UniProtKB - Q9UPN9 (TRI33_HUMAN)
E3 ubiquitin-protein ligase TRIM33
TRIM33
Functioni
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity).
Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
By similarity4 PublicationsCatalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 217 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 220 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 241 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 245 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 276 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 279 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 299 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 304 | Zinc 2PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 125 – 154 | RING-typePROSITE-ProRule annotationAdd BLAST | 30 | |
Zinc fingeri | 212 – 259 | B box-type 1PROSITE-ProRule annotationAdd BLAST | 48 | |
Zinc fingeri | 271 – 312 | B box-type 2PROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 887 – 934 | PHD-typePROSITE-ProRule annotationAdd BLAST | 48 |
GO - Molecular functioni
- co-SMAD binding Source: BHF-UCL
- DNA binding Source: UniProtKB-KW
- R-SMAD binding Source: BHF-UCL
- ubiquitin-protein transferase activity Source: Reactome
- zinc ion binding Source: InterPro
GO - Biological processi
- negative regulation of BMP signaling pathway Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: Reactome
- protein ubiquitination Source: UniProtKB
- regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
Keywordsi
Molecular function | DNA-binding, Repressor, Transferase |
Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9UPN9 |
Reactomei | R-HSA-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity |
SignaLinki | Q9UPN9 |
SIGNORi | Q9UPN9 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase TRIM33 (EC:2.3.2.27)Alternative name(s): Ectodermin homolog RET-fused gene 7 protein Short name: Protein Rfg7 RING-type E3 ubiquitin transferase TRIM33Curated Transcription intermediary factor 1-gamma Short name: TIF1-gamma Tripartite motif-containing protein 33 |
Gene namesi | Name:TRIM33 Synonyms:KIAA1113, RFG7, TIF1G |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16290, TRIM33 |
MIMi | 605769, gene |
neXtProti | NX_Q9UPN9 |
VEuPathDBi | HostDB:ENSG00000197323 |
Subcellular locationi
Nucleus
- Nucleus 3 Publications
Note: In discrete nuclear dots resembling nuclear bodies.By similarity
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 125 | C → A: Abolishes E3 activity but does not affect interaction with SMAD4; when associated with A-128. 1 Publication | 1 | |
Mutagenesisi | 128 | C → A: Abolishes E3 activity but does not affect interaction with SMAD4; when associated with A-125. 1 Publication | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 964 – 965 | Breakpoint for translocation to form TRIM33-RET oncogene | 2 |
Organism-specific databases
DisGeNETi | 51592 |
MalaCardsi | TRIM33 |
OpenTargetsi | ENSG00000197323 |
Orphaneti | 146, Differentiated thyroid carcinoma |
PharmGKBi | PA38118 |
Miscellaneous databases
Pharosi | Q9UPN9, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2176772 |
Genetic variation databases
BioMutai | TRIM33 |
DMDMi | 313104270 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056395 | 1 – 1127 | E3 ubiquitin-protein ligase TRIM33Add BLAST | 1127 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 329 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 334 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 481 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 504 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 515 | Asymmetric dimethylarginine; alternateCombined sources | 1 | |
Modified residuei | 515 | Omega-N-methylarginine; alternateCombined sources | 1 | |
Cross-linki | 527 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 535 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 577 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 591 | Asymmetric dimethylarginine; alternateBy similarity | 1 | |
Modified residuei | 591 | Omega-N-methylarginine; alternateCombined sources | 1 | |
Modified residuei | 598 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 604 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 763 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 763 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 769 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 769 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 774 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 776 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 776 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 793 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 793 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 793 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 796 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 803 | PhosphoserineBy similarity | 1 | |
Modified residuei | 815 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 861 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 862 | PhosphoserineCombined sources | 1 | |
Modified residuei | 951 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 953 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 953 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 1007 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1043 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1051 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 1057 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1102 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1105 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1118 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 1119 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9UPN9 |
jPOSTi | Q9UPN9 |
MassIVEi | Q9UPN9 |
MaxQBi | Q9UPN9 |
PaxDbi | Q9UPN9 |
PeptideAtlasi | Q9UPN9 |
PRIDEi | Q9UPN9 |
ProteomicsDBi | 85392 [Q9UPN9-1] 85393 [Q9UPN9-2] |
PTM databases
GlyGeni | Q9UPN9, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UPN9 |
PhosphoSitePlusi | Q9UPN9 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000197323, Expressed in endometrium epithelium and 255 other tissues |
ExpressionAtlasi | Q9UPN9, baseline and differential |
Genevisiblei | Q9UPN9, HS |
Organism-specific databases
HPAi | ENSG00000197323, Low tissue specificity |
Interactioni
Subunit structurei
Homooligomer and heterooligomer with TRIM24 and TRIM28 family members.
