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Protein

Serine/threonine-protein phosphatase 6 regulatory subunit 1

Gene

PPP6R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein phosphatase binding Source: MGI
  • Rho GTPase binding Source: UniProtKB

GO - Biological processi

  • COPII vesicle coating Source: Reactome
  • regulation of phosphoprotein phosphatase activity Source: MGI

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204005 COPII-mediated vesicle transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory subunit 1
Alternative name(s):
SAPS domain family member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP6R1
Synonyms:KIAA1115, PP6R1, SAPS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000105063.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29195 PPP6R1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610875 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UPN7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000105063

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165394108

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP6R1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
261260102

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000460961 – 881Serine/threonine-protein phosphatase 6 regulatory subunit 1Add BLAST881

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei232PhosphoserineBy similarity1
Modified residuei524PhosphothreonineCombined sources1
Modified residuei529PhosphoserineCombined sources1
Modified residuei530PhosphoserineCombined sources1
Modified residuei531PhosphoserineCombined sources1
Modified residuei635PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei702PhosphoserineCombined sources1
Modified residuei726PhosphoserineCombined sources1
Modified residuei759PhosphoserineCombined sources1
Modified residuei846PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UPN7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9UPN7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UPN7

PeptideAtlas

More...
PeptideAtlasi
Q9UPN7

PRoteomics IDEntifications database

More...
PRIDEi
Q9UPN7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85391

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UPN7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UPN7

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q9UPN7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous with higher expression in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105063 Expressed in 93 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_SAPS1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UPN7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UPN7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043989
HPA063681

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed of the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6C and NFKBIE. Interacts with ANKRD28, ANKRD44 and ANKRD52.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116537, 71 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9UPN7

Database of interacting proteins

More...
DIPi
DIP-27589N

Protein interaction database and analysis system

More...
IntActi
Q9UPN7, 60 interactors

Molecular INTeraction database

More...
MINTi
Q9UPN7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000414202

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9UPN7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni10 – 403Interaction with PPP6CAdd BLAST394

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi624 – 685Glu-richAdd BLAST62
Compositional biasi624 – 631Poly-Glu8
Compositional biasi671 – 685Poly-GluAdd BLAST15
Compositional biasi697 – 878Pro-richAdd BLAST182

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SAPS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2073 Eukaryota
ENOG410XRM1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009899

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG069733

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UPN7

KEGG Orthology (KO)

More...
KOi
K15499

Identification of Orthologs from Complete Genome Data

More...
OMAi
CFHQLLL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0893

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UPN7

TreeFam database of animal gene trees

More...
TreeFami
TF313227

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR007587 SAPS

The PANTHER Classification System

More...
PANTHERi
PTHR12634 PTHR12634, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04499 SAPS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9UPN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFWKFDLHTS SHLDTLLERE DLSLPELLDE EDVLQECKVV NRKLLDFLLQ
60 70 80 90 100
PPHLQAMVAW VTQEPPDSGE ERLRYKYPSV ACEILTSDVP QINDALGADE
110 120 130 140 150
SLLNRLYGFL QSTGSLNPLL ASFFSKVMGI LINRKTDQLV SFLRKKDDFV
160 170 180 190 200
DLLLQHIGTS AIMDLLLRLL TCVERPQLRQ DVVNWLNEEK IVQRLIEQIH
210 220 230 240 250
PSKDENQHSN ASQSLCDIIR LSREQMIQVQ DSPEPDQLLA TLEKQETIEQ
260 270 280 290 300
LLSNMFEGEQ SQSVIVSGIQ VLLTLLEPRR PRSESVTVNS FFSSVDGQLE
310 320 330 340 350
LLAQGALEST VSSVGALHAL RPRLSCFHQL LLEPPKLEPL QMTWGMLAPP
360 370 380 390 400
LGNTRLHVVK LLASALSAND AALTHELLAL DVPNTMLDLF FHYVFNNFLH
410 420 430 440 450
AQVEGCVSTM LSLGPPPDSS PETPIQNPVV KHLLQQCRLV ERILTSWEEN
460 470 480 490 500
DRVQCAGGPR KGYMGHLTRV AGALVQNTEK GPNAEQLRQL LKELPSEQQE
510 520 530 540 550
QWEAFVSGPL AETNKKNMVD LVNTHHLHSS SDDEDDRLKE FNFPEEAVLQ
560 570 580 590 600
QAFMDFQMQR MTSAFIDHFG FNDEEFGEQE ESVNAPFDKT ANITFSLNAD
610 620 630 640 650
DENPNANLLE ICYKDRIQQF DDDEEEEDEE EAQGSGESDG EDGAWQGSQL
660 670 680 690 700
ARGARLGQPP GVRSGGSTDS EDEEEEDEEE EEDEEGIGCA ARGGATPLSY
710 720 730 740 750
PSPGPQPPGP SWTATFDPVP TDAPTSPRVS GEEELHTGPP APQGPLSVPQ
760 770 780 790 800
GLPTQSLASP PARDALQLRS QDPTPPSAPQ EATEGSKVTE PSAPCQALVS
810 820 830 840 850
IGDLQATFHG IRSAPSSSDS ATRDPSTSVP ASGAHQPPQT TEGEKSPEPL
860 870 880
GLPQSQSAQA LTPPPIPNGS APEGPASPGS Q
Length:881
Mass (Da):96,724
Last modified:October 13, 2009 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36DDA2E945ED599A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EM28K7EM28_HUMAN
Serine/threonine-protein phosphatas...
PPP6R1
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA83067 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB029038 mRNA Translation: BAA83067.3 Different initiation.
BC002799 mRNA Translation: AAH02799.2
BC068014 mRNA Translation: AAH68014.1
BC094753 mRNA Translation: AAH94753.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46186.1

