translation: CAD97899.1
CR749205 mRNA Translation: CAH18063.1
CR933645 mRNA Translation: CAI45946.1
CR936601 mRNA Translation: CAI56749.1
CR936610 mRNA Translation: CAI56754.1
CR936664 mRNA No translation available.
AC095043 Genomic DNA No translation available.
AC105389 Genomic DNA No translation available.
AC108050 Genomic DNA No translation available.
AC121159 Genomic DNA No translation available.
AC124009 Genomic DNA No translation available.
BC023546 mRNA Translation: AAH23546.1
BC029735 mRNA Translation: AAH29735.1
BC095394 mRNA Translation: AAH95394.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33977.1 [Q9UPQ0-1]
CCDS47047.1 [Q9UPQ0-6]
CCDS54763.1 [Q9UPQ0-2]
CCDS54764.1 [Q9UPQ0-10]
CCDS54765.1 [Q9UPQ0-9]
CCDS75119.1 [Q9UPQ0-4]
CCDS75121.1 [Q9UPQ0-5]
CCDS82919.1 [Q9UPQ0-3]
CCDS87222.1 [Q9UPQ0-8]

NCBI Reference Sequences

More...RefSeqi		NP_001106188.1, NM_001112717.3 [Q9UPQ0-2]
NP_001106189.1, NM_001112718.3 [Q9UPQ0-10]
NP_001106190.1, NM_001112719.3 [Q9UPQ0-6]
NP_001106191.1, NM_001112720.3 [Q9UPQ0-9]
NP_001276051.1, NM_001289122.2 [Q9UPQ0-4]
NP_001276053.1, NM_001289124.1 [Q9UPQ0-5]
NP_001317601.1, NM_001330672.1
NP_001317603.1, NM_001330674.1
NP_001317713.1, NM_001330784.1
NP_001317715.1, NM_001330786.1 [Q9UPQ0-8]
NP_055803.2, NM_014988.4 [Q9UPQ0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000313860; ENSP00000316891; ENSG00000064042 [Q9UPQ0-1]
ENST00000381753; ENSP00000371172; ENSG00000064042 [Q9UPQ0-9]
ENST00000396595; ENSP00000379840; ENSG00000064042 [Q9UPQ0-6]
ENST00000508501; ENSP00000424825; ENSG00000064042 [Q9UPQ0-10]
ENST00000511496; ENSP00000421242; ENSG00000064042 [Q9UPQ0-8]
ENST00000512820; ENSP00000424437; ENSG00000064042 [Q9UPQ0-4]
ENST00000512946; ENSP00000424645; ENSG00000064042 [Q9UPQ0-2]
ENST00000513024; ENSP00000425222; ENSG00000064042 [Q9UPQ0-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22998

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:22998

UCSC genome browser

More...UCSCi		uc003gvu.6, human [Q9UPQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029025 mRNA Translation: BAA83054.2 Different initiation.
AL831962 mRNA Translation: CAD38604.1
BX537916 mRNA Translation: CAD97899.1
CR749205 mRNA Translation: CAH18063.1
CR933645 mRNA Translation: CAI45946.1
CR936601 mRNA Translation: CAI56749.1
CR936610 mRNA Translation: CAI56754.1
CR936664 mRNA No translation available.
AC095043 Genomic DNA No translation available.
AC105389 Genomic DNA No translation available.
AC108050 Genomic DNA No translation available.
AC121159 Genomic DNA No translation available.
AC124009 Genomic DNA No translation available.
BC023546 mRNA Translation: AAH23546.1
BC029735 mRNA Translation: AAH29735.1
BC095394 mRNA Translation: AAH95394.1
CCDSiCCDS33977.1 [Q9UPQ0-1]
CCDS47047.1 [Q9UPQ0-6]
CCDS54763.1 [Q9UPQ0-2]
CCDS54764.1 [Q9UPQ0-10]
CCDS54765.1 [Q9UPQ0-9]
CCDS75119.1 [Q9UPQ0-4]
CCDS75121.1 [Q9UPQ0-5]
CCDS82919.1 [Q9UPQ0-3]
CCDS87222.1 [Q9UPQ0-8]
RefSeqiNP_001106188.1, NM_001112717.3 [Q9UPQ0-2]
NP_001106189.1, NM_001112718.3 [Q9UPQ0-10]
NP_001106190.1, NM_001112719.3 [Q9UPQ0-6]
NP_001106191.1, NM_001112720.3 [Q9UPQ0-9]
NP_001276051.1, NM_001289122.2 [Q9UPQ0-4]
NP_001276053.1, NM_001289124.1 [Q9UPQ0-5]
NP_001317601.1, NM_001330672.1
NP_001317603.1, NM_001330674.1
NP_001317713.1, NM_001330784.1
NP_001317715.1, NM_001330786.1 [Q9UPQ0-8]
NP_055803.2, NM_014988.4 [Q9UPQ0-1]