Interacts with SMAD4 in unstimulated cells.
Found in a complex with SMAD2 and SMAD3 upon addition of TGF-beta.
Interacts with SMAD2 and SMAD3.
Interacts with SMAD4 under basal and induced conditions and, upon TGF-beta signaling, with activated SMAD2.
Forms a ternary complex with SMAD4 and SMAD2 upon TGF-beta signaling.
5 PublicationsBinary interactionsi
GO - Molecular functioni
- co-SMAD binding Source: BHF-UCL
- R-SMAD binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 119625, 227 interactors |
CORUMi | Q9UPN9 |
DIPi | DIP-54262N |
IntActi | Q9UPN9, 85 interactors |
MINTi | Q9UPN9 |
STRINGi | 9606.ENSP00000351250 |
Chemistry databases
BindingDBi | Q9UPN9 |
Miscellaneous databases
RNActi | Q9UPN9, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9UPN9 |
SMRi | Q9UPN9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 974 – 1046 | BromoPROSITE-ProRule annotationAdd BLAST | 73 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 147 | Necessary for E3 ubiquitin-protein ligase activity and repression of SMAD4 signaling and transcriptional repressionAdd BLAST | 147 | |
Regioni | 1 – 118 | DisorderedSequence analysisAdd BLAST | 118 | |
Regioni | 299 – 401 | Necessary for oligomerizationAdd BLAST | 103 | |
Regioni | 536 – 563 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 608 – 629 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 673 – 692 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 703 – 818 | DisorderedSequence analysisAdd BLAST | 116 | |
Regioni | 1088 – 1127 | DisorderedSequence analysisAdd BLAST | 40 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 299 – 401 | Sequence analysisAdd BLAST | 103 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 100 – 118 | Pro residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 703 – 774 | Polar residuesSequence analysisAdd BLAST | 72 | |
Compositional biasi | 1106 – 1127 | Basic and acidic residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 125 – 154 | RING-typePROSITE-ProRule annotationAdd BLAST | 30 | |
Zinc fingeri | 212 – 259 | B box-type 1PROSITE-ProRule annotationAdd BLAST | 48 | |
Zinc fingeri | 271 – 312 | B box-type 2PROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 887 – 934 | PHD-typePROSITE-ProRule annotationAdd BLAST | 48 |
Keywords - Domaini
Bromodomain, Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000156361 |
InParanoidi | Q9UPN9 |
OMAi | WCVECEE |
OrthoDBi | 756911at2759 |
PhylomeDBi | Q9UPN9 |
TreeFami | TF106455 |
Family and domain databases
Gene3Di | 1.20.920.10, 1 hit 3.30.40.10, 2 hits |
IDEALi | IID00505 |
InterProi | View protein in InterPro IPR003649, Bbox_C IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR019786, Zinc_finger_PHD-type_CS IPR027370, Znf-RING_LisH IPR000315, Znf_B-box IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00439, Bromodomain, 1 hit PF00628, PHD, 1 hit PF00643, zf-B_box, 1 hit PF13445, zf-RING_UBOX, 1 hit |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00502, BBC, 1 hit SM00336, BBOX, 2 hits SM00297, BROMO, 1 hit SM00249, PHD, 2 hits SM00184, RING, 2 hits |