NCBI Reference Sequences

More...
RefSeqi
NP_055746.3, NM_014931.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.515610

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000412770; ENSP00000414202; ENSG00000105063
ENST00000587283; ENSP00000467521; ENSG00000105063

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22870

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22870

UCSC genome browser

More...
UCSCi
uc002qjw.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029038 mRNA Translation: BAA83067.3 Different initiation.
BC002799 mRNA Translation: AAH02799.2
BC068014 mRNA Translation: AAH68014.1
BC094753 mRNA Translation: AAH94753.2
CCDSiCCDS46186.1
RefSeqiNP_055746.3, NM_014931.3
UniGeneiHs.515610

3D structure databases

ProteinModelPortaliQ9UPN7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116537, 71 interactors
CORUMiQ9UPN7
DIPiDIP-27589N
IntActiQ9UPN7, 60 interactors
MINTiQ9UPN7
STRINGi9606.ENSP00000414202

PTM databases

iPTMnetiQ9UPN7
PhosphoSitePlusiQ9UPN7

Polymorphism and mutation databases

BioMutaiPPP6R1
DMDMi261260102

Proteomic databases

EPDiQ9UPN7
MaxQBiQ9UPN7
PaxDbiQ9UPN7
PeptideAtlasiQ9UPN7
PRIDEiQ9UPN7
ProteomicsDBi85391

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412770; ENSP00000414202; ENSG00000105063
ENST00000587283; ENSP00000467521; ENSG00000105063
GeneIDi22870
KEGGihsa:22870
UCSCiuc002qjw.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22870
EuPathDBiHostDB:ENSG00000105063.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPP6R1
HGNCiHGNC:29195 PPP6R1
HPAiHPA043989
HPA063681
MIMi610875 gene
neXtProtiNX_Q9UPN7
OpenTargetsiENSG00000105063
PharmGKBiPA165394108

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2073 Eukaryota
ENOG410XRM1 LUCA
GeneTreeiENSGT00390000009899
HOVERGENiHBG069733
InParanoidiQ9UPN7
KOiK15499
OMAiCFHQLLL
OrthoDBiEOG091G0893
PhylomeDBiQ9UPN7
TreeFamiTF313227

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPP6R1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22870
PMAP-CutDBiQ9UPN7

Protein Ontology

More...
PROi
PR:Q9UPN7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105063 Expressed in 93 organ(s), highest expression level in testis
CleanExiHS_SAPS1
ExpressionAtlasiQ9UPN7 baseline and differential
GenevisibleiQ9UPN7 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR007587 SAPS
PANTHERiPTHR12634 PTHR12634, 1 hit
PfamiView protein in Pfam
PF04499 SAPS, 2 hits
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPP6R1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UPN7
Secondary accession number(s): Q2M2H3
, Q504V2, Q6NVJ6, Q9BU97
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 13, 2009
Last modified: December 5, 2018
This is version 154 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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