3D structure databases

SMRiQ9UPQ0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116645, 65 interactors
IntActiQ9UPQ0, 33 interactors
STRINGi9606.ENSP00000316891

PTM databases

iPTMnetiQ9UPQ0
PhosphoSitePlusiQ9UPQ0

Genetic variation databases

BioMutaiLIMCH1
DMDMi296439483

Proteomic databases

EPDiQ9UPQ0
jPOSTiQ9UPQ0
MassIVEiQ9UPQ0
PaxDbiQ9UPQ0
PeptideAtlasiQ9UPQ0
PRIDEiQ9UPQ0
ProteomicsDBi20568
85402 [Q9UPQ0-1]
85403 [Q9UPQ0-2]
85404 [Q9UPQ0-3]
85405 [Q9UPQ0-4]
85406 [Q9UPQ0-5]
85407 [Q9UPQ0-6]
85408 [Q9UPQ0-7]
85409 [Q9UPQ0-8]
85410 [Q9UPQ0-9]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1336, 68 antibodies

The DNASU plasmid repository

More...DNASUi		22998

Genome annotation databases

EnsembliENST00000313860; ENSP00000316891; ENSG00000064042 [Q9UPQ0-1]
ENST00000381753; ENSP00000371172; ENSG00000064042 [Q9UPQ0-9]
ENST00000396595; ENSP00000379840; ENSG00000064042 [Q9UPQ0-6]
ENST00000508501; ENSP00000424825; ENSG00000064042 [Q9UPQ0-10]
ENST00000511496; ENSP00000421242; ENSG00000064042 [Q9UPQ0-8]
ENST00000512820; ENSP00000424437; ENSG00000064042 [Q9UPQ0-4]
ENST00000512946; ENSP00000424645; ENSG00000064042 [Q9UPQ0-2]
ENST00000513024; ENSP00000425222; ENSG00000064042 [Q9UPQ0-5]
GeneIDi22998
KEGGihsa:22998
UCSCiuc003gvu.6, human [Q9UPQ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22998
DisGeNETi22998

GeneCards: human genes, protein and diseases

More...GeneCardsi		LIMCH1
HGNCiHGNC:29191, LIMCH1
HPAiENSG00000064042, Tissue enhanced (skeletal)
MIMi617750, gene
neXtProtiNX_Q9UPQ0
OpenTargetsiENSG00000064042
PharmGKBiPA162393957
VEuPathDBiHostDB:ENSG00000064042.17

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1704, Eukaryota
GeneTreeiENSGT00950000183159
InParanoidiQ9UPQ0
OrthoDBi298177at2759
PhylomeDBiQ9UPQ0
TreeFamiTF332155

Enzyme and pathway databases

PathwayCommonsiQ9UPQ0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		22998, 1 hit in 980 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LIMCH1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		LIMCH1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		22998
PharosiQ9UPQ0, Tdark

Protein Ontology

More...PROi		PR:Q9UPQ0
RNActiQ9UPQ0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000064042, Expressed in substantia nigra and 240 other tissues
ExpressionAtlasiQ9UPQ0, baseline and differential
GenevisibleiQ9UPQ0, HS

Family and domain databases

CDDicd00014, CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001997, Calponin/LIMCH1
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR031865, DUF4757
IPR029980, LIMCH1
IPR003096, SM22_calponin
IPR001781, Znf_LIM
PANTHERiPTHR15551:SF3, PTHR15551:SF3, 1 hit
PfamiView protein in Pfam
PF00307, CH, 1 hit
PF15949, DUF4757, 1 hit
PF00412, LIM, 1 hit
PRINTSiPR00889, CALPONIN
PR00888, SM22CALPONIN
SMARTiView protein in SMART
SM00033, CH, 1 hit
SM00132, LIM, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit
PS00478, LIM_DOMAIN_1, 1 hit
PS50023, LIM_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIMC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPQ0
Secondary accession number(s): A8MXC3
, E9PHM7, Q503B5, Q5CZB1, Q5CZB6, Q5H9S8, Q68E07, Q6PJ44, Q7Z3G5, Q8N3S9, Q8N6M2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 18, 2010
Last modified: April 7, 2021
This is version 150 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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