SUPFAMi | SSF47370, SSF47370, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50014, BROMODOMAIN_2, 1 hit PS50119, ZF_BBOX, 2 hits PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAENKGGGEA ESGGGGSGSA PVTAGAAGPA AQEAEPPLTA VLVEEEEEEG
60 70 80 90 100
GRAGAEGGAA GPDDGGVAAA SSGSAQAASS PAASVGTGVA GGAVSTPAPA
110 120 130 140 150
PASAPAPGPS AGPPPGPPAS LLDTCAVCQQ SLQSRREAEP KLLPCLHSFC
160 170 180 190 200
LRCLPEPERQ LSVPIPGGSN GDIQQVGVIR CPVCRQECRQ IDLVDNYFVK
210 220 230 240 250
DTSEAPSSSD EKSEQVCTSC EDNASAVGFC VECGEWLCKT CIEAHQRVKF
260 270 280 290 300
TKDHLIRKKE DVSESVGASG QRPVFCPVHK QEQLKLFCET CDRLTCRDCQ
310 320 330 340 350
LLEHKEHRYQ FLEEAFQNQK GAIENLLAKL LEKKNYVHFA ATQVQNRIKE
360 370 380 390 400
VNETNKRVEQ EIKVAIFTLI NEINKKGKSL LQQLENVTKE RQMKLLQQQN
410 420 430 440 450
DITGLSRQVK HVMNFTNWAI ASGSSTALLY SKRLITFQLR HILKARCDPV
460 470 480 490 500
PAANGAIRFH CDPTFWAKNV VNLGNLVIES KPAPGYTPNV VVGQVPPGTN
510 520 530 540 550
HISKTPGQIN LAQLRLQHMQ QQVYAQKHQQ LQQMRMQQPP APVPTTTTTT
560 570 580 590 600
QQHPRQAAPQ MLQQQPPRLI SVQTMQRGNM NCGAFQAHQM RLAQNAARIP
610 620 630 640 650
GIPRHSGPQY SMMQPHLQRQ HSNPGHAGPF PVVSVHNTTI NPTSPTTATM
660 670 680 690 700
ANANRGPTSP SVTAIELIPS VTNPENLPSL PDIPPIQLED AGSSSLDNLL
710 720 730 740 750
SRYISGSHLP PQPTSTMNPS PGPSALSPGS SGLSNSHTPV RPPSTSSTGS
760 770 780 790 800
RGSCGSSGRT AEKTSLSFKS DQVKVKQEPG TEDEICSFSG GVKQEKTEDG
810 820 830 840 850
RRSACMLSSP ESSLTPPLST NLHLESELDA LASLENHVKI EPADMNESCK
860 870 880 890 900
QSGLSSLVNG KSPIRSLMHR SARIGGDGNN KDDDPNEDWC AVCQNGGDLL
910 920 930 940 950
CCEKCPKVFH LTCHVPTLLS FPSGDWICTF CRDIGKPEVE YDCDNLQHSK
960 970 980 990 1000
KGKTAQGLSP VDQRKCERLL LYLYCHELSI EFQEPVPASI PNYYKIIKKP
1010 1020 1030 1040 1050
MDLSTVKKKL QKKHSQHYQI PDDFVADVRL IFKNCERFNE MMKVVQVYAD
1060 1070 1080 1090 1100
TQEINLKADS EVAQAGKAVA LYFEDKLTEI YSDRTFAPLP EFEQEEDDGE
1110 1120
VTEDSDEDFI QPRRKRLKSD ERPVHIK
The sequence of this isoform differs from the canonical sequence as follows:
1041-1057: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0Y612 | H0Y612_HUMAN | E3 ubiquitin-protein ligase TRIM33 | TRIM33 | 888 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 89 | V → E in CAB55313 (PubMed:10439047).Curated | 1 | |
Sequence conflicti | 451 – 453 | PAA → LLH in CAB55313 (PubMed:10439047).Curated | 3 | |
Sequence conflicti | 909 | F → S in CAB55313 (PubMed:10439047).Curated | 1 | |
Sequence conflicti | 1037 | R → T in AAD17259 (PubMed:10022127).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029494 | 67 | V → A. Corresponds to variant dbSNP:rs6691166Ensembl. | 1 | |
Natural variantiVAR_042376 | 580 | M → I in a glioblastoma multiforme sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042377 | 696 | L → S1 PublicationCorresponds to variant dbSNP:rs56151583Ensembl. | 1 | |
Natural variantiVAR_042378 | 811 | E → K in a lung adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_024616 | 840 | I → T4 PublicationsCorresponds to variant dbSNP:rs6537825Ensembl. | 1 | |
Natural variantiVAR_042379 | 885 | P → S in a glioblastoma multiforme sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_042380 | 961 | V → M1 PublicationCorresponds to variant dbSNP:rs55688622Ensembl. | 1 | |
Natural variantiVAR_042381 | 1090 | P → T1 PublicationCorresponds to variant dbSNP:rs55784699Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005774 | 1041 – 1057 | Missing in isoform Beta. 2 PublicationsAdd BLAST | 17 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF119043 mRNA Translation: AAD17259.1 Frameshift. AF220136 mRNA Translation: AAG53509.1 AF220137 mRNA Translation: AAG53510.1 AB029036 mRNA Translation: BAA83065.1 Different initiation. AL035410 Genomic DNA No translation available. AL390241 Genomic DNA No translation available. AJ132948 mRNA Translation: CAB55313.1 |
CCDSi | CCDS872.1 [Q9UPN9-1] CCDS873.1 [Q9UPN9-2] |
RefSeqi | NP_056990.3, NM_015906.3 [Q9UPN9-1] NP_148980.2, NM_033020.2 [Q9UPN9-2] |
Genome annotation databases
Ensembli | ENST00000358465.7; ENSP00000351250.2; ENSG00000197323.12 ENST00000369543.6; ENSP00000358556.2; ENSG00000197323.12 [Q9UPN9-2] |
GeneIDi | 51592 |
KEGGi | hsa:51592 |
MANE-Selecti | ENST00000358465.7; ENSP00000351250.2; NM_015906.4; NP_056990.3 |
UCSCi | uc001eew.3, human [Q9UPN9-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF119043 mRNA Translation: AAD17259.1 Frameshift. AF220136 mRNA Translation: AAG53509.1 AF220137 mRNA Translation: AAG53510.1 AB029036 mRNA Translation: BAA83065.1 Different initiation. AL035410 Genomic DNA No translation available. AL390241 Genomic DNA No translation available. AJ132948 mRNA Translation: CAB55313.1 |
CCDSi | CCDS872.1 [Q9UPN9-1] CCDS873.1 [Q9UPN9-2] |
RefSeqi | NP_056990.3, NM_015906.3 [Q9UPN9-1] NP_148980.2, NM_033020.2 [Q9UPN9-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3U5M | X-ray | 3.08 | A/B/C/D/E/F/G/H/I/J/K/L | 882-1087 | [»] | |
3U5N | X-ray | 1.95 | A/B | 882-1087 | [»] | |
3U5O | X-ray | 2.70 | A/B/C/D/E/F/G/H | 882-1087 | [»] | |
3U5P | X-ray | 2.80 | A/B/C/D/E/F/G/H | 882-1087 | [»] | |
5MR8 | X-ray | 1.74 | A | 882-1090 | [»] | |
AlphaFoldDBi | Q9UPN9 | |||||
SMRi | Q9UPN9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119625, 227 interactors |
CORUMi | Q9UPN9 |
DIPi | DIP-54262N |
IntActi | Q9UPN9, 85 interactors |
MINTi | Q9UPN9 |
STRINGi | 9606.ENSP00000351250 |
Chemistry databases
BindingDBi | Q9UPN9 |
ChEMBLi | CHEMBL2176772 |
PTM databases
GlyGeni | Q9UPN9, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9UPN9 |
PhosphoSitePlusi | Q9UPN9 |
Genetic variation databases
BioMutai | TRIM33 |
DMDMi | 313104270 |
Proteomic databases
EPDi | Q9UPN9 |
jPOSTi | Q9UPN9 |
MassIVEi | Q9UPN9 |
MaxQBi | Q9UPN9 |
PaxDbi | Q9UPN9 |
PeptideAtlasi | Q9UPN9 |
PRIDEi | Q9UPN9 |
ProteomicsDBi | 85392 [Q9UPN9-1] 85393 [Q9UPN9-2] |
Protocols and materials databases
ABCDi | Q9UPN9, 1 sequenced antibody |
Antibodypediai | 1303, 425 antibodies from 36 providers |
DNASUi | 51592 |
Genome annotation databases
Ensembli | ENST00000358465.7; ENSP00000351250.2; ENSG00000197323.12 ENST00000369543.6; ENSP00000358556.2; ENSG00000197323.12 [Q9UPN9-2] |
GeneIDi | 51592 |
KEGGi | hsa:51592 |
MANE-Selecti | ENST00000358465.7; ENSP00000351250.2; NM_015906.4; NP_056990.3 |
UCSCi | uc001eew.3, human [Q9UPN9-1] |
Organism-specific databases
CTDi | 51592 |
DisGeNETi | 51592 |
GeneCardsi | TRIM33 |
HGNCi | HGNC:16290, TRIM33 |
HPAi | ENSG00000197323, Low tissue specificity |
MalaCardsi | TRIM33 |
MIMi | 605769, gene |
neXtProti | NX_Q9UPN9 |
OpenTargetsi | ENSG00000197323 |
Orphaneti | 146, Differentiated thyroid carcinoma |
PharmGKBi | PA38118 |
VEuPathDBi | HostDB:ENSG00000197323 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000156361 |
InParanoidi | Q9UPN9 |
OMAi | WCVECEE |
OrthoDBi | 756911at2759 |
PhylomeDBi | Q9UPN9 |
TreeFami | TF106455 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q9UPN9 |
Reactomei | R-HSA-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity |
SignaLinki | Q9UPN9 |
SIGNORi | Q9UPN9 |
Miscellaneous databases
BioGRID-ORCSi | 51592, 35 hits in 1139 CRISPR screens |
ChiTaRSi | TRIM33, human |
GeneWikii | TRIM33 |
GenomeRNAii | 51592 |
Pharosi | Q9UPN9, Tchem |
PROi | PR:Q9UPN9 |
RNActi | Q9UPN9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197323, Expressed in endometrium epithelium and 255 other tissues |
ExpressionAtlasi | Q9UPN9, baseline and differential |
Genevisiblei | Q9UPN9, HS |
Family and domain databases
Gene3Di | 1.20.920.10, 1 hit 3.30.40.10, 2 hits |
IDEALi | IID00505 |
InterProi | View protein in InterPro IPR003649, Bbox_C IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR019786, Zinc_finger_PHD-type_CS IPR027370, Znf-RING_LisH IPR000315, Znf_B-box IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00439, Bromodomain, 1 hit PF00628, PHD, 1 hit PF00643, zf-B_box, 1 hit PF13445, zf-RING_UBOX, 1 hit |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00502, BBC, 1 hit SM00336, BBOX, 2 hits SM00297, BROMO, 1 hit SM00249, PHD, 2 hits SM00184, RING, 2 hits |
SUPFAMi | SSF47370, SSF47370, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50014, BROMODOMAIN_2, 1 hit PS50119, ZF_BBOX, 2 hits PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRI33_HUMAN | |
Accessioni | Q9UPN9Primary (citable) accession number: Q9UPN9 Secondary accession number(s): O95855 Q9UJ79 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | November 30, 2010 | |
Last modified: | May 25, 2022 | |
This is version 206 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families